Page last updated: 2024-09-05

atropine and prochlorperazine

atropine has been researched along with prochlorperazine in 24 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(prochlorperazine)
Trials
(prochlorperazine)
Recent Studies (post-2010) (prochlorperazine)
26,7111,2591,6971,125206110

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)prochlorperazine (IC50)
Mcl-1Homo sapiens (human)3.7733
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.078
Bile salt export pumpHomo sapiens (human)10
Cytochrome P450 1A2Homo sapiens (human)2
Tyrosine-protein kinase FynHomo sapiens (human)5.684
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.4
Muscarinic acetylcholine receptor M2Homo sapiens (human)3.112
Muscarinic acetylcholine receptor M4Homo sapiens (human)1.363
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.22
Alpha-2A adrenergic receptorHomo sapiens (human)0.169
Cytochrome P450 2D6Homo sapiens (human)0.3
Muscarinic acetylcholine receptor M1Homo sapiens (human)1.013
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)1.8481
D(2) dopamine receptorHomo sapiens (human)0.011
Alpha-2B adrenergic receptorHomo sapiens (human)0.01
Alpha-2C adrenergic receptorHomo sapiens (human)0.082
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.95
Muscarinic acetylcholine receptor M3Homo sapiens (human)1.514
D(1A) dopamine receptorHomo sapiens (human)0.155
D(4) dopamine receptorHomo sapiens (human)2.311
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.4
Alpha-1D adrenergic receptorHomo sapiens (human)0.034
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.0071
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.078
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.95
Sodium-dependent serotonin transporterHomo sapiens (human)1.169
Pleiotropic ABC efflux transporter of multiple drugsSaccharomyces cerevisiae S288C1.7
Histamine H1 receptorHomo sapiens (human)0.024
D(3) dopamine receptorHomo sapiens (human)0.013
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.102
5-hydroxytryptamine receptor 6Homo sapiens (human)0.267
Sodium-dependent dopamine transporter Homo sapiens (human)1.735
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.8481
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)1.8481
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.054

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199013 (54.17)18.7374
1990's1 (4.17)18.2507
2000's4 (16.67)29.6817
2010's6 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Honigberg, IL; Justice, EL; Plunkett, RD; Smith, AP; Stewart, JT1
Brenner, WE; Dingfelder, R; Staurovsky, LG1
Wortman, J1
Ihamäki, T; Jussila, J; Kalima, T; Salmi, HJ; Siurala, M; Tarpila, S1
Marbury, BE1
Elliott, RC1
Fahmy, K1
Berger, T; Rentzhog, L; Udén, P1
Gin, T1
LESLIE, GB; MAXWELL, DR1
ABREU, BE; RAHDERT, E; RICHARDS, AB; WEAVER, LC1
ROSENBLUM, W; SWEIFACH, BW1
BOISSIER, JR; SIMON, P1
CLARKE, RS; DUNDEE, JW; LOVE, WJ; MOORE, J; NICHOLL, RM1

Reviews

1 review(s) available for atropine and prochlorperazine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for atropine and prochlorperazine

ArticleYear
A comparative study on the analgesic effects of indomethacin and hydromorphinechloride-atropine in acute, ureteral-stone pain.
    Acta chirurgica Scandinavica, 1983, Volume: 149, Issue:5

    Topics: Adult; Analgesics; Atropine; Dihydromorphine; Humans; Indomethacin; Injections, Intravenous; Injections, Subcutaneous; Middle Aged; Morphine Derivatives; Pain; Prochlorperazine; Prospective Studies; Ureteral Calculi

1983

Other Studies

22 other study(ies) available for atropine and prochlorperazine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Liquid chromatography in pharmaceutical analysis IV: determination of antispasmodic mixtures.
    Journal of pharmaceutical sciences, 1975, Volume: 64, Issue:8

    Topics: Atropine; Chemical Phenomena; Chemistry; Chlordiazepoxide; Chromatography; Drug Combinations; Hydrogen-Ion Concentration; Methods; Parasympatholytics; Phenobarbital; Prochlorperazine; Propantheline; Quaternary Ammonium Compounds; Quinuclidines; Scopolamine

1975
The efficacy and safety of intramuscularly administered 15(S) 15 methyl prostaglandin E2 methyl ester for induction of artificial abortion.
    American journal of obstetrics and gynecology, 1975, Sep-01, Volume: 123, Issue:1

    Topics: Abortion, Induced; Adolescent; Adult; Aspirin; Atropine; Diarrhea; Diphenoxylate; Drug Administration Schedule; Drug Evaluation; Female; Fever; Gestational Age; Humans; Injections, Intramuscular; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Prochlorperazine; Prostaglandins E; Shivering; Vomiting

1975
Female sterilization using the culdoscope.
    Population reports. Series C: Sterilization [Female], 1975, Issue:6

    Topics: Anesthesia, Local; Atropine; Chlorpromazine; Culdoscopy; Female; Humans; Meperidine; Postoperative Care; Pregnancy; Premedication; Preoperative Care; Prochlorperazine; Rectum; Scopolamine; Shock, Surgical; Sterilization, Tubal

1975
Premedication for endoscopy: a controlled trial.
    Acta hepato-gastroenterologica, 1974, Volume: 21, Issue:4

    Topics: Anesthesia, Local; Anxiety; Atropine; Diazepam; Endoscopy; Esophagoscopy; Gastroscopy; Humans; Nausea; Phenobarbital; Premedication; Prochlorperazine; Time Factors

1974
Anesthesia in abortions.
    Clinical obstetrics and gynecology, 1971, Volume: 14, Issue:1

    Topics: Abortion, Legal; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Obstetrical; Atropine; Cyclopropanes; Female; Humans; Pentobarbital; Preanesthetic Medication; Pregnancy; Prochlorperazine; Thiopental

1971
Centrally active drugs and the medullary vasopressor response of the cat; a method of distinguishing between drug actions on the central and peripheral parts of the sympathetic nervous system.
    International journal of neuropharmacology, 1969, Volume: 8, Issue:2

    Topics: Adrenalectomy; Animals; Atropine; Benactyzine; Blood Pressure; Carbamates; Cats; Chlorpromazine; Dextrans; Electric Stimulation; Femoral Artery; Hydroxyzine; Medulla Oblongata; Methods; Perphenazine; Piperidines; Pressoreceptors; Prochlorperazine; Promazine; Sympathetic Nervous System; Temperature; Tranquilizing Agents

1969
Prophylaxis against prostaglandin-induced gastrointestinal side effects.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1981, Volume: 19, Issue:6

    Topics: Abortion, Induced; Antiemetics; Atropine; Diarrhea; Dinoprost; Diphenoxylate; Drug Combinations; Female; Humans; Isonipecotic Acids; Pregnancy; Prochlorperazine; Prostaglandins F; Vomiting

1981
Anaesthesia and breast feeding.
    Anaesthesia and intensive care, 1993, Volume: 21, Issue:2

    Topics: Anesthesia, Obstetrical; Anesthetics; Atropine; Breast Feeding; Female; Humans; Infant, Newborn; Metoclopramide; Milk, Human; Neostigmine; Prochlorperazine

1993
INHIBITION OF TREMORINE BY A GROUP OF NON-ANTI-PARKINSON PHENOTHIAZINE DERIVATIVES.
    Nature, 1964, Apr-04, Volume: 202

    Topics: Antipsychotic Agents; Atropine; Benactyzine; Chlorpromazine; Histamine H1 Antagonists; Mice; Muscle Relaxants, Central; Parasympatholytics; Pharmacology; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Research; Scopolamine; Tranquilizing Agents; Tremor; Tremorine; Trihexyphenidyl

1964
EFFECT OF ANTIEMETICS AND OTHER COMPOUNDS ON PROTOVERATRINE INDUCED EMESIS IN DOGS.
    Journal of pharmaceutical sciences, 1964, Volume: 53

    Topics: Antiemetics; Atropine; Benzamides; Dogs; Haloperidol; Meclizine; Niacin; Perphenazine; Pharmacology; Prochlorperazine; Protoveratrines; Research; Triflupromazine; Veratrum; Vomiting

1964
THE EFFECT OF TRANQUILIZERS ON THE CONTRACTILE RESPONSE OF CEREBRAL ARTERIES.
    The Journal of pharmacology and experimental therapeutics, 1964, Volume: 145

    Topics: Acetylcholine; Atropine; Barium; Cerebral Arteries; Cerebrovascular Circulation; Chlorides; Chlorpromazine; Guanethidine; Histamine; Methacholine Compounds; Methysergide; Mice; Muscle Contraction; Pharmacology; Procaine; Prochlorperazine; Research; Reserpine; Vasomotor System

1964
[EXPERIMENTAL ANTICATALEPTIC ACTION OF SOME ANTIPARKINSONIAN AGENTS].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1964, Volume: 158

    Topics: Antiparkinson Agents; Atropine; Catalepsy; Nortropanes; Orphenadrine; Parasympatholytics; Pharmacology; Prochlorperazine; Rats; Research; Scopolamine; Toxicology

1964
STUDIES OF DRUGS GIVEN BEFORE ANAESTHESIA. VI. THE PHENOTHIAZINE DERIVATIVES.
    British journal of anaesthesia, 1965, Volume: 37

    Topics: Anesthesia; Anesthesia, General; Atropine; Chlorpromazine; Chlorprothixene; Fluphenazine; Humans; Meperidine; Methohexital; Methotrimeprazine; Nitrous Oxide; Oxygen; Perphenazine; Pharmacology; Phenothiazines; Preanesthetic Medication; Prochlorperazine; Promazine; Promethazine; Thiazines; Thiethylperazine; Toxicology; Tranquilizing Agents; Trifluoperazine; Triflupromazine; Trimeprazine

1965