Compounds > atropine
Page last updated: 2024-09-05

atropine and wortmannin

atropine has been researched along with wortmannin in 5 studies

Compound Research Comparison

Studies
(atropine)		Trials
(atropine)		Recent Studies (post-2010)
(atropine)		Studies
(wortmannin)		Trials
(wortmannin)		Recent Studies (post-2010) (wortmannin)
26,7111,2591,6974,0662726

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)wortmannin (IC50)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)0.0465
Myosin light chain kinase, smooth muscleGallus gallus (chicken)0.26
Metabotropic glutamate receptor 1Rattus norvegicus (Norway rat)0.0085
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)0.2368
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)0.1309
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)0.0493
Serine/threonine-protein kinase mTORHomo sapiens (human)0.04
Phosphatidylinositol 4-kinase alphaHomo sapiens (human)0.28
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)0.0492
Serine/threonine-protein kinase PLK1Homo sapiens (human)0.4433
Myosin light chain kinase, smooth muscleHomo sapiens (human)2.3567
Phosphoinositide 3-kinase regulatory subunit 5Homo sapiens (human)0.019
Serine/threonine-protein kinase PLK3Homo sapiens (human)0.1057
Phosphatidylinositol 4-kinase betaHomo sapiens (human)0.44

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Challiss, RA; Nahorski, SR; Willars, GB1
Benoit, JN; Cohen, MV; Downey, JM; Oldenburg, O; Qin, Q; Sharma, AR1
Brink, CB; de Kock, SE; Harvey, BH; Stein, DJ; Viljoen, SL1

Other Studies

5 other study(ies) available for atropine and wortmannin

ArticleYear
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells.
    The Journal of biological chemistry, 1998, Feb-27, Volume: 273, Issue:9

    Topics: Androstadienes; Atropine; Carbachol; Cations, Monovalent; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Sympathetic; Hydrolysis; Inositol 1,4,5-Trisphosphate; Lithium; Morpholines; Muscarinic Agonists; Muscarinic Antagonists; Neuroblastoma; Neurons; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Receptor, Muscarinic M3; Receptors, Muscarinic; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases; Wortmannin

1998
Acetylcholine leads to free radical production dependent on K(ATP) channels, G(i) proteins, phosphatidylinositol 3-kinase and tyrosine kinase.
    Cardiovascular research, 2002, Aug-15, Volume: 55, Issue:3

    Topics: Acetylcholine; Analysis of Variance; Androstadienes; Animals; Aorta; Atropine; Cell Line; Decanoic Acids; Diazoxide; Enzyme Inhibitors; Female; Free Radical Scavengers; Genistein; GTP-Binding Protein alpha Subunits, Gi-Go; Hydroxy Acids; Ionophores; Ischemic Preconditioning; Male; Methacholine Chloride; Microscopy, Fluorescence; Muscarinic Agonists; Muscle, Smooth, Vascular; Perfusion; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Potassium Channel Blockers; Potassium Channels; Protein-Tyrosine Kinases; Rabbits; Rats; Reactive Oxygen Species; Receptors, Cholinergic; Signal Transduction; Tiopronin; Valinomycin; Wortmannin

2002
Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells.
    Metabolic brain disease, 2004, Volume: 19, Issue:1-2

    Topics: Adrenergic Uptake Inhibitors; Androstadienes; Atropine; Cell Line, Tumor; Enzyme Inhibitors; Estrenes; Fluoxetine; Humans; Imipramine; Inositol; Muscarinic Antagonists; Neuroblastoma; Phosphatidylinositols; Phosphodiesterase Inhibitors; Pyrrolidinones; Receptor, Serotonin, 5-HT2A; Receptors, Muscarinic; Selective Serotonin Reuptake Inhibitors; Tritium; Wortmannin

2004