Page last updated: 2024-09-05

atropine and promazine

atropine has been researched along with promazine in 41 studies

Compound Research Comparison

Studies (atropine)	Trials (atropine)	Recent Studies (post-2010) (atropine)	Studies (promazine)	Trials (promazine)	Recent Studies (post-2010) (promazine)
26,711	1,259	1,697	1,178	60	76

Protein Interaction Comparison

Protein	Taxonomy	promazine (IC50)
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	0.099
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	0.013
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	1.089
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	0.299
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	0.064
Alpha-2A adrenergic receptor	Homo sapiens (human)	0.337
Cytochrome P450 2D6	Homo sapiens (human)	0.3
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	0.487
D(2) dopamine receptor	Homo sapiens (human)	0.505
Alpha-2B adrenergic receptor	Homo sapiens (human)	0.018
Alpha-2C adrenergic receptor	Homo sapiens (human)	0.253
D	Rattus norvegicus (Norway rat)	1.04
D(3) dopamine receptor	Rattus norvegicus (Norway rat)	1.04
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	5.172
D(2) dopamine receptor	Bos taurus (cattle)	0.13
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	0.416
D(1A) dopamine receptor	Homo sapiens (human)	2.464
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	0.013
Histamine H2 receptor	Homo sapiens (human)	2.858
Alpha-1D adrenergic receptor	Homo sapiens (human)	0.013
D(1B) dopamine receptor	Rattus norvegicus (Norway rat)	1.04
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	0.023
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	0.099
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	5.172
D(4) dopamine receptor	Rattus norvegicus (Norway rat)	1.04
Sodium-dependent serotonin transporter	Homo sapiens (human)	0.086
Histamine H1 receptor	Homo sapiens (human)	1.2291
D(3) dopamine receptor	Homo sapiens (human)	0.205
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	0.347
5-hydroxytryptamine receptor 6	Homo sapiens (human)	0.274
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	1.04
D	Bos taurus (cattle)	0.13
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	0.271

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	32 (78.05)	18.7374
1990's	1 (2.44)	18.2507
2000's	6 (14.63)	29.6817
2010's	2 (4.88)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Duffy, EM; Jorgensen, WL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Glen, RC; Lowe, R; Mitchell, JB	1
Bellman, K; Knegtel, RM; Settimo, L	1
Penney, BE; White, RJ	1
Scheurecker, F; Schneider, J; Thalhammer, F	1
De Moor, A; Gasthuys, F; Parmentier, D	1
Haigh, AL; Lloyd, S; Pickford, M	1
Gyermek, L; Hill, RT; Sigg, EB	1
Jensen, EC; Klemm, WR	1
Del Rio, J; Fuentes, JA	1
Gerald, MC; Maickel, RP	1
Keeling, ME; Martin, DE; Warner, H	1
Haffner, JF; Landmark, K	1
Aviles, TA; Laboy-Torres, JA; Lopez, JE; Santos-Martinez, J	1
Saxena, PN	1
Landmark, K	2
Baum, T; Eckfeld, DK; Rowles, G; Shropshire, AT; Varner, LL	1
Burtles, R	1
Clarke, RS; Dundee, JW; Love, WJ; Moore, J; Nicholl, RM	2
Fok, AK; Ziegler, DM	1
Jesseph, JE; Kraft, AR; Tompkins, RK	1
Campkin, TV; Dallas, SH	1
Elliott, RC	1
Bossù, M; Colarossi, G	1
Fuller, TK; Kuehn, DW	1
MARIANI, L	1
DAVISON, MH; INGRAM, HV	1
KOERNER, M	1
BOFF, E; SCHECKEL, CL	1
LESLIE, GB; MAXWELL, DR	1
MCCANCE, I	1
MODELL, J; SCHWARTZ, S	1
BARROW, ME; INGLIS, JM	1

Trials

2 trial(s) available for atropine and promazine

Article	Year
A trial of some anaesthetic procedures. (600 cases). Transactions of the ophthalmological societies of the United Kingdom, 1964, Volume: 84 Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Local; Atropine; Eye Diseases; Female; Halothane; Humans; Male; Meperidine; Middle Aged; Nitrous Oxide; Postoperative Complications; Preanesthetic Medication; Promazine; Promethazine; Thiopental	1964
Studies of drugs given before anaesthesia. VII. Pethidine-phenothiazine combinations. British journal of anaesthesia, 1965, Volume: 37, Issue:8 Topics: Adult; Anesthesia, General; Atropine; Clinical Trials as Topic; Female; Humans; Meperidine; Phenothiazines; Preanesthetic Medication; Promazine; Promethazine	1965

