atropine has been researched along with trimedoxime bromide in 43 studies
| Studies (atropine) | Trials (atropine) | Recent Studies (post-2010) (atropine) | Studies (trimedoxime bromide) | Trials (trimedoxime bromide) | Recent Studies (post-2010) (trimedoxime bromide) |
|---|---|---|---|---|---|
| 26,711 | 1,259 | 1,697 | 151 | 2 | 31 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (41.86) | 18.7374 |
| 1990's | 5 (11.63) | 18.2507 |
| 2000's | 9 (20.93) | 29.6817 |
| 2010's | 11 (25.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benes, J; Hrusovský, J; Proksová, M | 3 |
| Anshelevich, IuV; Bystrova, NK; Okun', KV; Panchenko, NA; Valuk, VA | 1 |
| Brown, ND; Demaree, GE; Doctor, BP; Hall, LL; Sleeman, HK | 1 |
| Babaeva, KhB | 1 |
| Bajgar, J; Hrdina, V; Jakl, A; Patocka, J | 1 |
| Adams, NL; Groff, WA; Vick, JA; von Bredow, JD | 1 |
| Bajgar, J; Fusek, J; Jakl, A; Patocka, J | 1 |
| Churchill, L; Cross, RS; Giesler, MP; Nelson, SR; Pazdernik, TL; Samson, FE | 1 |
| Klemm, WR | 1 |
| Ardab'eva, TV; Khramova, EA; Prozorovskiĭ, VB | 1 |
| Cross, R; McDonough, J; Nelson, S; Pazdernik, TL; Samson, F | 1 |
| Cross, RS; Giesler, MP; McDonough, JH; Mewes, K; Nelson, SR; Pazdernik, TL; Samson, FE | 1 |
| Ellin, RI; Zvirblis, P | 1 |
| Ghosh, AK; Jaiswal, DK; Sikder, AK | 1 |
| Jokanović, M; Maksimović, M | 1 |
| Jokanović, M; Kosanović, M; Maksimović, M; Stepanović, RM; Stojiljković, MP | 1 |
| Bosković, B; Jokanović, M; Maksimović, M; Petrović, RM; Ugresić, N | 1 |
| Jokanović, M; Jovanovic, D; Kosanović, M; Maksimović, M; Piperski, V; Stepanović Petrović, RM | 1 |
| FLEISHER, JH; HARRISON, CS; MICHEL, HO; YATES, L | 1 |
| BINENFELD, Z; VOJVODIC, V | 1 |
| BINENFELD, Z; LIKAR, D; STEVANOVIC, M; VOJVODIC, V | 1 |
| LEHMAN, RA | 1 |
| CROOK, JW; KOON, WS; OBERST, FW | 1 |
| Bentur, Y; Berkovitch, M; Bulkowstein, M; Haim, SB; Kozer, E; Mordel, A | 1 |
| Antonijevic, B; Bokonjic, D; Milovanovic, ZA; Nedeljkovic, M; Stefanovic, D; Stojiljkovic, MP | 1 |
| Kassa, J; Kunesova, G | 2 |
| Bentur, Y; Berkovitch, M; Haim, SB; Kozer, E; Krivoy, A; Layish, I; Rotman, E; Yehezkelli, Y | 1 |
| Karasova, J; Kassa, J; Kuca, K; Musilek, K | 1 |
| Humlicek, V; Kassa, J | 1 |
| Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Pohanka, M | 1 |
| Berend, S; Katalinić, M; Kovarik, Z; Kuca, K; Radić, B; Vrdoljak, AL | 1 |
| Kassa, J; Kuca, K; Pikula, J; Pohanka, M | 1 |
| Bajgar, J; Caisberger, F; Karasova, JZ; Kassa, J; Sepsova, V | 1 |
| Karasova, JZ; Kassa, J; Misik, J | 1 |
| Horova, A; Kassa, J; Musilek, K; Sepsova, V; Tumova, M | 1 |
| Hatlapatková, J; Kassa, J; Žďárová Karasová, J | 1 |
| Caisberger, F; Hatlapatkova, J; Kassa, J; Misik, J; Pejchal, J; Sepsova, V; Zdarova Karasova, J | 1 |
| Chapman, S; Gez, R; Lazar, S; Pittel, Z | 1 |
| Bloch-Shilderman, E; Cohen, L; Egoz, I; Gez, R; Gutman, H; Nili, U; Rabinovitz, I; Yacov, G | 1 |
| Chapman, S; Egoz, I; Gez, R; Grauer, E; Lazar, S | 1 |
1 trial(s) available for atropine and trimedoxime bromide
| Article | Year |
|---|---|
[New possibilities of action on the cholinergic system in gastric and duodenal ulcer].
