atropine has been researched along with trazodone in 18 studies
| Studies (atropine) | Trials (atropine) | Recent Studies (post-2010) (atropine) | Studies (trazodone) | Trials (trazodone) | Recent Studies (post-2010) (trazodone) |
|---|---|---|---|---|---|
| 26,711 | 1,259 | 1,697 | 1,466 | 295 | 312 |
| Protein | Taxonomy | atropine (IC50) | trazodone (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.091 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.909 | |
| D(2) dopamine receptor | Homo sapiens (human) | 4.485 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.017 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.281 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.389 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 1.942 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.311 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 0.281 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.265 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.1315 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.091 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.311 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.192 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.361 | |
| D(3) dopamine receptor | Homo sapiens (human) | 3.743 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.107 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.281 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 2.203 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 9 (50.00) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Lisciani, R; Silvestrini, B | 1 |
| Barrett, MJP; Ferrari, KD; Glück, C; Stobart, JL; Stobart, MJ; Weber, B; Zuend, M | 1 |
| Brearley, JC; Gittel, C; Walters, K | 1 |
1 review(s) available for atropine and trazodone
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
17 other study(ies) available for atropine and trazodone
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Experimental data suggesting an adrenergic mechanism in the production of parkinsonian symptoms.
Topics: 5-Hydroxytryptophan; Animals; Atropine; Clonidine; Female; Fenclonine; Imipramine; Male; Mice; Mice, Inbred Strains; Nicotine; Oxotremorine; Parkinson Disease, Secondary; Phenoxybenzamine; Piloerection; Pyrilamine; Rabbits; Salivation; Sympathetic Nervous System; Trazodone; Tremor | 1976 |
Cortical Circuit Activity Evokes Rapid Astrocyte Calcium Signals on a Similar Timescale to Neurons.
Topics: Adrenergic Agents; Animals; Astrocytes; Atropine; Benzylamines; Calcium Signaling; Cerebral Cortex; Inositol 1,4,5-Trisphosphate Receptors; Intravital Microscopy; Membrane Microdomains; Metergoline; Mice; Mice, Knockout; Muscarinic Antagonists; Neurons; Optical Imaging; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Somatosensory Cortex; Spatio-Temporal Analysis; Time Factors; Touch; Trazodone; Vibrissae | 2018 |
The effect of preanaesthetic oral trazodone hydrochloride on the induction dose of propofol: a preliminary retrospective study.
Topics: Alfentanil; Anesthetics, Intravenous; Animals; Atropine; Dogs; Humans; Propofol; Retrospective Studies; Trazodone | 2022 |