Page last updated: 2024-09-05

atropine and tropicamide

atropine has been researched along with tropicamide in 40 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(tropicamide)
Trials
(tropicamide)
Recent Studies (post-2010) (tropicamide)
26,7111,2591,697697148231

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)tropicamide (IC50)
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.105
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.025
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.089
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.281
Cytochrome P450 2C9 Homo sapiens (human)1
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.142
Cytochrome P450 2C19Homo sapiens (human)1

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199010 (25.00)18.7374
1990's5 (12.50)18.2507
2000's15 (37.50)29.6817
2010's8 (20.00)24.3611
2020's2 (5.00)2.80

Authors

AuthorsStudies
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Abu-Oun, S; Baurmann, H; Chioralia, G1
Pecora, JL1
Gray, LG1
Alimgil, ML; Erda, N1
Vogel, R1
Cadera, W; Nishizawa, AR; Orton, RB1
Broussin, B; Daoud, P; Moriette, G; Relier, JP; Ryzman, P; Walti, H1
Banyś, J; Jastrzebska-Bujna, J; Pyzowski, J1
Hiatt, RL; Jerkins, G1
Doughty, CB; Rengstorff, RH1
Dorff, RJ; Gaginella, TS; O'Dorisio, TM; Rimele, TJ1
Dusting, GJ; Loke, KE; Sobey, CG; Woodman, OL1
Goldstein, JH; Schneekloth, BB1
Chou, AC; Ho, TC; Lin, LL; Shih, YF1
Pagano, AP; Parkman, HP; Ryan, JP1
Kwon, SC1
Decraene, T; Goossens, A1
Koh, A; Saw, SM; Shih-Yen, EC; Tan, D1
Au Eong, KG; Gazzard, G; Saw, SM; Tan, DT1
Crittenden, EL; García, DM; González, A1
Fan, DS; Lam, DS; Ng, JS; Rao, SK; Yu, CB1
Harun, S; McCormick, A; Srinivasan, S; Watts, M1
Ebri, A; Kuper, H; Wedner, S1
Chang, JH; Chung, JK; Lee, W; Ohn, YH; Roh, KH1
Chan, SH; Chang, AY; Tsai, CY; Wu, CH1
Betz, AJ; Burgos, M; McLaughlin, PJ; Salamone, JD; Weber, SM1
Eguchi, K; Ohtubo, Y; Yoshii, K1
Iribarren, R1
Kim, JY; Kwag, JY; Lee, DG; Lee, SB1
Chen, WQ; Jun Hu, Y1
Bacon, G; Eiseman, H; Hoehn, AS; Kronberg, BP; Narváez, J; Park, H; Rauser, M; Wong, B; Zimmerman, G; Zumwalt, JR1
Castillo-Alcala, F; Lizarraga, I; Whelan, NC1
Ba, EA; De Medeiros, ME; Diagne, JP; Diallo, HM; Ka, AM; Kane, A; Ndiaye, JM; Ndiaye, MR; Ndiaye, PA; Ndoye Roth, PA; Sow, AS; Wane, AM; Weladji, C1
Bloch-Shilderman, E; Brandeis, R; Egoz, I; Gore, A; Grauer, E; Nili, U; Turetz, J1
Dhillon, ES; Ludwig, J; Sharma, N; Steidl, S1
Grootendorst, DC; Joosse, MV; Schalij-Delfos, NE; van Minderhout, HM1
Angelova, S; Dobrev, S; Dudev, T; Kircheva, N; Nikolova, V; Yordanova, V1
Cheng, X; Huang, J; Li, M; Liu, X; Ouyang, J; Tan, J; Tao, Y; Xie, P; Zhou, Q1

Reviews

4 review(s) available for atropine and tropicamide

ArticleYear
Pharmaceutical agents and the prevention or reduction of progressive myopia.
    Acta ophthalmologica. Supplement, 1988, Volume: 185

    Topics: Atropine; Epinephrine; Humans; Intraocular Pressure; Myopia; Ophthalmic Solutions; Sclera; Timolol; Tropicamide

1988
Mydriatic and cycloplegic drugs: a review of ocular and systemic complications.
    American journal of optometry and physiological optics, 1982, Volume: 59, Issue:2

