Page last updated: 2024-09-05

atropine and sulfasalazine

atropine has been researched along with sulfasalazine in 15 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(sulfasalazine)
Trials
(sulfasalazine)
Recent Studies (post-2010) (sulfasalazine)
26,7111,2591,6974,437585938

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)sulfasalazine (IC50)
Multidrug resistance-associated protein 4Homo sapiens (human)1.5
Solute carrier organic anion transporter family member 2B1 Homo sapiens (human)3
Carbonic anhydrase 1Homo sapiens (human)3.04
Carbonic anhydrase 2Homo sapiens (human)4.49
Mitogen-activated protein kinase 1Homo sapiens (human)6.332
Sodium/bile acid cotransporterHomo sapiens (human)9.6
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)0.46
Cystine/glutamate transporterHomo sapiens (human)0.16
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.56

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19905 (33.33)18.7374
1990's1 (6.67)18.2507
2000's3 (20.00)29.6817
2010's6 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Haga, K; Kawazoe, Y; Mizuta, H; Ogawa, K; Yokobe, T1
Neugebauer, A; Terhaag, B1
Tumen, HJ1
Brandborg, LL; Goldberg, HI; Moss, AA; Pepper, HW; Shanser, JD1
Hansen, W1
Amstutz, I; Diener, M1

Reviews

2 review(s) available for atropine and sulfasalazine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Dietary and drug therapy of intestinal disease].
    Medizinische Klinik, 1980, Jun-06, Volume: 75, Issue:12

    Topics: Aerophagy; Anti-Inflammatory Agents; Atropine; beta-Galactosidase; Cathartics; Colitis, Ulcerative; Colonic Diseases, Functional; Constipation; Crohn Disease; Diarrhea; Dietary Fiber; Flatulence; Food, Formulated; Gastrointestinal Motility; Glutens; Humans; Intestinal Diseases; Malabsorption Syndromes; Metoclopramide; Parenteral Nutrition; Substance-Related Disorders; Sulfasalazine; Water-Electrolyte Imbalance

1980

Other Studies

13 other study(ies) available for atropine and sulfasalazine

ArticleYear
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
[Determination of small intestinal transit time in beagle dogs using salicylazosulfapyridine].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1989, Volume: 109, Issue:10

    Topics: Animals; Atropine; Dogs; Female; Intestinal Absorption; Intestine, Small; Sulfasalazine; Time Factors

1989
[Modification of orocecal transit time of salazosulfapyridine by atropine and metoclopramide in healthy probands].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1986, Volume: 46, Issue:6

    Topics: Adult; Atropine; Gastrointestinal Motility; Humans; Intestinal Absorption; Kinetics; Male; Metoclopramide; Sulfasalazine

1986
The drug therapy of ulcerative colitis and of Crohn's disease.
    Seminars in drug treatment, 1974,Spring, Volume: 3, Issue:4

    Topics: Adrenocorticotropic Hormone; Atropine; Azathioprine; Colitis, Ulcerative; Crohn Disease; Diarrhea; Diet; Glucocorticoids; Humans; Immunosuppressive Agents; Mercaptopurine; Nutrition Disorders; Pain; Prednisolone; Prednisone; Sulfasalazine

1974
Collagenous sprue.
    The American journal of roentgenology, radium therapy, and nuclear medicine, 1974, Volume: 121, Issue:2

    Topics: Adrenocorticotropic Hormone; Adult; Aged; Animals; Atropine; Biopsy; Celiac Disease; Collagen; Diet Therapy; Drug Combinations; Glutens; Humans; Intestinal Mucosa; Isonipecotic Acids; Jejunum; Male; Milk; Prednisone; Radiography; Sulfasalazine

1974
Inhibition of antigen-induced muscle contractions by inhibitors of thromboxane pathway in rat small intestine.
    Zentralblatt fur Veterinarmedizin. Reihe A, 1997, Volume: 44, Issue:6

    Topics: Animals; Antigens; Atropine; Benzimidazoles; Benzoxepins; Carbachol; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Hexamethonium; Histamine H1 Antagonists; Imidazoles; Intestine, Small; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Ovalbumin; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Thromboxane; Sulfasalazine; Sulfonamides; Tetrodotoxin; Thromboxanes

1997