atropine has been researched along with sr141716 in 10 studies
| Studies (atropine) | Trials (atropine) | Recent Studies (post-2010) (atropine) | Studies (sr141716) | Trials (sr141716) | Recent Studies (post-2010) (sr141716) |
|---|---|---|---|---|---|
| 26,711 | 1,259 | 1,697 | 2,229 | 60 | 631 |
| Protein | Taxonomy | atropine (IC50) | sr141716 (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 10 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.0069 | |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | 0.0081 | |
| Cannabinoid receptor 1 | Homo sapiens (human) | 0.0219 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.0069 | |
| Cannabinoid receptor 2 | Homo sapiens (human) | 2.4666 | |
| Cannabinoid receptor 1 | Mus musculus (house mouse) | 0.025 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.108 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 3.795 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Borrelli, F; Capasso, F; Izzo, AA; Mascolo, N | 1 |
| Eglen, RM; Luong, LA; MacLennan, SJ; Martin, GR; Martin, RS; Welsh, NJ | 1 |
| Adinolfi, B; Breschi, MC; Calderone, V; Martinotti, E; Nieri, P; Testai, L | 1 |
| Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N | 1 |
| Baldassano, S; Mule', F; Serio, R | 1 |
| Allescher, HD; Broedl, U; Göke, B; Kemmer, M; Sibaev, A; Storr, M; Timmermans, JP; Van Nassauw, L; Yüce, B | 1 |
| Allescher, HD; Kurjak, M; Saur, D; Sibaev, A; Storr, M; Yuece, B | 1 |
10 other study(ies) available for atropine and sr141716
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Defaecation, intestinal fluid accumulation and motility in rodents: implications of cannabinoid CB1 receptors.
Topics: Animals; Atropine; Benzamides; Benzoxazines; Body Fluids; Cannabinoids; Defecation; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hexamethonium Compounds; Intestines; Male; Mice; Morpholines; Muscarinic Agonists; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrazoles; Quinuclidines; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Receptors, Muscarinic; Receptors, Neurokinin-2; Rimonabant | 1999 |
Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Atropine; Benzoxazines; Calcium Channel Blockers; Carbachol; Cholinergic Agonists; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Humans; In Vitro Techniques; Macaca fascicularis; Male; Mice; Morpholines; Muscle Contraction; Naphthalenes; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Receptors, Muscarinic; Rimonabant; Species Specificity; Swine; Urinary Bladder | 2000 |
R+-methanandamide inhibits tracheal response to endogenously released acetylcholine via capsazepine-sensitive receptors.
Topics: Acetylcholine; Animals; Arachidonic Acids; Atropine; Benzoxazines; Cannabinoid Receptor Modulators; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indoles; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Trachea | 2003 |
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anthracenes; Antidepressive Agents; Atropine; Bridged Bicyclo Compounds; Capsaicin; Depression; Electric Stimulation; Female; Haloperidol; Hypericum; Kaempferols; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Naloxone; Perylene; Phentolamine; Phloroglucinol; Piperidines; Plant Extracts; Propranolol; Pyrazoles; Quercetin; Rats; Rats, Wistar; Rimonabant; Rutin; Terpenes; Tetrodotoxin; Urinary Bladder; Urinary Incontinence; Verapamil | 2004 |
Cannabinoid CB(1) receptor activation modulates spontaneous contractile activity in mouse ileal longitudinal muscle.
Topics: Animals; Apamin; Arachidonic Acids; Atropine; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Endocannabinoids; Hexamethonium; Ileum; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Tetrodotoxin | 2008 |
Cannabinoid-1 (CB1) receptors regulate colonic propulsion by acting at motor neurons within the ascending motor pathways in mouse colon.
Topics: Anesthetics, Local; Animals; Atropine; Benzoxazines; Cholinergic Antagonists; Cholinergic Fibers; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Enteric Nervous System; Excitatory Postsynaptic Potentials; Hexamethonium; Immunohistochemistry; Inhibitory Postsynaptic Potentials; Interneurons; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Motor Neurons; Naphthalenes; Peristalsis; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reflex; Rimonabant; Synaptic Transmission; Tetrodotoxin | 2009 |
The endocannabinoid anandamide regulates the peristaltic reflex by reducing neuro-neuronal and neuro-muscular neurotransmission in ascending myenteric reflex pathways in rats.
Topics: Animals; Arachidonic Acids; Atropine; Endocannabinoids; Excitatory Postsynaptic Potentials; Ileum; Male; Mice; Mice, Inbred C57BL; Myenteric Plexus; Peristalsis; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reflex; Rimonabant; Synaptic Transmission | 2014 |