atropine has been researched along with pirenzepine in 559 studies
| Studies (atropine) | Trials (atropine) | Recent Studies (post-2010) (atropine) | Studies (pirenzepine) | Trials (pirenzepine) | Recent Studies (post-2010) (pirenzepine) |
|---|---|---|---|---|---|
| 26,711 | 1,259 | 1,697 | 3,812 | 587 | 140 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 214 (38.28) | 18.7374 |
| 1990's | 247 (44.19) | 18.2507 |
| 2000's | 64 (11.45) | 29.6817 |
| 2010's | 30 (5.37) | 24.3611 |
| 2020's | 4 (0.72) | 2.80 |
| Authors | Studies |
|---|---|
| Kashihara, K; Roeske, WR; Varga, EV; Waite, SL; Yamamura, HI | 1 |
| DeHaven-Hudkins, DL; Hudkins, RL; Stubbins, JF | 1 |
| Bonner, TI; Brann, MR; Buckley, CM; Buckley, NJ | 1 |
| Chiang, PK; Doctor, BP; Gordon, RK; Leader, H; Padilla, FN; Payne, CS; Smejkal, RM | 1 |
| Ferkany, JW; Kinnier, WJ; Kirkien-Rzeszotarski, A; McPherson, DW; Noronha-Blob, L; Rzeszotarski, WJ | 1 |
| Abraham, P; Ahmad, A; Carroll, FI; Chiang, PK; Griffith, RC; Padilla, FN; Parham, K; Richard, MM; Witkin, JM | 1 |
| Callahan, AP; DeHaven-Hudkins, DL; Knapp, FF; McPherson, DW | 1 |
| Kovacs, I; Roeske, WR; Varga, EV; Waite, SL; Yamamura, HI | 1 |
| Go, ML; Sim, MK; Xu, R | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Bodor, N; Browne, CE; Buchwald, P; Farag, HH; Hochhaus, G; Huang, F; Ji, F; Wu, WM | 1 |
| Challiss, RA; Nahorski, SR; Nelson, CP | 1 |
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Bhattacharjee, AK; Evans, SA; Gordon, RK; Pervitsky, D; Pomponio, JW | 1 |
| Chierichetti, SM; Gaetani, M; Petrin, G | 1 |
| Kashima, K; Kataoka, K; Kato, M; Kuriyama, K; Ohkuma, S | 1 |
| Sastry, BV; Stephan, CC | 1 |
| Ishihara, H; Shimura, S | 1 |
| Flogerzi, B; Halter, F; Kromer, W; Postius, S; Schuerer-Maly, CC; Varga, L | 1 |
| Ciesla, W; Li, M; Wall, SJ; Wolfe, BB; Yasuda, RP | 1 |
| Abdallah, EA; Eldefrawi, AT; Eldefrawi, ME; Jett, DA | 1 |
| Fields, JZ; Gordon, JH; Keshavarzian, A; Urban, G; Willson, C | 1 |
| Hato, F; Kinoshita, Y; Tominaga, K; Tominaga, M; Yamada, M | 1 |
| Dohi, T; Minami, N; Morita, K; Ohtsuki, H; Suemitsu, T; Tsujimoto, A | 1 |
| Chen, HY; Lee, EH; Lin, YP | 1 |
| Cazzola, M; Constantino, M; De Santis, D; Matera, MG; Rossi, F | 1 |
| Cosentino, M; Crema, A; D'Angelo, L; De Ponti, F | 1 |
| Fisher, A; Segal, M | 1 |
| Boucher, M; Breysse, C; Chassaing, C; Duchêne-Marullaz, P | 1 |
| Bian, CF; Qin, W; Yu, AY; Zheng, JL | 1 |
| Aguilar, JS; Ballesta, JJ; Criado, M; Palmero, M; Reig, JA; Viniegra, S | 1 |
| Akerman, KE; Kukkonen, J | 1 |
| Hendriks, MG; Pfaffendorf, M; Van Zwieten, PA | 2 |
| Kawamoto, M; Kawasaki, H; Shiraishi, S; Takasaki, M | 1 |
| Biren, T; Erçil, A; Gürmen, N; Oktay, S; Onat, F; Tankurt, E; Ulusoy, NB; Yegen, BC | 1 |
| Kajimura, M; Reuben, MA; Sachs, G | 1 |
| Badini, I; Beani, L; Bianchi, C; Cintra, A; Fuxe, K; Siniscalchi, A | 1 |
| Lebrun, F; Marchetti, J; Morel, F; Vassent, G | 1 |
| Bloom, JW; Halonen, M; Mahesh, VK; Nunan, LM; Palmer, JD; Yamamura, HI | 1 |
| Alves-do-Prado, W; Corrado, AP; Prado, WA | 1 |
| Bellido, I; Garcia, AJ; Gómez, A; Marquez, E; Martos, F; Pavia, J; Sanchez de la Cuesta, F | 1 |
| Li, M; Morley, P; Schwartz, JL; Tsang, BK; Whitfield, JF | 1 |
| Dohi, T; Kitayama, S; Morita, K; Tsujimoto, A | 1 |
| Funakoshi, A; Jimi, A; Kono, A; Tateishi, K; Tsuru, M; Wakasugi, H | 1 |
| FitzGibbon, F; Osborne, NN; Schwartz, G | 1 |
| Akerman, KE; Heikkilä, J; Jansson, C | 1 |
| Hynie, S; Kadlec, O; Masek, K; Seferna, I; Sevcík, J | 1 |
| Eltze, M; Kromer, W | 1 |
| Cho, CH; Ogle, CW | 1 |
| Gil, MZ; Madrid, JA; Pariente, JA; Pozo, MJ; Salido, GM | 1 |
| Bindslev, N; Winding, B | 1 |
| Cohen, S; Heldman, E; Pittel, Z; Rubinstein, R | 1 |
| Ringdahl, B; Vargas, HM | 1 |
| Madrid, JA; Pozo, MJ; Salido, GM | 2 |
| Matsumoto, K; Pappano, AJ | 1 |
| Choo, LK; Darroch, SA; Gardner, A; Mitchelson, F; Vong, YM | 1 |
| Cost, M; Majewski, H | 1 |
| Kiraly, M; Liao, GS; Maillard, M | 1 |
| Donoff, B; Lad, R; Rangachari, PK | 1 |
| Jaiswal, N; Lambrecht, G; Malik, KU; Mutschler, E; Tacke, R | 1 |
| Nishimura, S; Sorimachi, M; Yamagami, K | 1 |
| Alonso, MJ; Arribas, S; Balfagón, G; Marín, J; Salaices, M | 1 |
| Berenguer, J; Cano, C; Del Val, A; Garrigues, V; Hoyos, M; Ponce, J; Sopena, R | 1 |
| Barker, JL; Fiszman, ML; Jones, SV | 1 |
| Angeli, P; Brasili, L; Cingolani, ML; Marucci, G; Pigini, P; Tonnini, MC | 1 |
| Catravas, JD; Ehrhart, IC; el-Kashef, HA; Hofman, WF | 1 |
| Gousse, A; Latifpour, J; Weiss, RM; Yoshida, M | 1 |
| Aikawa, T; Itabashi, S; Ohrui, T; Sasaki, H; Sekizawa, K; Takishima, T | 1 |
| Igarashi, M; Komiya, Y; Saito, S | 1 |
| Black, JW; Durant, PA; Shankley, NP; Welsh, NJ | 1 |
| Ashmarin, IP; Natsvlishvili, NA; Samonina, GE | 1 |
| Akaike, N; Harata, N; Tateishi, N | 1 |
| Aggestrup, S; Jensen, SL | 1 |
| Bian, CF; Hong, XM; Yin, XX; Zhou, J | 1 |
| Levin, SL | 2 |
| Angelucci, L; Ghirardi, O; Imperato, A; Ramacci, MT; Scrocco, MG | 1 |
| Fujimoto, K; Hayakawa, T; Kashima, Y; Kawashima, K; Oohata, H; Suzuki, T | 1 |
| Cozzi, NV; Lee, HJ; Weiler, MH | 1 |
| Brudzynski, SM; Girvin, JP; McLachlan, RS | 1 |
| Low, PA; Torres, NE; Zollman, PJ | 1 |
| Freschi, JE | 1 |
| Benedito, S; García-Sacristán, A; Hernández, M; Prieto, D; Rivera, L | 1 |
| Richards, MH | 1 |
| Lawrence, R; Oktay, A; Oktay, S; Onat, FY; Yegen, BC | 1 |
| Bianconi, L; Buonanno, G; Caiazza, A; Capretti, L; Cavazzini, U; Chiodera, P; Coiro, V; Marcato, A; Speroni, G; Volpi, R | 1 |
| Manjeet, S; Sim, MK | 2 |
| Madrid, JA; Pozo, MJ; Salido, GM; Salido, MD | 1 |
| Ballabeni, V; Barocelli, E; Impicciatore, M; Lavezzo, A; Morini, G | 1 |
| Chariot, J; Hugonet, F; Nagain, C; Rozé, C; Tsocas, A | 2 |
| Bernardini, MC; Blandizzi, C; Danesi, R; Del Tacca, M | 1 |
| Gonzalez, FM; Jimenez-Heffernan, A; Latre, JM; Llamas-Elvira, JM; Martínez-Paredes, M; Mateo, A; Sopena, R; Torres, M | 1 |
| Chiba, S; Tsukada, M | 1 |
| Arruebo, MP; Bueno, L; Liberge, M | 1 |
| Abraham, P; Carroll, FI; Kwon, YW; Mascarella, SW; Moreland, CG; Sankar, SS; Singh, P; Triggle, DJ | 1 |
| Yang, CM | 1 |
| Kaneda, T; Kitamura, Y; Nomura, Y | 1 |
| Cherwinski, HM; Delmendo, RE; Eglen, R; Ransom, JT; Sharif, NA | 1 |
| Gillin, JC; Shalauta, M; Shiromani, PJ; Velazquez-Moctezuma, J | 1 |
| Felix, W; Schneider, E | 1 |
| Avenant, JC; Meyer, EC; Sommers, DK | 1 |
| Braida, D; Calcaterra, P; Comotti, FA; Gianola, S; Gori, E; Leone, MP; Sala, M | 1 |
| Davidson, A; Matus-Leibovitch, N; Mengod, G; Oron, Y | 1 |
| Chiba, S; Furukawa, Y; Karasawa, Y; Murakami, M; Narita, M; Ren, LM; Takei, M | 1 |
| Inukai, T; Ishii, A; Iwashita, A; Kobayashi, I; Kobayashi, S; Mori, M; Ohshima, K; Shimomura, Y; Takahashi, M | 1 |
| Fleming, N; Laniyonu, A; Sliwinski-Lis, E | 1 |
| Bizzarri, C; Corda, D; D'Orazio, MC; Di Girolamo, M | 1 |
| Buck, MA; Fraser, CM | 1 |
| Hartmann, T; Kahan, C; Pouyssegur, J; Seuwen, K | 1 |
| Andrioli, GC; Marchi, M; Raiteri, M; Ruelle, A | 1 |
| Entzeroth, M; Mayer, N | 1 |
| Lebrun, F; Marchetti, J; Morel, F; Taniguchi, S | 1 |
| Bevilacqua, M; Iovino, M; Monteleone, P; Norbiato, G; Steardo, L | 1 |
| Gillin, JC; Shalauta, MD; Shiromani, PJ; Velazquez-Moctezuma, J | 1 |
| Bartolini, A; Ghelardini, C; Giotti, A; Malcangio, M; Malmberg-Aiello, P | 1 |
| Ashe, JH; Metherate, R; Weinberger, NM | 1 |
| McLeskey, SW; Wojcik, WJ | 1 |
| Akahane, K; Chiba, S; Furukawa, Y; Karasawa, Y | 1 |
| Dolezal, V; Wecker, L | 1 |
| Haga, T; Honda, N; Ichiyama, A; Kajimura, M; Kaneko, E | 1 |
| Jackson, KN; Kachur, JF; Lowe, VC; Noronha-Blob, L; Sturm, BL | 1 |
| Meyer, EC; Sommers, DK; van Wyk, M | 1 |
| Alonso, R; Didier, M; Soubrie, P | 1 |
| De Boer, P; Horn, AS; Rollema, H; Westerink, BH; Zaagsma, J | 1 |
| Bayram, M; Gürmen, N; Oktay, S; Tankurt, E; Ulusoy, NB; Yegen, BC | 1 |
| Meyer, EC; Moncrieff, J; Sommers, DK; van Wyk, M | 1 |
| Chiang, PK; Covington, J; Jackson, BW; Leader, H; Newman, AH; Oleshansky, M; Weissman, BA | 1 |
| Baba, S; Fujii, M; Nakamura, T; Oka, T; Okabayashi, Y; Otsuki, M | 1 |
| Bartus, RT; Fisher, SK | 1 |
| Adami, M; Bertaccini, G; Coruzzi, G; Poli, E | 1 |
| Black, JW; Shankley, NP | 3 |
| Daniel, EE; Fox, JE | 1 |
| Kitagawa, H; Kohei, H; Takeda, F | 2 |
| Ackerman, MS; Korc, M; Roeske, WR | 1 |
| McKinney, M; Rubanyi, GM; Vanhoutte, PM | 1 |
| Jaworek, J; Konturek, SJ | 1 |
| Baba, S; Fujii, M; Nakamura, T; Oka, T; Okabayashi, Y; Otsuki, M; Tani, S | 1 |
| Goode, TL; Mathiasen, JR; Raffa, RB; Vaught, JL | 1 |
| Cieszkowski, M; Jaworek, J; Konturek, SJ; Tasler, J; Yanaihara, N | 1 |
| Bowker, P; Daniel, EE; Jury, J | 1 |
| Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
| Clementi, F; Gotti, C; Madeddu, L; Pandiella, A; Sher, E | 1 |
| Schuurkes, JA; Van Bergen, PJ; Van Nueten, JM | 1 |
| Dwyer, TM; Farley, JM; Murali Mohan, P; Yang, CM | 1 |
| Harrington, B; Kalbfleisch, JH; Nowak, TV | 1 |
| Eltz, M; Gmelin, G; Lambrecht, G; Mutschler, E; Strohmann, C; Tacke, R; Wess, J | 1 |
| Hongo, K; Kassell, NF; Ogawa, H; Tsukahara, T | 1 |
| Goritski, W; Mega, A; Nattie, EE; Wood, J | 1 |
| Weiler, MH | 1 |
| Kenimer, JG; Takashima, A | 1 |
| Laitinen, JT; Saavedra, JM; Torda, T | 1 |
| Misgeld, U; Müller, W; Polder, HR | 1 |
| Lee, W; Wolfe, BB | 1 |
| Blank, EL; Dodds, WJ; Greenwood, B | 1 |
| Cieszkowski, M; Konturek, SJ; Kromer, W; Szewczyk, K; Tasler, J | 1 |
| Kiselman, IM; Levin, SL | 1 |
| Gil, DW; Wolfe, BB | 1 |
| Choo, LK; Mitchelson, F; Vong, YM | 1 |
| Daniel, EE; Fox, JE; Jury, J; Robotham, H | 1 |
| Biziere, K; Kan, JP; Perio, A; Steinberg, R; Terranova, JP; Worms, P | 1 |
| Hara, M; Karasawa, H; Miwa, T; Mutoh, N; Tani, N; Watanabe, Y | 1 |
| Catravas, JD; Orphanos, SE | 1 |
| Bianconi, L; Caiazza, A; Capretti, L; Chiodera, P; Coiro, V; Fagnoni, F; Schianchi, L; Speroni, G; Volpi, R | 1 |
| Cotman, CW; Kahle, JS | 1 |
| Cazzola, M; Cenicola, ML; D'Amato, G; De Santis, D; Lisa, M; Maione, S; Marmo, E; Matera, MG | 1 |
| Connolly, GP; Newberry, NR | 1 |
| Chiba, S; Haruta, K; Homma, N; Horiuchi, A; Iwatsuki, K; Yonekura, H | 1 |
| Ackerman, MS; Heck, RJ; Korc, M; Roeske, WR | 1 |
| Dulaney, MD; Ho, IK; Hoskins, B; Porter, AC; Rockhold, RW | 1 |
| Barnes, PJ; Mak, JC | 1 |
| Ghataorre, AS; Lambert, DG; Nahorski, SR | 1 |
| Palm, D; Pitschner, HF; Schlepper, M; Schulte, B; Wellstein, A | 1 |
| Boselli, C; Kenakin, T | 1 |
| Hyman, AL; Kadowitz, PJ | 1 |
| Jansen, JB; Kleibeuker, JH; Lamers, CB | 1 |
| Borasio, PG; Capuzzo, A; Fabbri, E | 1 |
| Bianconcini, G; Chiodera, P; Coiro, V; Davoli, C; Delia, P; Fagnoni, F; Gelmini, G; Minelli, R; Passeri, M; Volpi, R | 1 |
| Herz, A; Paumgartner, G; Pfeiffer, A; Rochlitz, H | 1 |
| Hadjiconstantinou, M; Moroi-Fetters, SE; Neff, NH | 1 |
| Ek, B; Nahorski, S | 1 |
| Amrhein, CL; Cioffi, CL; el-Fakahany, EE; McKinney, M; Richelson, E; Stenstrom, S; Surichamorn, W | 1 |
| Anderson, DJ; el-Fakahany, EE; Lee, NH; McKinney, M; Vella-Rountree, L | 1 |
| Soll, AH; Sue, R; Todisco, A; Toomey, ML; Yamada, T | 1 |
| Saakian, Ag | 1 |
| Vatier, J | 1 |
| Dodds, WJ; Gilbert, RJ | 1 |
| Cook, PG; Hanson, CA; Risley, EA; Torchiana, ML; Wesley, CA; Westrick, BL; Wiese, SR; Williams, M | 1 |
| Ghigo, E; Locatelli, V; Massare, F; Müller, EE; Redaelli, M; Torsello, A | 1 |
| Giachetti, A; Micheletti, R; Montagna, E | 1 |
| Hsu, CT; Hyman, PE; Kao, HW; Ringer, MJ; Snape, WJ; Tomomasa, T | 1 |
| Bellini, M; Bernardini, C; Costa, F; Del Tacca, M; Polloni, A; Soldani, G | 1 |
| Iijima, T; Kudo, Y; Ogura, A | 1 |
| Kunysz, EL; Michel, AD; Whiting, RL | 1 |
| Anderson, W; Dickinson, KE; Hirschowitz, BI; Matsumoto, H; Pruitt, RE; Uemura, N | 1 |
| Iwai, S; Shirakawa, J; Tanaka, C; Taniyama, K | 1 |
| Giachetti, A; Pagani, F; Sagrada, A; Schiavone, A | 1 |
| Morrow, C; Murphy, S; Pearce, B | 1 |
| Akiyama, K; Reisine, TD; Roeske, WR; Smith, TL; Vickroy, TW; Watson, M; Yamamura, HI | 1 |
| Chuang, DM | 1 |
| Barnes, PJ; Cuss, FM; Grandordy, BM; Palmer, JB; Sampson, AS | 1 |
| Misgeld, U; Müller, W | 1 |
| Enna, SJ; Nomura, S; Zorn, SH | 1 |
| Chuang, DM; Xu, J | 1 |
| André, C; Convents, A; Guillet, JG; Hoebeke, J; Kaveri, S; Lauwereys, M; Marullo, S; Strosberg, AD | 1 |
| Henquin, JC; Nenquin, M | 1 |
| Angeli, P; Lambrecht, G; Melchiorre, C; Moser, U; Mutschler, E; Wess, J | 1 |
| Camanni, F; Demislis, K; Ghigo, E; Locatelli, V; Massara, F; Mazza, E; Molinatti, GM; Müller, EE; Tangolo, D | 1 |
| Dwyer, TM; Farley, JM; Yang, CM | 2 |
| Guelfi, M; Maggi, CA; Meli, A; Subissi, A | 1 |
| Pitschner, HF; Wellstein, A | 2 |
| Miranda, HI; Silva, WI; Wolstenholme, WW | 1 |
| Kigoshi, S; Muramatsu, I; Yamanaka, K | 3 |
| Baumgartener-Folkerts, C; Bloom, JW; Halonen, M; Palmer, JD; Yamamura, HI | 1 |
| Meyer, EC; Sommers, DK | 1 |
