Page last updated: 2024-09-05

atropine and pralidoxime

atropine has been researched along with pralidoxime in 225 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(pralidoxime)
Trials
(pralidoxime)
Recent Studies (post-2010) (pralidoxime)
26,7111,2591,69765828156

Research

Studies (225)

TimeframeStudies, this research(%)All Research%
pre-199054 (24.00)18.7374
1990's50 (22.22)18.2507
2000's65 (28.89)29.6817
2010's49 (21.78)24.3611
2020's7 (3.11)2.80

Authors

AuthorsStudies
Beasley, VR; Fikes, JD; Parker, AJ; Zachary, JF1
De Bleecker, J; Van Den Neucker, K; Willems, J1
de Silva, HJ; Senanayake, N; Wijewickrema, R1
Dochterman, LW; Gresham, VC; Kaminskis, A; Koplovitz, I; Stewart, JR1
Awal, MA; Malik, JK1
De Bleecker, J; De Reuck, J; Van Den Neucker, K; Vogelaers, D; Willems, J1
Clement, JG1
Brar, GK; Kumar, H; Singh, CP; Singh, N1
McCart, GM; Poikonen, J; Veatch, RM1
Mays, MZ; Murrow, ML; Romano, JA; Terry, MR1
Shih, T; Valdes, JJ; Whalley, CE1
Culp, DJ; Marin, MG; McBride, RK; Stone, KK; Zwierzynski, DJ1
Anderson, DR; Harris, LW; Lennox, WJ; Lieske, CN1
Johnson, RF; Kobrick, JL; McMenemy, DJ2
Cadarette, BS; Kolka, MA1
Heath, A; Meredith, TJ; Vale, JA1
Baux, G; Fossier, P; Poulain, B; Tauc, L1
Colardyn, F; De Wilde, V; Vogelaers, D1
Juang, YC; Lan, RS; Lee, CH; Shieh, WB; Tsao, TC1
Anderson, DR; Harris, LW; Lennox, WJ; Talbot, BG2
Culp, DJ; Marin, MG; McBride, RK; Zwierzynski, D1
Hänninen, O; Kaliste-Korhonen, E; Ryhänen, R; Ylitalo, P1
Andre, RG; Golenda, CF; Roberts, DR; Wirtz, RA1
Bonner, GD; Gildengorin, VL; Trail, DS; Wade, CE; Waring, PP; Williams, BF1
Haegerstrom-Portnoy, G; Jones, RT; Penetar, DM1
Doukas, PH; O'Neill, JJ; Sheldon, RJ; Sterling, GH1
Borowitz, SM1
Mortensen, ML1
Garber, M1
Malik, JK; Srivastava, AK1
Bruttig, SP; Cadarette, BS; Gonzalez, RR; Kolka, MA; Stephenson, LA1
Halle, A; Sloas, DD1
Bokonjić, D; Jokanović, M; Jovanović, D; Maksimović, M1
Bowles, AM; Dretchen, KL; Raines, A1
Anderson, DR; Green, MD; Harris, LW; Lennox, WJ; Talbot, BG1
Adams, AJ; Haegerstrom-Portnoy, G; Jampolsky, A; Jones, R1
Cruickshank, AN; Kipling, RM1
Donzanti, BA; Green, MD; Shores, EI1
Klemm, WR1
Anthony, A; Bocan, TM; Doebler, JA; Moore, RA; Shih, TM1
Chow, E; Higgins, RJ; Hooper, M; Knaak, JB; Wilson, BW1
Bosković, B; Cetković, S; Cosić, M; Cvetković, M; Jandrić, D1
Green, PG; Kitchen, I1
Bosković, B; Jovanović, D; Kovacević, V1
Headley, DB1
Clay, C; Stewart, GO1
Delgado, M; Suazo, M1
Goto, T; Ichikawa, S; Umetsu, N1
Koplovitz, I; Young, GD1
Bernay, I; Cantürk, F; Demirçali, AE; Sahin, M1
Hillman, JV1
Blick, DW; Brown, GC; Hartgraves, SL; Murphy, MR1
Bahat, O; Bellaiche, M; Hanji, V; Heymann, GD; Lublin, A; Mechani, S; Nyska, A; Shlosberg, A1
Almog, S; Lifshitz, M; Rotenberg, M; Shahak, E; Sofer, S; Tamiri, T1
Koplovitz, I; Stewart, JR1
Buckley, NA; Dawson, AH; Whyte, IM1
Das Gupta, S; Pant, SC; Vijayaraghavan, R1
Ghosh, AK; Jaiswal, DK; Sikder, AK1
Beers, ET; Brennecke, LH; Sparenborg, S1
Ayebo, AD; Fuortes, LJ; Kross, BC1
Arai, T; Hatakenaka, S; Ochi, G; Tokuoka, H; Watanabe, K1
Jokanović, M; Maksimović, M1
Pei, L; Petrikovics, I; Way, JL1
Barahona, MV; Sánchez-Fortún, S; Sanz, F1
Baubichon, D; Blanchet, G; Brochier, G; Clarencon, D; Galonnier, M; Lallement, G; Mestries, JC1
Anstead, MI; Tush, GM1
Göktaş, Z; Güven, M; Kurtoğlu, S; Unlühizarci, K1
Liang, J; Luo, C1
Bellaiche, M; Ershov, E; Hanji, V; Shlosberg, A1
Baubichon, D; Burckhart, MF; Clarençon, D; Galonnier, M; Lallement, G; Masqueliez, C; Mestries, JC; Peoc'h, M1
Agouridakis, P; Anastasaki, M; Delaki, C; Katsanoulas, K; Manousakis, A; Tsatsakis, AM; Tzatzarakis, M1
Ameri, A; Cezard, C; Forceville, X; Mathieu-Nolf, M; Nisse, P1
Baubichon, D; Burckhart, MF; Clarençon, D; Galonnier, M; Lallement, G; Peoc'h, M1
Chen, Y; Qin, F; Xu, H1
McDonough, JH; Shih, TM1
Baubichon, D; Burckhart, MF; Clarençon, D; Galonnier, M; Jourdil, N; Lallement, G; Peoc'h, M; Renault, F1
Chavonnet, A; Daijardin, JB; Kintz, P; Pileire, B; Ragoucy-Sengler, C; Simonetti, M; Tracqui, A1
Barahona, V; Sánchez-Fortún, S1
DeRoos, F; Hoffman, RS; Nelson, LS; Perrone, J; Stork, C1
Al-Mandhiry, ZA; Javad, H; Nair, PM1
Lall, SB; Mittra, S; Peshin, SS1
Flesch, F; Géraut, A; Jaeger, A; Ludes, B; Raul, JS; Sauder, P; Tracqui, A1
Buckley, N; Eddleston, M; Eyer, P; Szinicz, L1
Bertsias, GK; Liakou, V; Mammas, IN; Stiakakis, I; Tsatsakis, AM; Tzanakakis, GN1
Go, ML; Loke, WK; Sim, MK2
Huang, S; Qiu, Z; Shi, Y; Zhao, D1
Henretig, FM; Jew, R; Mechem, C1
Bowls, BJ; Freeman, JM; Luna, JA; Meggs, WJ1
Agostini, M; Bianchin, A1
Breton, P; Buée, J; Calvet, JH; Christin, D; Delamanche, S; Taysse, L1
Kassa, J; Krejèová, G1
Namera, A1
Baskin, SI; Cheng, TC; Hong, K; Jaszberenyi, JC; Jiang, J; Logue, BA; McGuinn, WD; Papahadjopoulos, D; Petrikovics, I; Szilasi, M; Way, JL1
ASKEW, BM1
HOBBIGER, F1
DAVIES, DR; GREEN, AL; WILLEY, GL1
BERRY, WK; DAVIES, DR; GREEN, AL1
HOBBIGER, F; SADLER, PW1
COLBOURN, JL; CROOK, JW; GOODMAN, AI; OBERST, FW1
SCHAUMANN, W1
CROOK, JW; KOON, WS; OBERST, FW2
FLEISHER, JH; HARRISON, CS; MICHEL, HO; YATES, L1
COLBOURN, JL; CROOK, JW; GOODMAN, AI; OBERST, FW; WILLS, JH; ZVIRBLIS, P1
EDERY, H1
BINENFELD, Z; VOJVODIC, V1
TONG, HS; WAY, JL1
DECANDOLE, CA1
QUINBY, GE1
BYRON, HM; POSNER, I1
JAQUES, R1
DIPALMA, JR; ZARRO, VJ1
LI, KM1
RADELEFF, RD; YOUNGER, RL1
KAWEL, HG; SCHNEIDER, JA; SCHUCHTER, A1
LEHMAN, RA1
PAYNE, JR; ROBINSON, BR1
HANZAWA, A; OGAMI, O; SANADA, H; SHIRAISHI, S; SUZUKI, N1
Bryant, SM; Cumpston, KL; Mycyk, MB1
Meggs, WJ1
Wood, SP1
Benjamin, A; McDonough, JH; McMonagle, JD; Rowland, T; Shih, TM1
Newmark, J1
Aygun, D1
Eser, B; Güven, M; Sungur, M1
Altuntaş, F; Eser, B; Güven, M; Sari, I; Sungur, M1
Bambery, P; Parthasarathy, S; Ranjit, A; Sharma, N; Singh, S1
Abdi, M; Abdollahi, M; Pajoumand, A; Rezaie, A; Shadnia, S1
Adheir, FS; Al Omary, IY; Hanssens, Y; Kamha, AA; Zalabany, HA1
Buckley, NA; Eddleston, M; Srinivas Rao, Ch; Surender, T; Venkateswarlu, V1
Petroianu, GA1
Akgun, A; Ergur, BU; Kalkan, S; Kaplan, YC; Kinay, AO; Tuncok, Y1
Lynch, M1
Sánchez-Fortún, S; Victoria Barahona, M1
Kiateboonsri, S; Thithapandha, A; Wananukul, W1
Asaeda, G; Bove, J; Cherson, A; Cooper, A; Curran, J; Foltin, G; Gonzalez, D; Kaufman, B; Langsam, Y; Marshall, L; Tunik, M; van Amerongen, R1
Abdullat, IM; Battah, AH; Hadidi, KA1
Kellar, KJ1
Ansarin, K; Ardalan, MR; Ghaffari, AR; Nezami, N; Noshad, H; Safa, J1
Hack, JB; Hoffman, RS; Mercurio-Zappala, M; Salvador, A1
Aggarwal, P; Bhoi, S; Goel, A; Gupta, V1
Joshi, R; Kalantri, SP1
Abroug, F1
Kirk, MA; Lawrence, DT1
Baker, MD1
Bhalla, A; Bhardwaj, U; Gill, K; Singh, S; Verma, SK1
Barahona, MV; Sánchez-Fortún, S1
Hrobak, PK1
Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F1
Iseki, K1
Chan, HM; Chang, JS; Chase, JS; Deng, JF; Denninghoff, K; Hu, SC; Hung, DZ; Lin, TJ; Tsai, JL; Walter, FG1
Abbara, C; Bardot, I; Cailleux, A; Clair, P; Diquet, B; Lallement, G; Le Bouil, A; Turcant, A1
Oode, Y; Sumi, Y; Tanaka, H1
Buckley, N; Davies, J; Eddleston, M; Eyer, P; Roberts, D1
Bretholz, A; Hoffman, RS; Morrisey, R1
Cevik, Y; Durukan, P; Kavalci, C; Kavalci, G; Ozer, M1
Demiryurek, AT; Gunay, N; Kose, A; Sari, I; Tarakcioglu, M; Yildirim, C1
Barr, D; Chang, A; Geller, R; Montesano, MA; Thomas, J1
Alder, N; Azher, S; Buckley, NA; Dawson, AH; Eddleston, M; Eyer, P; Hittarage, A; Jayamanne, S; Jeganathan, K; Juszczak, E; Mohamed, F; Senarathna, L; Sheriff, MH; von Meyer, L; Worek, F1
Clark, MG; Finneran, K; Hilmas, CJ; Poole, MJ; Williams, PT1
McDonough, JH; O'Donnell, JC; Shih, TM; Skovira, JW1
Abbara, C; Bardot, I; Clair, P; Comets, E; Diquet, B; Lallement, G; Rousseau, JM; Turcant, A1
Felberbaum, M; Hoffman, RS; Manini, AF; Mercurio-Zappala, M; Russell-Haders, AL1
Demiryurek, AT; Gunay, N; Kose, A; Tarakcioglu, M; Togun, N1
Azher, S; Buckley, NA; Eddleston, M; Eyer, P; Moffatt, A; Mohammed, F1
Jayapandian, P; Rajasekaran, D; Subbaraghavalu, G1
Jajoo, M; Pandey, M; Saxena, S1
Abbara, C; Bardot, I; Diquet, B; Ferec, S; Lallement, G; Lelièvre, B; Rousseau, JM; Turcant, A1
Kawamata, M; Kawamata, T; Narimatsu, E; Niiya, T; Yamakage, M1
Abdollahi, M; Baeeri, M; Karimi, G; Mohammadi, H; Nikfar, S; Sabzevari, O; Shafiee, H1
Baccaro, F; Framarini, S; Rovasio, L1
Arbelot, C; Boroli, F; Fournier, E; Megarbane, B; Moesch, C; Rouby, JJ; Saleh, M; Soummer, A1
Carrasco, M; Cuadrado, BL; Eterović, VA; Ferchmin, PA; Martins, AH; Pérez, D2
Ghosh, S; Kundu, AK; Maisnam, I; Maity, A; Saha, SP; Tanima, D1
Dillman, JF; Lumley, LA; Meyerhoff, JL; Robison, CL; Spradling, KD1
Auta, J; Brown, A; Doctor, BP; Guiodotti, A; Jensen, N; Nambiar, MP; Oguntayo, S; Wang, Y; Wei, Y; Wood, E1
Beigi, MJ; Pazooki, S; Shadnia, S; Solhi, H; Vishteh, HR1
Jacob, J; Tarabar, AF1
Batra, B; Gogia, AR; Pramanik, V; Verma, PK1
Can, I; Gul, EE; Kusumoto, FM1
Blain, PG; Clutton, RE; Dunn, M; Eddleston, M; Jefferson, RD; Murray, DB; Thomas, S; Thompson, A; Vidler, DS1
Gerszten, RE; Jin, S; Jin, YN; Kokel, D; Liu, Y; Macrae, CA; Peterson, RT; Roberts, LD; Sarkar, KS; Van Ham, TJ1
Kutti, SK; Mathew, A; Parvez, Y1
Ak, A; Bayir, A; Kara, H; Kocabas, R; Köylü, O1
Prakash, P; Subbiah, S; Sundaram, M; Swaminathan, K1
Arif, SM; Basher, A; Dawson, AH; Faiz, MA; Ghose, A; Rahman, SH1
D'Haenens, JP; Farquhar, PN; Higgins, SA; Langley, RL; McDonald, KW; Meggs, WJ; Scott, R1
Hu, J; Tang, X; Wang, R; Xie, H; Zhao, W1
Antonijević, B; Bošković, B; Ćurčić, M; Vučinić, S; Zlatković, M1
Chen, B; Chen, K; Chen, QF; Ruan, HL; Wang, W; Wen, JM1
Blair, RE; Carter, DS; DeLorenzo, RJ; Deshpande, LS; Phillips, KF1
Cheon, YJ; Choi, YH; Jung, KY; Lee, DH1
DeLorenzo, RJ; Deshpande, LS; Huang, B; Phillips, K1
Acharya, J; Jatav, PC; Karade, HN; Kumar, A; Kumar, P; Meena, MK; Swami, D1
Asghar, A; Mahar, SA; Nakeer, R; Sarfaraz, A; Shahid, M1
Chun, B; Moon, J; Song, K1
Brewer, KL; Meggs, WJ; Tran, T1
Altiti, M; Balkaya, S; Bursal Duramaz, B; Ersoy, M; Kihtir, HS; Petmezci, MT; Sevketoglu, E; Yesilbas, O1
Agarwal, R; Behera, D; Dhooria, S1
Liu, CF; Liu, HX; Yang, WH1
Gao, D; Jian, X; Sun, B; Xiao, L; Yang, L; Zhao, B; Zou, X1
Babin, MC; Brittain, MK; Jett, DA; McGarry, KG; Moyer, RA; Platoff, GE; Yeung, DT1
Babin, MC; Jett, DA; Platoff, GE; Snider, TH; Yeung, DT1
Bealer, SL; Dudek, FE; Pouliot, W; Roach, B1
Bao, HX; Chen, BY; Du, J; Huang, ZH; Li, CX; Tong, PJ; Wang, Y1
Farzaneh, E; Mostafazadeh, B; Nikkhah, F; Paeezi, M1
Çağ, Y; Özçetin, M; Yıldızdaş, D; Yılmaz, HL; Yükselmiş, U1
Marques, GLM; Minassa, VS; Pelição, FS; Peres, MD; Sampaio, KN; Siqueira, AA1
Chowdhury, M; Das, JC; Faisal, MA; Hasan, SH; Khyrunnessa, F; Muhuri, BR; Paul, N; Paul, S; Sharma, JD; Sharmin, T1
Al-Saud, AA; Alaska, YA; Almas, A; Malabaey, MAT; Malik, A1
Basrai, Z; Celedon, M; Koh, C; Warren, J1
Beijamini, V; Cavadino, A; Dos Santos, L; Felippe, ISA; Müller, CJT; Paton, JFR; Sampaio, KN; Siqueira, AA1
Harada, K; Inoue, H; Kakizaki, R; Kyan, R; Narimatsu, E; Nomura, K; Sawamoto, K; Uemura, S1
Chan, MJ; Chen, CY; Fu, JF; Hou, YC; Hsu, CW; Huang, WH; Wang, IK; Weng, CH; Yang, HY; Yen, TH; Yu, JR1
Cornelissen, AS; Garcia, EE; Joosen, MJA; Laney, J; Raulli, RE1
Huang, C; Liu, J; Wang, Y; Yang, Y; Zhang, L; Zhao, D; Zhong, Y; Zhou, Y1
Clayman, CL; Ehinger, JK; Elmér, E; Hansson, MJ; Jang, DH; Janowska, JI; Jose, JS; Karlsson, M; Kilbaugh, TJ; McManus, MJ; Piel, S; Sheldon, M; Starr, J; Ward, JL1
Narimatsu, E; Nomura, K; Oke, Y; Oku, Y1