Other Studies

39 other study(ies) available for atropine and promazine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Narcotic analgesics in the domestic cat. The Veterinary clinics of North America, 1978, Volume: 8, Issue:2 Topics: Analgesia; Animals; Atropine; Cats; Drug Therapy, Combination; Meperidine; Morphine; Narcotic Antagonists; Narcotics; Oxymorphone; Preanesthetic Medication; Promazine	1978
[Changes in the internal cuff pressure in intubated patients (author's transl)]. Der Anaesthesist, 1978, Volume: 27, Issue:7 Topics: Anesthesia, General; Atropine; Halothane; Humans; Intubation; Meperidine; Nitrous Oxide; Oxygen; Premedication; Pressure; Promazine	1978
Haemodynamic changes during sedation in ponies. Veterinary research communications, 1990, Volume: 14, Issue:4 Topics: Animals; Atropine; Blood Gas Analysis; Blood Pressure; Cardiac Output; Female; Heart Rate; Hematocrit; Hemodynamics; Horses; Hypnotics and Sedatives; Imidazoles; Male; Promazine; Promethazine; Xylazine	1990
A relationship between adrenaline and the mode of action of oxytocin and oestrogen on vascular smooth muscle. The Journal of physiology, 1965, Volume: 178, Issue:3 Topics: Animals; Atropine; Blood Vessels; Dogs; Epinephrine; Ergotamine; Estriol; Extremities; Haplorhini; Histamine H1 Antagonists; Muscle, Smooth; Oxytocin; Physostigmine; Plethysmography; Promazine; Reserpine	1965
Antagonism to reserpine induced depression by imipramine, related psychoactive drugs, and some autonomic agents. Psychopharmacologia, 1965, Feb-15, Volume: 7, Issue:2 Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Behavior, Animal; Cyproheptadine; Desipramine; Diphenhydramine; Hallucinogens; Histamine H1 Antagonists; Imipramine; Lysergic Acid Diethylamide; Mice; Promazine; Psychopharmacology; Reserpine; Serotonin	1965
Clinical evaluation of the analeptic, doxapram, in dogs and cats. Journal of the American Veterinary Medical Association, 1967, Mar-01, Volume: 150, Issue:5 Topics: Anesthesia; Animals; Atropine; Cats; Central Nervous System Stimulants; Dogs; Doxapram; Electrocardiography; Fentanyl; Heart Rate; Morphine; Preanesthetic Medication; Promazine; Spirometry	1967
Further studies on the antagonism of stereotyped behaviour induced by amphetamine. European journal of pharmacology, 1969, Volume: 8, Issue:1 Topics: Amphetamine; Animals; Atropine; Behavior, Animal; Benperidol; Chlorpromazine; Exploratory Behavior; Haloperidol; Male; Perphenazine; Phenothiazines; Phenoxybenzamine; Phentolamine; Pilocarpine; Promazine; Propranolol; Rats; Thioridazine; Tremorine; Trifluperidol	1969
Studies on the possible role of brain histamine in behaviour. British journal of pharmacology, 1972, Volume: 44, Issue:3 Topics: Animals; Atropine; Avoidance Learning; Behavior, Animal; Brain; Catheterization; Cerebral Ventricles; Cyproheptadine; Diphenhydramine; Drinking Behavior; Histamine; Histamine H1 Antagonists; Male; Promazine; Rats; Reinforcement, Psychology; Thirst; Time Factors; Tripelennamine; Water	1972
Electroejaculation of the great apes. Annals of biomedical engineering, 1974, Volume: 2, Issue:4 Topics: Anesthesia, General; Animals; Atropine; Cell Count; Ejaculation; Electric Stimulation; Hominidae; Male; Penis; Phenothiazines; Promazine; Rectum; Semen; Spermatozoa	1974
Opposing anticholinergic and cardio-depressive effects of promazine and thioridazine in isolated rat atria. Acta pharmacologica et toxicologica, 1972, Volume: 31, Issue:5 Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Atropine; Depression, Chemical; Electric Stimulation; Female; Heart Atria; Heart Rate; Promazine; Rats; Thioridazine	1972
Electrocardiographic changes induced by some phenothiazine derivatives. Research communications in chemical pathology and pharmacology, 1973, Volume: 5, Issue:2 Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Atropine; Chlorpromazine; Dogs; Electrocardiography; Potassium; Promazine; Sodium; Tachycardia	1973
