Page last updated: 2024-09-05

atropine and vx

atropine has been researched along with vx in 37 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(vx)
Trials
(vx)
Recent Studies (post-2010) (vx)
26,7111,2591,6974764206

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.41)18.7374
1990's12 (32.43)18.2507
2000's7 (18.92)29.6817
2010's12 (32.43)24.3611
2020's4 (10.81)2.80

Authors

AuthorsStudies
Dettbarn, WD; Gupta, RC1
Anderson, DR; Harris, LW; Koplovitz, I; Lennox, WJ; Stewart, JR1
Fiekers, JF; Heppner, TJ1
Anderson, DR; Harris, LW; Lennox, WJ; Solana, RP; Talbot, BG1
Albuquerque, EX; Aracava, Y; Boyne, AF; Deshpande, SS; Idriss, M; Kawabuchi, M; Rickett, DL1
Tanasijević, D1
Szinicz, L; Worek, F1
Kirchner, T; Szinicz, L; Worek, F1
Koplovitz, I; Stewart, JR1
Dube, SN; Kumar, D; Mazumder, PK1
Kassa, J; Vachek, J1
Albuquerque, EX; Aracava, Y; Chebabo, SR; Rocha, ES; Santos, MD1
Cao, CJ; Eldefrawi, AT; Eldefrawi, ME; Katz, EJ; Menking, DE; Mioduszewski, RJ; Valdes, JJ1
Anderson, RS; Broomfield, CA; Duysen, EG; Li, B; Lockridge, O; Schopfer, LM; Xie, W1
Benschop, HP; Lander, BJ; Langenberg, JP; van der Schans, MJ; van der Wiel, H1
Newmark, J1
Barak, D; Pittel, Z; Segall, Y1
Hrobak, PK1
Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F1
Clark, MG; Finneran, K; Hilmas, CJ; Poole, MJ; Williams, PT1
Cui, W; Ge, X; Luo, W; Wang, H1
Joosen, MJ; van der Schans, MJ; van Helden, HP1
Bohnert, S; Mikler, J; Reiter, G; Sawyer, TW; Tenn, C; Thiermann, H; Weatherby, K; Worek, F1
Bajgar, J; Caisberger, F; Karasova, JZ; Kassa, J; Sepsova, V1
Armstrong, SJ; Docx, CJ; Green, AC; Mumford, H; Price, ME; Tattersall, JE1
Kehe, K; Thiermann, H; Worek, F1
Armstrong, SJ; Green, AC; Mann, TM; Price, ME; Rice, H; Tattersall, JEH1
Babin, MC; Jett, DA; Platoff, GE; Snider, TH; Yeung, DT1
Egoz, I; Gore, A; Grauer, E; Nili, U1
Armstrong, SJ; Cook, AR; Emery, E; Flint, D; Mann, T; Price, ME; Rice, H; Roughley, N; Stubbs, S; Tattersall, JEH; Whitmore, C1
Emery, ER; Green, AC; Laws, TR; Mann, TM; McColm, RR; Perrott, RL; Price, ME; Rice, H; Tattersall, JEH; Whitmore, CL1
Bloch-Shilderman, E; Cohen, L; Egoz, I; Gez, R; Gutman, H; Nili, U; Rabinovitz, I; Yacov, G1
Barry, J; Bohnert, S; Cochrane, L; Cornelissen, AS; Joosen, MJA; Kentrop, J; Klaassen, SD; Savransky, V; van Groningen, T1
Bucht, A; Forsberg, E; Thors, L; Wigenstam, E1
Cornelissen, AS; Garcia, EE; Joosen, MJA; Laney, J; Raulli, RE1
Artursson, E; Bucht, A; Thors, L; Wigenstam, E1

Reviews

2 review(s) available for atropine and vx

ArticleYear
Therapy for nerve agent poisoning.
    Archives of neurology, 2004, Volume: 61, Issue:5

    Topics: Antidotes; Atropine; Chemical Warfare Agents; Humans; Neurotoxicity Syndromes; Neurotoxins; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Soman

2004
Limitations and challenges in treatment of acute chemical warfare agent poisoning.
    Chemico-biological interactions, 2013, Dec-05, Volume: 206, Issue:3

    Topics: Antidotes; Atropine; Chemical Warfare; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Mustard Gas; Organothiophosphorus Compounds; Oximes; Sarin

2013

Other Studies

35 other study(ies) available for atropine and vx

ArticleYear
Potential of memantine, D-tubocurarine, and atropine in preventing acute toxic myopathy induced by organophosphate nerve agents: soman, sarin, tabun and VX.
    Neurotoxicology, 1992,Fall, Volume: 13, Issue:3

    Topics: Acetylcholinesterase; Acute Disease; Animals; Atropine; Cholinesterase Inhibitors; Male; Memantine; Muscular Diseases; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman; Tubocurarine

1992
Reduction by pyridostigmine pretreatment of the efficacy of atropine and 2-PAM treatment of sarin and VX poisoning in rodents.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1992, Volume: 18, Issue:1

    Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin

1992
The effects of irreversible acetylcholinesterase inhibitors on transmission through sympathetic ganglia of the bullfrog.
    Neuropharmacology, 1991, Volume: 30, Issue:8

    Topics: Acetylcholine; Action Potentials; Animals; Atropine; Carbachol; Cholinesterase Inhibitors; Ganglia, Sympathetic; Organothiophosphorus Compounds; Rana catesbeiana; Sarin; Soman; Synaptic Transmission

1991
Physostigmine (alone and together with adjunct) pretreatment against soman, sarin, tabun and VX intoxication.
    Drug and chemical toxicology, 1991, Volume: 14, Issue:3

    Topics: Animals; Atropine; Benztropine; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organothiophosphorus Compounds; Physostigmine; Sarin; Soman; Trihexyphenidyl

1991
Multiple actions of anticholinesterase agents on chemosensitive synapses: molecular basis for prophylaxis and treatment of organophosphate poisoning.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1985, Volume: 5, Issue:6 Pt 2

    Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Female; Ganglionic Blockers; Grasshoppers; In Vitro Techniques; Muscle Contraction; Organophosphate Poisoning; Organothiophosphorus Compounds; Physostigmine; Rana pipiens; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Sarin; Synapses

1985
[The effect of atropine, Hi-6 and diazepam on the levels and metabolism of monoamines in the brain of rats poisoned with VX].
    Godisnjak Vojnomedicinske akademije = Annual of the Military Medical Academy, 1986, Volume: 28

    Topics: Animals; Atropine; Caudate Nucleus; Cholinesterase Inhibitors; Diazepam; Neurotransmitter Agents; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Rats

1986
Cardiorespiratory function in nerve agent poisoned and oxime + atropine treated guinea-pigs: effect of pyridostigmine pretreatment.
    Archives of toxicology, 1995, Volume: 69, Issue:5

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Drug Synergism; Female; Guinea Pigs; Heart Function Tests; Organothiophosphorus Compounds; Oximes; Pyridostigmine Bromide; Respiration; Respiratory Function Tests; Sarin

1995
Treatment of nerve gas poisoning.
    The Medical letter on drugs and therapeutics, 1995, May-12, Volume: 37, Issue:948

    Topics: Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Gases; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Respiratory Protective Devices; Sarin; Soman

1995
Effect of atropine, HLö 7 and HI 6 on respiratory and circulatory function in guinea-pigs poisoned by O-ethyl S-[2-(diisopropylamino) ethyl] methylphosponothioate (VX).
    Pharmacology & toxicology, 1994, Volume: 75, Issue:5

    Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Combinations; Erythrocytes; Female; Guinea Pigs; Hemodynamics; Organothiophosphorus Compounds; Oximes; Poisoning; Pyridines; Pyridinium Compounds; Respiration

1994
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
    Toxicology letters, 1994, Feb-15, Volume: 70, Issue:3

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms

1994
Cardiorespiratory and neuromuscular effects of O-ethyl S--2-(diisopropylamino) ethyl- methylphosphonothioate (VX) in rats.
    Bulletin of environmental contamination and toxicology, 1997, Volume: 59, Issue:2

    Topics: Adrenalectomy; Animals; Atropine; Blood Pressure; Bronchi; Bronchoconstriction; Cardiovascular System; Carotid Arteries; Chemical Warfare Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Heart Rate; Male; Muscle, Skeletal; Neuromuscular Junction; Organothiophosphorus Compounds; Parasympatholytics; Rats; Rats, Wistar; Sympatholytics; Synaptic Transmission; Tolazoline; Trachea; Vagotomy

1997
[The effect of parasympatholytics on the therapeutic effectiveness of the oxime HI-6 against organophosphorus compounds (Soman, substance VX, Fosdrin) in mice].
    Casopis lekaru ceskych, 1997, Feb-12, Volume: 136, Issue:4

    Topics: Animals; Antidotes; Atropine; Benactyzine; Biperiden; Cholinesterase Reactivators; Male; Mevinphos; Mice; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Parasympatholytics; Pyridinium Compounds; Soman

1997
Low concentrations of the organophosphate VX affect spontaneous and evoked transmitter release from hippocampal neurons: toxicological relevance of cholinesterase-independent actions.
    Toxicology and applied pharmacology, 1999, Aug-15, Volume: 159, Issue:1

    Topics: Animals; Atropine; Calcium; Cells, Cultured; Cholinesterases; Dose-Response Relationship, Drug; Electrophysiology; Evoked Potentials; Female; gamma-Aminobutyric Acid; Glutamates; Hippocampus; Neurons; Organophosphorus Compounds; Organothiophosphorus Compounds; Patch-Clamp Techniques; Pregnancy; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetrodotoxin

1999
Cytotoxicity of organophosphate anticholinesterases.
    In vitro cellular & developmental biology. Animal, 1999, Volume: 35, Issue:9

    Topics: Acetylcholinesterase; Atropine; Biotransformation; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Humans; Insecticides; Organothiophosphorus Compounds; Phenobarbital; Receptors, Muscarinic

1999
Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2

    Topics: Acetylcholinesterase; Aging; Animals; Atropine; Behavior, Animal; Body Temperature; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterases; Hair; Hand Strength; Lethal Dose 50; Mice; Mice, Knockout; Motor Activity; Muscarinic Antagonists; Organothiophosphorus Compounds; Tissue Distribution; Tremor; Vasodilation

2001
Toxicokinetics of the nerve agent (+/-)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration.
    Toxicology and applied pharmacology, 2003, Aug-15, Volume: 191, Issue:1

    Topics: Acetylcholinesterase; Administration, Topical; Anesthesia; Animals; Atropine; Callithrix; Chemical Warfare Agents; Chromatography, Gas; Chromatography, High Pressure Liquid; Electrochemistry; Guinea Pigs; Injections, Intravenous; Kinetics; Lethal Dose 50; Male; Muscarinic Antagonists; Organothiophosphorus Compounds; Stereoisomerism

2003
Function-specific blockage of M(1) and M(3) muscarinic acetylcholine receptors by VX and echothiophate.
    Brain research, 2006, Apr-26, Volume: 1085, Issue:1

    Topics: Animals; Atropine; CHO Cells; Cholinesterase Inhibitors; Colforsin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Echothiophate Iodide; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Organothiophosphorus Compounds; Oxotremorine; Phosphatidylinositols; Protein Binding; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Transfection; Tritium

2006
Nerve agents: implications for anesthesia providers.
    AANA journal, 2008, Volume: 76, Issue:2

    Topics: Antidotes; Atropine; Chemical Terrorism; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Humans; Muscarinic Antagonists; Nurse Anesthetists; Nurse's Role; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Sarin; Soman; Time Factors

2008
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
    Toxicology and applied pharmacology, 2008, Sep-01, Volume: 231, Issue:2

    Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2008
Galantamine is a novel post-exposure therapeutic against lethal VX challenge.
    Toxicology and applied pharmacology, 2009, Oct-15, Volume: 240, Issue:2

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Erythrocytes; Galantamine; Guinea Pigs; Male; Muscle Fatigue; Muscle Tonus; Neurotoxicity Syndromes; Organothiophosphorus Compounds; Paralysis; Phrenic Nerve; Pralidoxime Compounds; Seizures; Time Factors

2009
Targeting cholinesterase inhibitor poisoning with a novel blocker against both nicotinic and muscarinic receptors.
    Neurotoxicity research, 2010, Volume: 18, Issue:2

    Topics: Animals; Atropine; Benzilates; Cell Line; Cholinergic Antagonists; Cholinesterase Inhibitors; Guinea Pigs; Membrane Potentials; Mice; Organothiophosphorus Compounds; Patch-Clamp Techniques; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Muscarinic; Receptors, Nicotinic; Sarin

2010
Percutaneous exposure to the nerve agent VX: Efficacy of combined atropine, obidoxime and diazepam treatment.
    Chemico-biological interactions, 2010, Oct-06, Volume: 188, Issue:1

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Diazepam; Guinea Pigs; Obidoxime Chloride; Organothiophosphorus Compounds; Skin

2010
The therapeutic use of localized cooling in the treatment of VX poisoning.
    Toxicology letters, 2011, Jul-04, Volume: 204, Issue:1

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cryotherapy; Male; Organothiophosphorus Compounds; Swine; Time Factors

2011
A comparison of the reactivating and therapeutic efficacy of chosen combinations of oximes with individual oximes against VX in rats and mice.
    International journal of toxicology, 2011, Volume: 30, Issue:5

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Lethal Dose 50; Male; Mice; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime

2011
Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning.
    Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Reactivators; Diazepam; Guinea Pigs; Humans; Injections, Intramuscular; Male; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds

2013
The potential role of bioscavenger in the medical management of nerve-agent poisoned casualties.
    Chemico-biological interactions, 2016, Nov-25, Volume: 259, Issue:Pt B

    Topics: Animals; Atropine; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Reactivators; First Aid; Guinea Pigs; Humans; Military Medicine; Nerve Agents; Organophosphate Poisoning; Organothiophosphorus Compounds

2016
Toxicity and median effective doses of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig.
    The Journal of toxicological sciences, 2016, Volume: 41, Issue:4

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Guinea Pigs; Lethal Dose 50; Male; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pesticides; Pralidoxime Compounds; Pyridinium Compounds; Time Factors

2016
Optimization of the Ocular Treatment Following Organophosphate Nerve Agent Insult.
    Toxicological sciences : an official journal of the Society of Toxicology, 2017, 09-01, Volume: 159, Issue:1

    Topics: Animals; Antidotes; Atropine; Eye; Male; Miosis; Nerve Agents; Organothiophosphorus Compounds; Pupil; Rats; Rats, Long-Evans; Sarin; Tropanes; Vision, Ocular

2017
The efficacy of HI-6 DMS in a sustained infusion against percutaneous VX poisoning in the guinea-pig.
    Toxicology letters, 2018, Sep-01, Volume: 293

    Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Guinea Pigs; Infusions, Intravenous; Male; Muscarinic Antagonists; Nerve Agents; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Survival Analysis

2018
Bioscavenger is effective as a delayed therapeutic intervention following percutaneous VX poisoning in the guinea-pig.
    Toxicology letters, 2018, Sep-01, Volume: 293

    Topics: Administration, Cutaneous; Animals; Antidotes; Atropine; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Reactivators; Cholinesterases; Dipeptides; Guinea Pigs; Male; Muscarinic Antagonists; Nerve Agents; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Time-to-Treatment; Toxicokinetics

2018
Repetitive antidotal treatment is crucial in eliminating eye pathology, respiratory toxicity and death following whole-body VX vapor exposure in freely moving rats.
    Archives of toxicology, 2019, Volume: 93, Issue:5

    Topics: Animals; Antidotes; Atropine; Benactyzine; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Administration Schedule; Drug Combinations; Environmental Exposure; Eye Diseases; Male; Obidoxime Chloride; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Respiratory Tract Diseases; Trimedoxime

2019
Pharmacokinetics and efficacy of atropine sulfate/obidoxime chloride co-formulation against VX in a guinea pig model.
    Regulatory toxicology and pharmacology : RTP, 2021, Volume: 119

    Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Drug Combinations; Guinea Pigs; Male; Muscarinic Antagonists; Obidoxime Chloride; Organothiophosphorus Compounds; Treatment Outcome

2021
Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX.
    Toxicology and applied pharmacology, 2021, 05-15, Volume: 419

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Cholinergic Fibers; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Female; GPI-Linked Proteins; Lung; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Organothiophosphorus Compounds; Rats, Sprague-Dawley; Scopolamine

2021
A delayed treatment model for the evaluation of scopolamine for VX nerve agent intoxication.
    Toxicology and applied pharmacology, 2021, 09-15, Volume: 427

    Topics: Animals; Atropine; Chemical Warfare Agents; Cholinergic Antagonists; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Guinea Pigs; Male; Midazolam; Nerve Agents; Organothiophosphorus Compounds; Pralidoxime Compounds; Scopolamine; Survival Rate; Time-to-Treatment

2021
Pharmacological prophylaxis with pyridostigmine bromide against nerve agents adversely impact on airway function in an
    Toxicology mechanisms and methods, 2023, Volume: 33, Issue:9

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Lung; Nerve Agents; Pyridostigmine Bromide; Rats

2023