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Cholinesterase Reactivators; Clinical Trials as Topic; Dogs; Drug Evaluation; Drug Evaluation, Preclinical; Duodenal Ulcer; Enzyme Activation; Humans; Receptors, Cholinergic; Stomach Ulcer; Trimedoxime | 1979 |
42 other study(ies) available for atropine and trimedoxime bromide
| Article | Year |
|---|---|
[Therapy of domestic animals affected by alkylphosphates].
Topics: Acetylcholinesterase; Animals; Atropine; Butyrylcholinesterase; Cholinesterase Inhibitors; Organothiophosphorus Compounds; Oximes; Sheep; Sheep Diseases; Trimedoxime | 1979 |
Ion-pair high-performance liquid chromatographic separation of a multicomponent anticholinergic drug formulation.
Topics: Atropine; Benactyzine; Chromatography, High Pressure Liquid; Drug Combinations; Parabens; Parasympatholytics; Pralidoxime Compounds; Trimedoxime | 1978 |
[Treatment of animals poisoned with ricid].
Topics: Animals; Antidotes; Atropine; Dose-Response Relationship, Drug; Drug Evaluation; Insecticides; Organothiophosphorus Compounds; Oximes; Rabbits; Sheep; Trimedoxime | 1978 |
[Therapy of organophosphate poisoning in animals].
Topics: Animals; Antidotes; Atropine; Organothiophosphorus Compounds; Oximes; Rats; Sheep; Sheep Diseases; Trimedoxime | 1976 |
[Treatment with antidotes in sheep perorally intoxicated].
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Butyrylcholinesterase; Poisoning; Sheep; Sheep Diseases; Trichlorfon; Trimedoxime | 1976 |
Antidotal therapy and changes of acetylcholinesterase activity following isopropyl methylphosphonofluoridate intoxication in mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Sarin; Trimedoxime | 1975 |
Effectiveness of oral pyridostigmine pretreatment and cholinolytic-oxime therapy against soman intoxication in nonhuman primates.
Topics: Administration, Oral; Animals; Antidotes; Atropine; Benactyzine; Drug Combinations; Female; Lethal Dose 50; Macaca mulatta; Male; Parasympatholytics; Pyridostigmine Bromide; Soman; Trimedoxime | 1991 |
Efficacy of various pretreatment and therapy regimens against soman lethality in mice.
Topics: Animals; Atropine; Diazepam; Female; Male; Mice; Obidoxime Chloride; Poisoning; Pyridostigmine Bromide; Soman; Trihexyphenidyl; Trimedoxime | 1991 |
Cholinergic systems influence local cerebral glucose use in specific anatomical areas: diisopropyl phosphorofluoridate versus soman.
Topics: Animals; Atropine; Benactyzine; Brain; Cholinergic Fibers; Glucose; Isoflurophate; Male; Rats; Rats, Inbred Strains; Soman; Trimedoxime | 1987 |
Efficacy and toxicity of drug combinations in treatment of physostigmine toxicosis.
Topics: Animals; Atropine; Benactyzine; Cholinesterase Reactivators; Diazepam; Drug Therapy, Combination; Ganglionic Blockers; Hexamethonium; Hexamethonium Compounds; Male; Mecamylamine; Mice; Physostigmine; Pralidoxime Compounds; Tranquilizing Agents; Trimedoxime | 1983 |
[Trial of cholinesterase reactivators as proserine antagonists].
Topics: Animals; Antidotes; Atropine; Butanones; Cholinesterase Reactivators; Diphenylacetic Acids; Drug Synergism; Male; Mice; Neostigmine; Obidoxime Chloride; Oximes; Parasympatholytics; Pralidoxime Compounds; Pyridinium Compounds; Trimedoxime | 1983 |
Soman-induced depression of brain activity in TAB-pretreated rats: 2-deoxyglucose study.
Topics: Animals; Antidotes; Atropine; Benactyzine; Brain; Deoxyglucose; Depression, Chemical; Drug Combinations; Drug Interactions; Male; Organophosphorus Compounds; Oximes; Rats; Seizures; Soman; Trimedoxime | 1983 |
Soman induced changes in brain regional glucose use.