| Brezenoff, HE; Xiao, YF | 1 |
| Auriga, C; Birdsall, NJ; Boer, R; Schudt, C | 1 |
| Fujimoto, K; Kawashima, K; Oohata, H; Suzuki, T | 2 |
| Benson, DM; Blitzer, RD; Landau, EM | 1 |
| Abdel-Latif, AA; Honkanen, RE | 1 |
| Carmeliet, P; Denef, C | 1 |
| Kunelius, R; Laurén, L; Syvälahti, EK | 1 |
| Audigier, SM; Greengard, P; Wang, JK | 1 |
| Jeck, D; Lindmar, R; Löffelholz, K; Wanke, M | 1 |
| Lui, GK; Mei, L; Roeske, WR; Serra, M; Watson, M; Yamamura, HI | 1 |
| Davidesko, D; Doods, HN; Rinner, I; van Charldorp, KJ; van Zwieten, PA | 1 |
| Chung, FZ; Lai, J; Mei, L; Roeske, WR; Venter, JC; Yamamura, HI | 1 |
| Adem, A; Nordberg, A; Sabbagh, M | 1 |
| Bartfai, T; Goobar, L | 1 |
| Constanti, A; Williams, SH | 1 |
| Laurén, L; Scheinin, M; Syvälahti, EK; Tarvonen, S; Ylitalo, A | 1 |
| Bartel, P; Becker, P; Sommers, DK; Walters, L | 1 |
| Hebzda, Z; Konturek, SJ; Kwiecien, N; Obtulowicz, W; Oleksy, J | 1 |
| Komori, K; Suzuki, H | 1 |
| Angeli, P; Lambrecht, G; Melchiorre, C; Mutschler, E; Wess, J | 1 |
| Harasawa, S; Kikuchi, K; Miura, T; Miwa, T | 1 |
| Hayashi, T; Kinekawa, F; Kitagawa, H; Kohei, H; Takeda, F | 1 |
| Weight, FF; Yavari, P | 1 |
| Abdel-Latif, AA; Akhtar, RA; Howe, PH | 1 |
| Abdel-Latif, AA; Akhtar, RA; Honkanen, RE; Howe, PH | 1 |
| Arnulfo, C; Dato, D; Di Somma, C; Imbimbo, BP; Mortola, G; Reboa, G; Rezzo, R; Serafini, P | 1 |
| Ishii, K; Kato, R | 1 |
| Ballesta, JJ; Borges, R; García, AG | 1 |
| Baumgartener, C; Bloom, JW; Halonen, M; Yamamura, HI | 1 |
| Akaike, M; Konno, F; Nibori, Y; Takayanagi, I; Yamura, S | 1 |
| Cazzola, M; De Santis, D; Marmo, E; Principe, P; Russo, S | 1 |
| Buéno, L; Fargeas, MJ; Fioramonti, J | 1 |
| Burns, DL; Townes-Anderson, E; Vogt, BA | 1 |
| O'Rourke, ST; Vanhoutte, PM | 1 |
| Chariot, J; De la Tour, J; Rozé, C; Vaille, C | 1 |
| Brown, DA; Gähwiler, BH | 1 |
| Adem, A; Mattsson, ME; Nordberg, A; Påhlman, S | 1 |
| Ekelund, M; Håkanson, R; Vallgren, S | 1 |
| Bali, JP; Baudiere, B; Giraldo, E; Ladinsky, H; Monferini, E | 1 |
| Gower, AJ | 1 |
| Bitar, KN; Grider, JR; Makhlouf, GM | 1 |
| Ito, Y; Kato, H; Morikawa, K; Muramatsu, I; Ohashi, T; Oshita, M | 1 |
| Beck, KC; Flavahan, NA; Rehder, K; Vettermann, J | 1 |
| Benages, A; Míngez, M; Molina, R; Mora, F; Moreno-Osset, E; Tomás-Ridocci, M | 1 |
| Ebinger, G; Vanderheyden, P; Vauquelin, G | 1 |
| Adam, LP; Pappano, AJ; Sorota, S | 1 |
| Doggrell, SA | 1 |
| Baba, S; Matozaki, T; Nagao, M; Sakamoto, C | 1 |
| Christophe, J; Gillard, M; Waelbroeck, M | 1 |
| Banner, W; Duckles, SP; Hynes, MR; Yamamura, HI | 1 |
| Herz, A; Paumgartner, G; Pfeiffer, A | 1 |
| Bertaccini, G; Cartellà, A; Potenzoni, D; Zappia, L | 1 |
| Ferrari, M; Malandrino, S; Muzio, F; Tonon, G | 1 |
| Syvälahti, EK; Ylitalo, A | 1 |
| Brage, R; Esplugues, J; Esplugues, JV; Martí-Bonmati, E; Rodríguez, C | 1 |
| Berenguer, J; Garrigues, V; Pertejo, V; Ponce, J; Sala, T | 1 |
| Cubeddu, LX; James, MK | 1 |
| Stockbrügger, R | 1 |
| Geller, AL; Geller, LI; Petrenko, VG | 1 |
| Bassotti, G; Daniotti, S; Del Soldato, P; Morelli, A; Narducci, F; Pelli, MA | 1 |
| Eglen, RM; Whiting, RL | 1 |
| Gremo, F; Marchisio, AM; Mulas, ML; Palomba, M | 1 |
| Giraldo, E; Hammer, R; Monferini, E | 1 |
| Gaginella, TS; Tien, XY; Wahawisan, R; Wallace, LJ | 1 |
| Fujiwara, M; Kitagawa, H; Sano, M | 1 |
| Gremo, F; Marchisio, AM; Vernadakis, A | 1 |
| Ehlert, FJ; Jenden, DJ | 1 |
| Kendall, DA; Lazareno, S; Nahorski, SR | 1 |
| Egan, TM; North, RA | 1 |
| Marchi, M; Raiteri, M | 1 |
| Bianchi Porro, G; Del Soldato, P; Lazzaroni, M; Sangaletti, O | 1 |
| Abrahamsson, H; Dotevall, G; Jaup, BH; Rosengren, K; Stockbruegger, RW | 1 |
| Heathcote, BV; Parry, M | 2 |
| Dotevall, G; Jaup, BH | 1 |
| Blum, AL; Engler, H; Müller-Lissner, SA; Szelenyi, I | 1 |
| Parsons, ME; Price, C; Wintermeyer, D | 1 |
| Fong, J; Hirschowitz, BI; Molina, E | 1 |
| Bernardini, C; Del Tacca, M; Martinotti, E; Soldani, G | 1 |
| Rosenfeld, GC | 1 |
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10 review(s) available for atropine and pirenzepine
| Article | Year |
|---|---|
Is field (vagal) stimulation of gastric acid secretion mediated by M1 or non-M1 muscarinic receptors? A methodical problem exemplified in the mouse stomach in vitro.
Topics: Animals; Atropine; Bethanechol; Bethanechol Compounds; Dicyclomine; Gastric Acid; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Mice; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Regression Analysis | 1991 |
Pharmacology and second messenger interactions of cloned muscarinic receptors.
Topics: Animals; Atropine; Carbachol; Cell Line; Humans; Oxotremorine; Piperidines; Pirenzepine; Receptors, Muscarinic; Recombinant Proteins; Second Messenger Systems; Transfection | 1991 |
[MI cholinergic receptors of gastric secretion: current status].
Topics: Amino Acids; Animals; Atropine; Benzodiazepinones; Dogs; Gastric Acid; Gastric Emptying; Gastric Mucosa; Gastrins; Heart Rate; Histamine; Histamine Release; Molecular Conformation; Pirenzepine; Rats; Receptors, Muscarinic; Receptors, Nicotinic; Salivation; Somatostatin; Urinary Bladder; Vagus Nerve | 1985 |
[Selective muscarinic receptor antagonists].
Topics: Anti-Ulcer Agents; Atropine; Benzodiazepinones; Gastric Acid; Humans; Peptic Ulcer; Pirenzepine; Receptors, Muscarinic | 1984 |
[Subtypes of muscarinic receptors--aspects of their physiologic significance for controlling heart rate in the human].
Topics: Atropine; Cloning, Molecular; DNA, Complementary; Dose-Response Relationship, Drug; Heart Rate; Humans; Parasympatholytics; Pirenzepine; Radioligand Assay; Receptors, Muscarinic | 1994 |
Myopia: attempts to arrest progression.
Topics: Accommodation, Ocular; Adolescent; Adult; Atropine; Biofeedback, Psychology; Child; Contact Lenses; Disease Progression; Eye Movements; Eyeglasses; Humans; Intraocular Pressure; Medicine, Chinese Traditional; Myopia; Ophthalmic Solutions; Pirenzepine; Timolol; Tropicamide | 2002 |
Treatment options for myopia.
Topics: Atropine; Contact Lenses; Equipment Design; Eyeglasses; Humans; Muscarinic Antagonists; Mydriatics; Myopia; Pirenzepine; Refractive Surgical Procedures | 2009 |
Interventions to slow progression of myopia in children.
Topics: Atropine; Child; Contact Lenses; Cyclopentolate; Disease Progression; Eyeglasses; Humans; Muscarinic Antagonists; Myopia; Ophthalmic Solutions; Pirenzepine; Randomized Controlled Trials as Topic | 2011 |
Epidemiology of myopia and prevention of myopia progression in children in East Asia: a review.
Topics: Administration, Ophthalmic; Asia, Eastern; Atropine; Child; Contact Lenses; Disease Progression; Eyeglasses; Hong Kong; Humans; Muscarinic Antagonists; Myopia; Pirenzepine; Prevalence | 2018 |
Interventions to slow progression of myopia in children.
Topics: Atropine; Child; Contact Lenses; Cyclopentolate; Humans; Muscarinic Antagonists; Myopia, Degenerative; Ophthalmic Solutions; Pirenzepine; Randomized Controlled Trials as Topic | 2020 |
20 trial(s) available for atropine and pirenzepine
| Article | Year |
|---|---|
Pirenzepine in peptic ulcer. Introduction to clinical trials reports.
Topics: Anti-Ulcer Agents; Atropine; Benzodiazepinones; Clinical Trials as Topic; Humans; Peptic Ulcer; Piperazines; Pirenzepine | 1979 |
Effects of pirenzepine and atropine on basal lower esophageal pressure and gastric acid secretion in man: a placebo-controlled randomized study.
Topics: Atropine; Dose-Response Relationship, Drug; Double-Blind Method; Esophagogastric Junction; Gastric Acid; Gastrointestinal Motility; Humans; Infusions, Intravenous; Pirenzepine; Pressure; Reference Values | 1991 |
5-HT1-, but not 5-HT2-serotonergic, M1-, M2-muscarinic cholinergic or dopaminergic receptors mediate the ACTH/cortisol response to metoclopramide in man.
Topics: Adrenocorticotropic Hormone; Adult; Atropine; Bromocriptine; Dose-Response Relationship, Drug; Humans; Hydrocortisone; Ketanserin; Male; Metergoline; Metoclopramide; Pirenzepine; Receptors, Adrenergic; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Muscarinic; Receptors, Serotonin | 1990 |
Atropine and verapamil interactions in healthy volunteers.
Topics: Adult; Atropine; Depression, Chemical; Drug Interactions; Heart Rate; Humans; Male; Pirenzepine; Single-Blind Method; Stimulation, Chemical; Verapamil | 1991 |
Inhibition of cholecystokinin-induced gallbladder contraction by atropine and pirenzepine in man.
Topics: Adult; Atropine; Gallbladder; Humans; Male; Muscle Contraction; Muscle, Smooth; Pirenzepine; Receptors, Muscarinic; Sincalide | 1990 |
The effects of anticholinergics on the photopalpebral reflex, memory and mood.
Topics: Adult; Affect; Atropine; Blinking; Double-Blind Method; Humans; Male; Memory; Pirenzepine; Random Allocation | 1988 |
Effects of protective drugs on gastric alkaline secretion in man.
Topics: 16,16-Dimethylprostaglandin E2; Adult; Antacids; Aspirin; Atropine; Bicarbonates; Gastric Mucosa; Humans; Pirenzepine; Sucralfate | 1987 |
Effects of pirenzepine and atropine on gastroduodenal motor patterns in duodenal ulcer patients.
Topics: Adult; Aged; Atropine; Clinical Trials as Topic; Duodenal Ulcer; Duodenum; Female; Gastrointestinal Motility; Humans; Male; Middle Aged; Pirenzepine; Random Allocation; Stomach | 1986 |
Differences in cardiac but not in neuroendocrine responses in healthy volunteers after administration of two antimuscarinic agents, atropine and pirenzepine.
Topics: Adult; Atropine; Benzodiazepinones; Female; Growth Hormone; Heart; Heart Rate; Humans; Male; Metoclopramide; Pirenzepine; Prolactin; Reference Values; Time Factors | 1986 |
Effects of atropine and pirenzepine on sphincter of Oddi motility. A manometric study.
Topics: Adult; Aged; Aged, 80 and over; Ampulla of Vater; Atropine; Double-Blind Method; Female; Gastrointestinal Motility; Humans; Male; Manometry; Middle Aged; Pirenzepine; Random Allocation | 1986 |
Identification of muscarinic receptor subtype mediating colonic response to eating.
Topics: Adult; Atropine; Benzodiazepinones; Colon; Eating; Electrophysiology; Female; Heart Rate; Humans; Male; Pirenzepine; Receptors, Muscarinic; Xerostomia | 1985 |
Effect of pirenzepine and atropine on peptone meal-stimulated gastric secretion and plasma gastrin in healthy volunteers, patients with duodenal ulcer and vagotomized patients.
Topics: Adult; Atropine; Benzodiazepinones; Duodenal Ulcer; Female; Gastric Acid; Gastrins; Humans; Kinetics; Male; Middle Aged; Peptones; Pirenzepine; Vagotomy | 1985 |
Effect of selective and non-selective antimuscarinics on rectosigmoid motility and gastrointestinal transit.
Topics: Adult; Atropine; Benzodiazepinones; Colon, Sigmoid; Female; Gastric Acid; Gastrointestinal Motility; Humans; Male; Middle Aged; Parasympatholytics; Pirenzepine; Pressure; Receptors, Muscarinic; Rectum; Time Factors | 1985 |
The effect of pirenzepine and L-hyoscyamine on gastric emptying and salivary secretion in healthy volunteers.
Topics: Adult; Atropine; Benzodiazepinones; Clinical Trials as Topic; Depression, Chemical; Female; Gastric Emptying; Histamine H2 Antagonists; Humans; Male; Middle Aged; Piperazines; Pirenzepine; Research Design; Saliva; Salivation | 1981 |
[Effect of pirenzepine and atropine on the transmural gastric mucosal potential difference (author's transl)].
Topics: Atropine; Benzodiazepinones; Gastric Mucosa; Humans; Membrane Potentials; Parasympatholytics; Piperazines; Pirenzepine | 1980 |
Comparison between the effects of pirenzepine and L-hyoscyamine in man.
Topics: Accommodation, Ocular; Adult; Atropine; Benzodiazepinones; Double-Blind Method; Esophagus; Gastric Acid; Humans; Peristalsis; Pirenzepine; Pupil | 1982 |
In vivo characterization of muscarinic receptor subtypes that mediate vasodilatation in patients with essential hypertension.
Topics: Atropine; Forearm; Humans; Hypertension; Male; Methacholine Chloride; Middle Aged; Nitroprusside; Parasympatholytics; Pirenzepine; Plethysmography; Receptors, Muscarinic; Vasodilation | 1995 |
Selective and unselective blockade of sympathicus and parasympathicus and vagal enhancement by pirenzepine: effects on heart rate and heart rate variability in healthy subjects.
Topics: Adrenergic beta-Antagonists; Adult; Atropine; Autonomic Nervous System; Electrocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Neuromuscular Blocking Agents; Parasympatholytics; Pirenzepine; Propanolamines; Signal Processing, Computer-Assisted | 1996 |
Patients with AV nodal reentrant tachycardias show a reduced vagal impact on heart rate compared to healthy subjects with further decrease of vagal tone after radiofrequency catheter modification.