Mechanism of cholinergic potentiation of tranquilizer activity. Indian journal of physiology and pharmacology, 1968, Volume: 12, Issue:1 Topics: 5-Hydroxytryptophan; Animals; Atropine; Cholinesterase Inhibitors; Drug Synergism; Ergoloid Mesylates; Hexobarbital; Lysergic Acid Diethylamide; Mice; Neostigmine; Pargyline; Phenothiazines; Promazine; Tetraethylammonium Compounds; Tranquilizing Agents	1968
The action of promazine and thioridazine in isolated rat atria. 2. Effects of varying concentrations of potassium and sodium on automaticity, mechanical performance, refractoriness and excitability. European journal of pharmacology, 1972, Volume: 17, Issue:1 Topics: Animals; Atropine; Depression, Chemical; Electric Stimulation; Female; Heart Atria; In Vitro Techniques; Muscle Contraction; Potassium; Promazine; Rats; Sodium; Thioridazine	1972
The action of promazine and thioridazine in isolated rat atria. 3. Effects of varying concentrations of calcium and different frequencies and strengths of stimulation on contractile force and excitability. European journal of pharmacology, 1972, Volume: 17, Issue:3 Topics: Acetanilides; Amino Alcohols; Animals; Atropine; Calcium; Electric Stimulation; Heart Atria; In Vitro Techniques; Muscle Contraction; Osmolar Concentration; Promazine; Propylamines; Rats; Sympatholytics; Thioridazine	1972
Observations on models used for the evaluation of antiarrhythmic drugs. Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 193, Issue:1 Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Atropine; Benzazepines; Bretylium Compounds; Chlorpheniramine; Diazepam; Disease Models, Animal; Dogs; Drug Antagonism; Guinea Pigs; Imipramine; Ketones; Lidocaine; Male; Meperidine; Mephentermine; Ouabain; Phentolamine; Phenytoin; Procainamide; Promazine; Promethazine; Propranolol; Quinidine	1971
Estimation of amine oxides in the presence of hepatic microsomes. Biochemical and biophysical research communications, 1970, Nov-09, Volume: 41, Issue:3 Topics: Aldehydes; Amines; Animals; Atropine; Benzphetamine; Brompheniramine; Chlorpromazine; Codeine; Cold Temperature; Colorimetry; Meperidine; Methods; Microchemistry; Microsomes, Liver; Morphine; Nicotine; Oxides; Promazine; Rats; Scopolamine; Sulfur Dioxide; Swine	1970
Peritoneal electrolyte absorption: analysis of portal, systemic venous, and lymphatic transport. Surgery, 1968, Volume: 64, Issue:1 Topics: Absorption; Animals; Atropine; Biological Transport; Dogs; Injections, Intraperitoneal; Intubation, Intratracheal; Peritoneal Cavity; Portal Vein; Promazine; Sodium; Sodium Isotopes; Sulfates; Sulfur Isotopes; Thoracic Duct; Vena Cava, Inferior	1968
Elective circulatory arrest in neurosurgical operations. British journal of anaesthesia, 1968, Volume: 40, Issue:7 Topics: Adolescent; Adult; Aneurysm; Angiomatosis; Aorta; Atropine; Blood Circulation; Brain; Catheterization; Child; Coronary Vessels; Electrocardiography; Female; Humans; Hypotension, Controlled; Hypothermia, Induced; Intracranial Aneurysm; Ischemia; Male; Methods; Middle Aged; Perfusion; Preanesthetic Medication; Promazine; Propranolol; Succinylcholine; Thiopental; Thromboembolism; Ventricular Fibrillation	1968
Centrally active drugs and the medullary vasopressor response of the cat; a method of distinguishing between drug actions on the central and peripheral parts of the sympathetic nervous system. International journal of neuropharmacology, 1969, Volume: 8, Issue:2 Topics: Adrenalectomy; Animals; Atropine; Benactyzine; Blood Pressure; Carbamates; Cats; Chlorpromazine; Dextrans; Electric Stimulation; Femoral Artery; Hydroxyzine; Medulla Oblongata; Methods; Perphenazine; Piperidines; Pressoreceptors; Prochlorperazine; Promazine; Sympathetic Nervous System; Temperature; Tranquilizing Agents	1969
[Anesthesia with fluothane in pediatrics. Remarks on 600 cases]. Acta anaesthesiologica, 1966, Volume: 17 Topics: Anesthesia, Inhalation; Atropine; Child; Child, Preschool; Halothane; Humans; Infant; Infant, Newborn; Meperidine; Pediatrics; Preanesthetic Medication; Promazine; Promethazine	1966
Immobilization of wolves using ketamine in combination with xylazine or promazine. Journal of wildlife diseases, 1983, Volume: 19, Issue:1 Topics: Animals; Atropine; Carnivora; Drug Combinations; Female; Immobilization; Injections, Intramuscular; Injections, Intravenous; Ketamine; Male; Minnesota; Promazine; Thiazines; Xylazine	1983
[Drugs antagonistic to bradykinin]. Bollettino della Societa italiana di biologia sperimentale, 1961, Dec-31, Volume: 37 Topics: Anti-Allergic Agents; Atropine; Bradykinin; Chlorpromazine; Ergotamine; Histamine H1 Antagonists; Imipramine; Lysergic Acid Diethylamide; Papaverine; Phenylbutazone; Promazine; Promethazine	1961
HEAVY SEDATION AND LOCAL ANAESTHESIA FOR MAJOR EYE SURGERY. Proceedings of the Royal Society of Medicine, 1963, Volume: 56 Topics: Analgesics; Analgesics, Non-Narcotic; Anesthesia; Anesthesia, Local; Anesthesiology; Antipyretics; Atropine; Geriatrics; Humans; Meperidine; Methamphetamine; Ophthalmologic Surgical Procedures; Ophthalmology; Phenazocine; Preanesthetic Medication; Promazine; Promethazine; Surgical Procedures, Operative	1963
[RE-ANESTHESIA]. Der Anaesthesist, 1964, Volume: 13 Topics: Adjuvants, Anesthesia; Anesthesia; Anesthesia, General; Anesthesiology; Atropa belladonna; Atropine; Barbiturates; Chlorpromazine; Dihydroergotoxine; Ergot Alkaloids; Humans; Meperidine; Methadone; Morphine; Procainamide; Promazine; Promethazine; Reserpine; Scopolamine	1964
BEHAVIORAL EFFECTS OF INTERACTING IMIPRAMINE AND OTHER DRUGS WITH D-AMPHETAMINE, COCAINE, AND TETRABENAZINE. Psychopharmacologia, 1964, Feb-12, Volume: 5 Topics: Amitriptyline; Atropine; Avoidance Learning; Chlorpromazine; Cocaine; Desipramine; Dextroamphetamine; Guanethidine; Imipramine; Iproniazid; Isocarboxazid; Methylphenidate; Parasympatholytics; Pharmacology; Piperidines; Promazine; Promethazine; Rats; Research; Scopolamine; Tetrabenazine; Trihexyphenidyl; Tyramine	1964
INHIBITION OF TREMORINE BY A GROUP OF NON-ANTI-PARKINSON PHENOTHIAZINE DERIVATIVES. Nature, 1964, Apr-04, Volume: 202 Topics: Antipsychotic Agents; Atropine; Benactyzine; Chlorpromazine; Histamine H1 Antagonists; Mice; Muscle Relaxants, Central; Parasympatholytics; Pharmacology; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Research; Scopolamine; Tranquilizing Agents; Tremor; Tremorine; Trihexyphenidyl	1964
STUDIES OF POTENTIATION OF HEXOBARBITONE INFUSED INTRAVENOUSLY. Archives internationales de pharmacodynamie et de therapie, 1964, Mar-01, Volume: 148 Topics: Anesthesia; Anesthesia, Intravenous; Anti-Anxiety Agents; Anticonvulsants; Atropine; Benactyzine; Carbamates; Carisoprodol; Chlorpromazine; Chlorprothixene; Hexobarbital; Hydroxyzine; Hypnotics and Sedatives; Imipramine; Infusions, Parenteral; Meprobamate; Mice; Pharmacology; Phenothiazines; Promazine; Research; Serotonin; Thalidomide; Tranquilizing Agents	1964
SOME ANTAGONISTIC EFFECTS OF "HEMATOPORPHYRIN" AND PROTOPORPHYRIN IN MICE. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1964, Volume: 116 Topics: Atropine; Chlorpheniramine; Chlorpromazine; Dinitrophenols; Edetic Acid; Hematoporphyrins; Heparin; Hydrocortisone; Metabolism; Metaraminol; Methylene Blue; Mice; Neoplasms; Neostigmine; Papaverine; Pharmacology; Porphyrins; Promazine; Protoporphyrins; Research; Serotonin; Toxicology	1964
PREMEDICATION--A REASSESSMENT. Proceedings of the Royal Society of Medicine, 1965, Volume: 58 Topics: Anxiety; Anxiety Disorders; Atropine; Barbiturates; Chlordiazepoxide; Chlorpromazine; Drug Therapy; Humans; Hypotension; Hypotension, Orthostatic; Meprobamate; Preanesthetic Medication; Promazine; Scopolamine; Thiazines; Toxicology; Tranquilizing Agents	1965
STUDIES OF DRUGS GIVEN BEFORE ANAESTHESIA. VI. THE PHENOTHIAZINE DERIVATIVES. British journal of anaesthesia, 1965, Volume: 37 Topics: Anesthesia; Anesthesia, General; Atropine; Chlorpromazine; Chlorprothixene; Fluphenazine; Humans; Meperidine; Methohexital; Methotrimeprazine; Nitrous Oxide; Oxygen; Perphenazine; Pharmacology; Phenothiazines; Preanesthetic Medication; Prochlorperazine; Promazine; Promethazine; Thiazines; Thiethylperazine; Toxicology; Tranquilizing Agents; Trifluoperazine; Triflupromazine; Trimeprazine	1965