Reviews

11 review(s) available for atropine and pralidoxime

ArticleYear
The intermediate syndrome in organophosphate poisoning: presentation of a case and review of the literature.
    Journal of toxicology. Clinical toxicology, 1992, Volume: 30, Issue:3

    Topics: Adult; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dimethoate; Electromyography; Female; Humans; Neuromuscular Diseases; Pralidoxime Compounds; Respiratory Paralysis; Synaptic Transmission; Syndrome; Ventilators, Mechanical

1992
Management of acute childhood poisonings caused by selected insecticides and herbicides.
    Pediatric clinics of North America, 1986, Volume: 33, Issue:2

    Topics: Absorption; Adolescent; Animals; Anticonvulsants; Atropine; Carbamates; Central Nervous System; Child; Child, Preschool; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Gastric Lavage; Herbicides; Humans; Insecticides; Nausea; Organophosphorus Compounds; Paraquat; Pralidoxime Compounds; Seizures; Vomiting

1986
Effects of atropine sulfate and pralidoxime chloride on visual, physiological, performance, subjective, and cognitive variables in man: a review.
    Military medicine, 1982, Volume: 147, Issue:2

    Topics: Atropine; Cognition; Humans; Physical Exertion; Pralidoxime Compounds; Vision, Ocular

1982
Cholinesterase-inhibiting insecticide toxicity.
    American family physician, 1993, May-15, Volume: 47, Issue:7

    Topics: Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterases; Environmental Monitoring; Epidemiological Monitoring; Erythrocyte Count; Humans; Insecticides; Occupational Exposure; Poisoning; Pralidoxime Compounds; Risk Factors

1993
Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials.
    QJM : monthly journal of the Association of Physicians, 2002, Volume: 95, Issue:5

    Topics: Acute Disease; Atropine; Drug Overdose; Humans; Insecticides; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Randomized Controlled Trials as Topic; Research Design

2002
[Practical analysis of toxic substances useful for clinical toxicology--6--Organophosphates].
    Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 2003, Volume: 16, Issue:2

    Topics: Atropine; Cholinesterase Reactivators; Chromatography, Thin Layer; Female; Fenitrothion; Gas Chromatography-Mass Spectrometry; Humans; Insecticides; Malathion; Middle Aged; Muscarinic Antagonists; Pralidoxime Compounds

2003
Therapy for nerve agent poisoning.
    Archives of neurology, 2004, Volume: 61, Issue:5

    Topics: Antidotes; Atropine; Chemical Warfare Agents; Humans; Neurotoxicity Syndromes; Neurotoxins; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Soman

2004
Diagnosis in an acute organophosphate poisoning: report of three interesting cases and review of the literature.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2004, Volume: 11, Issue:1

    Topics: Acetylcholinesterase; Acute Disease; Adult; Aged; Antidotes; Atropine; Emergency Medicine; Female; Humans; Insecticides; Male; Organophosphorus Compounds; Poisoning; Pralidoxime Compounds; Treatment Outcome

2004
Chemical terrorism attacks: update on antidotes.
    Emergency medicine clinics of North America, 2007, Volume: 25, Issue:2

    Topics: Antidotes; Atropine; Botulinum Toxins; Chemical Terrorism; Humans; Muscarinic Antagonists; Potassium Iodide; Pralidoxime Compounds; Radiation Injuries

2007
Antidotes for nerve agent poisoning: should we differentiate children from adults?
    Current opinion in pediatrics, 2007, Volume: 19, Issue:2

    Topics: Adult; Antidotes; Atropine; Chemical Warfare Agents; Child; Humans; Organophosphate Poisoning; Pralidoxime Compounds

2007
[Antidose therapy for organophosphate poisoning].
    Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 2008, Volume: 21, Issue:2

    Topics: Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Organophosphate Poisoning; Pesticides; Pralidoxime Compounds

2008

Trials

13 trial(s) available for atropine and pralidoxime

ArticleYear
Does pralidoxime affect outcome of management in acute organophosphorus poisoning?
    Lancet (London, England), 1992, May-09, Volume: 339, Issue:8802

    Topics: Adolescent; Adult; Aged; Atropine; Cholinesterase Reactivators; Critical Care; Drug Therapy, Combination; Female; Humans; Length of Stay; Male; Middle Aged; Organophosphate Poisoning; Poisoning; Pralidoxime Compounds; Sri Lanka; Treatment Outcome; Ventilators, Mechanical

1992
Effects of nerve agent antidote and heat exposure on soldier performance in the BDU and MOPP-IV ensembles.
    Military medicine, 1990, Volume: 155, Issue:4

    Topics: Adolescent; Adult; Affect; Antidotes; Atropine; Drug Therapy, Combination; Efficiency; Heat Exhaustion; Humans; Male; Military Personnel; Pralidoxime Compounds; Protective Clothing

1990
Effects of atropine and 2-PAM chloride on vision and performance in humans.
    Aviation, space, and environmental medicine, 1987, Volume: 58, Issue:1

    Topics: Accommodation, Ocular; Adult; Atropine; Blood Pressure; Color Perception; Double-Blind Method; Emotions; Humans; Male; Pralidoxime Compounds; Psychomotor Performance; Pulse; Pupil; Vision, Ocular; Visual Acuity

1987
The effects of fresh frozen plasma on cholinesterase levels and outcomes in patients with organophosphate poisoning.
    Journal of toxicology. Clinical toxicology, 2004, Volume: 42, Issue:5

    Topics: Atropine; Butyrylcholinesterase; Cholinesterase Reactivators; Humans; Length of Stay; Muscarinic Antagonists; Organophosphate Poisoning; Plasma; Pralidoxime Compounds; Prospective Studies; Treatment Outcome

2004
Benefits of magnesium sulfate in the management of acute human poisoning by organophosphorus insecticides.
    Human & experimental toxicology, 2004, Volume: 23, Issue:12

    Topics: Adolescent; Adult; Aged; Atropine; Cholinesterase Reactivators; Drug Therapy, Combination; Female; Humans; Insecticides; Magnesium Sulfate; Male; Middle Aged; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Pralidoxime Compounds; Single-Blind Method

2004
Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial.
    PLoS medicine, 2009, Jun-30, Volume: 6, Issue:6

    Topics: Acetylcholinesterase; Adult; Antidotes; Atropine; Drug Therapy, Combination; Female; Humans; Insecticides; Intubation, Intratracheal; Male; Organoplatinum Compounds; Poisoning; Pralidoxime Compounds

2009
Bioavailability of diazepam after intramuscular injection of its water-soluble prodrug alone or with atropine-pralidoxime in healthy volunteers.
    British journal of pharmacology, 2009, Volume: 157, Issue:8

    Topics: Adolescent; Adult; Area Under Curve; Atropine; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Diazepam; Dipeptides; Drug Combinations; Humans; Injections, Intramuscular; Male; Middle Aged; Pralidoxime Compounds; Prodrugs; Solubility; Tandem Mass Spectrometry; Water

2009
Pharmacokinetic analysis of pralidoxime after its intramuscular injection alone or in combination with atropine-avizafone in healthy volunteers.
    British journal of pharmacology, 2010, Volume: 161, Issue:8

    Topics: Adolescent; Adult; Atropine; Dipeptides; Drug Combinations; Drug Interactions; Humans; Injections, Intramuscular; Male; Middle Aged; Models, Statistical; Pralidoxime Compounds

2010
Effectiveness of fresh frozen plasma as supplementary treatment in organophosphate poisoning.
    The Medical journal of Malaysia, 2011, Volume: 66, Issue:4

    Topics: Adult; Atropine; Female; Humans; Male; Middle Aged; Organophosphate Poisoning; Plasma; Pralidoxime Compounds

2011
Phase II study of magnesium sulfate in acute organophosphate pesticide poisoning.
    Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Atropine; Bangladesh; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Female; Hospitals, University; Humans; Infusions, Intravenous; Magnesium; Magnesium Sulfate; Male; Middle Aged; Muscarinic Antagonists; Organophosphate Poisoning; Pralidoxime Compounds; Severity of Illness Index; Young Adult

2013
Clinical study of continuous micropump infusion of atropine and pralidoxime chloride for treatment of severe acute organophosphorus insecticide poisoning.
    Journal of the Chinese Medical Association : JCMA, 2015, Volume: 78, Issue:12

    Topics: Adult; Atropine; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Insecticides; Male; Organophosphate Poisoning; Pralidoxime Compounds

2015
[The influence of sodium bicarbonate combined with ulinastatin on cholinesterase activity for patients with acute phoxim pesticide poisoning].
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2016, Volume: 34, Issue:1

    Topics: Atropine; Cholinesterases; Glycoproteins; Humans; Organophosphate Poisoning; Organothiophosphorus Compounds; Pesticides; Pralidoxime Compounds; Sodium Bicarbonate

2016
Efficacy of fresh packed red blood transfusion in organophosphate poisoning.
    Medicine, 2017, Volume: 96, Issue:11

    Topics: Acute Disease; Atropine; Cholinesterase Reactivators; Cholinesterases; Erythrocyte Transfusion; Female; Gastric Lavage; Humans; Male; Organophosphate Poisoning; Pralidoxime Compounds; Prospective Studies; Time Factors

2017

Other Studies

201 other study(ies) available for atropine and pralidoxime

ArticleYear
Clinical, biochemical, electrophysiologic, and histologic assessment of chlorpyrifos induced delayed neuropathy in the cat.
    Neurotoxicology, 1992,Fall, Volume: 13, Issue:3