Topics: Adrenergic beta-Antagonists; Adult; Atropine; Catheter Ablation; Female; Heart Rate; Humans; Male; Middle Aged; Parasympatholytics; Pirenzepine; Propanolamines; Sympathetic Nervous System; Tachycardia, Atrioventricular Nodal Reentry | 1996 |
Anticholinergic differences among patients receiving standard clinical doses of olanzapine or clozapine.
Topics: Adult; Antipsychotic Agents; Atropine; Autonomic Nervous System Diseases; Benzodiazepines; Cholinergic Antagonists; Clozapine; Female; Humans; Male; Muscarinic Antagonists; Olanzapine; Pirenzepine; Psychiatric Status Rating Scales; Psychotic Disorders; Radioligand Assay; Receptors, Muscarinic | 2000 |
529 other study(ies) available for atropine and pirenzepine
| Article | Year |
|---|---|
Cloning of the rat M3, M4 and M5 muscarinic acetylcholine receptor genes by the polymerase chain reaction (PCR) and the pharmacological characterization of the expressed genes.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Base Sequence; Carbachol; Cell Line; Cloning, Molecular; Cyclic AMP; Fibroblasts; Gene Expression; Inositol Phosphates; Molecular Sequence Data; Parasympatholytics; Polymerase Chain Reaction; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Receptors, Muscarinic; Transfection | 1992 |
Muscarinic receptor binding profile of para-substituted caramiphen analogues.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Cyclopentanes; Male; Molecular Structure; Parasympatholytics; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Structure-Activity Relationship | 1991 |
Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
Topics: Animals; Cell Line; Cloning, Molecular; Cricetinae; Humans; Kinetics; N-Methylscopolamine; Parasympatholytics; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1989 |
Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates.
Topics: Animals; Antidotes; Carbamates; Chemical Phenomena; Chemistry; Cholinesterase Inhibitors; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Organophosphate Poisoning; Parasympatholytics; Phenylpropionates; Rats; Rats, Inbred Strains | 1989 |
Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cattle; Chemical Phenomena; Chemistry; Corpus Striatum; Inositol Phosphates; Male; Muscarine; Myocardium; Pirenzepine; Quinuclidines; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Stereoisomerism; Structure-Activity Relationship | 1988 |
6-Methyl-6-azabicyclo[3.2.1]octan-3 alpha-ol 2,2-diphenylpropionate (azaprophen), a highly potent antimuscarinic agent.
Topics: Acetylcholine; alpha-Amylases; Animals; Behavior, Animal; Carbachol; Cell Line; Chemical Phenomena; Chemistry; Guinea Pigs; Humans; Male; Molecular Conformation; Muscle Contraction; Neuroblastoma; Pancreas; Phenylpropionates; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine; Tropanes | 1987 |
Synthesis and biodistribution of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate. A new ligand for the potential imaging of muscarinic receptors by single photon emission computed tomography.
Topics: Animals; Brain; Female; Iodine Radioisotopes; Ligands; Quinuclidines; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Structure-Activity Relationship; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 1993 |
Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line.
Topics: Amino Acid Sequence; Animals; Carbachol; Cloning, Molecular; Cyclic AMP; Humans; Mice; Molecular Sequence Data; Muscarinic Agonists; Muscarinic Antagonists; Phosphatidylinositols; Radioligand Assay; Rats; Receptors, Muscarinic; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Species Specificity | 1998 |
Synthesis and pharmacological characterization of O-alkynyloximes of tropinone and N-methylpiperidinone as muscarinic agonists.
Topics: Animals; Aorta; Binding, Competitive; Drug Design; Escape Reaction; In Vitro Techniques; Male; Maze Learning; Mice; Models, Molecular; Molecular Structure; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth, Vascular; N-Methylscopolamine; Nuclear Magnetic Resonance, Biomolecular; Piperidines; Pirenzepine; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Structure-Activity Relationship; Tropanes | 1998 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Receptor binding studies of soft anticholinergic agents.
Topics: Animals; Cholinergic Antagonists; Dose-Response Relationship, Drug; Drug Stability; Guinea Pigs; Humans; Ileum; Protein Binding; Quantitative Structure-Activity Relationship; Receptors, Muscarinic | 2001 |
Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor.
Topics: Animals; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Immunoblotting; Inositol Phosphates; Ligands; Muscarinic Agonists; Mutagenesis, Site-Directed; Radioligand Assay; Receptor, Muscarinic M2; Transfection | 2006 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods.
Topics: Atropine; Computer Simulation; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Receptor, Muscarinic M1; Structure-Activity Relationship | 2013 |
Characterization of muscarinic receptor subtypes on rat pancreatic acini: pharmacological identification by secretory responses and binding studies.
Topics: Amylases; Animals; Atropine; Carbachol; Dose-Response Relationship, Drug; Male; Pancreas; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Sincalide | 1992 |
Characterization of the subtype of muscarinic receptor coupled to the stimulation of phosphoinositide hydrolysis in 132-1N1 human astrocytoma cells.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Astrocytoma; Atropine; Carbachol; Diamines; Humans; Hydrolysis; Parasympathomimetics; Phosphatidylinositols; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine; Tumor Cells, Cultured | 1992 |
[The role of muscarinic receptor subtypes in feline tracheal submucosal gland secretion].
Topics: Animals; Atropine; Calcium; Cats; Electrolytes; Glycoproteins; In Vitro Techniques; Mucous Membrane; Piperidines; Pirenzepine; Receptors, Muscarinic; Second Messenger Systems; Trachea | 1992 |
Effect of acute and chronic acid suppression on plasma gastrin release in the rat.
Topics: Adenosine Triphosphatases; Animals; Atropine; Dose-Response Relationship, Drug; Female; Gastric Acid; Gastric Mucosa; Gastrins; H(+)-K(+)-Exchanging ATPase; Hydrogen-Ion Concentration; Muscarinic Antagonists; Parasympatholytics; Pirenzepine; Pyloric Antrum; Rats; Rats, Inbred Strains; Time Factors | 1992 |
Differential regulation of subtypes m1-m5 of muscarinic receptors in forebrain by chronic atropine administration.
Topics: Animals; Atropine; Oxotremorine; Phosphatidylinositols; Pirenzepine; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Up-Regulation | 1992 |
Differential effects of paraoxon on the M3 muscarinic receptor and its effector system in rat submaxillary gland cells.
Topics: Animals; Atropine; Binding Sites; Carbachol; Cyclic AMP; Hydrolysis; Male; Paraoxon; Phosphatidylinositols; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Regression Analysis; Submandibular Gland | 1992 |
Chronic ethanol feeding produces a muscarinic receptor upregulation, but not a muscarinic supersensitivity in lower esophageal sphincter muscle.
Topics: Animals; Atropine; Bethanechol; Bethanechol Compounds; Binding, Competitive; Cats; Esophagogastric Junction; Ethanol; Female; In Vitro Techniques; Male; Muscle, Smooth; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Cholinergic; Up-Regulation | 1992 |
Enhancement of DNA synthesis in rat thymocytes by stimulating their muscarinic acetylcholine receptors.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Cells, Cultured; DNA; Hexamethonium; Hexamethonium Compounds; Isoflurophate; Kinetics; Male; Nicotine; Oxotremorine; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Succinylcholine; T-Lymphocytes; Thymidine; Tritium; Tubocurarine | 1992 |
Involvement of Ca2+ entry and inositol trisphosphate-induced internal Ca2+ mobilization in muscarinic receptor-mediated catecholamine release in dog adrenal chromaffin cells.
Topics: Acetylcholine; Adrenal Medulla; Animals; Atropine; Bethanechol; Bethanechol Compounds; Biological Transport; Calcium; Calcium Channel Blockers; Catecholamines; Cells, Cultured; Dogs; Female; Gallic Acid; Inositol 1,4,5-Trisphosphate; Kinetics; Male; Muscarine; Neomycin; Nicotine; Oxotremorine; Pirenzepine; Polymyxin B; Potassium Chloride; Receptors, Muscarinic; Retinaldehyde; Tetradecanoylphorbol Acetate | 1992 |
Cholinergic and GABAergic mediations of the effects of apomorphine on serotonin neurons.
Topics: Acetylcholine; Analysis of Variance; Animals; Apomorphine; Atropine; Bicuculline; Carbachol; gamma-Aminobutyric Acid; Hydroxyindoleacetic Acid; Male; Mecamylamine; Neurons; Pirenzepine; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Tryptophan | 1992 |
Responsiveness and sensitivity to cholinergic agonists and antagonists in bovine isolated bronchial muscle.
Topics: Acetylcholine; Animals; Atropine; Bronchi; Cattle; Gallamine Triethiodide; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine | 1992 |
Motility of rabbit proximal colon. Relevance of cholinergic pathways and role of different muscarinic receptor subtypes.
Topics: Action Potentials; Animals; Atropine; Benzodiazepinones; Cholinergic Fibers; Colon; Gastrointestinal Motility; Heart Rate; Male; Parasympatholytics; Pirenzepine; Pupil; Rabbits; Receptors, Muscarinic | 1992 |
AF102B, a muscarinic M1 receptor agonist, mimics some effects of acetylcholine on neurons of rat hippocampus slices.
Topics: Acetylcholine; Animals; Atropine; Electrophysiology; Hippocampus; In Vitro Techniques; Parasympathomimetics; Pirenzepine; Quinuclidines; Rats; Receptors, Muscarinic; Thiophenes | 1992 |
Contribution of vagal blockade to the tachycardia induced by the antimuscarinic agents atropine and pirenzepine.
Topics: Animals; Atropine; Dogs; Female; Heart; Heart Rate; Male; Parasympatholytics; Pirenzepine; Sympathetic Nervous System; Vagus Nerve | 1992 |
[Muscarinic receptor subtypes in respiratory center and their functions].
Topics: Animals; Atropine; Blood Gas Analysis; Female; Male; Medulla Oblongata; Pilocarpine; Pirenzepine; Pons; Rabbits; Radioligand Assay; Rats; Rats, Inbred Strains; Rats, Wistar; Receptors, Muscarinic; Respiration; Respiratory Center; Scopolamine; Tidal Volume | 1992 |
Muscarinic receptor subtypes in bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Atropine; Binding Sites; Binding, Competitive; Cattle; Cell Membrane; Dicyclomine; Muscarine; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1992 |
Apparent noncompetitive antagonism of muscarinic receptor mediated Ca2+ mobilization by some muscarinic antagonists.
Topics: Atropine; Calcium; Fura-2; Humans; Kinetics; Muscarinic Antagonists; N-Methylscopolamine; Neuroblastoma; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Spectrometry, Fluorescence; Tumor Cells, Cultured | 1992 |
Characterization of the muscarinic receptor subtype mediating vasodilation in the rat perfused mesenteric vascular bed preparation.
Topics: Animals; Atropine; Benzodiazepinones; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Arteries; Mesenteric Veins; Methacholine Chloride; Parasympatholytics; Perfusion; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Vasodilation | 1992 |
[Effect of atropine and pirenzepine on bronchoconstriction during vagus nerve stimulation in dogs].
Topics: Animals; Atropine; Bronchoconstriction; Dogs; Electric Stimulation; Pirenzepine; Vagus Nerve | 1992 |
Influence of pirenzepine on gallbladder contraction in man induced by sham feeding or an intraduodenal meal.
Topics: Adult; Atropine; Dietary Fats; Food; Gallbladder; Gallbladder Emptying; Humans; Male; Pirenzepine; Receptors, Muscarinic | 1992 |
The muscarinic receptor gene expressed in rabbit parietal cells is the m3 subtype.
Topics: Animals; Atropine; Base Sequence; Blotting, Southern; Molecular Sequence Data; N-Methylscopolamine; Parietal Cells, Gastric; Piperidines; Pirenzepine; Polymerase Chain Reaction; Rabbits; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives | 1992 |
Muscarinic modulation of acetylcholine release from slices of guinea pig nucleus basalis magnocellularis.
Topics: Acetylcholine; Animals; Atropine; Calcium; Choline; Female; Guinea Pigs; Male; Parasympatholytics; Physostigmine; Piperidines; Pirenzepine; Receptors, Muscarinic; Substantia Innominata; Tetrodotoxin | 1992 |
Cholinergic effects on intracellular free calcium concentration in renal corpuscle: role of parietal sheet.
Topics: Acetylcholine; Animals; Atropine; Calcium; Carbachol; Dose-Response Relationship, Drug; Histological Techniques; Intracellular Membranes; Kidney Glomerulus; Male; Osmolar Concentration; Parasympathomimetics; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Cholinergic | 1992 |
A minority of muscarinic receptors mediate rabbit tracheal smooth muscle contraction.
Topics: Animals; Atropine; Female; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Myocardium; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Radioligand Assay; Receptors, Muscarinic; Trachea | 1992 |
Effects of atropine, pirenzepine, imipramine and phenothiazines on the mammalian neuromuscular junction.
Topics: Acetylcholine; Animals; Atropine; Diaphragm; Electric Stimulation; Female; Imipramine; Male; Muscle Contraction; Neuromuscular Junction; Oxotremorine; Phenothiazines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tubocurarine | 1992 |
Muscarinic receptor subtypes in human and rat colon smooth muscle.
Topics: Animals; Atropine; Binding, Competitive; Colon; Humans; Infant, Newborn; Male; Muscle, Smooth; N-Methylscopolamine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1992 |
Muscarinic cholinergic stimulation elevates intracellular pH in chicken granulosa cells by a Ca(2+)-dependent, Na(+)-independent mechanism.
Topics: Animals; Atropine; Calcium; Carbachol; Chickens; Cytosol; Female; Fluoresceins; Granulosa Cells; Hydrogen-Ion Concentration; Pirenzepine; Receptors, Muscarinic; Sodium | 1992 |
Calcium-dependent biosynthesis of platelet-activating factor by submandibular gland cells.
Topics: Acetylcholine; Acetyltransferases; Animals; Arachidonic Acid; Arachidonic Acids; Atropine; Calcium; Diacylglycerol Cholinephosphotransferase; Dithiothreitol; Dogs; Female; In Vitro Techniques; Kinetics; Male; Pirenzepine; Platelet Activating Factor; Submandibular Gland | 1991 |
Acetylcholine regulates pancreastatin secretion from the human pancreastatin-producing cell line (QGP-1N).
Topics: Acetylcholine; Adenoma, Islet Cell; Atropine; Calcimycin; Calcium; Carbachol; Chromogranin A; Gastrin-Releasing Peptide; Humans; Pancreatic Hormones; Pancreatic Neoplasms; Parasympatholytics; Peptides; Piperidines; Pirenzepine; Receptors, Muscarinic; Sincalide; Tumor Cells, Cultured | 1991 |
Muscarinic acetylcholine receptor-mediated phosphoinositide turnover in cultured human retinal pigment epithelium cells.
Topics: Adult; Atropine; Carbachol; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Pertussis Toxin; Phosphatidylinositols; Pigment Epithelium of Eye; Pirenzepine; Receptors, Muscarinic; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Differential coupling of muscarinic receptors to Ca2+ mobilization and cyclic AMP in SH-SY5Y and IMR 32 neuroblastoma cells.
Topics: Acetylcholine; Alprostadil; Atropine; Calcium; Carbachol; Cyclic AMP; Humans; Methacholine Chloride; Muscarine; Neuroblastoma; Pertussis Toxin; Pirenzepine; Receptors, Muscarinic; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1991 |
Non-synaptic cholinergic modulation of neurogenic twitches of the guinea-pig ileum.
Topics: Acetylcholine; Action Potentials; Adenylyl Cyclases; Animals; Atropine; Calcium; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Ouabain; Oxotremorine; Parasympathetic Nervous System; Pilocarpine; Pirenzepine; Potassium; Synapses | 1991 |
Cholinoceptor blockers protect against ethanol-induced gastric mucosal damage in rats.
Topics: Administration, Oral; Animals; Atropine; Ethanol; Gastric Mucosa; Hexamethonium; Hexamethonium Compounds; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Parasympatholytics; Pirenzepine; Rats; Rats, Inbred Strains | 1991 |
Effects of pirenzepine on CCK-stimulated canine pancreatic exocrine secretion.
Topics: Amylases; Anesthesia; Animals; Atropine; Cholecystokinin; Dogs; Hexamethonium Compounds; Male; Pancreas; Pancreatic Juice; Pirenzepine | 1990 |
Characterization of a muscarinic receptor controlling Cl- secretion in hen trachea.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Bumetanide; Calcium Channels; Chickens; Chlorides; Dicyclomine; Female; In Vitro Techniques; Ion Channels; Kinetics; Mucous Membrane; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1990 |
Distinct muscarinic receptor subtypes differentially modulate acetylcholine release from corticocerebral synaptosomes.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Binding, Competitive; Biological Transport; Cerebellum; Cerebral Cortex; Choline; Dioxolanes; Guinea Pigs; Isoflurophate; Kinetics; Oxotremorine; Pirenzepine; Potassium; Quinuclidinyl Benzilate; Receptors, Muscarinic; Synaptosomes | 1990 |
Antimuscarinic potency and functional selectivity of oxotremorine analogs at muscarinic receptor subtypes in the rat.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Blood Pressure; Heart Rate; Male; Muscarine; Oxotremorine; Parasympathomimetics; Physostigmine; Pirenzepine; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1990 |
Action of cholecystokinin on the dog sphincter of Oddi: influence of anti-cholinergic agents.