Topics: Animals; Atropine; Benactyzine; Brain; Cholinesterase Inhibitors; Deoxyglucose; Echothiophate Iodide; Glucose; Neostigmine; Organophosphorus Compounds; Rats; Seizures; Soman; Trimedoxime | 1984 |
Kinetics and stability of a multicomponent organophosphate antidote formulation in glass and plastic.
Topics: Antidotes; Atropine; Benactyzine; Drug Packaging; Drug Stability; Glass; Kinetics; Organophosphate Poisoning; Plastics; Trimedoxime | 1982 |
Quaternary salts of 3,3'-bis-pyridinium monooximes: synthesis and biological activity.
Topics: Animals; Antidotes; Atropine; Cholinesterase Reactivators; Isoflurophate; Kinetics; Magnetic Resonance Spectroscopy; Mice; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Spectrophotometry, Infrared; Structure-Activity Relationship; Trimedoxime | 1993 |
A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat.
Topics: Administration, Oral; Animals; Antidotes; Atropine; Diazepam; Dose-Response Relationship, Drug; Insecticides; Male; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Rats; Rats, Wistar; Trimedoxime | 1995 |
Modification of the rate of aging of diisopropylfluorophosphate-inhibited neuropathy target esterase of hen brain.
Topics: Acetylcholinesterase; Animals; Atropine; Brain; Carboxylic Ester Hydrolases; Chickens; Drug Interactions; Female; In Vitro Techniques; Isoflurophate; Oximes; Trimedoxime | 1998 |
The treatment of delayed polyneuropathy induced by diisopropylfluorophosphate in hens.
Topics: Animals; Atropine; Chickens; Cholinesterase Inhibitors; Female; GABA Modulators; Isoflurophate; Midazolam; Muscarinic Antagonists; Neurotoxicity Syndromes; Oximes; Trimedoxime | 2000 |
Effects of atropine, trimedoxime and methylprednisolone on the development of organophosphate-induced delayed polyneuropathy in the hen.
Topics: Animals; Ataxia; Atropine; Chickens; Drug Therapy, Combination; Female; Isoflurophate; Methylprednisolone; Movement; Paralysis; Polyneuropathies; Trimedoxime | 2001 |
1,1'-Trimethylene bis(4-formylpyridinium bromide) dioxime (TMB-4) and 2-pyridine aldoxime methiodide (2-PAM) as adjuvants to atropine in the treatment of anticholinesterase poisoning.
Topics: Atropine; Bromides; Cholinesterase Inhibitors; Cyclopropanes; Hydroxylamines; Phosphates; Pralidoxime Compounds; Pyridines; Trimedoxime | 1960 |
[Protective effect of atropine, pyridine-2-aldoxime methiodide (PAM-2) and 1,3-trimethylenebis-(4-formylpyridinium bromide) dioxime (TMB-4) in experimental armine poisoning].
Topics: Armin; Atropine; Bromides; Hydroxylamines; Parasympathomimetics; Phosphates; Pralidoxime Compounds; Pyridines; Trimedoxime | 1962 |
Relation between the chemical structure and the acute toxicity in the series of alkyl alkoxy derivatives of p-nitrophenylphosphoric acid and the protective effects of PAM-2, TMB-4 and atropine.
Topics: Alcohols; Atropine; Hydroxylamines; Phosphates; Pyridines; Trimedoxime | 1961 |
Mechanism of the antagonism by pralidoxime and 1,1-trimethylenebis(4-hydroxyiminomethylpyridinium) of the action of echothiphate on the intestine.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Echothiophate Iodide; Hydroxylamines; Intestine, Small; Intestines; Oximes; Parasympatholytics; Pralidoxime Compounds; Pyridines; Rabbits; Trimedoxime | 1962 |
The effectiveness of 2-PAM and TMB-4 as adjuncts to atropine therapy in dogs exposed to Sarin vapor by inhalation.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Dogs; Hydroxylamines; Phosphates; Pralidoxime Compounds; Pyridines; Sarin; Trimedoxime | 1962 |
Pediatric poisoning from trimedoxime (TMB4) and atropine automatic injectors.
Topics: Adolescent; Antidotes; Atropine; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Injections; Male; Muscarinic Antagonists; Poisoning; Trimedoxime | 2005 |
Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos.
Topics: Acidosis; Animals; Antidotes; Atropine; Blood Gas Analysis; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dichlorvos; Drug Synergism; Male; Obidoxime Chloride; Rats; Rats, Wistar; Sodium Bicarbonate; Trimedoxime | 2006 |
The influence of antidotal treatment of low-level tabun exposure on cognitive functions in rats using a water maze.
Topics: Animals; Antidotes; Atropine; Behavior, Animal; Cognition; Drug Interactions; Male; Maze Learning; Muscarinic Antagonists; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Reaction Time; Time Factors; Trimedoxime | 2006 |
Civilian adult self injections of atropine-trimedoxime (TMB4) auto-injectors.
Topics: Accidents; Adult; Antidotes; Atropine; Drug Combinations; Humans; Injections; Israel; Poisoning; Self Medication; Trimedoxime | 2006 |
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Injections, Intramuscular; Lethal Dose 50; Male; Mice; Molecular Structure; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Species Specificity; Toxicity Tests, Acute; Trimedoxime | 2008 |
A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, trimedoxime, HI-6) to counteract acute toxic effects of tabun and cyclosarin in mice.
Topics: Animals; Antidotes; Atropine; Butanes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Poisoning; Pyridinium Compounds; Trimedoxime | 2008 |
Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: induction of oxidative stress versus reactivation efficacy.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Injections, Intramuscular; Lethal Dose 50; Male; Molecular Structure; Molecular Weight; Obidoxime Chloride; Organophosphates; Oxidative Stress; Pyridinium Compounds; Rats; Rats, Wistar; Toxicity Tests, Acute; Trimedoxime | 2009 |
In vivo experimental approach to treatment against tabun poisoning.
Topics: Animals; Atropine; Butanes; Chemical Warfare Agents; Cholinesterase Inhibitors; Mice; Organophosphate Poisoning; Organophosphates; Oximes; Protective Agents; Pyridinium Compounds; Survival Rate; Treatment Outcome; Trimedoxime | 2010 |
Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model.
Topics: Animals; Antidotes; Atropine; Biomarkers; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Trimedoxime | 2011 |
A comparison of the reactivating and therapeutic efficacy of chosen combinations of oximes with individual oximes against VX in rats and mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Lethal Dose 50; Male; Mice; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2011 |
The benefit of combination of oximes for the neuroprotective efficacy of antidotal treatment of sarin-poisoned rats.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Molecular Structure; Neuroprotective Agents; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Trimedoxime | 2012 |
Evaluation of the potency of two novel bispyridinium oximes (K456, K458) in comparison with oxime K203 and trimedoxime to counteract tabun-induced neurotoxicity in rats.
Topics: Animals; Atropine; Chemical Warfare Agents; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2013 |
A comparison of the reactivating and therapeutic efficacy of two newly developed oximes (k727 and k733) with oxime k203 and trimedoxime in tabun-poisoned rats and mice.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Injections, Intramuscular; Lethal Dose 50; Male; Mice; Organophosphates; Oximes; Parasympatholytics; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2015 |
The Evaluation of the Potency of Newly Developed Oximes (K727, K733) and Trimedoxime to Counteract Acute Neurotoxic Effects of Tabun in Rats.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Muscarinic Antagonists; Nervous System; Neuroprotective Agents; Neurotoxicity Syndromes; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime | 2015 |
The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats-A Comparison with Trimedoxime and the Oxime K203.
Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Reactivators; Humans; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats, Wistar; Trimedoxime | 2017 |
Early changes in M2 muscarinic acetylcholine receptors (mAChRs) induced by sarin intoxication may be linked to long lasting neurological effects.
Topics: Animals; Atropine; Cerebral Cortex; Female; Male; Pirenzepine; Radioligand Assay; Rats; Receptor, Muscarinic M2; Sarin; Sex Characteristics; Time Factors; Trimedoxime; Tritium | 2018 |
Repetitive antidotal treatment is crucial in eliminating eye pathology, respiratory toxicity and death following whole-body VX vapor exposure in freely moving rats.
Topics: Animals; Antidotes; Atropine; Benactyzine; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Administration Schedule; Drug Combinations; Environmental Exposure; Eye Diseases; Male; Obidoxime Chloride; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Respiratory Tract Diseases; Trimedoxime | 2019 |
Time dependent dual effect of anti-inflammatory treatments on sarin-induced brain inflammation: Suggested role of prostaglandins.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Atropine; Brain Diseases; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dinoprostone; Encephalitis; Male; Midazolam; Nerve Agents; Neuroprotective Agents; Prostaglandins; Rats; Rats, Sprague-Dawley; Sarin; Seizures; Trimedoxime | 2019 |