    Topics: Animals; Antidotes; Atropine; Carboxylic Ester Hydrolases; Cats; Chlorpyrifos; Cholinesterases; Diazepam; Electromyography; Isoflurophate; Lymphocytes; Male; Motor Neurons; Nervous System Diseases; Neural Conduction; Pralidoxime Compounds; Time Factors

1992
Evaluation of the toxicity, pathology, and treatment of cyclohexylmethylphosphonofluoridate (CMPF) poisoning in rhesus monkeys.
    Archives of toxicology, 1992, Volume: 66, Issue:9

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Lethal Dose 50; Macaca mulatta; Male; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide

1992
Effects of oximes and atropine on acute phosphamidon intoxication in Bubalus bubalis.
    Bulletin of environmental contamination and toxicology, 1992, Volume: 49, Issue:3

    Topics: Animals; Antidotes; Atropine; Buffaloes; Cholinesterase Reactivators; Diacetyl; Drug Combinations; Fasciculation; Male; Phosphamidon; Pralidoxime Compounds; Sialorrhea; Tremor

1992
Prolonged toxicity with intermediate syndrome after combined parathion and methyl parathion poisoning.
    Journal of toxicology. Clinical toxicology, 1992, Volume: 30, Issue:3

    Topics: Adult; Antidotes; Atropine; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Electromyography; Erythrocytes; Female; Humans; Male; Methyl Parathion; Middle Aged; Neuromuscular Diseases; Parathion; Pralidoxime Compounds; Respiratory Paralysis

1992
Efficacy of various oximes against GF (cyclohexyl methylphosphonofluoridate) poisoning in mice.
    Archives of toxicology, 1992, Volume: 66, Issue:2

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; In Vitro Techniques; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Nervous System Diseases; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds

1992
Endosulfan poisoning: a study of 22 cases.
    The Journal of the Association of Physicians of India, 1992, Volume: 40, Issue:2

    Topics: Adult; Antidotes; Atropine; Cholinesterase Reactivators; Endosulfan; Humans; Male; Poisoning; Pralidoxime Compounds

1992
Waivers for military use of investigational agents.
    American journal of hospital pharmacy, 1991, Volume: 48, Issue:7

    Topics: Antidotes; Atropine; Botulinum Antitoxin; Drugs, Investigational; Ethics, Pharmacy; Federal Government; Government Regulation; Gulf War; Human Experimentation; Humans; Informed Consent; Military Personnel; Pralidoxime Compounds; Pyridostigmine Bromide; Risk Assessment; Saudi Arabia; United States; Warfare

1991
Protection from lethality and behavioral incapacitation resulting from intoxication by soman (pinacolyl methylphosphonofluoridate) and treatment with atropine sulfate and 2-PAM chloride in the guinea pig, cavia porcellus.
    Drug and chemical toxicology, 1991, Volume: 14, Issue:1-2

    Topics: Animals; Atropine; Avoidance Learning; Cholinesterase Reactivators; Drug Therapy, Combination; Guinea Pigs; Lethal Dose 50; Male; Pralidoxime Compounds; Soman

1991
A comparison of cholinergic effects of HI-6 and pralidoxime-2-chloride (2-PAM) in soman poisoning.
    Toxicology letters, 1991, Volume: 55, Issue:2

    Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Drug Interactions; Lethal Dose 50; Male; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Soman

1991
Variable effects of soman on macromolecular secretion by ferret trachea.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1991, Volume: 16, Issue:1

    Topics: Acetylcholine; Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Ferrets; L-Lactate Dehydrogenase; Male; Organ Culture Techniques; Pralidoxime Compounds; Soman; Sulfates; Sulfur Radioisotopes; Trachea

1991
Evaluation of phosphinates as potential pretreatments for nerve agents.
    Life sciences, 1991, Volume: 48, Issue:25

    Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Reactivators; Evaluation Studies as Topic; Guinea Pigs; Injections, Intramuscular; Lethal Dose 50; Male; Nitrobenzenes; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds

1991
Heat exchange after cholinolytic and oxime therapy in protective clothing.
    Military medicine, 1990, Volume: 155, Issue:9

    Topics: Adult; Atropine; Body Temperature Regulation; Cholinesterase Reactivators; Hot Temperature; Humans; Male; Pralidoxime Compounds; Protective Clothing; Stress, Physiological

1990
High dose atropine in organophosphorus poisoning.
    Postgraduate medical journal, 1990, Volume: 66, Issue:780

    Topics: Antidotes; Atropine; Cholinesterase Reactivators; Drug Administration Schedule; Humans; Insecticides; Organophosphorus Compounds; Pralidoxime Compounds; Time Factors

1990
Prevention and treatment of nerve gas poisoning.
    The Medical letter on drugs and therapeutics, 1990, Nov-16, Volume: 32, Issue:831

    Topics: Animals; Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Gas Poisoning; Humans; Pralidoxime Compounds; Protective Clothing; Pyridostigmine Bromide; Respiratory Protective Devices

1990
Receptor-mediated presynaptic facilitation of quantal release of acetylcholine induced by pralidoxime in Aplysia.
    Cellular and molecular neurobiology, 1990, Volume: 10, Issue:3

    Topics: Acetylcholine; Acetylcholinesterase; Action Potentials; Animals; Aplysia; Atropine; Enzyme Activation; Hemicholinium 3; Neurons; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Receptors, Nicotinic; Secretory Rate; Synapses; Tubocurarine

1990
Prompt recovery from severe cholinesterase-inhibitor poisoning--remarks on classification and therapy of organophosphate poisoning.
    Klinische Wochenschrift, 1990, Jun-19, Volume: 68, Issue:12

    Topics: Acetylcholinesterase; Adult; Aged; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Combined Modality Therapy; Drug Overdose; Erythrocytes; Female; Fenthion; Gastric Lavage; Humans; Insecticides; Male; Middle Aged; Neurologic Examination; Parathion; Pralidoxime Compounds

1990
Effects of atropine/2-PAM chloride, heat, and chemical protective clothing on visual performance.
    Aviation, space, and environmental medicine, 1990, Volume: 61, Issue:7

    Topics: Adolescent; Adult; Antidotes; Atropine; Chemical Warfare; Contrast Sensitivity; Depth Perception; Gas Poisoning; Hot Temperature; Humans; Humidity; Male; Pralidoxime Compounds; Protective Clothing; Time Factors; Vision, Ocular; Visual Acuity

1990
Respiratory failure of acute organophosphate and carbamate poisoning.
    Chest, 1990, Volume: 98, Issue:3

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Atropine; Carbamates; Child; Child, Preschool; Female; Humans; Infant; Insecticides; Male; Middle Aged; Organophosphorus Compounds; Pneumonia; Pralidoxime Compounds; Respiration, Artificial; Respiratory Insufficiency

1990
The relationship between oxime-induced reactivation of carbamylated acetylcholinesterase and antidotal efficacy against carbamate intoxication.
    Toxicology and applied pharmacology, 1989, Mar-15, Volume: 98, Issue:1

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Carbaryl; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Interactions; Erythrocytes; Lethal Dose 50; Male; Oximes; Physostigmine; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains

1989
Effects of soman and its antidotes on tracheal mucociliary transport of ferrets.
    Journal of applied physiology (Bethesda, Md. : 1985), 1989, Volume: 66, Issue:3

    Topics: Animals; Atropine; Blood Pressure; Carbon Dioxide; Cholinesterase Reactivators; Ferrets; Heart Rate; Hydrogen-Ion Concentration; Male; Mucociliary Clearance; Oxygen; Partial Pressure; Pralidoxime Compounds; Reference Values; Soman; Trachea

1989
Cold exposure decreases the effectiveness of atropine-oxime treatment in organophosphate intoxication in rats and mice.
    General pharmacology, 1989, Volume: 20, Issue:6

    Topics: Animals; Antidotes; Atropine; Carboxylic Ester Hydrolases; Cholinesterase Reactivators; Cold Temperature; Enzyme Reactivators; Isoflurophate; Lethal Dose 50; Mice; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Rats; Rats, Inbred F344

1989
An insect bioassay as a primary screen for nerve agent antidotes.
    Military medicine, 1986, Volume: 151, Issue:5

    Topics: Animals; Antidotes; Atropine; Biological Assay; Cholinesterase Reactivators; Female; Houseflies; Isoflurophate; Nervous System; Physostigmine; Pralidoxime Compounds

1986
Effects of atropine, 2-PAM, or pyridostigmine in euvolemic or hemorrhagic conscious swine.
    Military medicine, 1988, Volume: 153, Issue:9

    Topics: Acetylcholinesterase; Animals; Atropine; Blood Pressure; Erythrocytes; Heart Rate; Injections, Intra-Arterial; Pralidoxime Compounds; Pyridostigmine Bromide; Shock, Hemorrhagic; Swine

1988
Combined atropine and 2-PAM Cl effects on tracking performance and visual, physiological, and psychological functions.
    Aviation, space, and environmental medicine, 1988, Volume: 59, Issue:12

    Topics: Accommodation, Ocular; Adult; Arousal; Atropine; Cholinesterase Reactivators; Color Perception; Depth Perception; Dose-Response Relationship, Drug; Drug Synergism; Eye Movements; Humans; Male; Mental Recall; Pralidoxime Compounds; Psychological Tests; Psychomotor Performance; Pursuit, Smooth; Sensation; Visual Acuity

1988
In vivo protection against soman toxicity by known inhibitors of acetylcholine synthesis in vitro.
    Biochemical pharmacology, 1988, Feb-01, Volume: 37, Issue:3

    Topics: Acetylcholine; Animals; Atropine; Cholinesterase Reactivators; Hemicholinium 3; Kinetics; Lethal Dose 50; Male; Pralidoxime Compounds; Rats; Rats, Inbred Strains; Soman; Structure-Activity Relationship

1988
Prolonged organophosphate toxicity in a twenty-six-month-old child.
    The Journal of pediatrics, 1988, Volume: 112, Issue:2

    Topics: Accidents; Atropine; Child, Preschool; Drug Therapy, Combination; Fenthion; Humans; Male; Muscle Tonus; Organophosphate Poisoning; Pesticides; Pralidoxime Compounds; Respiration; Respiration, Artificial

1988
Carbamate poisoning: the 'other' insecticide.
    Pediatrics, 1987, Volume: 79, Issue:5

    Topics: Antidotes; Atropine; Carbamates; Female; Humans; Infant; Insecticides; Organophosphorus Compounds; Pralidoxime Compounds; Vitamin K

1987
Effects of cholinesterase reactivators and atropine on fenitrothion-induced hypothermia in Bubalus bubalis.
    Toxicology letters, 1987, Volume: 36, Issue:3

    Topics: Acetylcholinesterase; Animals; Atropine; Body Temperature; Buffaloes; Butanones; Cholinesterase Reactivators; Diacetyl; Erythrocytes; Fenitrothion; Hypothermia; Pralidoxime Compounds

1987
Human thermoregulation after atropine and/or pralidoxime administration.
    Aviation, space, and environmental medicine, 1987, Volume: 58, Issue:6

    Topics: Adult; Atropine; Body Temperature Regulation; Humans; Male; Physical Exertion; Plethysmography; Pralidoxime Compounds; Regional Blood Flow; Skin; Sweating

1987
Percutaneous organophosphate poisoning.
    Southern medical journal, 1987, Volume: 80, Issue:9

    Topics: Atropine; Coma; Diazinon; Humans; Insecticides; Lice Infestations; Male; Middle Aged; Pralidoxime Compounds; Seizures; Self Medication; Skin Absorption

1987
Protective effects of oximes HI-6 and PAM-2 applied by osmotic minipumps in quinalphos-poisoned rats.
    Archives internationales de pharmacodynamie et de therapie, 1987, Volume: 288, Issue:2

    Topics: Animals; Antidotes; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Diazepam; Insecticides; Lethal Dose 50; Male; Muscles; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats

1987
Protection by phenytoin and calcium channel blocking agents against the toxicity of diisopropylfluorophosphate.
    Toxicology and applied pharmacology, 1986, Volume: 83, Issue:3

    Topics: Animals; Anticonvulsants; Atropine; Calcium Channel Blockers; Isoflurophate; Lethal Dose 50; Male; Mice; Phenytoin; Pralidoxime Compounds

1986
Oxime-induced decarbamylation and atropine/oxime therapy of guinea pigs intoxicated with pyridostigmine.
    Life sciences, 1987, Feb-09, Volume: 40, Issue:6

    Topics: Acetylcholinesterase; Animals; Atropine; Erythrocytes; Guinea Pigs; Male; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide

1987
Organophosphate insecticide poisoning.
    Anaesthesia, 1985, Volume: 40, Issue:3

    Topics: Acute Disease; Adult; Atropine; Cholinesterase Reactivators; Critical Care; Humans; Insecticides; Male; Organophosphate Poisoning; Organothiophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds

1985
Relationship between reversible acetylcholinesterase inhibition and efficacy against soman lethality.
    Life sciences, 1985, Sep-02, Volume: 37, Issue:9

    Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Guinea Pigs; Male; Mecamylamine; Organophosphorus Compounds; Physostigmine; Pralidoxime Compounds; Pyridostigmine Bromide; Rats; Soman

1985
Atropine sulfate and 2-pyridine aldoxime methylchloride elicit stress-induced convulsions and lethality in mice and guinea pigs.
    Drug and chemical toxicology, 1985, Volume: 8, Issue:6

    Topics: Animals; Atropine; Blood Glucose; Body Temperature; Cold Temperature; Diazepam; Drug Interactions; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Pralidoxime Compounds; Seizures; Species Specificity; Stress, Physiological; Swimming; Time Factors

1985
Efficacy and toxicity of drug combinations in treatment of physostigmine toxicosis.
    Toxicology, 1983, Volume: 27, Issue:1