Topics: Animals; Atropine; Bile; Cholecystokinin; Dogs; Dose-Response Relationship, Drug; Hexamethonium; Hexamethonium Compounds; Male; Parasympatholytics; Pirenzepine; Sphincter of Oddi | 1990 |
Carbachol activates a novel sodium current in isolated guinea pig ventricular myocytes via M2 muscarinic receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Carbachol; Cells, Cultured; Electric Conductivity; GTP-Binding Proteins; Guinea Pigs; Heart; In Vitro Techniques; Myocardium; Pertussis Toxin; Pirenzepine; Receptors, Muscarinic; Sodium; Virulence Factors, Bordetella | 1991 |
Effect of temperature reduction on responsiveness to cholinomimetics in the taenia caeci of the guinea-pig.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Carbachol; Colon; Drug Interactions; Guinea Pigs; In Vitro Techniques; Inositol Phosphates; Kinetics; Muscle Contraction; Parasympathomimetics; Phenoxybenzamine; Pirenzepine; Propylbenzilylcholine Mustard; Quinuclidinyl Benzilate; Temperature | 1991 |
Evidence for facilitatory and inhibitory muscarinic receptors on postganglionic sympathetic nerves in mouse isolated atria.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Carbachol; Cocaine; Diamines; Dicyclomine; Female; Heart; Hexamethonium Compounds; In Vitro Techniques; Mice; Myocardium; Nerve Endings; Neurons; Norepinephrine; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Sympathetic Nervous System; Synaptic Transmission | 1991 |
Ion channels involved in the presynaptic hyperexcitability induced by herpes virus suis in rat superior cervical ganglion.
Topics: 4-Aminopyridine; Action Potentials; Animals; Atropine; Calcium Channel Blockers; Electric Stimulation; Evoked Potentials; Ganglia, Sympathetic; Herpesvirus 1, Suid; Hexamethonium; Hexamethonium Compounds; Ion Channels; Male; Neurons; Physostigmine; Pirenzepine; Pseudorabies; Rats; Rats, Inbred Strains; Synapses; Tetrodotoxin | 1991 |
Functional subtyping of muscarinic receptors on canine esophageal mucosa.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Amiloride; Animals; Atropine; Carbachol; Chlorides; Dogs; Electric Conductivity; Esophagus; Female; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Mucous Membrane; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Sodium | 1991 |
Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Antihypertensive Agents; Aorta, Abdominal; Arecoline; Atropine; Diamines; Endothelium, Vascular; Hexamethonium; Hexamethonium Compounds; Indomethacin; Male; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Norepinephrine; Parasympatholytics; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic | 1991 |
Internal Ca2+ mobilization by muscarinic stimulation increases secretion from adrenal chromaffin cells only in the presence of Ca2+ influx.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Atropine; Calcium; Catecholamines; Cats; Cattle; Cytosol; Gallopamil; Kinetics; Methacholine Chloride; Muscarine; Nicotine; Parasympatholytics; Pilocarpine; Pirenzepine; Receptors, Muscarinic | 1991 |
Presynaptic M2-muscarinic receptors on noradrenergic nerve endings and endothelium-derived M3 receptors in cat cerebral arteries.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Carbachol; Cats; Cerebral Arteries; Endothelium, Vascular; Female; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Parasympatholytics; Parasympathomimetics; Piperidines; Pirenzepine; Receptors, Muscarinic; Vasodilation | 1991 |
Effect of selective and nonselective muscarinic blockade on cholecystokinin-induced gallbladder emptying in man.
Topics: Adult; Atropine; Bile Ducts; Cholecystokinin; Dose-Response Relationship, Drug; Female; Gallbladder Emptying; Humans; Male; Middle Aged; Muscarinic Antagonists; Parasympathomimetics; Pirenzepine; Radionuclide Imaging | 1992 |
Electrophysiological responses to muscarinic receptor stimulation in cultured hippocampal neurons.
Topics: Action Potentials; Animals; Atropine; Carbachol; Cells, Cultured; Electrophysiology; Female; Hippocampus; Kinetics; Membrane Potentials; Muscarine; Muscarinic Antagonists; Neurons; Parasympathomimetics; Pirenzepine; Pregnancy; Rats; Receptors, Muscarinic; Stimulation, Chemical | 1991 |
Pharmacological characterization of muscarinic receptor subtypes in rabbit isolated tissue preparations.
Topics: Animals; Aorta, Thoracic; Atropine; Diamines; Jejunum; Male; Muscarinic Antagonists; Muscle Contraction; Myocardium; Parasympatholytics; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic; Vas Deferens; Vasodilation | 1991 |
Multiple muscarinic receptor subtypes in the canine pulmonary circulation.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Dogs; Gallamine Triethiodide; In Vitro Techniques; Muscarinic Antagonists; Parasympatholytics; Phenethylamines; Pirenzepine; Pulmonary Circulation; Receptors, Muscarinic; Vascular Resistance; Vasoconstriction; Vasodilation | 1991 |
Muscarinic receptors in diabetic rat prostate.
Topics: Animals; Atropine; Blood Glucose; Diabetes Mellitus, Experimental; Down-Regulation; Inositol; Insulin; Male; Pirenzepine; Prostate; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1991 |
Pre- and postjunctional muscarinic receptor subtypes in dog airways.
Topics: Acetylcholine; Animals; Atropine; Bronchi; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic | 1991 |
Muscarinic acetylcholine receptors are expressed and enriched in growth cone membranes isolated from fetal and neonatal rat forebrain: pharmacological demonstration and characterization.
Topics: Animals; Animals, Newborn; Atropine; Axons; Binding, Competitive; Cell Membrane; Nerve Tissue Proteins; Pirenzepine; Prosencephalon; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1991 |
Pharmacological analysis of agonist-antagonist interactions at acetylcholine muscarinic receptors in a new urinary bladder assay.
Topics: Animals; Atropine; Atropine Derivatives; Guinea Pigs; Hemicholinium 3; In Vitro Techniques; Male; Mice; Muscarine; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Parasympathomimetics; Pirenzepine; Receptors, Muscarinic; Trachea; Urinary Bladder | 1991 |
[Comparison of the inhibitory effects of a psychostimulant of the sydnonimine series on the development of stress and ethanol induced lesions in the rat gastric mucosa].
Topics: Animals; Antidepressive Agents; Atropine; Cold Temperature; Ethanol; Gastric Mucosa; Immobilization; Male; Parasympatholytics; Pirenzepine; Rats; Stomach Ulcer; Stress, Physiological; Sydnones | 1991 |
Acetylcholine receptors in dissociated nucleus basalis of Meynert neurons of the rat.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Membrane Potentials; Neurons; Nicotine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Substantia Innominata | 1991 |
Effects of anticholinergic drugs on rabbit efferent phrenic discharges.
Topics: Animals; Atropine; Electrophysiology; Female; Injections, Intraventricular; Male; Phrenic Nerve; Pirenzepine; Rabbits; Respiratory Center; Scopolamine; Vagotomy | 1991 |
Salivation from the denervated human parotid gland induced by pirenzepine and telenzepine.
Topics: Atropine; Humans; Parasympatholytics; Parotid Gland; Pirenzepine; Salivation; Sympathectomy | 1991 |
In vivo probing of the brain cholinergic system in the aged rat. Effects of long-term treatment with acetyl-L-carnitine.
Topics: Acetylcarnitine; Acetylcholine; Aging; Analysis of Variance; Animals; Atropine; Hippocampus; Male; Parasympatholytics; Pirenzepine; Rats; Rats, Inbred F344; Rats, Inbred Strains; Reference Values | 1991 |
Determination of acetylcholine release in the striatum of anesthetized rats using in vivo microdialysis and a radioimmunoassay.
Topics: Acetylcholine; Administration, Topical; Animals; Atropine; Corpus Striatum; Dialysis; Male; Muscarine; Parasympatholytics; Physostigmine; Pirenzepine; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1991 |
Age-related differences in the effects of some muscarinic agents on acetylcholine release from rat neostriatal slices.
Topics: Acetylcholine; Age Factors; Animals; Atropine; Corpus Striatum; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Oxotremorine; Pirenzepine; Potassium; Rats; Rats, Inbred F344; Receptors, Muscarinic | 1991 |
Involvement of M1 and M2 muscarinic receptors of the basal forebrain in cholinergically mediated changes in the rat locomotion.
Topics: Animals; Atropine; Behavior, Animal; Brain; Carbachol; Hypothalamus, Anterior; Injections; Male; Motor Activity; Parasympathetic Nervous System; Pirenzepine; Preoptic Area; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1991 |
Characterization of muscarinic receptor subtype of rat eccrine sweat gland by autoradiography.
Topics: Animals; Atropine; Autoradiography; Binding, Competitive; Eccrine Glands; Kinetics; Male; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tritium | 1991 |
The effect of subtype-selective muscarinic receptor antagonists on the cholinergic current in motoneurons of the lobster cardiac ganglion.
Topics: Acetylcholine; Animals; Atropine; Binding, Competitive; Ganglia; In Vitro Techniques; Mammals; Methacholine Chloride; Motor Neurons; Nephropidae; Parasympathomimetics; Piperidines; Pirenzepine; Receptors, Muscarinic | 1991 |
Distribution and function of cholinergic receptors in the sheep detrusor muscle.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Carbachol; Cholinesterase Inhibitors; Ganglia, Parasympathetic; Male; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Piperidines; Pirenzepine; Receptors, Muscarinic; Sheep; Tetraisopropylpyrophosphamide; Urinary Bladder | 1991 |
Mad honey poisoning in man and rat.
Topics: Aged; Animals; Atropine; Bradycardia; Diterpenes; Female; Honey; Humans; Hypotension; Male; Middle Aged; Parasympatholytics; Pirenzepine; Rats; Respiration; Turkey | 1991 |
Properties of muscarinic receptors mediating second messenger responses in the rabbit aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Atropine; Cyclic AMP; Endothelium, Vascular; In Vitro Techniques; Inositol Phosphates; Male; Muscle, Smooth, Vascular; Nitric Oxide; Parasympatholytics; Pirenzepine; Rabbits; Receptors, Muscarinic; Scopolamine; Second Messenger Systems | 1990 |
In-vitro effect of pirenzepine on motility of canine gall-bladder.
Topics: Acetylcholine; Animals; Atropine; Cholecystokinin; Dogs; Gallbladder; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth; Pirenzepine; Receptors, Muscarinic | 1990 |
Effects of two new pirenzepine analogs on the contractile response of the guinea-pig oesophageal muscularis mucosae to acetylcholine, bethanechol, histamine and high potassium.
Topics: Acetylcholine; Animals; Atropine; Benzodiazepinones; Bethanechol; Bethanechol Compounds; Esophagus; Guinea Pigs; Histamine; Histamine Antagonists; Male; Muscle Contraction; Piperidines; Pirenzepine; Potassium; Pyrilamine; Receptors, Muscarinic | 1990 |
Control of interdigestive and intraduodenal meal-stimulated pancreatic secretion in rats.
Topics: Animals; Atropine; Benzodiazepinones; Cholecystokinin; Devazepide; Digestion; Duodenum; Eating; Hexamethonium; Hexamethonium Compounds; Kinetics; Male; Muscle, Smooth; Pancreas; Pirenzepine; Proglumide; Rats; Rats, Inbred Strains; Reference Values; Vagotomy | 1990 |
Differential affinities of AF-DX 116, atropine and pirenzepine for muscarinic receptors of guinea pig gastric fundus, atria and urinary bladder: might atropine distinguish among muscarinic receptor subtypes?
Topics: Animals; Atropine; Bethanechol; Bethanechol Compounds; Dose-Response Relationship, Drug; Female; Gastric Fundus; Guinea Pigs; Heart Atria; Kinetics; Male; Muscarinic Antagonists; Myocardium; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Urinary Bladder | 1990 |
Muscarinic control of gallbladder dynamics. A study using 99Tcm-HIDA and cholinergic agonists and antagonists.
Topics: Adult; Atropine; Bethanechol; Bethanechol Compounds; Female; Gallbladder; Humans; Imino Acids; Male; Organotechnetium Compounds; Parasympatholytics; Parasympathomimetics; Pirenzepine; Radionuclide Imaging; Technetium Tc 99m Lidofenin | 1990 |
Predominant acetylcholine-induced vasoconstriction in isolated, perfused simian facial veins.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Atropine; Blood Pressure; Diltiazem; Face; Female; In Vitro Techniques; Macaca; Male; Muscle, Smooth, Vascular; Parasympatholytics; Physostigmine; Piperidines; Pirenzepine; Potassium Chloride; Quinazolines; Receptors, Muscarinic; Saponins; Vasoconstriction; Veins | 1990 |
Role of hypothalamic cholecystokinin octapeptide in the colonic motor response to a meal in rats.
Topics: Animals; Atropine; Benzodiazepinones; Cholecystokinin; Colon; Devazepide; Electromyography; Food; Gastrointestinal Motility; Hypothalamic Area, Lateral; Hypothalamus; Male; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Receptors, Muscarinic; Sincalide; Ventromedial Hypothalamic Nucleus | 1991 |
Crystal, solution, and molecular modeling structural properties and muscarinic antagonist activity of azaprophen.
Topics: Animals; Atropine; Brain; Cell Line; Guinea Pigs; In Vitro Techniques; Kinetics; Magnetic Resonance Spectroscopy; Male; Microsomes; Models, Molecular; Molecular Conformation; Molecular Structure; Muscle, Smooth; Phenylpropionates; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Solutions; Transfection; Tropanes; X-Ray Diffraction | 1991 |
Characterization of muscarinic receptors in dog tracheal smooth muscle cells.
Topics: Animals; Atropine; Carbachol; Diamines; Dogs; In Vitro Techniques; Kinetics; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Trachea | 1991 |
Effects of nebracetam (WEB 1881 FU), a novel nootropic, as a M1-muscarinic agonist.
Topics: Animals; Atropine; Calcium; Humans; Parasympathomimetics; Pirenzepine; Psychotropic Drugs; Pyrrolidinones; Tumor Cells, Cultured; Xenopus | 1991 |
Characterization of the m4 muscarinic receptor Ca2+ response in a subclone of PC-12 cells by single cell flow cytometry. Inhibition of the response by bradykinin.
Topics: Acetylcholinesterase; Animals; Atropine; Bradykinin; Calcium; Cholinesterase Inhibitors; Flow Cytometry; Muscarinic Antagonists; Pertussis Toxin; Pirenzepine; Rats; Receptors, Muscarinic; Substrate Specificity; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1991 |
Cholinergic antagonists and REM sleep generation.
Topics: Animals; Atropine; Brain; Dioxolanes; Electroencephalography; Electromyography; Electrooculography; Gallamine Triethiodide; Male; Pirenzepine; Rats; Receptors, Muscarinic; Reticular Formation; Sleep, REM | 1991 |
Effects of acetylcholine on different muscarinic receptors in the perfused porcine ear vein.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Ear; Feedback; Gallamine Triethiodide; Indomethacin; Muscarine; Muscle, Smooth, Vascular; Organ Culture Techniques; Perfusion; Pirenzepine; Receptors, Muscarinic; Swine; Vasomotor System | 1991 |
Effect of centrally administered atropine and pirenzepine on radial arm maze performance in the rat.
Topics: Animals; Atropine; Body Weight; Exploratory Behavior; Injections, Intraventricular; Male; Pirenzepine; Rats; Rats, Inbred Strains; Regression Analysis | 1991 |
Native Xenopus oocytes express two types of muscarinic receptors.
Topics: Animals; Atropine; Elapid Venoms; Female; Oligonucleotide Probes; Oligonucleotides, Antisense; Oocytes; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Xenopus laevis | 1991 |
Functional participation in M1 receptor subtype on chronotropic and dromotropic responses to vagus stimulation in anesthetized dogs.
Topics: Animals; Atropine; Dogs; Electric Stimulation; Heart; Heart Conduction System; Heart Rate; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Vagus Nerve | 1991 |
Pirenzepine, telenzepine, atropine and metacine as agonists for the muscarinic cholinoreceptors in the denervated human parotid gland.
Topics: Anti-Ulcer Agents; Atropine; Benzilates; Choline; Humans; Parasympathetic Nervous System; Parotid Gland; Pirenzepine; Receptors, Muscarinic | 1990 |
Influence of thyrotropin-releasing hormone on autonomic nervous system determined by the variations in R-R interval on electrocardiogram.
Topics: Adult; Antitussive Agents; Atropine; Autonomic Nervous System; Catecholamines; Electrocardiography; Graves Disease; Humans; Pirenzepine; Propanolamines; Thyrotropin-Releasing Hormone | 1990 |
Muscarinic M3 receptors are coupled to two signal transduction pathways in rat submandibular cells.
Topics: Animals; Atropine; Carbachol; Cyclic AMP; Parasympatholytics; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Signal Transduction; Submandibular Gland | 1990 |
Evidence that a guanine nucleotide-binding protein linked to a muscarinic receptor inhibits directly phospholipase C.
Topics: Alkaloids; Animals; Atropine; Calcimycin; Calcium; Carbachol; Cell Line; Cell Membrane Permeability; Colforsin; Cyclic AMP; Cytosol; GTP-Binding Proteins; Guanosine Triphosphate; Inositol Phosphates; Kinetics; Norepinephrine; Pertussis Toxin; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Staurosporine; Type C Phospholipases; Virulence Factors, Bordetella | 1990 |
Muscarinic acetylcholine receptor subtypes which selectively couple to phospholipase C: pharmacological and biochemical properties.
Topics: Animals; Atropine; Carbachol; Cell Line; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Inositol Phosphates; Ligands; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Cholinergic; Tritium; Type C Phospholipases | 1990 |
Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not Go to S phase progression in hamster fibroblasts. Comparison of thrombin and carbachol action in cells expressing M1 muscarinic acetylcholine receptors.
Topics: Adenylate Cyclase Toxin; Animals; Atropine; Calcium; Carbachol; Cell Cycle; Cell Line; Clone Cells; Cricetinae; Cricetulus; DNA Replication; Fibroblasts; Inositol; Inositol Phosphates; Kinetics; Lung; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Pirenzepine; Proto-Oncogenes; Receptors, Muscarinic; Resting Phase, Cell Cycle; S Phase; Thrombin; Transfection; Virulence Factors, Bordetella | 1990 |
Pirenzepine-insensitive muscarinic autoreceptors regulate acetylcholine release in human neocortex.
Topics: Acetylcholine; Atropine; Cerebral Cortex; Humans; Kinetics; Membrane Potentials; Pirenzepine; Potassium Chloride; Receptors, Muscarinic; Synaptosomes | 1990 |
Labeling of rat heart muscarinic receptors using the new M2 selective antagonist [3H]AF-DX 384.
Topics: Affinity Labels; Animals; Atropine; Binding, Competitive; Male; Muscarinic Antagonists; Myocardium; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1990 |
Cholinergic agonists increase cell calcium in rat medullary collecting tubules. A fura-2 study.
Topics: Acetylcholine; Animals; Atropine; Calcium; Carbachol; Fluorescent Dyes; Fura-2; Kidney Medulla; Kidney Tubules, Collecting; Male; Microscopy, Fluorescence; Pirenzepine; Rats; Receptors, Muscarinic | 1990 |
Evidence that cholinergic receptors of muscarinic type may modulate vasopressin release induced by metoclopramide.
Topics: Animals; Atropine; Drug Interactions; Male; Metoclopramide; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Secretory Rate; Vasopressins; Water | 1990 |
[Relative importance of cholecystokinin and cholinergic nerve mechanisms in the regulation of pancreatic secretion in rats].
Topics: Animals; Atropine; Cholecystokinin; Hexamethonium Compounds; Male; Pancreas; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Cholinergic | 1990 |
Differential effects of cholinergic antagonists on REM sleep components.
Topics: Animals; Atropine; Cats; Cortical Synchronization; Dioxolanes; Electroencephalography; Gallamine Triethiodide; Male; Muscarinic Antagonists; Muscle Tonus; Pirenzepine; Sleep, REM | 1990 |
Investigation into atropine-induced antinociception.
Topics: Analgesics; Animals; Atropine; Dicyclomine; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Muscle, Smooth; Naloxone; Oxotremorine; Pain; Parasympatholytics; Pirenzepine; Postural Balance; Rats; Rats, Inbred F344; Rats, Inbred Strains; Reaction Time; Sensory Thresholds | 1990 |
Acetylcholine modifies neuronal acoustic rate-level functions in guinea pig auditory cortex by an action at muscarinic receptors.
Topics: Acetylcholine; Acoustic Stimulation; Animals; Atropine; Auditory Cortex; Gallamine Triethiodide; Guinea Pigs; In Vitro Techniques; Iontophoresis; Neurons; Parasympatholytics; Pirenzepine; Receptors, Muscarinic | 1990 |
Identification of muscarinic receptor subtypes present in cerebellar granule cells: prevention of [3H]propylbenzilyl choline mustard binding with specific antagonists.
Topics: Adenylyl Cyclase Inhibitors; Animals; Atropine; Cell Membrane; Cells, Cultured; Cerebellum; Diamines; Electrophoresis, Polyacrylamide Gel; Parasympatholytics; Pirenzepine; Propylbenzilylcholine Mustard; Quinuclidines; Receptors, Muscarinic; Xanthenes | 1990 |
Muscarinic receptor subtypes mediating negative chrono- and inotropic responses in isolated, blood-perfused dog right atria.
Topics: Animals; Atropine; Carbachol; Cardiotonic Agents; Dogs; Electric Stimulation; Female; Heart Atria; Male; Myocardial Contraction; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Vagus Nerve | 1990 |
Muscarinic receptor blockade increases basal acetylcholine release from striatal slices.
Topics: Acetylcholine; Animals; Atropine; Calcium; Corpus Striatum; In Vitro Techniques; Male; Oxotremorine; Parasympatholytics; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tetrodotoxin | 1990 |
Carbachol-induced potentiation and inhibition of acid secretion by guinea pig gastric gland.
Topics: Aminopyrine; Animals; Atropine; Binding, Competitive; Carbachol; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Guinea Pigs; Histamine; In Vitro Techniques; Male; N-Methylscopolamine; Parasympathomimetics; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1990 |
In vitro and in vivo antimuscarinic effects of (-)cis 2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5 benzothiazepin-4-(5H)one HCl (BTM-1086) in guinea pig peripheral tissues.
Topics: Animals; Atropine; Calcium; Female; Guinea Pigs; Heart Atria; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Neurons; Parasympatholytics; Piperidines; Pirenzepine; Structure-Activity Relationship; Thiazepines; Tumor Cells, Cultured; Urinary Bladder; Vas Deferens | 1990 |
The effect of neostigmine on metoclopramide-induced aldosterone secretion after the administration of muscarinic antagonists in man.
Topics: Adult; Aldosterone; Atropine; Humans; Male; Metoclopramide; Muscarinic Antagonists; Neostigmine; Pirenzepine | 1990 |
[3H]N-methylscopolamine binding studies reveal M2 and M3 muscarinic receptor subtypes on cerebellar granule cells in primary culture.
Topics: Animals; Atropine; Binding, Competitive; Cell Survival; Cells, Cultured; Cerebellum; Diamines; Granulocytes; N-Methylscopolamine; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Tritium | 1990 |
An M3-like muscarinic autoreceptor regulates the in vivo release of acetylcholine in rat striatum.
Topics: Acetylcholine; Animals; Atropine; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dose-Response Relationship, Drug; Male; Neostigmine; Oxotremorine; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Time Factors | 1990 |
The mean cumulative fraction absorbed-time profiles of paracetamol as an index of gastric emptying.
Topics: Acetaminophen; Adult; Atropine; Biological Availability; Gastric Emptying; Humans; Intestinal Absorption; Male; Metoclopramide; Neostigmine; Pirenzepine | 1990 |
Aprophit: an irreversible antagonist for muscarinic receptors.
Topics: Adrenal Glands; Animals; Atropine; Binding, Competitive; Brain; Catecholamines; Guinea Pigs; Male; N-Methylscopolamine; Parasympatholytics; Phenylpropionates; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Thiocyanates | 1990 |
Comparative inhibitory effects of pirenzepine and atropine on cholinergic stimulation of exocrine and endocrine rat pancreas.
Topics: Amylases; Animals; Atropine; Benzodiazepinones; Carbachol; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pancreas; Pancreatic Juice; Parasympatholytics; Parasympathomimetics; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1985 |
Regional differences in the coupling of muscarinic receptors to inositol phospholipid hydrolysis in guinea pig brain.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Benzodiazepinones; Bethanechol; Bethanechol Compounds; Brain; Carbachol; Corpus Striatum; Guinea Pigs; Hydrolysis; Oxotremorine; Phosphatidylinositols; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Time Factors; Tissue Distribution | 1985 |
Characterization of cholinoreceptors in the rat urinary bladder by the use of agonists and antagonists of the cholinergic system.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Benzodiazepinones; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Male; Muscle Contraction; Parasympatholytics; Parasympathomimetics; Pirenzepine; Rats; Receptors, Cholinergic; Tubocurarine; Urinary Bladder | 1985 |
Pharmacological analysis of the muscarinic receptors involved when McN-A 343 stimulates acid secretion in the mouse isolated stomach.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Benzodiazepinones; Cimetidine; Drug Interactions; Gastric Acid; Histamine H2 Antagonists; In Vitro Techniques; Mice; Muscarine; Parietal Cells, Gastric; Pirenzepine; Quaternary Ammonium Compounds; Receptors, Muscarinic; Tetrodotoxin | 1985 |
Substance P: a potent inhibitor of the canine small intestine in vivo.
Topics: Acetylcholine; Animals; Atropine; Benzodiazepinones; Dogs; Dose-Response Relationship, Drug; Enkephalin, Methionine; Female; Gastrointestinal Motility; Hexamethonium Compounds; Intestine, Small; Male; Motilin; Muscle Contraction; Naloxone; Narcotics; Norepinephrine; Pirenzepine; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Nicotinic; Receptors, Opioid; Reserpine; Substance P; Tetrodotoxin | 1986 |
A simple method for estimation of gastric mucus and effects of antiulcerogenic agents on the decrease in mucus during water-immersion stress in rats.
Topics: Alcian Blue; Animals; Anti-Ulcer Agents; Atropine; Bombesin; Gastric Mucosa; Immersion; Irritants; Male; Mucus; Pirenzepine; Rats; Secretin; Staining and Labeling; Stomach Ulcer; Stress, Psychological | 1986 |
A cholinergic antagonist identifies a subclass of muscarinic receptors in isolated rat pancreatic acini.
Topics: Amylases; Animals; Atropine; Carbachol; Cerebral Cortex; Dose-Response Relationship, Drug; Kinetics; Male; Myocardium; N-Methylscopolamine; Pancreas; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
Biphasic release of endothelium-derived relaxing factor(s) by acetylcholine from perfused canine femoral arteries. Characterization of muscarinic receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Carbachol; Dogs; Endothelium; Female; Femoral Artery; In Vitro Techniques; Male; Nitric Oxide; Pirenzepine; Receptors, Muscarinic; Vasodilator Agents | 1987 |
Effects of pirenzepine and atropine on amylase response to various secretagogues from the rat pancreatic acini.
Topics: Amylases; Animals; Atropine; Bethanechol Compounds; Bombesin; Dose-Response Relationship, Drug; Kinetics; Pancreas; Pirenzepine; Rats; Secretin; Sincalide | 1987 |
Inhibitory effects of pirenzepine on cholecystokinin and secretin stimulation on exocrine and endocrine rat pancreas.
Topics: Amylases; Animals; Atropine; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pancreas; Pancreatic Juice; Pirenzepine; Proteins; Rats; Rats, Inbred Strains; Secretin; Sincalide | 1987 |
Evidence that reciprocal hindlimb scratching elicited in mice by intrathecal administration of muscarinic agonists is mediated through M1 type receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Injections, Spinal; Male; Mice; Parasympathomimetics; Pilocarpine; Pirenzepine; Receptors, Muscarinic; Spinal Cord; Stereotyped Behavior | 1987 |
Subtypes of muscarinic receptors in canine pancreatic secretion in vivo and in vitro.
Topics: Amylases; Animals; Atropine; Bethanechol Compounds; Bicarbonates; Dogs; Eating; Gastrins; In Vitro Techniques; Male; Pancreas; Pancreatic Polypeptide; Pirenzepine; Proteins; Receptors, Muscarinic; Secretin; Sincalide | 1987 |
Muscarinic receptors on nerves and muscles in opossum esophagus muscularis mucosa.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Carbachol; Electric Stimulation; Esophagus; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Muscle, Smooth; Neurons; Opossums; Parasympatholytics; Pirenzepine; Receptors, Muscarinic | 1987 |
M-1 and M-2 muscarinic receptor-mediated inhibition of dopamine-sensitive adenylate cyclase in rat neostriatum: a permissive role for D-2 dopamine receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Adenosine; Adenylyl Cyclase Inhibitors; Animals; Atropine; Corpus Striatum; Cyclic AMP; Dopamine; In Vitro Techniques; Isoproterenol; Kinetics; Male; Oxotremorine; Pirenzepine; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Muscarinic; Sulpiride; Vasoactive Intestinal Peptide | 1988 |
Intracellular calcium homeostasis in a human neuroblastoma cell line: modulation by depolarization, cholinergic receptors, and alpha-latrotoxin.
Topics: Aminoquinolines; Arthropod Venoms; Atropine; Calcimycin; Calcium; Carbachol; Cytoplasm; Egtazic Acid; Fluorescent Dyes; Homeostasis; Humans; Ion Channels; Membrane Potentials; Neuroblastoma; Pirenzepine; Potassium Chloride; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, Nicotinic; Spectrometry, Fluorescence; Spider Venoms; Tumor Cells, Cultured; Verapamil | 1988 |
Prejunctional muscarinic (M1)-receptor interactions on guinea-pig ileum: lack of effect of cisapride.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Cisapride; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Piperidines; Pirenzepine; Receptors, Muscarinic | 1988 |
Contractile responses of tracheal smooth muscle in organophosphate-treated swine: 2. Effects of antagonists.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Dose-Response Relationship, Drug; In Vitro Techniques; Isoflurophate; Mecamylamine; Muscle Contraction; Parasympatholytics; Pirenzepine; Swine; Trachea | 1988 |
Evidence for muscarinic inhibitory neurotransmission in rodent small intestine.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Intestine, Small; Male; Muscle Contraction; Neural Inhibition; Pirenzepine; Rats; Receptors, Muscarinic; Synaptic Transmission | 1989 |
Presynaptic muscarinic receptors mediating inhibition of neurogenic contractions in rabbit vas deferens are of the ganglionic M1-type.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Binding Sites; Blood Pressure; Electric Stimulation; Ganglia, Sympathetic; Male; Muscle Contraction; Piperazines; Piperidines; Pirenzepine; Rabbits; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Receptors, Neurotransmitter; Vas Deferens | 1988 |
Cholecystokinin induced gallbladder contraction is influenced by nicotinic and muscarinic receptors.
Topics: Animals; Atropine; Cholecystokinin; Dogs; Gallbladder; Hexamethonium; Hexamethonium Compounds; Male; Muscle Contraction; Pirenzepine; Receptors, Muscarinic; Receptors, Nicotinic | 1989 |
Characterization of muscarinic cholinergic receptors on the endothelium and the smooth muscle of the rabbit thoracic aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Atropine; Endothelium, Vascular; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Pirenzepine; Rabbits; Receptors, Muscarinic | 1989 |
Rostral ventrolateral medulla muscarinic receptor involvement in central ventilatory chemosensitivity.
Topics: Animals; Atropine; Blood Pressure; Carbachol; Carbon Dioxide; Cats; Female; Male; Medulla Oblongata; Phrenic Nerve; Pirenzepine; Receptors, Muscarinic; Reference Values; Respiration; Vagotomy | 1989 |
Characterization of muscarinic receptors modulating acetylcholine release in the rat neostriatum.
Topics: Acetylcholine; Animals; Atropine; Corpus Striatum; In Vitro Techniques; Kinetics; Oxotremorine; Pirenzepine; Rats; Rats, Inbred F344; Receptors, Muscarinic | 1989 |
Muscarinic-stimulated norepinephrine release and phosphoinositide hydrolysis in PC12 cells are independent events.
Topics: Adrenal Gland Neoplasms; Animals; Atropine; Cell Line; Diamines; Hydrolysis; Kinetics; Methacholine Chloride; Methacholine Compounds; Norepinephrine; Parasympathomimetics; Pheochromocytoma; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Pirenzepine; Rats; Receptors, Muscarinic | 1989 |
Pineal muscarinic phosphoinositide response: pertussis toxin resistant signaling with very low receptor number.
Topics: Animals; Atropine; Carbachol; Male; Norepinephrine; Organ Culture Techniques; Pertussis Toxin; Phosphatidylinositols; Pineal Gland; Pirenzepine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Signal Transduction; Virulence Factors, Bordetella | 1989 |
Potentiation and suppression by eserine of muscarinic synaptic transmission in the guinea-pig hippocampal slice.
Topics: Action Potentials; Animals; Atropine; Carbachol; Guinea Pigs; Hippocampus; In Vitro Techniques; Neurons; Physostigmine; Pirenzepine; Synapses; Synaptic Transmission | 1989 |
Regulation of muscarinic receptor subtypes and their responsiveness in rat brain following chronic atropine administration.
Topics: Animals; Atropine; Brain; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Dose-Response Relationship, Drug; Drug Administration Schedule; Hippocampus; In Vitro Techniques; Oxotremorine; Phosphatidylinositols; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic | 1989 |
Cholinergic control of smooth muscle peristalsis in the cat esophagus.
Topics: Animals; Atropine; Bethanechol Compounds; Cats; Deglutition; Esophagus; Female; Gastrointestinal Motility; Hexamethonium; Hexamethonium Compounds; Male; Muscle, Smooth; Parasympathomimetics; Peristalsis; Pirenzepine | 1989 |
Comparison of telenzepine, pirenzepine and atropine on gastric acid and pepsin secretion in response to histamine, pentagastrin, bethanechol, sham-feeding and feeding.
Topics: Animals; Atropine; Bethanechol; Bethanechol Compounds; Dogs; Food; Gastric Acid; Gastric Fistula; Histamine; Parasympatholytics; Pentagastrin; Pepsin A; Pirenzepine; Stomach | 1989 |
Salivatory effects induced by pirenzepine, atropine, metacine and hexamethonium in preganglionar chronically denervated human parotid gland.
Topics: Adult; Amitriptyline; Atropine; Benzilates; Choline; Denervation; Female; Hexamethonium Compounds; Humans; Male; Middle Aged; Parasympatholytics; Parotid Gland; Pirenzepine; Salivation | 1989 |
Pirenzepine distinguishes between muscarinic receptor-mediated phosphoinositide breakdown and inhibition of adenylate cyclase.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Adenylyl Cyclase Inhibitors; Animals; Atropine; Benzodiazepinones; Brain; Carbachol; In Vitro Techniques; Inositol; Inositol Phosphates; Male; Myocardium; Oxotremorine; Parotid Gland; Phosphatidylinositols; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1985 |
The interaction of McN-A-343 with pirenzepine and other selective muscarine receptor antagonists at a prejunctional muscarine receptor.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Alkaloids; Animals; Atropine; Benzodiazepinones; Binding, Competitive; Carbachol; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Pancuronium; Pirenzepine; Quaternary Ammonium Compounds; Rabbits; Receptors, Muscarinic | 1985 |
Muscarinic inhibition of canine small intestinal motility in vivo.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Benzodiazepinones; Dogs; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Intestine, Small; Male; Pirenzepine; Receptors, Muscarinic; Reserpine; Tetrodotoxin | 1985 |
Cholinomimetic activities of minaprine.
Topics: Animals; Atropine; Avoidance Learning; Behavior, Animal; Female; Guinea Pigs; In Vitro Techniques; Male; Mice; Mydriatics; Oxotremorine; Parasympathomimetics; Pirenzepine; Pyridazines; Radioligand Assay; Rats; Rats, Inbred Strains; Scopolamine; Social Behavior; Stereotyped Behavior; Tremor | 1989 |
Effect of pirenzepine on aminopyrine uptake by isolated guinea pig parietal cells.
Topics: Aminopyrine; Animals; Atropine; Dose-Response Relationship, Drug; Gastric Acid; Guinea Pigs; Male; Parietal Cells, Gastric; Pirenzepine | 1989 |
Muscarinic receptor subtype (M1) identification on rabbit pulmonary vascular endothelium in vivo.
Topics: Animals; Atropine; Blood Gas Analysis; Blood Pressure; Endothelium, Vascular; Evans Blue; Hematocrit; Hemodynamics; Male; Pirenzepine; Pulmonary Circulation; Rabbits; Receptors, Muscarinic | 1989 |
Muscarinic cholinergic, but not serotoninergic mediation of arginine vasopressin response to metoclopramide in man.
Topics: Adult; Arginine Vasopressin; Atropine; Dose-Response Relationship, Drug; Humans; Ketanserin; Kinetics; Male; Metergoline; Metoclopramide; Pirenzepine; Receptors, Muscarinic; Receptors, Serotonin | 1989 |
Carbachol depresses synaptic responses in the medial but not the lateral perforant path.
Topics: Action Potentials; Animals; Atropine; Carbachol; Electric Stimulation; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Neural Inhibition; Pirenzepine; Time Factors | 1989 |
Evidence of muscarinic receptor subtypes in airway smooth muscle of normal volunteers and of chronic obstructive pulmonary disease patients.
Topics: Atropine; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Muscle, Smooth; Piperidines; Pirenzepine; Receptors, Muscarinic; Respiratory Muscles | 1989 |
Muscarinic pharmacology of the spinal cord of the neonatal rat in vitro.
Topics: Action Potentials; Animals; Animals, Newborn; Atropine; In Vitro Techniques; Muscarine; Pirenzepine; Rats; Rats, Inbred Strains; Spinal Cord | 1989 |
Subtypes of muscarinic receptors in pancreatic exocrine secretion in anesthetized dog.
Topics: Animals; Atropine; Bethanechol Compounds; Dogs; Female; Kinetics; Male; Pancreas; Pancreatic Juice; Parasympathomimetics; Piperidines; Pirenzepine; Receptors, Muscarinic; Reference Values | 1989 |
Identification and characterization of muscarinic receptors in cultured human pancreatic carcinoma cells.
Topics: Atropine; Carbachol; Cell Line; Humans; Inositol Phosphates; Kinetics; N-Methylscopolamine; Pancreatic Neoplasms; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Tumor Cells, Cultured | 1989 |
Changes in drinking activity, urine volume and urinary electrolyte excretion after intracerebroventricular administration of diisopropylfluorophosphate.
Topics: Animals; Atropine; Cerebral Ventricles; Diuresis; Drinking Behavior; Injections, Intraventricular; Isoflurophate; Male; Mecamylamine; Pirenzepine; Potassium; Rats; Rats, Inbred Strains; Reference Values; Sodium | 1989 |
Muscarinic receptor subtypes in human and guinea pig lung.
Topics: Adamantane; Adult; Aged; Animals; Atropine; Guinea Pigs; Humans; In Vitro Techniques; Lung; Middle Aged; Parasympatholytics; Piperidines; Pirenzepine; Protease Inhibitors; Quinuclidinyl Benzilate; Receptors, Muscarinic; Species Specificity | 1989 |
Muscarinic receptor binding characteristics of a human neuroblastoma SK-N-SH and its clones SH-SY5Y and SH-EP1.
Topics: Arecoline; Atropine; Carbachol; Cell Membrane; Humans; Neuroblastoma; Piperidines; Pirenzepine; Receptors, Muscarinic; Tumor Cells, Cultured | 1989 |
AF-DX 116 discriminates heart from gland M2-cholinoceptors in man.
Topics: Adult; Animals; Atropine; Blood Pressure; Cattle; Cell Membrane; Cerebral Cortex; Heart Rate; Humans; Kinetics; Male; Myocardium; N-Methylscopolamine; Organ Specificity; Pirenzepine; Propranolol; Receptors, Cholinergic; Reference Values; Saliva; Salivary Glands; Scopolamine Derivatives; Swine | 1989 |
Pharmacologic discrimination between receptor heterogeneity and allosteric interaction: resultant analysis of gallamine and pirenzepine antagonism of muscarinic responses in rat trachea.
Topics: Allosteric Regulation; Animals; Atropine; Binding Sites; Carbachol; Dose-Response Relationship, Drug; Gallamine Triethiodide; In Vitro Techniques; Male; Muscarine; Oxotremorine; Parasympatholytics; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine; Trachea | 1989 |
Influence of tone on responses to acetylcholine in the rabbit pulmonary vascular bed.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Dose-Response Relationship, Drug; Female; Gallamine Triethiodide; Indomethacin; Lung; Male; Meclofenamic Acid; Pirenzepine; Rabbits; Receptors, Muscarinic; Vascular Resistance; Vasodilation | 1989 |
Cholinergic regulation of PP release is mediated through muscarinic M1-receptors.
Topics: Adult; Atropine; Bombesin; Duodenum; Gastrins; Humans; Hydrogen-Ion Concentration; Male; Pancreatic Polypeptide; Peptones; Pirenzepine; Receptors, Muscarinic | 1989 |
Presynaptic muscarinic receptors in guinea pig superior cervical ganglion.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Ganglia, Sympathetic; Guinea Pigs; Oxotremorine; Pirenzepine; Receptors, Muscarinic; Synapses | 1989 |
Nicotinic and M1-, M2-muscarinic cholinergic control of ACTH response to insulin-induced hypoglycaemia in man.
Topics: Adrenocorticotropic Hormone; Adult; Atropine; Blood Glucose; Glucose Tolerance Test; Humans; Insulin; Male; Pirenzepine; Receptors, Muscarinic; Receptors, Nicotinic; Trimethaphan | 1987 |
Stimulation of acid secretion and phosphoinositol production by rat parietal cell muscarinic M2 receptors.
Topics: Aminopyrine; Animals; Atropine; Binding, Competitive; Bucladesine; Carbachol; Gastric Acid; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Male; Parietal Cells, Gastric; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Sugar Phosphates | 1988 |
Muscarinic receptor-mediated phosphoinositide hydrolysis in the rat retina.
Topics: Adenylyl Cyclases; Animals; Atropine; Carbachol; Hydrolysis; In Vitro Techniques; Male; Phosphatidylinositols; Physostigmine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Retina | 1988 |
Muscarinic receptor coupling to inositol phospholipid metabolism in guinea-pig cerebral cortex, parotid gland and ileal smooth muscle.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Guanosine Triphosphate; Guinea Pigs; Ileum; Muscle, Smooth; N-Methylscopolamine; Oxotremorine; Parotid Gland; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1988 |
Pseudo-noncompetitive antagonism of muscarinic receptor-mediated cyclic GMP formation and phosphoinositide hydrolysis by pirenzepine.
Topics: Animals; Atropine; Carbachol; Cyclic GMP; Hydrolysis; Mice; N-Methylscopolamine; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1988 |
Non-selectivity of amitriptyline for subtypes of brain muscarinic receptors demonstrated in binding and functional assays.
Topics: Amitriptyline; Animals; Atropine; Brain; Cerebral Cortex; Cyclic AMP; Drug Interactions; Hydrolysis; In Vitro Techniques; Kinetics; Male; Phosphatidylinositols; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1988 |
Pirenzepine-sensitive muscarinic receptors regulate gastric somatostatin and gastrin.
Topics: Animals; Atropine; Benzodiazepinones; Carbachol; Dose-Response Relationship, Drug; Gastric Mucosa; Gastrins; Male; Pirenzepine; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Somatostatin; Stimulation, Chemical | 1985 |
[Effect of gastrozepin on the rate of gastric emptying in patients with peptic ulcer and dumping syndrome following gastric resection].
Topics: Adult; Anti-Ulcer Agents; Atropine; Benzodiazepinones; Chronic Disease; Drug Evaluation; Dumping Syndrome; Duodenal Ulcer; Female; Gastric Emptying; Histamine H2 Antagonists; Humans; Male; Pirenzepine | 1985 |
Pharmacological analysis of muscarinic receptors coupled to oxyntic cell secretion in the mouse stomach.
Topics: Animals; Atropine; Atropine Derivatives; Benzodiazepinones; Binding, Competitive; Cimetidine; Guinea Pigs; Histamine H2 Antagonists; In Vitro Techniques; Mice; Muscarine; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Parietal Cells, Gastric; Pirenzepine; Receptors, Muscarinic; Trachea | 1985 |
Effect of selective muscarinic antagonists on peristaltic contractions in opossum smooth muscle.
Topics: Animals; Atropine; Benzodiazepinones; Bethanechol; Bethanechol Compounds; Dose-Response Relationship, Drug; Electric Stimulation; Esophagus; Female; Male; Manometry; Muscle Contraction; Muscle, Smooth; Opossums; Peristalsis; Piperidines; Pirenzepine; Receptors, Muscarinic; Vagus Nerve | 1986 |
Gastric antisecretory and pharmacologic properties of N,N-dimethyl-N'-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyridyl)ur ea (L-634,366).
Topics: Animals; Anti-Ulcer Agents; Atropine; Benzodiazepinones; Blood Pressure; Cimetidine; Dogs; Female; Gastric Juice; Guinea Pigs; Heart Rate; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Male; Methylurea Compounds; Mice; Myocardial Contraction; Parasympathetic Nervous System; Pirenzepine; Rats; Stomach; Uterine Contraction | 1986 |
Cholinergic agonist and antagonist drugs modulate the growth hormone response to growth hormone-releasing hormone in the rat: evidence for mediation by somatostatin.
Topics: Afferent Pathways; Animals; Atropine; Cysteamine; Growth Hormone; Growth Hormone-Releasing Hormone; Hypothalamus; Hypothalamus, Middle; In Vitro Techniques; Male; Parasympatholytics; Parasympathomimetics; Pilocarpine; Pirenzepine; Rats; Rats, Inbred Strains; Somatostatin | 1986 |
AF-DX 116, a cardioselective muscarinic antagonist.
Topics: Animals; Atropine; Bethanechol; Bethanechol Compounds; Carbachol; Cats; Dimethylphenylpiperazinium Iodide; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gastric Acid; Gastric Emptying; Guinea Pigs; Heart; Heart Rate; Male; Muscarine; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Pirenzepine; Rats; Receptors, Muscarinic | 1987 |
[3H]QNB binding and contraction of rabbit colonic smooth muscle cells.
Topics: Animals; Atropine; Bethanechol; Bethanechol Compounds; Binding, Competitive; Cell Count; Colon; Kinetics; Male; Microbial Collagenase; Muscle Contraction; Muscle, Smooth; Phenethylamines; Pirenzepine; Quinuclidines; Quinuclidinyl Benzilate; Rabbits; Receptors, Cholinergic | 1987 |
The effects of the antimuscarinic drugs pirenzepine and atropine on plasma portal levels of somatostatin and gastrin in the dog.
Topics: Animals; Atropine; Bethanechol; Bethanechol Compounds; Dogs; Gastrins; Parasympathomimetics; Pirenzepine; Somatostatin | 1987 |
Stimulation of muscarinic receptor in hippocampal neuron induces characteristic increase in cytosolic free Ca2+ concentration.
Topics: Acetylcholine; Animals; Atropine; Calcium; Cells, Cultured; Cytosol; Glutamates; Glutamic Acid; Hippocampus; Pirenzepine; Potassium; Rats; Receptors, Muscarinic; Tetrodotoxin; Time Factors | 1988 |
Functional and direct binding studies using subtype selective muscarinic receptor antagonists.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Dicyclomine; Diphenylacetic Acids; Gallamine Triethiodide; Guinea Pigs; In Vitro Techniques; Inositol Phosphates; Myocardium; Phenethylamines; Phenylacetates; Pirenzepine; Receptors, Muscarinic | 1988 |
Muscarinic cholinergic receptor subtype on frog esophageal peptic cells: binding and secretion studies.
Topics: Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Carbachol; Esophagus; Imipramine; Kinetics; N-Methylscopolamine; Oxotremorine; Pepsinogens; Pirenzepine; Propranolol; Radioligand Assay; Rana catesbeiana; Receptors, Muscarinic; Scopolamine Derivatives | 1988 |
Regulation of [3H]GABA release from strips of guinea pig urinary bladder.
Topics: Acetylcholine; Animals; Atropine; Baclofen; Bicuculline; Clonazepam; Clonidine; Female; gamma-Aminobutyric Acid; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Male; Muscimol; Pentobarbital; Phenylephrine; Pirenzepine; Potassium; Prazosin; Tritium; Urinary Bladder; Yohimbine | 1988 |
Role of muscarinic receptor subtypes in the regulation of migrating myoelectric complex in the dog.
Topics: Animals; Atropine; Dogs; Electrophysiology; Female; Intestine, Small; Male; Pirenzepine; Receptors, Muscarinic | 1989 |
Astrocytes have both M1 and M2 muscarinic receptor subtypes.
Topics: Animals; Astrocytes; Atropine; Benzodiazepinones; Carbachol; Cyclic AMP; Inositol; Isoproterenol; Phospholipids; Pirenzepine; Propranolol; Rats; Receptors, Muscarinic | 1986 |
Muscarinic cholinergic ligand binding to intact mouse pituitary tumor cells (AtT-20/D16-16) coupling with two biochemical effectors: adenylate cyclase and phosphatidylinositol turnover.
Topics: Adenylyl Cyclase Inhibitors; Animals; Atropine; Benzodiazepinones; Carbachol; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Kinetics; Mice; Phosphatidylinositols; Pirenzepine; Pituitary Neoplasms; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tritium | 1986 |
Carbachol-induced accumulation of inositol-1-phosphate in neurohybridoma NCB-20 cells: effects of lithium and phorbol esters.
Topics: Animals; Atropine; Benzodiazepinones; Brain; Carbachol; Cell Line; Chlorides; Cricetinae; Cricetulus; Embryo, Mammalian; Hybridomas; Inositol Phosphates; Lithium; Lithium Chloride; Mice; Neuroblastoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Pirenzepine; Sugar Phosphates; Tetradecanoylphorbol Acetate | 1986 |
Phosphatidylinositol response to cholinergic agonists in airway smooth muscle: relationship to contraction and muscarinic receptor occupancy.
Topics: Acetylcholine; Animals; Atropine; Benzodiazepinones; Carbachol; Cattle; Chlorides; Dose-Response Relationship, Drug; Guanylyl Imidodiphosphate; Lithium; Lithium Chloride; Membrane Lipids; Muscle Contraction; Muscle, Smooth; Phosphatidylinositols; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Respiratory System; Trachea | 1986 |
Slow cholinergic excitation of guinea pig hippocampal neurons is mediated by two muscarinic receptor subtypes.
Topics: Animals; Atropine; Benzodiazepinones; Carbachol; Cholinergic Fibers; Electric Stimulation; Evoked Potentials; Guinea Pigs; Hippocampus; Membrane Potentials; Pirenzepine; Receptors, Muscarinic; Synapses; Synaptic Transmission | 1986 |
Selective interaction of tricyclic antidepressants with a subclass of rat brain cholinergic muscarinic receptors.
Topics: Adenylyl Cyclase Inhibitors; Animals; Antidepressive Agents, Tricyclic; Atropine; Brain; Inositol Phosphates; Male; Parasympatholytics; Pirenzepine; Prazosin; Quinuclidinyl Benzilate; Rats; Receptors, Adrenergic, alpha; Receptors, Muscarinic | 1987 |
Muscarinic acetylcholine receptor-mediated phosphoinositide turnover in cultured cerebellar granule cells: desensitization by receptor agonists.
Topics: Animals; Atropine; Carbachol; Cells, Cultured; Cerebellum; Kinetics; Male; N-Methylscopolamine; Oxotremorine; Phorbol Esters; Phosphatidylinositols; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Virulence Factors, Bordetella | 1987 |
Immunochemical studies of the muscarinic acetylcholine receptor.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Antibodies, Monoclonal; Atropine; Brain Chemistry; Cattle; Cell Line; Chromatography, Affinity; Cyclic GMP; Female; Fibroblasts; Guinea Pigs; Humans; Pirenzepine; Receptors, Muscarinic; Uterine Contraction | 1987 |
The muscarinic receptor subtype in mouse pancreatic B-cells.
Topics: Acetylcholine; Animals; Atropine; Calcium; Female; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Pirenzepine; Potassium; Receptors, Muscarinic; Rubidium Radioisotopes | 1988 |
Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo.
Topics: Animals; Atropine; Blood Pressure; Diamines; Heart Rate; Male; Methacholine Chloride; Methacholine Compounds; Muscarine; Myocardium; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1988 |
Cholinergic involvement in the growth hormone releasing hormone-induced growth hormone release: studies in normal and acromegalic subjects.
Topics: Acromegaly; Adult; Aged; Atropine; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Male; Middle Aged; Peptide Fragments; Pirenzepine; Pyridostigmine Bromide; Receptors, Cholinergic; Thyrotropin-Releasing Hormone | 1986 |
Acetylcholine-stimulated chloride flux in tracheal submucosal gland cells.
Topics: Acetylcholine; Animals; Atropine; Biological Transport; Calcium; Chlorides; Egtazic Acid; Electrochemistry; Exocrine Glands; Furosemide; Isoflurophate; Male; Mucus; ortho-Aminobenzoates; Ouabain; Pirenzepine; Swine; Trachea | 1988 |
Influence of "selective" antimuscarinic agents on gastric acid secretion and motility.
Topics: Animals; Atropine; Benzodiazepinones; Gastric Acid; Gastric Emptying; Gastrointestinal Motility; Ipratropium; Male; Parasympatholytics; Phenethylamines; Pirenzepine; Pylorus; Rats; Rats, Inbred Strains | 1985 |
Dose-response curves of pirenzepine in man in relation to M1- and M2-cholinoceptor occupancy.
Topics: Adult; Animals; Atropine; Cattle; Dose-Response Relationship, Drug; Female; Heart Rate; Humans; Male; Pirenzepine; Radioligand Assay; Rats; Receptors, Muscarinic; Salivation | 1988 |
Pre- and post-synaptic muscarinic receptors of the rat vas deferens: an update.
Topics: Animals; Atropine; Binding, Competitive; Male; Membrane Potentials; Muscle, Smooth; N-Methylscopolamine; Neuromuscular Junction; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives; Synapses; Terminology as Topic; Vas Deferens | 1988 |
Tetranitromethane modification of the muscarinic receptors in bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Atropine; Carbachol; Cattle; Dithiothreitol; In Vitro Techniques; Kinetics; Methane; Microsomes; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tetranitromethane | 1988 |
A muscarinic receptor subtype modulates vagally stimulated bronchial contraction.
Topics: Animals; Atropine; Bronchi; Electric Stimulation; Female; In Vitro Techniques; Male; Muscle Contraction; Parasympatholytics; Pirenzepine; Rabbits; Receptors, Muscarinic; Vagus Nerve | 1988 |
Possible mechanisms of anti-cholinergic drug-induced bradycardia.
Topics: Adult; Atenolol; Atropine; Bradycardia; Drug Interactions; Ganglia, Sympathetic; Heart Rate; Humans; Male; Parasympatholytics; Pirenzepine; Receptors, Muscarinic | 1988 |
Complex dose-response curves of atropine in man explained by different functions of M1- and M2-cholinoceptors.
Topics: Adult; Animals; Atropine; Cattle; Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Female; Half-Life; Heart Rate; Humans; In Vitro Techniques; Male; Pirenzepine; Propranolol; Rats; Receptors, Cholinergic; Salivary Glands; Salivation | 1988 |
The role of M2 muscarinic receptors in the posterior hypothalamus in the pressor response to intracerebroventricularly-injected neostigmine.
Topics: Animals; Atropine; Blood Pressure; Heart Rate; Hypothalamus; Injections, Intraventricular; Male; Neostigmine; Parasympathomimetics; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1988 |
Does the prolonged occupancy of M1 receptors by telenzepine protect them against the action of vagally released acetylcholine?
Topics: Acetylcholine; Animals; Atropine; Binding, Competitive; Brain; Cattle; In Vitro Techniques; Kinetics; N-Methylscopolamine; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Vagus Nerve | 1988 |
Direct determination of acetylcholine release by radioimmunoassay and presence of presynaptic M1 muscarinic receptors in guinea pig ileum.
Topics: Acetylcholine; Animals; Atropine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Pirenzepine; Radioimmunoassay; Receptors, Muscarinic; Tetrodotoxin | 1988 |
An analysis of the depolarization produced in guinea-pig hippocampus by cholinergic receptor stimulation.
Topics: Animals; Atropine; Barium; Cadmium; Carbachol; Cesium; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Pirenzepine; Potassium Channels; Receptors, Cholinergic; Serotonin | 1988 |
Characterization of cholinergic muscarinic receptors in the rabbit iris.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Ileum; Iris; Kinetics; Methacholine Chloride; Methacholine Compounds; Microsomes; N-Methylscopolamine; Oxotremorine; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives | 1988 |
Immunocytochemical and pharmacological evidence for an intrinsic cholinomimetic system modulating prolactin and growth hormone release in rat pituitary.
Topics: Acetylcholine; Animals; Atropine; Benztropine; Carbachol; Cells, Cultured; Choline O-Acetyltransferase; Dexamethasone; Female; Growth Hormone; Hemicholinium 3; Histocytochemistry; Immunoenzyme Techniques; Isoproterenol; Male; Naphthylvinylpyridine; Organ Culture Techniques; Pirenzepine; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Vasoactive Intestinal Peptide | 1988 |
Presynaptic M1 muscarinic receptor modulates spontaneous release of acetylcholine from rat basal forebrain slices.
Topics: Acetylcholine; Animals; Atropine; Calcium; Diencephalon; In Vitro Techniques; Male; Pirenzepine; Radioimmunoassay; Rats; Receptors, Muscarinic; Sulfones; Synapses; Telencephalon | 1988 |
Effects of antiparkinsonian drugs on muscarinic receptor binding in rat brain, heart and lung.
Topics: Animals; Antiparkinson Agents; Atropine; Brain; Heart; In Vitro Techniques; Lung; Myocardium; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1988 |
Muscarinic stimulation of submucosal glands in swine trachea.
Topics: Animals; Atropine; Binding, Competitive; Carbachol; Exocrine Glands; Isoflurophate; Male; Mucus; N-Methylscopolamine; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Scopolamine Derivatives; Swine; Trachea | 1988 |
Membrane depolarization and carbamoylcholine stimulate phosphatidylinositol turnover in intact nerve terminals.
Topics: Animals; Atropine; Calcium; Carbachol; Cerebral Cortex; In Vitro Techniques; Inositol Phosphates; Male; Membrane Potentials; Phosphatidylinositols; Pirenzepine; Potassium; Rats; Receptors, Muscarinic; Sugar Phosphates; Synaptosomes; Time Factors | 1988 |
Subtypes of muscarinic receptor on cholinergic nerves and atrial cells of chicken and guinea-pig hearts.
Topics: Acetylcholine; Animals; Atropine; Chickens; Electric Stimulation; Guinea Pigs; Heart; In Vitro Techniques; Methacholine Compounds; Myocardial Contraction; Parasympathetic Nervous System; Pirenzepine; Receptors, Muscarinic; Tubocurarine; Vagus Nerve | 1988 |
The intact human neuroblastoma cell (SH-SY5Y) exhibits high-affinity [3H]pirenzepine binding associated with hydrolysis of phosphatidylinositols.
Topics: Atropine; Binding, Competitive; Humans; Hydrolysis; Kinetics; Neuroblastoma; Phosphatidylinositols; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tumor Cells, Cultured | 1988 |
Binding of muscarine receptor antagonists to pig coronary smooth muscle.
Topics: Animals; Atropine; Carbachol; Coronary Vessels; Heart Atria; In Vitro Techniques; Muscle, Smooth, Vascular; Piperazines; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Swine; Tritium | 1988 |
The cloned murine M1 muscarinic receptor is associated with the hydrolysis of phosphatidylinositols in transfected murine B82 cells.
Topics: Animals; Atropine; Binding, Competitive; Carbachol; Cell Line; Cell Membrane; DNA, Recombinant; Fibroblasts; Guanylyl Imidodiphosphate; Hydrolysis; Mice; Muscarine; Nucleic Acid Hybridization; Phosphatidylinositols; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Recombinant Proteins; Sequence Homology, Nucleic Acid; Transfection | 1988 |
Characterization of agonist and antagonist binding to muscarinic cholinergic receptors solubilized from rat cerebral cortex.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; In Vitro Techniques; Male; Oxotremorine; Pirenzepine; Quinuclidines; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1988 |
Long-term atropine treatment lowers the efficacy of carbachol to stimulate phosphatidylinositol breakdown in the cerebral cortex and hippocampus of rats.
Topics: Animals; Atropine; Carbachol; Cell Membrane; Cerebral Cortex; Hippocampus; Inositol Phosphates; Male; Phosphatidylinositols; Pirenzepine; Potassium; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1988 |
A quantitative study of the effects of some muscarinic antagonists on the guinea-pig olfactory cortex slice.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Drug Interactions; Evoked Potentials; Gallamine Triethiodide; Guinea Pigs; In Vitro Techniques; Oxotremorine; Parasympathomimetics; Pirenzepine | 1988 |
Comparison of the effects of metoclopramide on sympathetic and muscarinic responses after pretreatment with atropine and pirenzepine.
Topics: Adult; Atropine; Blood Pressure; Catecholamines; Female; Heart Rate; Hemodynamics; Humans; Male; Metoclopramide; Pirenzepine; Receptors, Muscarinic; Salivation; Sympathetic Nervous System | 1988 |
Heterogeneous distribution of muscarinic receptors in the rabbit saphenous artery.
Topics: Acetylcholine; Animals; Arteries; Atropine; Female; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Norepinephrine; Pirenzepine; Rabbits; Receptors, Muscarinic | 1987 |
Selective blockade in vivo of cardiac muscarinic M2 receptors by a polymethylene tetramine, BHC-9C.
Topics: Anesthesia; Animals; Atropine; Blood Pressure; Decerebrate State; Diamines; Heart; Heart Rate; In Vitro Techniques; Male; Myocardium; Parasympatholytics; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1987 |
Endoscopic manometry of the sphincter of Oddi in dogs. Pharmacological effects of anticholinergic and selective antimuscarinic agents.
Topics: Ampulla of Vater; Animals; Atropine; Atropine Derivatives; Butylscopolammonium Bromide; Dogs; Endoscopy; Manometry; Parasympatholytics; Pirenzepine; Sphincter of Oddi | 1987 |
Effects of antimuscarinic agents and prostaglandin E2 on the gastric mucosal lesions induced by necrotizing agents and water-immersion stress in rats.
Topics: Animals; Anti-Ulcer Agents; Atropine; Cimetidine; Dinoprostone; Male; Parasympatholytics; Pirenzepine; Prostaglandins E; Rats; Rats, Inbred Strains; Stomach Ulcer; Stress, Physiological | 1986 |
Antagonists discriminate muscarinic excitation and inhibition in sympathetic ganglion.
Topics: Alcuronium; Animals; Atropine; Electric Stimulation; Evoked Potentials; Gallamine Triethiodide; Ganglia, Sympathetic; In Vitro Techniques; Pancuronium; Pirenzepine; Rana catesbeiana; Receptors, Muscarinic | 1987 |
Muscarinic-receptor induced myo-inositol trisphosphate accumulation, myosin light chain phosphorylation and contraction in the rabbit iris sphincter smooth muscle.
Topics: Animals; Atropine; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Iris; Isometric Contraction; Kinetics; Muscle, Smooth; Myosin Subfragments; Myosin-Light-Chain Kinase; Myosins; Peptide Fragments; Phosphorylation; Pirenzepine; Rabbits; Receptors, Muscarinic; Sugar Phosphates | 1987 |
M2 muscarinic receptor subtype is associated with inositol trisphosphate accumulation, myosin light chain phosphorylation and contraction in sphincter smooth muscle of rabbit iris.
Topics: Animals; Atropine; Carbachol; Female; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Iris; Male; Muscle Contraction; Muscle, Smooth; Myosins; Phosphorylation; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Receptors, Muscarinic; Sugar Phosphates | 1987 |
Suppression by muscarinic M2 stimulation of the contractile mechanism via histamine H1 receptors in the longitudinal muscle of guinea pig ileum.
Topics: Animals; Atropine; Calcium; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histamine; Ileum; Male; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Phentolamine; Pirenzepine; Propranolol; Pyrilamine; Receptors, Histamine; Receptors, Histamine H1; Temperature; Tetrodotoxin | 1987 |
M2 muscarinoceptor-associated ionophore at the cat adrenal medulla.
Topics: Adrenal Medulla; Animals; Atropine; Binding, Competitive; Calcium; Catecholamines; Cats; Kinetics; Methacholine Chloride; Methacholine Compounds; Pirenzepine; Potassium; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1987 |
A muscarinic receptor with high affinity for pirenzepine mediates vagally induced bronchoconstriction.
Topics: Action Potentials; Animals; Atropine; Bronchi; Electric Stimulation; Female; Gallamine Triethiodide; Heart Rate; In Vitro Techniques; Male; Pirenzepine; Rabbits; Receptors, Muscarinic; Vagus Nerve | 1987 |
cis(-)-2,3-Dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5- benzothiazepin-4(5H)-one monohydrochloride and its butylbromide as M1-receptor antagonists.
Topics: Acetylcholine; Animals; Atropine; Binding, Competitive; Cerebral Cortex; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Thiazepines | 1987 |
Respiratory responses to pirenzepine in healthy subjects.
Topics: Adolescent; Adult; Atropine; Double-Blind Method; Female; Forced Expiratory Volume; Heart Rate; Humans; Male; Maximal Midexpiratory Flow Rate; Middle Aged; Pirenzepine; Respiration; Vital Capacity | 1987 |
Central muscarinic control of the pattern of small intestinal motility in rats.
Topics: Animals; Atropine; Brain; Electromyography; Gastrointestinal Motility; Injections, Intraperitoneal; Injections, Intraventricular; Intestine, Small; Male; Oxotremorine; Parasympathetic Nervous System; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1987 |
Dissociated cingulate cortical neurons: morphology and muscarinic acetylcholine receptor binding properties.
Topics: Animals; Atropine; Autoradiography; Binding, Competitive; Dendrites; Gyrus Cinguli; Male; Microscopy, Electron; Pirenzepine; Propylbenzilylcholine Mustard; Rats; Receptors, Muscarinic; Synapses | 1987 |
Subtypes of muscarinic receptors on adrenergic nerves and vascular smooth muscle of the canine saphenous vein.
Topics: Acetylcholine; Adrenergic Fibers; Animals; Atropine; Dogs; Electric Stimulation; Gallamine Triethiodide; Mathematics; Muscle Contraction; Muscle, Smooth, Vascular; Pirenzepine; Receptors, Muscarinic; Saphenous Vein | 1987 |
Comparative effects of pirenzepine and atropine on pancreatic secretion in conscious rats.
Topics: Animals; Atropine; Bicarbonates; Male; Pancreas; Pirenzepine; Rats; Rats, Inbred Strains | 1987 |
Muscarine affects calcium-currents in rat hippocampal pyramidal cells in vitro.
Topics: Animals; Atropine; Calcium; Electric Conductivity; Hippocampus; In Vitro Techniques; Membrane Potentials; Muscarine; Neurons; Pirenzepine; Rats; Tubocurarine | 1987 |
Muscarinic receptors in human SH-SY5Y neuroblastoma cell line: regulation by phorbol ester and retinoic acid-induced differentiation.
Topics: Acetylcholinesterase; Atropine; Binding, Competitive; Cell Differentiation; Cell Line; Choline O-Acetyltransferase; Humans; Neuroblastoma; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Tretinoin | 1987 |
Effects of cimetidine, atropine and pirenzepine on basal and stimulated gastric acid secretion in the rat.
Topics: Animals; Atropine; Cimetidine; Dose-Response Relationship, Drug; Gastric Acid; Histamine; Male; Monoamine Oxidase; Pentagastrin; Pirenzepine; Pupil; Rats; Rats, Inbred Strains | 1987 |
Characterization of the muscarinic receptor subtype in isolated gastric fundic cells of the rabbit.
Topics: Aminopyrine; Animals; Atropine; Carbachol; Gastric Fundus; Kinetics; Male; N-Methylscopolamine; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives | 1987 |
Effects of acetylcholine agonists and antagonists on yawning and analgesia in the rat.
Topics: Acetylcholine; Analgesia; Animals; Atropine; Injections, Intraventricular; Male; Pirenzepine; Rats; Rats, Inbred Strains; Reaction Time; Yawning | 1987 |
Identification of muscarinic M2 receptors on single muscle cells of the human and guinea pig intestine.
Topics: Acetylcholine; Animals; Atropine; Guinea Pigs; Humans; Jejunum; Muscle Contraction; Muscle, Smooth; Piperidines; Pirenzepine; Receptors, Muscarinic | 1987 |
Studies on the affinity and selectivity of tiquizium bromide (HSR-902), a novel spasmolytic agent, for muscarinic receptors.
Topics: Animals; Atropine; Binding, Competitive; Cerebral Cortex; Gastric Mucosa; Ileum; In Vitro Techniques; Male; Myocardium; Parasympatholytics; Pirenzepine; Quinolizines; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1987 |
Muscarinic M1 receptors mediate the increase in pulmonary resistance during vagus nerve stimulation in dogs.
Topics: Airway Resistance; Animals; Atropine; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gallamine Triethiodide; Heart Rate; Lung; Male; Pirenzepine; Receptors, Muscarinic; Vagus Nerve | 1987 |
[Effect of pirenzepine and atropine on the motile function of the esophagus. Comparative study].
Topics: Adult; Atropine; Esophagogastric Junction; Esophagus; Female; Humans; Male; Manometry; Middle Aged; Peristalsis; Pirenzepine | 1987 |
Different agonist binding properties of M1 and M2 muscarinic receptors in calf brain cortex membranes.
Topics: Animals; Atropine; Binding, Competitive; Carbachol; Cattle; Cell Membrane; Cerebral Cortex; Ethylmaleimide; Guanosine Triphosphate; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1987 |
Comparison of muscarinic receptor properties in hatched chick heart atrium and ventricle.
Topics: Animals; Atropine; Benzodiazepinones; Carbachol; Chickens; Guanylyl Imidodiphosphate; Heart; In Vitro Techniques; Myocardial Contraction; Myocardium; Pirenzepine; Potassium; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tritium | 1986 |
M1 and M2-muscarinic receptors in the epididymal half of the rat vas deferens.
Topics: Animals; Atropine; Benzodiazepinones; Epididymis; In Vitro Techniques; Male; Methacholine Compounds; Muscle, Smooth; Organ Size; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Vas Deferens | 1986 |
Difference in effects of pirenzepine and atropine on carbachol-induced pepsinogen secretion from isolated gastric glands.
Topics: Animals; Atropine; Benzodiazepinones; Carbachol; Dose-Response Relationship, Drug; Drug Synergism; Gastric Mucosa; Guinea Pigs; Pepsinogens; Pirenzepine; Receptors, Muscarinic | 1986 |
Pharmacological analysis of the inhibition by pirenzepine and atropine of vagal-stimulated acid secretion in the isolated stomach of the mouse.
Topics: Acetylcholine; Animals; Atropine; Benzodiazepinones; Electric Stimulation; Gastric Acid; In Vitro Techniques; Mice; Models, Biological; Pirenzepine; Vagus Nerve | 1986 |
In vitro effects of gallamine on dissociation kinetics of (3H)N-methylscopolamine and (3H)pirenzepine from rat brain muscarinic receptors.
Topics: Animals; Atropine; Benzodiazepinones; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Gallamine Triethiodide; Hippocampus; Kinetics; Male; Myocardium; N-Methylscopolamine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Substrate Specificity | 1986 |
Characterization of muscarinic receptors of the rabbit ear artery smooth muscle and endothelium.
Topics: Acetylcholine; Animals; Atropine; Benzodiazepinones; Ear; Endothelium; Hexamethonium Compounds; Kinetics; Mathematics; Muscle, Smooth, Vascular; Nicotine; Oxotremorine; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Receptors, Muscarinic | 1986 |
Muscarinic M2-receptors enhance polyphosphoinositol release in rat gastric mucosal cells.
Topics: Aminopyrine; Animals; Atropine; Benzodiazepinones; Binding, Competitive; Carbachol; Drug Synergism; Gastric Mucosa; Inositol Phosphates; Pirenzepine; Rats; Receptors, Muscarinic; Sugar Phosphates | 1986 |
Action of pirenzepine on the human urinary bladder in vitro.
Topics: Acetylcholine; Atropine; Benzodiazepinones; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pirenzepine; Urinary Bladder | 1986 |
Temperature effect on subclasses of muscarinic receptors in rat colon, heart and cerebral cortex.
Topics: Animals; Atropine; Benzodiazepinones; Binding, Competitive; Cerebral Cortex; Colon; In Vitro Techniques; Male; Myocardium; Oxotremorine; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Temperature | 1986 |
Muscarinic receptor subtypes in bovine adrenal medulla.
Topics: Acetylcholine; Adrenal Medulla; Animals; Atropine; Benzodiazepinones; Cattle; Gallamine Triethiodide; Guanosine Triphosphate; Kinetics; Magnesium; Microsomes; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1986 |
Copper-induced alteration of muscarinic binding in bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Atropine; Carbachol; Cattle; Copper; In Vitro Techniques; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1986 |
Comparison of the inhibitory effect of three antimuscarinic drugs: pirenzepine, atropine and propantheline on acid secretion and gastric emptying in the conscious rat.
Topics: Animals; Atropine; Gastric Acid; Gastric Emptying; Male; Parasympatholytics; Pirenzepine; Propantheline; Rats; Rats, Inbred Strains | 1986 |
Pharmacologic characterization and functional role of muscarinic autoreceptors in the rabbit striatum.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Corpus Striatum; Dose-Response Relationship, Drug; Drug Synergism; Haloperidol; Oxotremorine; Physostigmine; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Receptors, Muscarinic; Scopolamine; Time Factors | 1987 |
[Do anticholinergic drugs still have significance in the therapy of ulcer?].
Topics: Atropine; Cimetidine; Drug Therapy, Combination; Duodenal Ulcer; Gastric Acid; Humans; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Stomach Ulcer; Vagotomy, Proximal Gastric; Vagus Nerve | 1986 |
[Clinical pharmacology of agents affecting the tonus of the lower esophageal sphincter].
Topics: Aminophylline; Atropine; Diazepam; Esophagogastric Junction; Humans; Manometry; Muscle Tonus; Pentagastrin; Pirenzepine; Secretin | 1986 |
Determination of the muscarinic receptor subtype mediating vasodilatation.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Atropine; Benzodiazepinones; Carbachol; Dogs; Female; Femoral Artery; Gallamine Triethiodide; In Vitro Techniques; Male; Pancuronium; Parasympatholytics; Phenethylamines; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic; Vasodilation | 1985 |
Heterogeneity of muscarinic cholinergic receptors in the developing chick embryo retina.
Topics: Acetylcholine; Animals; Atropine; Benzodiazepinones; Carbachol; Chick Embryo; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Retina; Synapses | 1985 |
Selective labelling of M1-receptors in autonomic ganglia with 3H-pirenzepine.
Topics: Animals; Atropine; Benzodiazepinones; Binding, Competitive; Cattle; Ganglia, Autonomic; Ganglia, Sympathetic; In Vitro Techniques; N-Methylscopolamine; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Muscarinic; Scopolamine Derivatives; Synaptosomes | 1985 |
Intestinal epithelial cells and musculature contain different muscarinic binding sites.
Topics: Animals; Atropine; Benzodiazepinones; Binding Sites; Binding, Competitive; Cerebral Cortex; Colon; Epithelium; Ileum; Jejunum; Male; Muscle, Smooth; Myocardium; Oxotremorine; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1985 |
Effects of atropine and pirenzepine on healing of gastric ulcer induced by mucosal excision in rats.
Topics: Animals; Atropine; Benzodiazepinones; Electric Stimulation; Gastric Acid; Gastric Mucosa; Male; Parasympatholytics; Pirenzepine; Rats; Rats, Inbred Strains; Stomach Ulcer; Vagus Nerve | 1985 |
Muscarinic receptor subclasses in the chick embryo retina: influence of corticosterone treatment.
Topics: Acetylcholine; Animals; Atropine; Benzodiazepinones; Carbachol; Chick Embryo; Corticosterone; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Retina | 1985 |
The binding of a 2-chloroethylamine derivative of oxotremorine (BM 123) to muscarinic receptors in the rat cerebral cortex.
Topics: Alkylation; Animals; Atropine; Benzodiazepinones; Binding Sites; Binding, Competitive; Cerebral Cortex; Gallamine Triethiodide; Kinetics; N-Methylscopolamine; Oxotremorine; Pirenzepine; Pyrrolidinones; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Structure-Activity Relationship; Thiosulfates | 1985 |
Pirenzepine indicates heterogeneity of muscarinic receptors linked to cerebral inositol phospholipid metabolism.
Topics: Animals; Atropine; Benzodiazepinones; Brain; Carbachol; Cerebral Cortex; In Vitro Techniques; Inositol; Inositol Phosphates; Medulla Oblongata; Pirenzepine; Pons; Rats; Receptors, Muscarinic; Stimulation, Chemical | 1985 |
Acetylcholine acts on m2-muscarinic receptors to excite rat locus coeruleus neurones.
Topics: Acetylcholine; Action Potentials; Animals; Atropine; Benzodiazepinones; Dose-Response Relationship, Drug; Hexamethonium Compounds; Locus Coeruleus; Neurons; Oxotremorine; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine | 1985 |
On the presence in the cerebral cortex of muscarinic receptor subtypes which differ in neuronal localization, function and pharmacological properties.
Topics: Acetylcholine; Animals; Atropine; Benzodiazepinones; Carbachol; Cerebral Cortex; Dicyclomine; Dopamine; Drug Synergism; Neurons; Phenethylamines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Synaptosomes | 1985 |
Gastric cytoprotection by pirenzepine in rats: evaluating method for cytoprotective activity by antisecretory agents.
Topics: Animals; Anti-Ulcer Agents; Atropine; Benzodiazepinones; Buffers; Cimetidine; Dinoprostone; Ethanol; Gastric Acid; Gastric Mucosa; Hydrochloric Acid; Male; Necrosis; Pirenzepine; Prostaglandins E; Rats; Stomach Ulcer | 1985 |
Pirenzepine selectively inhibits gastric acid secretion: a comparative pharmacological study between pirenzepine and seven other antiacetylcholine drugs.
Topics: Acetylcholine; Animals; Atropine; Benzilates; Benzodiazepinones; Dose-Response Relationship, Drug; Gastric Acid; Glycopyrrolate; Male; Mice; Piperazines; Pirenzepine; Propantheline; Pupil; Pyrimidines; Quaternary Ammonium Compounds; Rats; Trihexyphenidyl | 1980 |
Pirenzepine inhibits acid and pepsinogen secretion by the isolated perfused mouse stomach.
Topics: Animals; Atropine; Benzodiazepinones; Bethanechol; Bethanechol Compounds; Drug Interactions; Gastric Acid; Gastric Mucosa; Hydrogen-Ion Concentration; In Vitro Techniques; Mice; Pepsinogens; Pirenzepine; Time Factors | 1982 |
Inhibition of acetylcholine-stimulated secretion in the isolated whole stomach of the rat.
Topics: Acetylcholine; Animals; Atropine; Benzodiazepinones; Gastric Mucosa; In Vitro Techniques; Metiamide; Pepsin A; Pirenzepine; Rats; Time Factors | 1983 |
Effects of pirenzepine and atropine on vagal and cholinergic gastric secretion and gastrin release and on heart rate in the dog.
Topics: Animals; Atropine; Benzodiazepinones; Bethanechol; Bethanechol Compounds; Cholinergic Fibers; Dogs; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Gastrins; Heart Rate; Pepsin A; Pirenzepine; Vagus Nerve | 1983 |
Comparative study of pA2 values of pirenzepine and atropine for guinea-pig gastric fundus and gastric smooth muscle.
Topics: Animals; Atropine; Benzodiazepinones; Bethanechol; Bethanechol Compounds; Female; Gastric Fundus; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Pirenzepine; Receptors, Muscarinic; Stomach | 1984 |
Pirenzepine (LS 519): a weak inhibitor of acid secretion by isolated rat parietal cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atropine; Benzodiazepinones; Bucladesine; Carbachol; Gastric Acid; Gastric Mucosa; Histamine; In Vitro Techniques; Pirenzepine; Rats | 1982 |
Pharmacologic identification, activation and antagonism of two muscarine receptor subtypes in the lower esophageal sphincter.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Benzodiazepinones; Bethanechol; Bethanechol Compounds; Esophagogastric Junction; Hexamethonium Compounds; Opossums; Piperidines; Pirenzepine; Receptors, Muscarinic; Tetrodotoxin; Vagus Nerve | 1984 |
Quantitative receptor autoradiography: application to the characterization of multiple receptor subtypes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Atropine; Autoradiography; Benzodiazepinones; Binding, Competitive; Brain; Carbachol; Hippocampus; Indoles; Oxotremorine; Pindolol; Pirenzepine; Rats; Receptors, Muscarinic; Receptors, Serotonin; Superior Colliculi; Tetrahydronaphthalenes | 1984 |
Cellular origin and release of intrinsic factor from isolated rat gastric mucosal cells.
Topics: Aminopyrine; Animals; Atropine; Benzodiazepinones; Carbachol; Carbon Radioisotopes; Cobalt Radioisotopes; Female; Gastrointestinal Agents; Intrinsic Factor; Kinetics; Parietal Cells, Gastric; Pepsin A; Pirenzepine; Rats; Rats, Inbred Strains; Subcellular Fractions | 1983 |
High-affinity [3H]pirenzepine binding to putative M1 muscarinic sites in the neuroblastoma x glioma hybrid cell line (NG 108-15).
Topics: Animals; Atropine; Benzodiazepinones; Binding, Competitive; Cell Line; Glioma; Hybrid Cells; Mice; Neuroblastoma; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Structure-Activity Relationship | 1984 |
Comparative studies of the effects of some antimuscarinic agents on gastric damage and pupillary reflex in the rat.
Topics: Animals; Atropine; Benzodiazepinones; Female; N-Methylscopolamine; Oxotremorine; Parasympatholytics; Pirenzepine; Propantheline; Rats; Rats, Inbred Strains; Reflex, Pupillary; Scopolamine Derivatives; Stomach Diseases | 1984 |
Evidence for multiple muscarinic receptor subtypes in human brain.
Topics: Amygdala; Atropine; Benzodiazepinones; Binding, Competitive; Brain; Cerebral Cortex; Humans; Kinetics; Parasympatholytics; Pirenzepine; Pons; Quinuclidinyl Benzilate; Receptors, Muscarinic; Tissue Distribution | 1984 |
Inhibition of gastric emptying and secretion by pirenzepine and atropine in rats.
Topics: Animals; Atropine; Benzodiazepinones; Gastric Emptying; Gastric Mucosa; Heart Rate; Kinetics; Male; Parasympatholytics; Pirenzepine; Rats; Rats, Inbred Strains | 1984 |
Comparison of central gastric antisecretory effects of desmethylimipramine, doxepin and pirenzepine in rats.
Topics: Animals; Anti-Ulcer Agents; Atropine; Benzodiazepinones; Brain; Chlorpromazine; Desipramine; Doxepin; Gastric Acid; Male; Pirenzepine; Rats; Rats, Inbred Strains | 1984 |
Motor effects of gastrin releasing peptide (GRP) and bombesin in the canine stomach and small intestine.
Topics: Animals; Atropine; Benzodiazepinones; Bombesin; Dogs; Female; Gastrin-Releasing Peptide; Gastrointestinal Agents; Gastrointestinal Motility; Ileum; Jejunum; Male; Peptides; Pirenzepine; Pyloric Antrum; Reserpine; Stomach; Tetrodotoxin | 1984 |
Pharmacological evidence for cardiac muscarinic receptor subtypes.
Topics: Acetylcholine; Animals; Arecoline; Atropine; Benzodiazepinones; Binding Sites; Butylscopolammonium Bromide; Carbachol; Female; Guinea Pigs; Heart Rate; Male; Myocardial Contraction; Myocardium; N-Methylscopolamine; Pirenzepine; Quaternary Ammonium Compounds; Receptors, Muscarinic; Scopolamine Derivatives | 1984 |
Differential and selective antagonism of the slow-inhibitory postsynaptic potential and slow-excitatory postsynaptic potential by gallamine and pirenzepine in the superior cervical ganglion of the rabbit.
Topics: Animals; Atropine; Benzodiazepinones; Gallamine Triethiodide; Ganglia, Sympathetic; In Vitro Techniques; Membrane Potentials; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Receptors, Muscarinic; Synapses | 1984 |
Gastric cytoprotection by pirenzepine is not mediated by catecholamines.
Topics: Animals; Anti-Ulcer Agents; Atropine; Benzodiazepinones; Disease Models, Animal; Gastric Mucosa; Male; Norepinephrine; Pirenzepine; Rats; Rats, Inbred Strains; Stomach Ulcer | 1984 |
Eserine-induced hypertone of guinea pig distal colon in vivo: a new pharmacological procedure for testing smooth muscle relaxants.
Topics: Animals; Atropine; Benzodiazepinones; Colon; Dicyclomine; Dose-Response Relationship, Drug; Guinea Pigs; Male; Methods; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Physostigmine; Pirenzepine; Quaternary Ammonium Compounds; Verapamil | 1984 |
Inhibitory effects of pirenzepine on muscarinic stimulation of rat pancreas.
Topics: alpha-Amylases; Animals; Atropine; Benzodiazepinones; Calcium; Carbachol; Male; Muscarine; Pancreas; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1983 |
Subclasses of muscarinic receptors in isolated gastric mucosal cells: receptor characterization and parietal cell function.
Topics: Animals; Atropine; Benzodiazepinones; Binding, Competitive; Carbachol; Dogs; Gastric Mucosa; Guanine Nucleotides; Guinea Pigs; In Vitro Techniques; Male; Models, Biological; N-Methylscopolamine; Pilocarpine; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives | 1983 |
Muscarinic receptor: multiple sites or unitary concept?
Topics: Animals; Atropine; Benzodiazepinones; Brain; Dexetimide; Dogs; Gastric Mucosa; In Vitro Techniques; Microsomes; Piperazines; Piperidines; Pirenzepine; Receptors, Cholinergic; Receptors, Muscarinic | 1981 |
Pharmacodynamic evaluation of selective antimuscarinic properties of pirenzepine in the rat.
Topics: Animals; Anti-Ulcer Agents; Atropine; Behavior, Animal; Benzodiazepinones; Drug Interactions; Gastric Acid; Male; Oxotremorine; Parasympatholytics; Piperazines; Pirenzepine; Rats; Rats, Inbred Strains; Salivation | 1982 |
Two ligands may bind simultaneously to the muscarine receptor.
Topics: Animals; Atropine; Benzilates; Benzodiazepinones; Binding Sites; Binding, Competitive; In Vitro Techniques; Kinetics; Ligands; Male; Models, Biological; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine | 1982 |
Effect of pirenzepine compared with atropine and L-hyoscyamine on esophageal peristaltic activity in humans.
Topics: Adult; Atropine; Benzodiazepinones; Deglutition; Double-Blind Method; Esophagus; Female; Gastrointestinal Agents; Humans; Male; Muscle Contraction; Muscle, Smooth; Pirenzepine; Pressure; Random Allocation; Receptors, Muscarinic | 1982 |
A comparison of the effects of pirenzepine and atropine on gastric acid secretion, salivary secretion and pupil diameter in the rat.
Topics: Animals; Atropine; Benzodiazepinones; Dose-Response Relationship, Drug; Gastric Acid; Male; Pirenzepine; Pupil; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Saliva; Salivary Glands; Stomach | 1982 |
[3h]pirenzepine selectively identifies a high affinity population of muscarinic cholinergic receptors in the rat cerebral cortex.
Topics: Animals; Atropine; Benzodiazepinones; Binding, Competitive; Cerebellar Cortex; Cerebral Cortex; Female; Myocardium; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic | 1982 |
Does pirenzepine distinguish between 'subtypes' of muscarinic receptors?
Topics: Animals; Atropine; Benzodiazepinones; Bethanechol Compounds; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Mice; Muscle, Smooth; Myocardial Contraction; Pirenzepine; Receptors, Cholinergic; Receptors, Muscarinic | 1982 |
Muscarinic receptor subtypes: M1 and M2 biochemical and functional characterization.
Topics: Animals; Atrial Function; Atropine; Benzodiazepinones; Electric Stimulation; Ganglia, Sympathetic; Heart; Male; Pirenzepine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic; Regression Analysis | 1982 |
Effects of pirenzepine and atropine on gastric secretory and plasma hormonal responses to sham-feeding in patients with duodenal ulcer.
Topics: Adult; Atropine; Benzodiazepinones; Dose-Response Relationship, Drug; Duodenal Ulcer; Eating; Gastric Acid; Gastrins; Humans; Pancreatic Polypeptide; Piperazines; Pirenzepine | 1980 |
Comparison of the action of pirenzepine and L-hyoscyamine on gastric acid secretion and other muscarinic effects.
Topics: Adult; Atropine; Benzodiazepinones; Female; Gastric Acid; Heart Rate; Humans; Male; Pentagastrin; Piperazines; Pirenzepine; Pupil; Salivation; Time Factors | 1980 |
Effects of cimetidine and pirenzepine on peroperative electrical vagal stimulation of gastric acid secretion.
Topics: Adult; Atropine; Benzodiazepinones; Cimetidine; Electric Stimulation; Gastric Acid; Gastrins; Guanidines; Humans; Male; Middle Aged; Pentagastrin; Piperazines; Pirenzepine; Vagus Nerve | 1980 |
Influence of atropine, pirenzepine and cimetidine on nocturnal gastro-intestinal motility and gastric acid secretion.
Topics: Adult; Atropine; Benzodiazepinones; Cimetidine; Drug Interactions; Gastric Acid; Gastrointestinal Motility; Guanidines; Humans; Hydrogen-Ion Concentration; Pirenzepine | 1982 |
The inhibition of vagal stimulated acid secretion by pirenzepine and cimetidine.
Topics: Atropine; Benzodiazepinones; Cimetidine; Electric Stimulation; Gastric Acid; Guanidines; Humans; Pentagastrin; Pirenzepine; