Page last updated: 2024-09-05

atropine and rofecoxib

atropine has been researched along with rofecoxib in 9 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(rofecoxib)
Trials
(rofecoxib)
Recent Studies (post-2010) (rofecoxib)
26,7111,2591,6971,914307163

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)rofecoxib (IC50)
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.43
Cytochrome c oxidase subunit 2Homo sapiens (human)1.51
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)0.5
Calpain-2 catalytic subunitHomo sapiens (human)0.02
Prostaglandin G/H synthase 1Homo sapiens (human)1.8
Prostaglandin G/H synthase 2Homo sapiens (human)0.3602
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.76
Prostaglandin G/H synthase 2Ovis aries (sheep)0.486
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.036
Sodium-dependent serotonin transporterMacaca mulatta (Rhesus monkey)0.5

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (55.56)29.6817
2010's4 (44.44)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bohlin, L; Huss, U; Perera, P; Ringbom, T; Vasänge, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Hayashi, Y; Kubo, Y; Takeuchi, K; Tanaka, A1
Takahira, Y; Takeuchi, K; Tanaka, A; Taniguchi, M; Yokota, A1
Takeuchi, K; Tanaka, A; Taniguchi, M; Yokota, A1

Other Studies

9 other study(ies) available for atropine and rofecoxib

ArticleYear
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.
    Journal of natural products, 2002, Volume: 65, Issue:11

    Topics: Acrolein; Alkaloids; Animals; Anthraquinones; Aspirin; Biological Assay; Catalysis; Cinnamomum zeylanicum; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eugenol; Flavonoids; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Lactones; Models, Molecular; Nitrobenzenes; Oleanolic Acid; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Pyrogallol; Steroids; Sulfonamides; Sulfones; Syzygium; Terpenes; Triterpenes; Ursolic Acid

2002
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs: importance of gastric hypermotility.
    Digestive diseases and sciences, 2004, Volume: 49, Issue:2

    Topics: Animals; Atropine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastrointestinal Motility; Indomethacin; Isoenzymes; Lactones; Male; Omeprazole; Peroxidase; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stomach; Stomach Ulcer; Sulfones

2004
Rofecoxib produces intestinal but not gastric damage in the presence of a low dose of indomethacin in rats.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Colony Count, Microbial; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enterobacteriaceae; Gastric Mucosa; Gastrointestinal Motility; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Lactones; Male; Membrane Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach Ulcer; Sulfones

2005
Development of intestinal, but not gastric damage caused by a low dose of indomethacin in the presence of rofecoxib.
    Inflammopharmacology, 2005, Volume: 13, Issue:1-3

    Topics: Ampicillin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Gastric Mucosa; Gastrointestinal Motility; Gene Expression; Guanidines; Indomethacin; Intestinal Mucosa; Intestine, Small; Lactones; Male; Pyrazoles; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Stomach; Sulfones

2005