    Topics: Animals; Atropine; Benactyzine; Cholinesterase Reactivators; Diazepam; Drug Therapy, Combination; Ganglionic Blockers; Hexamethonium; Hexamethonium Compounds; Male; Mecamylamine; Mice; Physostigmine; Pralidoxime Compounds; Tranquilizing Agents; Trimedoxime

1983
Brain neuronal RNA metabolism during acute soman toxication: effects of antidotal pretreatments.
    Neurochemical research, 1983, Volume: 8, Issue:8

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Caudate Nucleus; Cerebral Cortex; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Neurons; Organophosphorus Compounds; Physostigmine; Pralidoxime Compounds; Rats; Rats, Inbred Strains; RNA; Soman

1983
Antidotes and neuropathic potential of isofenphos.
    Bulletin of environmental contamination and toxicology, 1984, Volume: 33, Issue:4

    Topics: Animals; Antidotes; Atropine; Carboxylic Ester Hydrolases; Chickens; Dose-Response Relationship, Drug; Female; Insecticides; Lethal Dose 50; Male; Nervous System Diseases; Organothiophosphorus Compounds; Pralidoxime Compounds; Rats; Rats, Inbred Strains

1984
Effect of PAM-2 Cl, HI-6, and HGG-12 in poisoning by tabun and its thiocholine-like analog in the rat.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:2 Pt 2

    Topics: Animals; Atropine; Choline; Cholinesterase Reactivators; Cholinesterases; Female; Guinea Pigs; Heart; Humans; Lethal Dose 50; Male; Muscle Contraction; Muscle, Smooth; Organophosphate Poisoning; Organophosphates; Oximes; Phrenic Nerve; Pralidoxime Compounds; Pyridinium Compounds; Rats; Thiocholine

1984
Differential effects of di-isopropylfluorophosphate poisoning and its treatment on opioid antinociception in the mouse.
    Life sciences, 1983, Volume: 33 Suppl 1

    Topics: Animals; Atropine; Cholinesterase Reactivators; Isoflurophate; Male; Mice; Narcotics; Nociceptors; Pain; Pralidoxime Compounds

1983
PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:2 Pt 2

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Dogs; Guinea Pigs; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Species Specificity

1984
Two unusual presentations of organophosphate poisoning.
    Anaesthesia and intensive care, 1982, Volume: 10, Issue:3

    Topics: Aged; Atropine; Cholinesterase Reactivators; Cholinesterases; Erythrocytes; Humans; Male; Middle Aged; Organophosphate Poisoning; Pralidoxime Compounds

1982
[Poisoning by organo-phosphorate compounds (author's transl)].
    Revista medica de Chile, 1981, Volume: 109, Issue:9

    Topics: Adult; Atropine; Cholinesterase Inhibitors; Female; Humans; Insecticides; Male; Organophosphorus Compounds; Pralidoxime Compounds; Respiration, Artificial

1981
Antidotal action of atropine sulfate against insecticide benfuracarb poisoning in rats.
    The Journal of toxicological sciences, 1995, Volume: 20, Issue:2

    Topics: Administration, Oral; Animals; Antidotes; Atropine; Benzofurans; beta-Alanine; Carbamates; Cholinesterase Reactivators; Injections, Intraperitoneal; Insecticides; Male; Pralidoxime Compounds; Rats; Rats, Sprague-Dawley

1995
Acute toxicity of cyclohexylmethylphosphonofluoridate (CMPF) in rhesus monkeys: serum biochemical and hematologic changes.
    Archives of toxicology, 1995, Volume: 69, Issue:6

    Topics: Alanine Transaminase; Animals; Antidotes; Aspartate Aminotransferases; Atropine; Biomarkers; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Creatine Kinase; Injections, Intramuscular; L-Lactate Dehydrogenase; Lethal Dose 50; Macaca mulatta; Male; Organophosphorus Compounds; Oximes; Potassium; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Seizures

1995
Reflex sympathetic dystrophy syndrome secondary to organophosphate intoxication induced neuropathy.
    Annals of nuclear medicine, 1994, Volume: 8, Issue:4

    Topics: Action Potentials; Adult; Atropine; Bone and Bones; Calcitonin; Cholinesterase Reactivators; Dimethoate; Electromyography; Follow-Up Studies; Humans; Male; Median Nerve; Motor Neurons; Muscle, Skeletal; Nervous System Diseases; Pralidoxime Compounds; Radiography; Radionuclide Imaging; Reflex Sympathetic Dystrophy; Ulnar Nerve

1994
Treatment of nerve gas poisoning.
    The Medical letter on drugs and therapeutics, 1995, May-12, Volume: 37, Issue:948

    Topics: Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Gases; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Respiratory Protective Devices; Sarin; Soman

1995
Emergency care of insecticide poisonings.
    The Journal of the Florida Medical Association, 1994, Volume: 81, Issue:11

    Topics: Antidotes; Atropine; Blood Circulation; Carbamates; Cholinesterases; Critical Care; Decontamination; Emergency Medical Services; Emergency Service, Hospital; Humans; Insecticides; Organophosphorus Compounds; Poisoning; Pralidoxime Compounds; Respiration; Treatment Outcome

1994
Primate performance decrements following acute soman exposure: failure of chemical countermeasures.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:3

    Topics: Animals; Atropine; Cholinesterase Reactivators; Cholinesterases; Dose-Response Relationship, Drug; Macaca mulatta; Male; Pralidoxime Compounds; Psychomotor Performance; Pyridostigmine Bromide; Soman

1994
Percutaneous exposure to ethyl parathion in a feral Griffon vulture (Gyps fulvus).
    Veterinary and human toxicology, 1994, Volume: 36, Issue:3

    Topics: Administration, Cutaneous; Animals; Atropine; Bird Diseases; Birds; Fatal Outcome; Paralysis; Parathion; Pralidoxime Compounds

1994
Carbamate poisoning and oxime treatment in children: a clinical and laboratory study.
    Pediatrics, 1994, Volume: 93, Issue:4

    Topics: Aldicarb; Antidotes; Atropine; Carbamates; Child; Child, Preschool; Cholinesterases; Drug Therapy, Combination; Female; Humans; Infant; Male; Methomyl; Obidoxime Chloride; Oximes; Paraoxon; Poisoning; Pralidoxime Compounds; Retrospective Studies

1994
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
    Toxicology letters, 1994, Feb-15, Volume: 70, Issue:3

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms

1994
Organophosphate poisoning: peripheral vascular resistance--a measure of adequate atropinization.
    Journal of toxicology. Clinical toxicology, 1994, Volume: 32, Issue:1

    Topics: Acetylcholinesterase; Aged; Alprazolam; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dimethoate; Drug Interactions; Fenthion; Humans; Male; Middle Aged; Poisoning; Pralidoxime Compounds; Vascular Diseases; Vascular Resistance

1994
Sarin induced lung pathology and protection by standard therapy regime.
    Biomedical and environmental sciences : BES, 1993, Volume: 6, Issue:2

    Topics: Animals; Atropine; Cholinesterase Reactivators; Diazepam; Environmental Exposure; Lung; Male; Pralidoxime Compounds; Rats; Sarin

1993
Quaternary salts of 3,3'-bis-pyridinium monooximes: synthesis and biological activity.
    Journal of pharmaceutical sciences, 1993, Volume: 82, Issue:3

    Topics: Animals; Antidotes; Atropine; Cholinesterase Reactivators; Isoflurophate; Kinetics; Magnetic Resonance Spectroscopy; Mice; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Spectrophotometry, Infrared; Structure-Activity Relationship; Trimedoxime

1993
Pharmacological dissociation of the motor and electrical aspects of convulsive status epilepticus induced by the cholinesterase inhibitor soman.
    Epilepsy research, 1993, Volume: 14, Issue:2

    Topics: Analysis of Variance; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Diazepam; Electroencephalography; Guinea Pigs; Image Processing, Computer-Assisted; Male; Pralidoxime Compounds; Pyridostigmine Bromide; Scopolamine; Soman; Status Epilepticus

1993
Neuroleptic malignant-like syndrome: a complication of acute organophosphate poisoning.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:11

    Topics: Atropine; Cholinesterase Reactivators; Cholinesterases; Dantrolene; Female; Humans; Middle Aged; Miosis; Muscarinic Antagonists; Muscle Relaxants, Central; Neuroleptic Malignant Syndrome; Organophosphate Poisoning; Organothiophosphorus Compounds; Poisoning; Pralidoxime Compounds; Respiration; Salivation; Schizophrenia; Seizures; Suicide, Attempted; Therapeutic Irrigation

1995
A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat.
    Archives of toxicology, 1995, Volume: 70, Issue:2

    Topics: Administration, Oral; Animals; Antidotes; Atropine; Diazepam; Dose-Response Relationship, Drug; Insecticides; Male; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Rats; Rats, Wistar; Trimedoxime

1995
Antagonism of the lethal effects of paraoxon by carrier erythrocytes containing phosphotriesterase.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1995, Volume: 28, Issue:2

    Topics: Animals; Antidotes; Aryldialkylphosphatase; Atropine; Cholinesterases; Dose-Response Relationship, Drug; Drug Carriers; Drug Combinations; Erythrocytes; Esterases; Insecticides; Male; Mice; Mice, Inbred BALB C; Mortality; Paraoxon; Pralidoxime Compounds; Survival; Time Factors

1995
Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae.
    Archives of environmental contamination and toxicology, 1996, Volume: 31, Issue:3

    Topics: Animals; Artemia; Atropine; Chlorpyrifos; Cholinergic Antagonists; Cholinesterase Reactivators; Cysts; Hexamethonium; Insecticides; Larva; Methyl Parathion; Parasympatholytics; Parathion; Pirenzepine; Poisoning; Pralidoxime Compounds; Species Specificity; Structure-Activity Relationship

1996
Efficacy of atropine/pralidoxime/diazepam or atropine/HI-6/prodiazepam in primates intoxicated by soman.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:2

    Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Diazepam; Dipeptides; Drug Therapy, Combination; Electrocardiography; Electroencephalography; Macaca fascicularis; Male; Oximes; Poisoning; Pralidoxime Compounds; Prodrugs; Pyridinium Compounds; Soman

1997
Pralidoxime continuous infusion in the treatment of organophosphate poisoning.
    The Annals of pharmacotherapy, 1997, Volume: 31, Issue:4

    Topics: Adult; Antidotes; Atropine; Chlorpyrifos; Drug Therapy, Combination; Humans; Infusions, Intravenous; Insecticides; Male; Muscarinic Antagonists; Poisoning; Pralidoxime Compounds

1997
Intravenous organophosphate injection: an unusual way of intoxication.
    Human & experimental toxicology, 1997, Volume: 16, Issue:5

    Topics: Adult; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Injections, Intravenous; Insecticides; Male; Muscarinic Antagonists; Nervous System Diseases; Organothiophosphorus Compounds; Pralidoxime Compounds; Schizophrenia; Suicide, Attempted

1997
Evaluation of combined toxic effects of GB/GF and efficacy of jielin injection against combined poisoning in mice.
    Toxicology letters, 1997, Aug-22, Volume: 92, Issue:3

    Topics: Animals; Antidotes; Atropine; Benactyzine; Chemical Warfare Agents; Cholinesterase Reactivators; Female; Humans; Injections; Male; Mice; Organophosphorus Compounds; Pralidoxime Compounds; Sarin; Software

1997
Poisonings associated with illegal use of aldicarb as a rodenticide -- New York City, 1994-1997.
    MMWR. Morbidity and mortality weekly report, 1997, Oct-17, Volume: 46, Issue:41

    Topics: Adult; Aldicarb; Anti-Arrhythmia Agents; Atropine; Child, Preschool; Cholinesterase Reactivators; Female; Humans; Insecticides; Male; New York City; Pest Control; Poisoning; Pralidoxime Compounds; Rodenticides

1997
New treatment regimens in organophosphate (diazinon) and carbamate (methomyl) insecticide-induced toxicosis in fowl.
    Veterinary and human toxicology, 1997, Volume: 39, Issue:6

    Topics: Animals; Antidotes; Atropine; Chickens; Diazinon; Dose-Response Relationship, Drug; Insecticides; Methomyl; Pralidoxime Compounds

1997
Nerve agent poisoning in primates: antilethal, anti-epileptic and neuroprotective effects of GK-11.
    Archives of toxicology, 1998, Volume: 72, Issue:2

    Topics: Animals; Anticonvulsants; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cyclohexanes; Cyclohexenes; Diazepam; Drug Combinations; Excitatory Amino Acid Antagonists; Injections, Intravenous; Macaca fascicularis; Male; Muscarinic Antagonists; Neuroprotective Agents; Piperidines; Pralidoxime Compounds; Seizures; Soman; Staining and Labeling; Time Factors

1998
Clinical and toxicological data in fenthion and omethoate acute poisoning.
    Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 1998, Volume: 33, Issue:6

    Topics: Adult; Antidotes; Atropine; Charcoal; Cholinesterase Inhibitors; Cholinesterase Reactivators; Critical Care; Dimethoate; Female; Fenthion; Gastric Lavage; Greece; Humans; Insecticides; Male; Middle Aged; Poisoning; Pralidoxime Compounds; Treatment Outcome

1998
Intermediate syndrome with delayed distal polyneuropathy from ethyl parathion poisoning.
    Veterinary and human toxicology, 1998, Volume: 40, Issue:6

    Topics: Acute Disease; Adult; Atropine; Cholinesterase Reactivators; Drug Overdose; Drug Therapy, Combination; Female; Gastric Lavage; Humans; Insecticides; Muscles; Parathion; Peripheral Nervous System Diseases; Pralidoxime Compounds; Recurrence; Respiration, Artificial; Suicide, Attempted; Syndrome; Treatment Outcome

1998
Acute soman poisoning in primates neither pretreated nor receiving immediate therapy: value of gacyclidine (GK-11) in delayed medical support.
    Archives of toxicology, 1999, Volume: 73, Issue:2

    Topics: Animals; Anticonvulsants; Antidotes; Atropine; Brain; Cerebellum; Cerebral Cortex; Chemical Warfare Agents; Cholinesterase Reactivators; Cyclohexanes; Cyclohexenes; Diazepam; Drug Therapy, Combination; Electrocardiography; Excitatory Amino Acid Antagonists; Haplorhini; Macaca fascicularis; Male; Piperidines; Poisoning; Pralidoxime Compounds; Seizures; Soman; Time Factors

1999
[Intermediate syndrome after acute organophosphorus pesticides poisoning: clinical analysis of 10 cases].
    Zhonghua nei ke za zhi, 1997, Volume: 36, Issue:9

    Topics: Adult; Antidotes; Atropine; Cholinesterase Reactivators; Deglutition Disorders; Female; Hoarseness; Humans; Insecticides; Male; Middle Aged; Organophosphorus Compounds; Pralidoxime Compounds; Respiration, Artificial; Respiratory Paralysis; Syndrome

1997
Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication.
    Archives of toxicology, 2000, Volume: 74, Issue:3

    Topics: Animals; Anticonvulsants; Atropine; Biperiden; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Drug Therapy, Combination; Electroencephalography; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Seizures; Soman

2000
Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics.
    Archives of toxicology, 2000, Volume: 74, Issue:8

    Topics: Animals; Atropine; Brain; Cholinesterase Inhibitors; Diazepam; Dipeptides; Drug Therapy, Combination; Electroencephalography; Macaca fascicularis; Male; Pralidoxime Compounds; Soman

2000
Aldicarb poisoning.
    Human & experimental toxicology, 2000, Volume: 19, Issue:12

    Topics: Adolescent; Adult; Aged; Aldicarb; Antidotes; Atropine; Child; Child, Preschool; Cholinesterases; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Female; Humans; Infant; Male; Middle Aged; Pesticides; Poisoning; Pralidoxime Compounds; West Indies

2000
The use of carbamates, atropine, and 2-pyridine aldoxime methoiodide in the protection of Artemia salina against poisoning by carbophenothion.
    Environmental toxicology and chemistry, 2001, Volume: 20, Issue:9

    Topics: Animals; Artemia; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Drug Interactions; Insecticides; Lethal Dose 50; Muscarinic Antagonists; Organothiophosphorus Compounds; Physostigmine; Pralidoxime Compounds; Pyridostigmine Bromide; Water Pollutants, Chemical

2001
Aldicarb poisoning by an illicit rodenticide imported into the United States: Tres Pasitos.
    Journal of toxicology. Clinical toxicology, 2001, Volume: 39, Issue:5

    Topics: Adolescent; Adult; Aldicarb; Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Chromatography, Paper; Disease Outbreaks; Gas Chromatography-Mass Spectrometry; Humans; Infant; Male; Mice; New York City; Pralidoxime Compounds; Prospective Studies; Rodenticides; Treatment Outcome

2001
Organophosphate poisoning in children - atropine, pralidoxime or both?
    Saudi medical journal, 2001, Volume: 22, Issue:9

    Topics: Antidotes; Atropine; Child, Preschool; Drug Therapy, Combination; Humans; Insecticides; Male; Muscarinic Antagonists; Organophosphate Poisoning; Positive-Pressure Respiration; Pralidoxime Compounds

2001
Cholinesterase inhibition by aluminium phosphide poisoning in rats and effects of atropine and pralidoxime chloride.
    Acta pharmacologica Sinica, 2001, Volume: 22, Issue:1

    Topics: Aluminum Compounds; Animals; Antidotes; Atropine; Blood Pressure; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Drug Interactions; Female; Male; Pesticides; Phosphines; Poisoning; Pralidoxime Compounds; Rats; Rats, Wistar

2001
Repeated measurements of aldicarb in blood and urine in a case of nonfatal poisoning.
    Human & experimental toxicology, 2001, Volume: 20, Issue:12

    Topics: Adult; Aldicarb; Atropine; Butyrylcholinesterase; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Insecticides; Poisoning; Pralidoxime Compounds; Suicide, Attempted; Treatment Outcome

2001
Severe fenthion intoxications due to ingestion and inhalation with survival outcome.
    Human & experimental toxicology, 2002, Volume: 21, Issue:1

    Topics: Administration, Oral; Adolescent; Aged; Antidotes; Atropine; Environmental Exposure; Fenthion; Humans; Inhalation Exposure; Insecticides; Intensive Care Units; Male; Poisoning; Pralidoxime Compounds; Suicide, Attempted; Treatment Outcome

2002
O-Substituted derivatives of pralidoxime: muscarinic properties and protection against soman effects in rats.
    European journal of pharmacology, 2002, May-10, Volume: 442, Issue:3

    Topics: Acetylcholinesterase; Animals; Atropine; Binding, Competitive; Blood Pressure; Brain; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Rate; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Myocardium; Oximes; Pralidoxime Compounds; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Respiration; Soman; Structure-Activity Relationship; Submandibular Gland

2002
[Experimental treatment of respiratory failure caused by omethoate poisoning in rats].
    Zhonghua nei ke za zhi, 2002, Volume: 41, Issue:4

    Topics: Animals; Antidotes; Atropine; Diaphragm; Dimethoate; Disease Models, Animal; Drug Therapy, Combination; Female; Male; Pralidoxime Compounds; Rats; Rats, Wistar; Recovery of Function; Respiration, Artificial; Respiratory Insufficiency

2002
Potential use of autoinjector-packaged antidotes for treatment of pediatric nerve agent toxicity.
    Annals of emergency medicine, 2002, Volume: 40, Issue:4

    Topics: Antidotes; Atropine; Bioterrorism; Child; Disaster Planning; Equipment Design; Humans; Injections, Intramuscular; Injections, Jet; Parasympatholytics; Pralidoxime Compounds

2002
Oral treatment of organophosphate poisoning in mice.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2003, Volume: 10, Issue:3

    Topics: Animals; Antidotes; Atropine; Insecticides; Male; Mice; Mice, Inbred BALB C; Muscarinic Antagonists; Paraoxon; Parasympatholytics; Pralidoxime Compounds

2003
Acute renal failure from organophospate poisoning: a case of success with haemofiltration.
    Human & experimental toxicology, 2003, Volume: 22, Issue:3

    Topics: Acute Kidney Injury; Adult; Antidotes; Atropine; Hemofiltration; Humans; Insecticides; Male; Organothiophosphorus Compounds; Pralidoxime Compounds; Suicide, Attempted; Treatment Outcome

2003
Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose.
    Toxicology, 2003, Jun-30, Volume: 188, Issue:2-3

    Topics: Animals; Anticonvulsants; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Dipeptides; Drug Interactions; Electroencephalography; Guinea Pigs; Histocytochemistry; Muscarinic Antagonists; Nervous System Diseases; Pralidoxime Compounds; Prodrugs; Pyridostigmine Bromide; Respiratory Insufficiency; Sarin; Seizures

2003
Neuroprotective effects of currently used antidotes in tabun-poisoned rats.
    Pharmacology & toxicology, 2003, Volume: 92, Issue:6

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Motor Activity; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar

2003
Comparing therapeutic and prophylactic protection against the lethal effect of paraoxon.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 77, Issue:2

    Topics: Animals; Antidotes; Aryldialkylphosphatase; Atropine; Cholinesterase Reactivators; Drug Combinations; Insecticides; Lethal Dose 50; Liposomes; Male; Mice; Mice, Inbred BALB C; Muscarinic Antagonists; Neurotoxicity Syndromes; Paraoxon; Pralidoxime Compounds

2004
Oximes and atropine in sarin poisoning.
    British journal of pharmacology and chemotherapy, 1957, Volume: 12, Issue:3

    Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Diacetyl; Drug-Related Side Effects and Adverse Reactions; Guinea Pigs; Hydroxylamines; Mice; Organophosphate Poisoning; Oximes; Phosphates; Pralidoxime Compounds; Rats; Sarin

1957
Protection against the lethal effects of organophosphates by pyridine-2-aldoxime methiodide.
    British journal of pharmacology and chemotherapy, 1957, Volume: 12, Issue:4

    Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterases; Diphosphates; Mice; Organophosphates; Oximes; Paraoxon; Phosphates; Phosphorylation; Picolines; Pralidoxime Compounds

1957
2-Hydroxyiminomethyl-N-methylpyridinium methanesulphonate and atropine in the treatment of severe organophosphate poisoning.
    British journal of pharmacology and chemotherapy, 1959, Volume: 14, Issue:1

    Topics: Animals; Atropine; Diphosphates; Humans; Insecticides; Male; Mesylates; Organophosphate Poisoning; Oximes; Phosphates; Pralidoxime Compounds; Pyrans; Pyridinium Compounds; Sarin

1959
Oximes of alpha omega-diquaternary alkane salts as antidotes to organophosphate anticholinesterases.
    British journal of pharmacology and chemotherapy, 1959, Volume: 14, Issue:2

    Topics: Alkanes; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Hydroxylamines; Mice; Organophosphates; Oximes; Phosphates; Pralidoxime Compounds; Pyridines; Pyridinium Compounds; Salts

1959
Protection against lethal organophosphate poisoning by quaternary pyridine aldoximes.
    British journal of pharmacology and chemotherapy, 1959, Volume: 14, Issue:2

    Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Hydroxylamines; Isoflurophate; Mice; Neostigmine; Organophosphate Poisoning; Oximes; Phosphates; Pralidoxime Compounds; Pyrans; Pyridines; Pyridinium Compounds

1959
The protective action of the oximes P2S and 2-PAM lactate alone or as adjuncts to atropine against GB vapor in dogs.
    Technical report. CRDLR. US Army Edgewood Arsenal Chemical Research and Development Laboratories, 1960, Volume: 3021

    Topics: Animals; Atropine; Dogs; Hydroxylamines; Lactates; Lactic Acid; Oximes; Phosphates; Pralidoxime Compounds

1960
Maximal inhibition of cholinesterase in the central nervous system.
    British journal of pharmacology and chemotherapy, 1960, Volume: 15

    Topics: Acetylcholine; Animals; Atropine; Central Nervous System; Cholinesterase Inhibitors; Cholinesterases; Mice; Nervous System; Pralidoxime Compounds

1960
The effectiveness of 2-PAM and of EA 1814 as adjuncts to atropine therapy in dogs exposed to GB vapor by inhalation.
    Technical report. CWLR. U.S. Army Chemical Warfare Laboratories, 1959, Volume: 2293

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Dogs; Gases; Phosphates; Pralidoxime Compounds; Pyridines

1959
1,1'-Trimethylene bis(4-formylpyridinium bromide) dioxime (TMB-4) and 2-pyridine aldoxime methiodide (2-PAM) as adjuvants to atropine in the treatment of anticholinesterase poisoning.
    The Journal of pharmacology and experimental therapeutics, 1960, Volume: 129

    Topics: Atropine; Bromides; Cholinesterase Inhibitors; Cyclopropanes; Hydroxylamines; Phosphates; Pralidoxime Compounds; Pyridines; Trimedoxime

1960
Adjunctive value of oral prophylaxis with the oximes 2-PAM lactate and 2-PAM methanesulfonate to therapeutic administration of atropine in dogs poisoned by inhaled Sarin vapor.
    The Journal of pharmacology and experimental therapeutics, 1962, Volume: 136

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Dogs; Hydroxylamines; Lactic Acid; Mesylates; Oximes; Phosphates; Pralidoxime Compounds; Pyridines; Sarin

1962
Effects of organophosphorous compounds, oximes and atropine injected into the third ventricle of unanaesthetized dogs.
    British journal of pharmacology and chemotherapy, 1962, Volume: 18

    Topics: Animals; Atropine; Brain; Cholinesterase Inhibitors; Dogs; Hydroxylamines; Insecticides; Isoflurophate; Oximes; Pralidoxime Compounds; Third Ventricle

1962
[Protective effect of atropine, pyridine-2-aldoxime methiodide (PAM-2) and 1,3-trimethylenebis-(4-formylpyridinium bromide) dioxime (TMB-4) in experimental armine poisoning].
    Vojnosanitetski pregled, 1962, Volume: 19

    Topics: Armin; Atropine; Bromides; Hydroxylamines; Parasympathomimetics; Phosphates; Pralidoxime Compounds; Pyridines; Trimedoxime

1962
Protection against alkylphosphate intoxication by intracerebral injection of 1-methyl-2-for-mylpyridinium iodide oxime (2-PAM).
    The Journal of pharmacology and experimental therapeutics, 1962, Volume: 138

    Topics: Atropine; Drug-Related Side Effects and Adverse Reactions; Iodides; Organophosphate Poisoning; Oximes; Phosphorus; Poisons; Pralidoxime Compounds; Pyridines

1962
Medical aspects of chemical warfare.
    Canadian Medical Association journal, 1962, Dec-01, Volume: 87

    Topics: Atropine; Chemical Warfare; Chemical Warfare Agents; Gas Poisoning; Mass Casualty Incidents; Oximes; Pralidoxime Compounds

1962
FURTHER THERAPEUTIC EXPERIENCE WITH PRALIDOXIMES IN ORGANIC PHOSPHORUS POISONING.
    JAMA, 1964, Jan-18, Volume: 187

    Topics: Atropine; Child; Diphosphates; Drug-Related Side Effects and Adverse Reactions; Organophosphate Poisoning; Oximes; Parathion; Phosphorus; Poisons; Pralidoxime Compounds; Pyridines; Toxicology

1964
CLINICAL EVALUATION OF PROTOPAM.
    American journal of ophthalmology, 1964, Volume: 57

    Topics: Atropa belladonna; Atropine; Cataract; Cataract Extraction; Epinephrine; Geriatrics; Infant; Ophthalmology; Oximes; Parasympathomimetics; Pharmacology; Phenylephrine; Pralidoxime Compounds; Pyridines; Scopolamine; Toxicology; Uveitis

1964
THE PROTECTIVE EFFECT OF PYRIDINE-2-ALDOXIME METHIODIDE (P2AM), BIS-(4-HYDROXYIMINO-METHYL-PYRIDINIUM-1-METHYL)-ETHER DICHLORIDE (TOXOGONIN) AND ATROPINE IN EXPERIMENTAL DDVP POISONING.
    Helvetica physiologica et pharmacologica acta, 1964, Volume: 22

    Topics: Animals; Antidotes; Atropine; Blood; Brain; Cholinesterase Inhibitors; Cholinesterases; Dichlorvos; Ethers; Horses; Insecticides; Mice; Obidoxime Chloride; Phosphates; Pralidoxime Compounds; Pyridines; Rats; Research; Succinylcholine; Toxicology

1964
THE SYMPATHOMIMETIC EFFECTS OF 2-PYRIDINE ALDOXIME METHYLCHLORIDE (2-PAM CL).
    The Journal of pharmacology and experimental therapeutics, 1965, Volume: 147

    Topics: Animals; Atropine; Blood; Blood Pressure; Catecholamines; Cats; Diphosphates; Dogs; Ganglia; Ganglionic Blockers; Heart; Hexamethonium Compounds; Methyl Chloride; Muscles; Neural Conduction; Nicotine; Nictitating Membrane; Norepinephrine; Pharmacology; Phenoxybenzamine; Pralidoxime Compounds; Research; Reserpine; Shock, Hemorrhagic; Sympathectomy; Sympathomimetics

1965
CIGUATERA FISH POISON: A CHOLINESTERASE INHIBITOR.
    Science (New York, N.Y.), 1965, Mar-26, Volume: 147, Issue:3665

    Topics: Animals; Antidotes; Asphyxia; Atropine; Cholinesterase Inhibitors; Cholinesterases; Ciguatera Poisoning; Fishes; Mice; Pharmacology; Poisons; Pralidoxime Compounds; Rabbits; Rats; Research; Toxicology

1965
USE OF PYRIDINE-2-ALDOXIME METHOCHLORIDE IN THE TREATMENT OF ORGANIC PHOSPHORUS COMPOUND POISONING IN LIVESTOCK.
    American journal of veterinary research, 1964, Volume: 25

    Topics: Animals; Atropine; Cattle; Cattle Diseases; Cholinesterases; Clinical Enzyme Tests; Goats; Insecticides; Livestock; Pharmacology; Phosphates; Poisoning; Pralidoxime Compounds; Sheep; Sheep Diseases; Statistics as Topic; Toxicology

1964
[Combined treatment of diethyl-p-nitrophenyl thiophosphate poisoning with pyridine-2-aldoxime methiodide and atropine].
    Arzneimittel-Forschung, 1960, Volume: 10

    Topics: Atropine; Combined Modality Therapy; Hydroxylamines; Parathion; Phosphates; Pralidoxime Compounds; Pyridines

1960
Mechanism of the antagonism by pralidoxime and 1,1-trimethylenebis(4-hydroxyiminomethylpyridinium) of the action of echothiphate on the intestine.
    British journal of pharmacology and chemotherapy, 1962, Volume: 18

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Echothiophate Iodide; Hydroxylamines; Intestine, Small; Intestines; Oximes; Parasympatholytics; Pralidoxime Compounds; Pyridines; Rabbits; Trimedoxime

1962
The effectiveness of 2-PAM and TMB-4 as adjuncts to atropine therapy in dogs exposed to Sarin vapor by inhalation.
    The Journal of pharmacology and experimental therapeutics, 1962, Volume: 136

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Dogs; Hydroxylamines; Phosphates; Pralidoxime Compounds; Pyridines; Sarin; Trimedoxime

1962
Pyridine-2-aldoxime methiodide. A valuable agent for phosphate poisoning.
    California medicine, 1962, Volume: 96

    Topics: Atropine; Drug Contamination; Humans; Hydroxylamines; Insecticides; Laboratories; Organophosphorus Compounds; Phosphates; Physicians; Pralidoxime Compounds; Pyridines; Pyrimidines; Suicidal Ideation

1962
[Severe cases of parathion poisoning successfully treated with massive doses of pyridine-2 -aldoxime methiodide and atropine].
    [Chiryo] [Therapy], 1962, Volume: 44

    Topics: Atropine; Parathion; Pralidoxime Compounds; Pyridines

1962
Organophosphate poisoning.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2003, Volume: 10, Issue:10

    Topics: Animals; Antidotes; Atropine; Humans; Insecticides; Mice; Organophosphorus Compounds; Pralidoxime Compounds

2003
Permanent paralysis at sites of dermal exposure to chlorpyrifos.
    Journal of toxicology. Clinical toxicology, 2003, Volume: 41, Issue:6

    Topics: Atropine; Chlorpyrifos; Cholinesterase Reactivators; Humans; Insecticides; Male; Middle Aged; Muscarinic Antagonists; Muscle Weakness; Paralysis; Peripheral Nervous System Diseases; Pralidoxime Compounds

2003
Nerve agent toxicology.
    JEMS : a journal of emergency medical services, 2003, Volume: 28, Issue:12

    Topics: Antidotes; Atropine; Bioterrorism; Chemical Warfare Agents; Cholinesterase Reactivators; Emergency Treatment; Humans; Muscarinic Antagonists; Pralidoxime Compounds; United States

2003
Effects of fosphenytoin on nerve agent-induced status epilepticus.
    Drug and chemical toxicology, 2004, Volume: 27, Issue:1

    Topics: Animals; Anticonvulsants; Atropine; Chemical Warfare Agents; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Guinea Pigs; Injections, Intraperitoneal; Male; Phenytoin; Pralidoxime Compounds; Pyridostigmine Bromide; Soman; Status Epilepticus

2004
The effect of plasmapheresis on plasma cholinesterase levels in a patient with organophosphate poisoning.
    Human & experimental toxicology, 2004, Volume: 23, Issue:7

    Topics: Antidotes; Atropine; Cholinesterase Reactivators; Cholinesterases; Fenitrothion; Humans; Insecticides; Male; Middle Aged; Plasmapheresis; Pralidoxime Compounds; Treatment Outcome

2004
Organo-phosphate induced delayed neuropathy: report of two cases.
    Neurology India, 2004, Volume: 52, Issue:4

    Topics: Adult; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dichlorvos; Female; Humans; Insecticides; Male; Monocrotophos; Muscarinic Antagonists; Neurotoxicity Syndromes; Organophosphate Poisoning; Pralidoxime Compounds; Suicide, Attempted

2004
Organophosphate poisoning in pregnancy: a case report.
    Basic & clinical pharmacology & toxicology, 2005, Volume: 96, Issue:5

    Topics: Adult; Antidotes; Apgar Score; Atropine; Diazinon; Female; Gestational Age; Humans; Infant, Newborn; Poisoning; Pralidoxime Compounds; Pregnancy; Pregnancy Complications; Pregnancy Outcome

2005
Pesticide poisoning in south India: opportunities for prevention and improved medical management.
    Tropical medicine & international health : TM & IH, 2005, Volume: 10, Issue:6

    Topics: Adolescent; Adult; Age Distribution; Antidotes; Atropine; Child; Endosulfan; Female; Humans; India; Insecticides; Length of Stay; Male; Middle Aged; Monocrotophos; Pesticides; Poisoning; Pralidoxime Compounds; Sex Distribution; Time Factors

2005
Pralidoxime rescues both muscarinic and nicotinic systems.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Muscarinic Antagonists; Organophosphorus Compounds; Pralidoxime Compounds; Receptors, Muscarinic; Receptors, Nicotinic; Swine; Swine, Miniature

2005
Efficacy of an adenosine A1 receptor agonist compared with atropine and pralidoxime in a rat model of organophosphate poisoning.
    Human & experimental toxicology, 2005, Volume: 24, Issue:7

    Topics: Adenosine A1 Receptor Agonists; Animals; Antidotes; Atropine; Cholinesterase Reactivators; Cholinesterases; Diaphragm; Drug Interactions; Insecticides; Male; Models, Animal; Muscarinic Antagonists; Organothiophosphorus Compounds; Phenylisopropyladenosine; Poisoning; Pralidoxime Compounds; Rats; Rats, Wistar; Respiration; Salivation; Survival Rate; Time Factors

2005
Novel neuroprotective effects with O-benzyl derivative of pralidoxime in soman-intoxicated rodents.
    European journal of pharmacology, 2005, Oct-03, Volume: 521, Issue:1-3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Analysis of Variance; Animals; Anticonvulsants; Atropine; Benzene Derivatives; Cholinesterase Inhibitors; Cholinesterase Reactivators; Corpus Striatum; Dopamine; Drug Synergism; Electroencephalography; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Mice; Microdialysis; Neuroprotective Agents; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Serotonin; Soman; Survival Rate; Time Factors

2005
Atropine use in children after nerve gas exposure.
    Journal of pediatric nursing, 2005, Volume: 20, Issue:6

    Topics: Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Child; Cholinesterase Reactivators; Disaster Planning; Humans; Muscarinic Antagonists; Neurotoxins; Pediatrics; Poisoning; Practice Guidelines as Topic; Pralidoxime Compounds; Terrorism; United States

2005
Protective effect induced by atropine, carbamates, and 2-pyridine aldoxime methoiodide Artemia salina larvae exposed to fonofos and phosphamidon.
    Ecotoxicology and environmental safety, 2007, Volume: 66, Issue:1

    Topics: Age Factors; Animals; Artemia; Atropine; Carbamates; Cholinesterase Inhibitors; Cholinesterase Reactivators; Fonofos; Insecticides; Larva; Muscarinic Antagonists; Phosphamidon; Pralidoxime Compounds; Toxicity Tests

2007
The "intermediate syndrome" as critical sequelae of organophosphate poisoning: the first report of two cases in Thailand.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2005, Volume: 88, Issue:9

    Topics: Adult; Atropine; Female; Humans; Insecticides; Male; Muscle Weakness; Organophosphate Poisoning; Paralysis; Pralidoxime Compounds; Respiratory Insufficiency; Syndrome; Thailand; Time Factors

2005
Pediatric nerve agent poisoning: medical and operational considerations for emergency medical services in a large American city.
    Pediatric emergency care, 2006, Volume: 22, Issue:4

    Topics: Antidotes; Atropine; Chemical Terrorism; Chemical Warfare Agents; Child; Child, Preschool; Clinical Protocols; Disaster Planning; Emergency Medical Services; Humans; Infant; Infant, Newborn; Needles; New York City; Pediatrics; Pralidoxime Compounds

2006
The use of serial measurement of plasma cholinesterase in the management of acute poisoning with organophosphates and carbamates.
    Forensic science international, 2006, Oct-16, Volume: 162, Issue:1-3

    Topics: Adolescent; Adult; Antidotes; Atropine; Butyrylcholinesterase; Carbamates; Child, Preschool; Cholinesterase Reactivators; Female; Forensic Medicine; Humans; Male; Middle Aged; Muscarinic Antagonists; Poisoning; Pralidoxime Compounds

2006
Overcoming inhibitions.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Sep-05, Volume: 103, Issue:36

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Benzodiazepines; Blood-Brain Barrier; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Neurons; Neurotransmitter Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Paraoxon; Pralidoxime Compounds; Pyridostigmine Bromide; Receptors, Cholinergic; Receptors, Muscarinic; Sarin; Seizures; Soman; Time Factors

2006
Respiratory failure in organophosphate insecticide poisoning.
    Saudi medical journal, 2007, Volume: 28, Issue:3

    Topics: Adolescent; Adult; Age Distribution; Antidotes; Atropine; Chi-Square Distribution; Cohort Studies; Emergency Service, Hospital; Female; Humans; Incidence; Infusions, Intravenous; Insecticides; Iran; Male; Middle Aged; Organophosphate Poisoning; Pralidoxime Compounds; Prognosis; Respiratory Insufficiency; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sex Distribution; Suicide, Attempted; Survival Analysis; Treatment Outcome

2007
Pralidoxime in carbaryl poisoning: an animal model.
    Human & experimental toxicology, 2007, Volume: 26, Issue:2

    Topics: Animals; Antidotes; Atropine; Carbaryl; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Female; Insecticides; Mice; Mice, Inbred ICR; Poisoning; Pralidoxime Compounds

2007
High-dose pralidoxime for organophosphorus poisoning.
    Lancet (London, England), 2007, Apr-28, Volume: 369, Issue:9571

    Topics: Atropine; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Humans; Organophosphate Poisoning; Parasympatholytics; Pralidoxime Compounds; Randomized Controlled Trials as Topic

2007
High-dose pralidoxime for organophosphorus poisoning.
    Lancet (London, England), 2007, Apr-28, Volume: 369, Issue:9571

    Topics: Atropine; Cholinesterase Reactivators; Clinical Trials as Topic; Ethics, Research; Humans; Mortality; Muscarinic Antagonists; Organophosphate Poisoning; Pralidoxime Compounds

2007
High-dose pralidoxime for organophosphorus poisoning.
    Lancet (London, England), 2007, Apr-28, Volume: 369, Issue:9571

    Topics: Atropine; Cholinesterase Reactivators; Humans; Intubation, Intratracheal; Muscarinic Antagonists; Organophosphate Poisoning; Pralidoxime Compounds; Respiration, Artificial; Time Factors

2007
Hyperamylasemia and acute pancreatitis following anticholinesterase poisoning.
    Human & experimental toxicology, 2007, Volume: 26, Issue:6

    Topics: Acute Disease; Adolescent; Adult; Amylases; Atropine; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hyperamylasemia; Male; Middle Aged; Occupational Exposure; Organophosphate Poisoning; Organophosphates; Pancreatitis; Pralidoxime Compounds; Prospective Studies; Radiography; Respiration, Artificial; Suicide, Attempted; Transaminases; Ultrasonography

2007
Toxicity and characterization of cholinesterase-inhibition induced by diisopropyl fluorophosphate in Artemia salina larvae.
    Ecotoxicology and environmental safety, 2009, Volume: 72, Issue:3

    Topics: Animals; Artemia; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Isoflurophate; Larva; Longevity; Muscarinic Antagonists; Physostigmine; Pralidoxime Compounds; Pyridostigmine Bromide; Toxicity Tests, Acute; Water Pollutants, Chemical

2009
Nerve agents: implications for anesthesia providers.
    AANA journal, 2008, Volume: 76, Issue:2

    Topics: Antidotes; Atropine; Chemical Terrorism; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Humans; Muscarinic Antagonists; Nurse Anesthetists; Nurse's Role; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Sarin; Soman; Time Factors

2008
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
    Toxicology and applied pharmacology, 2008, Sep-01, Volume: 231, Issue:2

    Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2008
Epidemiology of organophosphate pesticide poisoning in Taiwan.
    Clinical toxicology (Philadelphia, Pa.), 2008, Volume: 46, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Atropine; Child; Child, Preschool; Female; Humans; Infant; Male; Middle Aged; Organophosphate Poisoning; Pesticides; Poison Control Centers; Poisoning; Pralidoxime Compounds; Retrospective Studies; Suicide, Attempted; Taiwan

2008
High-performance liquid chromatography coupled with electrospray tandem mass spectrometry (LC/MS/MS) method for the simultaneous determination of diazepam, atropine and pralidoxime in human plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Oct-15, Volume: 874, Issue:1-2

    Topics: Atropine; Chromatography, High Pressure Liquid; Diazepam; Humans; Pralidoxime Compounds; Reproducibility of Results; Tandem Mass Spectrometry

2008
Chinese dumpling scare hits Japan--a case of methamidophos food poisoning.
    The Journal of toxicological sciences, 2008, Volume: 33, Issue:4

    Topics: Atropine; Child, Preschool; China; Coma; Female; Foodborne Diseases; Humans; Insecticides; Japan; Midazolam; Organothiophosphorus Compounds; Pralidoxime Compounds

2008
Hypotension in severe dimethoate self-poisoning.
    Clinical toxicology (Philadelphia, Pa.), 2008, Volume: 46, Issue:9

    Topics: Antidotes; Atropine; Cardiotonic Agents; Dimethoate; Humans; Hypotension; Insecticides; Male; Middle Aged; Pralidoxime Compounds; Suicide; Vasodilation

2008
The use of OpdA in rat models of organic phosphorus (OP) poisoning.
    Toxicology, 2009, Mar-29, Volume: 257, Issue:3

    Topics: Animals; Aryldialkylphosphatase; Atropine; Bacterial Proteins; Cholinesterase Reactivators; Drug Synergism; Organophosphate Poisoning; Parasympathetic Nervous System; Pralidoxime Compounds; Rats; Synapses

2009
Organophosphate poisoning due to a wheat bagel.
    Internal medicine (Tokyo, Japan), 2009, Volume: 48, Issue:2

    Topics: Acetylcholinesterase; Adolescent; Adult; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dichlorvos; Female; Food Contamination; Foodborne Diseases; Humans; Insecticides; Male; Organophosphate Poisoning; Pralidoxime Compounds; Retrospective Studies; Triticum; Turkey; Young Adult

2009
Cardiac damage in acute organophosphate poisoning in rats: effects of atropine and pralidoxime.
    The American journal of emergency medicine, 2009, Volume: 27, Issue:2

    Topics: Acute Disease; Analysis of Variance; Animals; Antidotes; Atropine; Biomarkers; Cholinesterase Inhibitors; Dichlorvos; Heart; Immunohistochemistry; In Situ Nick-End Labeling; Male; Nitric Oxide; Organophosphate Poisoning; Pralidoxime Compounds; Random Allocation; Rats; Rats, Wistar; Survival Rate

2009
Urinary elimination kinetics of acephate and its metabolite, methamidophos, in urine after acute ingestion.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2009, Volume: 5, Issue:2

    Topics: Antidotes; Atmospheric Pressure; Atropine; Butyrylcholinesterase; Child, Preschool; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Erythrocytes; Humans; Insecticides; Male; Muscarinic Antagonists; Organothiophosphorus Compounds; Phosphoramides; Poisoning; Pralidoxime Compounds; Respiration, Artificial; Tandem Mass Spectrometry; Treatment Outcome

2009
Galantamine is a novel post-exposure therapeutic against lethal VX challenge.
    Toxicology and applied pharmacology, 2009, Oct-15, Volume: 240, Issue:2

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Erythrocytes; Galantamine; Guinea Pigs; Male; Muscle Fatigue; Muscle Tonus; Neurotoxicity Syndromes; Organothiophosphorus Compounds; Paralysis; Phrenic Nerve; Pralidoxime Compounds; Seizures; Time Factors

2009
Treatment with tertiary oximes prevents seizures and improves survival following sarin intoxication.
    Journal of molecular neuroscience : MN, 2010, Volume: 40, Issue:1-2

    Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diacetyl; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Guinea Pigs; Injections, Intramuscular; Male; Muscarinic Antagonists; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Sarin; Seizures; Treatment Outcome; Up-Regulation

2010
Use of pralidoxime without atropine in rivastigmine (carbamate) toxicity.
    Human & experimental toxicology, 2009, Volume: 28, Issue:9

    Topics: Administration, Cutaneous; Aged, 80 and over; Alzheimer Disease; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Overdose; Female; Humans; Phenylcarbamates; Pralidoxime Compounds; Rivastigmine; Treatment Outcome

2009
Formulation of effects of atropine, pralidoxime and magnesium sulfate on cardiac tissue levels of nitric oxide, malondialdehyde and glutathione in organophosphate poisoning using artificial neural network.
    Computers in biology and medicine, 2010, Volume: 40, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Antidotes; Atropine; Dichlorvos; Glutathione; Insecticides; Magnesium Sulfate; Male; Malondialdehyde; Muscarinic Antagonists; Myocardium; Neural Networks, Computer; Nitric Oxide; Poisoning; Pralidoxime Compounds; Random Allocation; Rats; Rats, Wistar

2010
Hypothermia and Fever after organophosphorus poisoning in humans--a prospective case series.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2010, Volume: 6, Issue:4

    Topics: Adolescent; Adult; Aged; Antidotes; Atropine; Body Temperature Regulation; Female; Fever; Humans; Hypothermia; Insecticides; Male; Middle Aged; Organophosphate Poisoning; Palliative Care; Pralidoxime Compounds; Prospective Studies; Suicide, Attempted; Young Adult

2010
Guillain-Barre syndrome due to organophosphate compound poison.
    The Journal of the Association of Physicians of India, 2009, Volume: 57

    Topics: Adult; Atropine; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Gastric Lavage; Guillain-Barre Syndrome; Humans; Insecticides; Male; Methylprednisolone; Neuroprotective Agents; Parasympatholytics; Plasmapheresis; Pralidoxime Compounds

2009
Transplacentally acquired organophosphorus poisoning in a newborn: case report.
    Annals of tropical paediatrics, 2010, Volume: 30, Issue:2

    Topics: Antitoxins; Atropine; Female; Humans; Infant, Newborn; Organophosphates; Poisoning; Pralidoxime Compounds; Pregnancy; Pregnancy Complications; Suicide, Attempted

2010
Effects of atropine and pralidoxime on neuronal actions of paraoxon in rat hippocampal slices.
    Neuroscience research, 2010, Volume: 68, Issue:4

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Excitatory Postsynaptic Potentials; Hippocampus; Muscarinic Antagonists; Neurons; Organ Culture Techniques; Paraoxon; Patch-Clamp Techniques; Pralidoxime Compounds; Rats; Rats, Wistar; Synaptic Transmission

2010
Benefit of nanocarrier of magnetic magnesium in rat malathion-induced toxicity and cardiac failure using non-invasive monitoring of electrocardiogram and blood pressure.
    Toxicology and industrial health, 2011, Volume: 27, Issue:5

    Topics: Acetylcholinesterase; Animals; Antioxidants; Atropine; Biomarkers; Blood Pressure; Disease Models, Animal; Electrocardiography; Heart Failure; Heart Rate; Lethal Dose 50; Lipid Peroxidation; Magnesium; Magnesium Sulfate; Magnetics; Malathion; Male; Metal Nanoparticles; Oxidative Stress; Pralidoxime Compounds; Rats; Rats, Wistar; Sulfhydryl Compounds

2011
[Multiple organ dysfunction in acute organophosphate poisoning].
    Medicina intensiva, 2011, Volume: 35, Issue:7

    Topics: Acetylcholinesterase; Adult; APACHE; Atropine; Cholinesterases; Erythrocytes; Female; Humans; Male; Multiple Organ Failure; Muscarinic Antagonists; Parathion; Poisoning; Pralidoxime Compounds; Receptors, Muscarinic; Receptors, Nicotinic; Respiratory Distress Syndrome; Retrospective Studies; Severity of Illness Index; Spain; Suicide, Attempted; Young Adult

2011
Severe and prolonged neurologic toxicity following subcutaneous chlorpyrifos self-administration: a case report.
    Clinical toxicology (Philadelphia, Pa.), 2011, Volume: 49, Issue:2

    Topics: Antidotes; Atropine; Brain; Chlorpyrifos; Humans; Injections, Subcutaneous; Insecticides; Magnetic Resonance Imaging; Male; Muscarinic Antagonists; Nervous System Diseases; Poisoning; Pralidoxime Compounds; Suicide, Attempted; Treatment Outcome; Young Adult

2011
A cembranoid protects acute hippocampal slices against paraoxon neurotoxicity.
    Toxicology in vitro : an international journal published in association with BIBRA, 2011, Volume: 25, Issue:7

    Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diterpenes; Dose-Response Relationship, Drug; Hippocampus; Male; Neuroprotective Agents; Paraoxon; Parasympatholytics; Pralidoxime Compounds; Rats; Rats, Sprague-Dawley

2011
Atypical central nervous system involvement in acute organophosphorous poisoning.
    The Journal of the Association of Physicians of India, 2011, Volume: 59

    Topics: Adult; Antidotes; Atropine; Basal Ganglia Diseases; Brain; Dimethoate; Female; Humans; Insecticides; Muscarinic Antagonists; Organophosphate Poisoning; Pralidoxime Compounds; Tomography, X-Ray Computed

2011
Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures.
    Journal of neuroinflammation, 2011, Jul-21, Volume: 8

    Topics: Animals; Anticonvulsants; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Male; Microarray Analysis; Muscarinic Antagonists; Pralidoxime Compounds; Principal Component Analysis; Rats; Rats, Sprague-Dawley; Sarin; Seizures; Signal Transduction; Transcription, Genetic

2011
Neuroprotective effects of imidazenil against chemical warfare nerve agent soman toxicity in guinea pigs.
    Neurotoxicology, 2012, Volume: 33, Issue:2

    Topics: Acetylcholinesterase; Analysis of Variance; Animals; Atropine; Benzodiazepines; Body Weight; Brain; Chemical Warfare Agents; Cholinesterase Reactivators; Disease Models, Animal; Drug Administration Schedule; Electrocardiography; Electroencephalography; Guinea Pigs; Imidazoles; Lethal Dose 50; Male; Muscarinic Antagonists; Neuroprotective Agents; Neurotoxicity Syndromes; Pralidoxime Compounds; Seizures; Soman; Telemetry; Time Factors

2012
A rare case of combined strychnine and propoxur toxicity from a single preparation.
    Clinical toxicology (Philadelphia, Pa.), 2012, Volume: 50, Issue:3

    Topics: Adult; Atropine; Charcoal; Diazepam; Drug Combinations; Gastric Lavage; Humans; Insecticides; Intubation, Gastrointestinal; Male; Midazolam; Poisoning; Poisons; Pralidoxime Compounds; Propoxur; Spasm; Strychnine; Suicide, Attempted

2012
Amitraz poisoning -- familiar presentation, unfamiliar diagnosis.
    Anaesthesia and intensive care, 2012, Volume: 40, Issue:2

    Topics: Adult; Antidotes; Atropine; Cardiotonic Agents; Cholinesterase Reactivators; Cholinesterases; Coma; Dopamine; Humans; Insecticides; Male; Muscarinic Antagonists; Pralidoxime Compounds; Suicide, Attempted; Toluidines

2012
Case report: an unusual heart rhythm associated with organophosphate poisoning.
    Cardiovascular toxicology, 2012, Volume: 12, Issue:3

    Topics: Anti-Arrhythmia Agents; Antidotes; Atrial Fibrillation; Atropine; Bundle-Branch Block; Drug Therapy, Combination; Electrocardiography; Heart; Humans; Long QT Syndrome; Male; Middle Aged; Organophosphate Poisoning; Pralidoxime Compounds; Suicide, Attempted; Tachycardia, Paroxysmal; Treatment Outcome

2012
Rapid and complete bioavailability of antidotes for organophosphorus nerve agent and cyanide poisoning in minipigs after intraosseous administration.
    Annals of emergency medicine, 2012, Volume: 60, Issue:4

    Topics: Animals; Antidotes; Atropine; Biological Availability; Chemical Warfare Agents; Cyanides; Hydroxocobalamin; Infusions, Intraosseous; Infusions, Intravenous; Injections, Intramuscular; Male; Organophosphate Poisoning; Pralidoxime Compounds; Swine; Swine, Miniature; Time Factors

2012
An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action.
    Journal of biomolecular screening, 2013, Volume: 18, Issue:1

    Topics: Animals; Antidotes; Atropine; Cell Line, Tumor; Cholinergic Antagonists; Cholinesterase Reactivators; Drug Evaluation, Preclinical; Emetine; Glycopyrrolate; High-Throughput Screening Assays; Humans; Lethal Dose 50; Metoclopramide; Neostigmine; Organophosphates; Parathion; Pirenzepine; Pralidoxime Compounds; Zebrafish

2013
Recurrent neonatal organophoshorus poisoning.
    Indian pediatrics, 2012, Volume: 49, Issue:9

    Topics: Atropine; Diazinon; Female; Humans; Infant, Newborn; Insecticides; Organophosphate Poisoning; Pralidoxime Compounds; Recurrence

2012
The effects of ubiquinone (CoQ10) on heart tissue in cardiac toxicity related to organophosphate poisoning.
    Human & experimental toxicology, 2013, Volume: 32, Issue:1

    Topics: Acetylcholinesterase; Animals; Antioxidants; Atropine; Cholinesterase Reactivators; Drug Therapy, Combination; Erythrocytes; Female; Heart Diseases; Lipid Peroxidation; Male; Malondialdehyde; Myocardium; Nitric Oxide; Organophosphate Poisoning; Pralidoxime Compounds; Rabbits; Ubiquinone

2013
Diabetic ketoacidosis: an uncommon manifestation of pesticide poisoning.
    Diabetes care, 2013, Volume: 36, Issue:1

    Topics: Adolescent; Atropine; Diabetic Ketoacidosis; Female; Humans; Pesticides; Pralidoxime Compounds; Risk Factors

2013
Aldicarb: a case series of watermelon-borne carbamate toxicity.
    Journal of agromedicine, 2013, Volume: 18, Issue:2

    Topics: Administration, Oral; Adult; Aldicarb; Atropine; Citrullus; Food Contamination; Humans; Insecticides; Male; Middle Aged; Poisoning; Pralidoxime Compounds; Retrospective Studies; Young Adult

2013
Repeated pulse intramuscular injection of pralidoxime chloride in severe acute organophosphorus pesticide poisoning.
    The American journal of emergency medicine, 2013, Volume: 31, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Atropine; Drug Therapy, Combination; Female; Humans; Injections, Intramuscular; Intensive Care Units; Length of Stay; Male; Middle Aged; Organophosphate Poisoning; Pralidoxime Compounds; Retrospective Studies; Young Adult

2013
Fresh frozen plasma as a successful antidotal supplement in acute organophosphate poisoning.
    Arhiv za higijenu rada i toksikologiju, 2013, Volume: 64, Issue:2

    Topics: Acetylcholinesterase; Antidotes; Atropine; Blood Transfusion; Butyrylcholinesterase; Erythrocytes; Gastric Lavage; Humans; Insecticides; Malathion; Male; Middle Aged; Organophosphate Poisoning; Plasma; Pralidoxime Compounds; Serum Albumin; Serum Albumin, Human

2013
Can anisodamine be a potential substitute for high-dose atropine in cases of organophosphate poisoning?
    Human & experimental toxicology, 2014, Volume: 33, Issue:11

    Topics: Antidotes; Atropine; Cholinesterase Reactivators; Female; Humans; Insecticides; Middle Aged; Muscarinic Antagonists; Organophosphate Poisoning; Pralidoxime Compounds; Solanaceous Alkaloids

2014
Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication.
    Neurotoxicology, 2014, Volume: 44

    Topics: Animals; Anticonvulsants; Atropine; Brain; Calcium; Diazepam; Disease Models, Animal; Electroencephalography; Hippocampus; Male; Neurons; Organophosphate Poisoning; Paraoxon; Pralidoxime Compounds; Rats; Rats, Sprague-Dawley; Status Epilepticus

2014
Body mass index as a prognostic factor in organophosphate-poisoned patients.
    The American journal of emergency medicine, 2014, Volume: 32, Issue:7

    Topics: Adult; Aged; Atropine; Body Mass Index; Cholinesterase Reactivators; Cohort Studies; Female; Glasgow Coma Scale; Humans; Intensive Care Units; Length of Stay; Male; Middle Aged; Muscarinic Antagonists; Obesity; Organophosphate Poisoning; Organophosphates; Pralidoxime Compounds; Prognosis; Respiration, Artificial; Retrospective Studies; Severity of Illness Index; Solubility

2014
Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity.
    Neurotoxicology, 2014, Volume: 44

    Topics: Anhedonia; Animals; Anxiety; Atropine; Behavior, Animal; Cognition Disorders; Depression; Diazepam; Male; Memory Disorders; Organophosphate Poisoning; Paraoxon; Pralidoxime Compounds; Rats; Rats, Sprague-Dawley; Recognition, Psychology

2014
In vivo protection of diisopropylphosphorofluoridate (DFP) poisoning by three bis-quaternary 2 -(hydroxyimino) -N -(pyridin-3-yl) acetamide derivatives in Swiss mice.
    Cellular and molecular biology (Noisy-le-Grand, France), 2014, Oct-25, Volume: 60, Issue:3

    Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Isoflurophate; Male; Mice; Oximes; Poisoning; Pralidoxime Compounds

2014
Organophosphorus poisoning presentating as diabetic ketoacidosis: a real challenge for the endocrinologist.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2014, Volume: 24, Issue:11

    Topics: Administration, Intravenous; Antidotes; Atropine; Child; Cholinesterases; Diabetic Ketoacidosis; Diagnosis, Differential; Humans; Male; Organophosphate Poisoning; Pesticides; Pralidoxime Compounds; Treatment Outcome

2014
An exploratory study; the therapeutic effects of premixed activated charcoal-sorbitol administration in patients poisoned with organophosphate pesticide.
    Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:2

    Topics: Adult; Aged; Antidotes; Atropine; Cathartics; Charcoal; Cholinesterase Reactivators; Drug Combinations; Female; Glasgow Coma Scale; Humans; Male; Middle Aged; Muscarinic Antagonists; Organophosphate Poisoning; Pesticides; Pralidoxime Compounds; Retrospective Studies; Sorbitol

2015
Chronic Treatment with Naltrexone Prevents Memory Retention Deficits in Rats Poisoned with the Sarin Analog Diisopropylfluorophosphate (DFP) and Treated with Atropine and Pralidoxime.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2015, Volume: 11, Issue:4

    Topics: Animals; Atropine; Female; Isoflurophate; Memory Disorders; Naltrexone; Pralidoxime Compounds; Rats; Rats, Long-Evans

2015
Acute severe organophosphate poisoning in a child who was successfully treated with therapeutic plasma exchange, high-volume hemodiafiltration, and lipid infusion.
    Journal of clinical apheresis, 2016, Volume: 31, Issue:5

    Topics: Atropine; Child; Hemodiafiltration; Humans; Infusions, Intravenous; Lipids; Organophosphate Poisoning; Plasma Exchange; Pralidoxime Compounds; Salvage Therapy

2016
Amitraz: a mimicker of organophosphate poisoning.
    BMJ case reports, 2015, Oct-01, Volume: 2015

    Topics: Atropine; Bradycardia; Cholinesterase Reactivators; Diagnosis, Differential; Diagnostic Errors; Follow-Up Studies; Humans; Hyperglycemia; Hypotension; Male; Miosis; Organophosphate Poisoning; Parasympatholytics; Pralidoxime Compounds; Suicide, Attempted; Toluidines; Treatment Outcome; Young Adult

2015
Neuroprotection Against Diisopropylfluorophosphate in Acute Hippocampal Slices.
    Neurochemical research, 2015, Volume: 40, Issue:10

    Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Inhibitors; Hippocampus; Isoflurophate; Male; Neuroprotection; Neuroprotective Agents; Pralidoxime Compounds; Rats, Sprague-Dawley; Synapses

2015
Efficacy of Recommended Prehospital Human Equivalent Doses of Atropine and Pralidoxime Against the Toxic Effects of Carbamate Poisoning in the Hartley Guinea Pig.
    International journal of toxicology, 2016, Volume: 35, Issue:3

    Topics: Acetylcholinesterase; Aldicarb; Animals; Antidotes; Atropine; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Emergency Medical Services; Guinea Pigs; Humans; Insecticides; Male; Methomyl; Muscarinic Antagonists; Organophosphate Poisoning; Pralidoxime Compounds

2016
Toxicity and median effective doses of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig.
    The Journal of toxicological sciences, 2016, Volume: 41, Issue:4

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Guinea Pigs; Lethal Dose 50; Male; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pesticides; Pralidoxime Compounds; Pyridinium Compounds; Time Factors

2016
A rodent model of human organophosphate exposure producing status epilepticus and neuropathology.
    Neurotoxicology, 2016, Volume: 56

    Topics: Animals; Antidotes; Atropine; Central Nervous System Diseases; Cholinesterase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Male; Organophosphates; Phosphoric Triester Hydrolases; Pralidoxime Compounds; Pyridostigmine Bromide; Rats; Rats, Sprague-Dawley; Status Epilepticus

2016
Toxic megacolon as a rare complication following atropine therapy due to organophosphate poisoning: A case report.
    The Medico-legal journal, 2017, Volume: 85, Issue:4

    Topics: Antidotes; Atropine; Drug Therapy, Combination; Humans; Male; Megacolon, Toxic; Middle Aged; Organophosphate Poisoning; Pralidoxime Compounds

2017
The role of plasmapheresis in organophosphate poisoning: Case reports of three pediatric patients.
    The Turkish journal of pediatrics, 2017, Volume: 59, Issue:4

    Topics: Adolescent; Atropine; Child; Child, Preschool; Cholinesterase Reactivators; Female; Humans; Male; Organophosphate Poisoning; Plasmapheresis; Pralidoxime Compounds

2017
Method validation for simultaneous determination of atropine, pralidoxime and 12 organophosphorus compounds in blood samples by means of high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018, Oct-15, Volume: 1097-1098

    Topics: Animals; Atropine; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Linear Models; Male; Organophosphorus Compounds; Pralidoxime Compounds; Rats; Rats, Wistar; Reproducibility of Results; Tandem Mass Spectrometry

2018
Organophosphorus Compounds Poisoning in a Neonate: A Case Report.
    Mymensingh medical journal : MMJ, 2019, Volume: 28, Issue:2

    Topics: Antidotes; Atropine; Humans; Infant, Newborn; Insecticides; Male; Organophosphate Poisoning; Organophosphorus Compounds; Pralidoxime Compounds; Treatment Outcome

2019
Pyridostigmine Suicidal Attempt in a Myasthenia Gravis Patient.
    The American journal of case reports, 2019, Sep-26, Volume: 20

    Topics: Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Humans; Middle Aged; Muscarinic Antagonists; Myasthenia Gravis; Pralidoxime Compounds; Pyridostigmine Bromide; Suicide, Attempted

2019
Clinical effects from household insecticide: pyrethroid or organophosphate toxicity?
    BMJ case reports, 2019, Nov-21, Volume: 12, Issue:11

    Topics: Antidotes; Atropine; Diagnosis, Differential; Household Products; Humans; Insecticides; Male; Middle Aged; Organophosphate Poisoning; Pralidoxime Compounds; Pyrethrins

2019
The antidotes atropine and pralidoxime distinctively recover cardiorespiratory components impaired by acute poisoning with chlorpyrifos in rats.
    Toxicology and applied pharmacology, 2020, 01-15, Volume: 389

    Topics: Animals; Antidotes; Atropine; Baroreflex; Blood Pressure; Bradycardia; Cardiovascular System; Chlorpyrifos; Cholinesterase Inhibitors; Heart Rate; Insecticides; Male; Organophosphate Poisoning; Pralidoxime Compounds; Rats; Rats, Wistar; Respiratory System

2020
Mechanism of central hypopnoea induced by organic phosphorus poisoning.
    Scientific reports, 2020, 09-28, Volume: 10, Issue:1

    Topics: Animals; Atropine; Brain; Organophosphate Poisoning; Paraoxon; Pralidoxime Compounds; Rats; Respiratory Burst; Sleep Apnea, Central

2020
Outcomes of elderly patients with organophosphate intoxication.
    Scientific reports, 2021, 06-02, Volume: 11, Issue:1

    Topics: Acute Kidney Injury; Affect; Aged; Antidotes; Atropine; Chlorpyrifos; Female; Humans; Insecticides; Male; Mevinphos; Middle Aged; Organophosphate Poisoning; Organothiophosphorus Compounds; Pneumonia, Aspiration; Pralidoxime Compounds; Psychotic Disorders; Respiratory Insufficiency; Retrospective Studies; Seizures; Shock; Survival Analysis; Treatment Outcome

2021
A delayed treatment model for the evaluation of scopolamine for VX nerve agent intoxication.
    Toxicology and applied pharmacology, 2021, 09-15, Volume: 427

    Topics: Animals; Atropine; Chemical Warfare Agents; Cholinergic Antagonists; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Guinea Pigs; Male; Midazolam; Nerve Agents; Organothiophosphorus Compounds; Pralidoxime Compounds; Scopolamine; Survival Rate; Time-to-Treatment

2021
Loading and Sustained Release of Pralidoxime Chloride from Swellable MIL-88B(Fe) and Its Therapeutic Performance on Mice Poisoned by Neurotoxic Agents.
    Inorganic chemistry, 2022, Jan-24, Volume: 61, Issue:3

    Topics: Acetylcholinesterase; Administration, Oral; Animals; Atropine; Dose-Response Relationship, Drug; Male; Metal-Organic Frameworks; Mice; Mice, Inbred Strains; Nanoparticles; Nerve Agents; Pralidoxime Compounds; Sarin

2022
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
    Scientific reports, 2022, 11-25, Volume: 12, Issue:1

    Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphate Poisoning; Prodrugs; Rats; Rodentia; Succinates; Succinic Acid

2022
The lesion site of organophosphorus-induced central apnea and the effects of antidotes.
    Scientific reports, 2023, Nov-21, Volume: 13, Issue:1

    Topics: Animals; Antidotes; Atropine; Neostigmine; Paraoxon; Pralidoxime Compounds; Pyridines; Rats; Rats, Sprague-Dawley; Sleep Apnea, Central

2023