    Topics: Adolescent; Adult; Aged; Atropine; Autonomic Nervous System Diseases; Child; Child, Preschool; Cyclopentolate; Epinephrine; Eye Diseases; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Mydriatics; Parasympatholytics; Phenylephrine; Pigmentation Disorders; Scopolamine; Sympathomimetics; Tropanes; Tropicamide

1982
Interventions to retard myopia progression in children: an evidence-based update.
    Ophthalmology, 2002, Volume: 109, Issue:3

    Topics: Atropine; Child; Child, Preschool; Contact Lenses, Hydrophilic; Databases, Factual; Disease Progression; Evidence-Based Medicine; Eyeglasses; Humans; Mydriatics; Myopia; Ophthalmic Solutions; Randomized Controlled Trials as Topic; Timolol; Tropicamide

2002
Myopia: attempts to arrest progression.
    The British journal of ophthalmology, 2002, Volume: 86, Issue:11

    Topics: Accommodation, Ocular; Adolescent; Adult; Atropine; Biofeedback, Psychology; Child; Contact Lenses; Disease Progression; Eye Movements; Eyeglasses; Humans; Intraocular Pressure; Medicine, Chinese Traditional; Myopia; Ophthalmic Solutions; Pirenzepine; Timolol; Tropicamide

2002

Trials

6 trial(s) available for atropine and tropicamide

ArticleYear
Comparison of 0.5% cyclopentolate plus 0.5% tropicamide and 1% cyclopentolate alone for mydriasis of dark irides.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1988, Volume: 23, Issue:7

    Topics: Atropine; Cyclopentolate; Drug Combinations; Eye Color; Humans; Phenylacetates; Pupil; Pyridines; Tropicamide

1988
[Cardiovascular and digestive effects of 2 mydriatics in the low-birth-weight newborn infant].
    Archives francaises de pediatrie, 1987, Volume: 44, Issue:1

    Topics: Atropine; Blood Pressure; Digestion; Heart Rate; Humans; Infant, Low Birth Weight; Infant, Newborn; Pupil; Pyridines; Tropicamide

1987
Comparative study on the safety and efficacy of different cycloplegic agents in children with darkly pigmented irides.
    Clinical & experimental ophthalmology, 2004, Volume: 32, Issue:5

    Topics: Atropine; Child; Child, Preschool; Cross-Over Studies; Cyclopentolate; Drug Therapy, Combination; Eye Color; Female; Humans; Hyperopia; Iris; Male; Mydriatics; Ophthalmic Solutions; Phenylephrine; Prospective Studies; Pupil; Refraction, Ocular; Safety; Tropicamide

2004
Pupil dilation using a pledget sponge: a randomized controlled trial.
    Clinical & experimental ophthalmology, 2006, Volume: 34, Issue:6

    Topics: Aged; Anesthetics, Local; Atropine; Cataract Extraction; Conjunctiva; Drug Therapy, Combination; Female; Humans; Male; Mydriatics; Ophthalmic Solutions; Phenylephrine; Photography; Propoxycaine; Pupil; Surgical Sponges; Tropicamide

2006
Cost-effectiveness of cycloplegic agents: results of a randomized controlled trial in nigerian children.
    Investigative ophthalmology & visual science, 2007, Volume: 48, Issue:3

    Topics: Accommodation, Ocular; Adolescent; Atropine; Child; Child, Preschool; Cost of Illness; Cost-Benefit Analysis; Cyclopentolate; Drug Costs; Drug Therapy, Combination; Female; Health Care Costs; Humans; Male; Mydriatics; Nigeria; Ophthalmic Solutions; Pupil; Refractive Errors; Tropicamide

2007
A randomized clinical trial using atropine, cyclopentolate, and tropicamide to compare refractive outcome in hypermetropic children with a dark iris; skin pigmentation and crying as significant factors for hypermetropic outcome.
    Strabismus, 2019, Volume: 27, Issue:3

    Topics: Administration, Ophthalmic; Amblyopia; Atropine; Child; Child, Preschool; Crying; Cyclopentolate; Double-Blind Method; Eye Color; Female; Humans; Hyperopia; Male; Mydriatics; Ophthalmic Solutions; Refraction, Ocular; Retinoscopy; Skin Pigmentation; Tropicamide

2019

Other Studies

30 other study(ies) available for atropine and tropicamide

ArticleYear
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
[Behavior of fluorescein dye in the vascularized cornea of the animal eye after local application of certain drugs (author's transl)].
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1979, Mar-05, Volume: 210, Issue:1

    Topics: Animals; Atropine; Blood Vessels; Capillary Permeability; Cornea; Fluorescent Dyes; Mydriatics; Pilocarpine; Rabbits; Tropicamide

1979
Malignant glaucoma worsened by miotics in a postoperative angle-closure glaucoma patient.
    Annals of ophthalmology, 1979, Volume: 11, Issue:9

    Topics: Acetazolamide; Atropine; Cyclopentolate; Female; Glaucoma; Humans; Intraocular Pressure; Middle Aged; Miotics; Phenylephrine; Pilocarpine; Tropicamide

1979
Avoiding adverse effects of cycloplegics in infants and children.
    Journal of the American Optometric Association, 1979, Volume: 50, Issue:4

    Topics: Anesthesia, Local; Atropine; Body Surface Area; Child, Preschool; Cyclopentolate; Dose-Response Relationship, Drug; Hot Temperature; Humans; Humidity; Infant; Infant, Newborn; Mydriatics; Ophthalmic Solutions; Scopolamine; Tropanes; Tropicamide

1979
[The cycloplegic effect of atropine in comparison with the cyclopentolate-tropicamide-phenylephrine combination].
    Klinische Monatsblatter fur Augenheilkunde, 1992, Volume: 201, Issue:1

    Topics: Accommodation, Ocular; Atropine; Child; Child, Preschool; Cyclopentolate; Drug Combinations; Humans; Hyperopia; Infant; Male; Mydriatics; Ophthalmic Solutions; Phenylephrine; Refraction, Ocular; Strabismus; Tropicamide

1992
[Comparative evaluation of various cycloplegics in the diagnosis of refractive errors in children].
    Klinika oczna, 1984, Volume: 86, Issue:10

    Topics: Atropine; Child; Child, Preschool; Cyclopentolate; Drug Evaluation; Humans; Mydriatics; Refraction, Ocular; Refractive Errors; Tropicamide

1984
Comparison of atropine and tropicamide in esotropia.
    Annals of ophthalmology, 1983, Volume: 15, Issue:4

    Topics: Atropine; Child, Preschool; Esotropia; Female; Humans; Infant; Male; Pupil; Pyridines; Refraction, Ocular; Strabismus; Tropicamide

1983
Pharmacologic identification of muscarinic receptors in the pylorus of the cat by binding of [3H]-quinuclidinyl benzilate.
    Life sciences, 1980, May-12, Volume: 26, Issue:19

    Topics: Animals; Atropine; Bethanechol Compounds; Cats; Dexetimide; Female; Kinetics; Male; Propantheline; Pylorus; Quinuclidines; Quinuclidinyl Benzilate; Receptors, Cholinergic; Receptors, Muscarinic; Stereoisomerism; Tropicamide

1980
Cholinergic neurogenic vasodilatation is mediated by nitric oxide in the dog hindlimb.
    Cardiovascular research, 1994, Volume: 28, Issue:4

    Topics: Acetylcholine; Animals; Arginine; Atropine; Cholinergic Fibers; Dogs; Electric Stimulation; Female; Hindlimb; Hypothalamus; Male; Nitric Oxide; Nitroarginine; Nitroglycerin; Tropicamide; Vasodilation

1994
Atropine versus cyclopentolate plus tropicamide in esodeviations.
    Ophthalmic surgery and lasers, 1996, Volume: 27, Issue:12

    Topics: Administration, Topical; Atropine; Child; Child, Preschool; Cyclopentolate; Drug Therapy, Combination; Esotropia; Female; Humans; Hyperopia; Infant; Infant, Newborn; Male; Mydriatics; Ointments; Ophthalmic Solutions; Treatment Outcome; Tropicamide; Visual Acuity

1996
The effectiveness of 0.5% atropine in controlling high myopia in children.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1997, Volume: 13, Issue:1

    Topics: Administration, Topical; Adolescent; Analysis of Variance; Atropine; Child; Disease Progression; Female; Humans; Male; Mydriatics; Myopia; Prospective Studies; Tropicamide

1997
Subtypes of muscarinic receptors regulating gallbladder cholinergic contractions.
    The American journal of physiology, 1999, Volume: 276, Issue:5

    Topics: Acetylcholine; Animals; Atropine; Diamines; Electric Stimulation; Gallbladder; Guinea Pigs; Hexamethonium; Muscarinic Antagonists; Muscle Contraction; Parasympatholytics; Piperidines; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Tetrodotoxin; Tropicamide

1999
Mechanisms of acetylcholine-induced vasorelaxation in high K+-stimulated rabbit renal arteries.
    The Journal of veterinary medical science, 2001, Volume: 63, Issue:1

    Topics: Acetylcholine; Animals; Atropine; Calcium; Calcium Channel Blockers; Cations, Monovalent; Endothelium, Vascular; Gadolinium; Imidazoles; In Vitro Techniques; Lanthanum; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Parasympatholytics; Piperidines; Pirenzepine; Potassium; Rabbits; Renal Artery; Tropicamide; Vasoconstriction; Vasodilation

2001
Contact allergy to atropine and other mydriatic agents in eye drops.
    Contact dermatitis, 2001, Volume: 45, Issue:5

    Topics: Adult; Atropa belladonna; Atropine; Dermatitis, Allergic Contact; Humans; Male; Mydriatics; Ophthalmic Solutions; Patch Tests; Scopolamine; Tropanes; Tropicamide

2001
Activation of muscarinic acetylcholine receptors elicits pigment granule dispersion in retinal pigment epithelium isolated from bluegill.
    BMC neuroscience, 2004, Jul-13, Volume: 5

    Topics: Adenylyl Cyclase Inhibitors; Animals; Arecoline; Atropine; Carbachol; Colforsin; Cyclic AMP; Cytoplasmic Granules; Light; Muscarinic Agonists; Muscarinic Antagonists; Perciformes; Pigment Epithelium of Eye; Piperidines; Pirenzepine; Quaternary Ammonium Compounds; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Receptors, Muscarinic; Retinal Pigments; Second Messenger Systems; Tropicamide

2004
Anorexiant-induced transient myopia after myopic laser in situ keratomileusis.
    Journal of cataract and refractive surgery, 2007, Volume: 33, Issue:4

    Topics: Adult; Appetite Depressants; Atropine; Choroid; Ciliary Body; Humans; Keratomileusis, Laser In Situ; Male; Morpholines; Mydriatics; Myopia; Obesity; Tropicamide; Ultrasonography

2007
Muscarinic receptor-independent activation of cyclic adenosine monophosphate-dependent protein kinase in rostral ventrolateral medulla underlies the sympathoexcitatory phase of cardiovascular responses during mevinphos intoxication in the rat.
    Shock (Augusta, Ga.), 2007, Volume: 27, Issue:5

    Topics: Animals; Atropine; Blotting, Western; Cardiovascular System; Cholinesterase Inhibitors; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Intracellular Signaling Peptides and Proteins; Male; Medulla Oblongata; Mevinphos; Muscarinic Antagonists; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Time Factors; Tropicamide

2007
The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors.
    Psychopharmacology, 2007, Volume: 194, Issue:3

    Topics: Animals; Atropine; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Jaw; Male; Memory; Muscarinic Agonists; Muscarinic Antagonists; Parkinsonian Disorders; Pilocarpine; Pimozide; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M4; Tremor; Tropicamide; Visual Perception

2007
Functional expression of M3, a muscarinic acetylcholine receptor subtype, in taste bud cells of mouse fungiform papillae.
    Chemical senses, 2008, Volume: 33, Issue:1

    Topics: Acetylcholine; Animals; Atropine; Calcium Signaling; Cells, Cultured; Diamines; Electrophysiology; Gene Expression; Inositol 1,4,5-Trisphosphate Receptors; Mice; Mice, Inbred Strains; Muscarinic Antagonists; Patch-Clamp Techniques; Phospholipase C beta; Piperidines; Pirenzepine; Receptor, Muscarinic M3; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; Synaptosomal-Associated Protein 25; Taste Buds; Tropicamide; Vesicular Acetylcholine Transport Proteins

2008
Tropicamide and myopia progression.
    Ophthalmology, 2008, Volume: 115, Issue:6

    Topics: Administration, Topical; Astigmatism; Atropine; Disease Progression; Humans; Muscarinic Antagonists; Myopia; Ophthalmic Solutions; Refraction, Ocular; Tropicamide

2008
The effect of mydriatics on posterior synechia after combined pars plana vitrectomy, phacoemulsification, and intraocular lens implantation.
    Retina (Philadelphia, Pa.), 2009, Volume: 29, Issue:8

    Topics: Aged; Atropine; Female; Humans; Iris; Lens Implantation, Intraocular; Lens, Crystalline; Male; Middle Aged; Mydriatics; Phacoemulsification; Phenylephrine; Postoperative Complications; Retinal Detachment; Retrospective Studies; Tissue Adhesions; Treatment Outcome; Tropicamide; Vitrectomy

2009
Mydriatic eye drops: severe adverse effects in children. Systemic reactions.
    Prescrire international, 2009, Volume: 18, Issue:101

    Topics: Aged; Atropine; Child; Child, Preschool; Cyclopentolate; Fever; France; Gastrointestinal Diseases; Humans; Infant; Mydriatics; Nervous System Diseases; Ophthalmic Solutions; Tropicamide; Urologic Diseases

2009
Correspondence: the effects of two kinds of mydriatics on preventing postoperative posterior synechia.
    Retina (Philadelphia, Pa.), 2010, Volume: 30, Issue:1

    Topics: Atropine; Humans; Iris; Lens Implantation, Intraocular; Lens, Crystalline; Mydriatics; Phacoemulsification; Phenylephrine; Postoperative Complications; Retinal Detachment; Tissue Adhesions; Treatment Outcome; Tropicamide; Vitrectomy

2010
Pupil dilation using a standard cataract surgery regimen alone or with atropine 1.0% pretreatment: prospective comparative evaluation.
    Journal of cataract and refractive surgery, 2010, Volume: 36, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Atropine; Cataract Extraction; Cyclopentolate; Diagnostic Techniques, Ophthalmological; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Mydriatics; Phenylephrine; Prospective Studies; Pupil; Self Administration; Tropicamide; Young Adult

2010
Efficacy of tropicamide, homatropine, cyclopentolate, atropine and hyoscine as mydriatics in Angora goats.
    New Zealand veterinary journal, 2011, Volume: 59, Issue:6

    Topics: Administration, Topical; Animals; Atropine; Cyclopentolate; Goats; Mydriatics; Ophthalmic Solutions; Scopolamine; Tropanes; Tropicamide

2011
[Objective refraction in black children: cyclopentolate and tropicamide combination, a reliable alternative to atropine?].
    Journal francais d'ophtalmologie, 2014, Volume: 37, Issue:9

    Topics: Adolescent; Atropine; Black People; Child; Child, Preschool; Cyclopentolate; Drug Therapy, Combination; Female; Humans; Male; Mydriatics; Prospective Studies; Refractive Errors; Tropicamide

2014
Synergism Between Anticholinergic and Oxime Treatments Against Sarin-Induced Ocular Insult in Rats.
    Toxicological sciences : an official journal of the Society of Toxicology, 2015, Volume: 146, Issue:2

    Topics: Administration, Ophthalmic; Animals; Atropine; Cholinesterase Reactivators; Drug Synergism; Eye; Male; Miosis; Oximes; Rats; Rats, Long-Evans; Sarin; Tropicamide

2015
Muscarinic cholinergic receptor antagonists in the VTA and RMTg have opposite effects on morphine-induced locomotion in mice.
    Behavioural brain research, 2017, 04-14, Volume: 323

    Topics: Acetylcholine; Animals; Atropine; Locomotion; Mice; Mice, Inbred C57BL; Morphine; Muscarinic Antagonists; Piperidines; Receptor, Muscarinic M3; Receptor, Muscarinic M4; Tropicamide; Ventral Tegmental Area

2017
Host-guest complexation of cucurbit[7]uril and cucurbit[8]uril with the antimuscarinic drugs tropicamide and atropine.
    Journal of molecular graphics & modelling, 2023, Volume: 119

    Topics: Atropine; Bridged-Ring Compounds; Muscarinic Antagonists; Pharmaceutical Preparations; Tropicamide

2023
Effects of atropine and tropicamide on ocular biological parameters in children: a prospective observational study.
    BMC ophthalmology, 2023, Mar-13, Volume: 23, Issue:1

    Topics: Adolescent; Atropine; Child; Child, Preschool; Ciliary Body; Humans; Mydriatics; Presbyopia; Refraction, Ocular; Tropicamide

2023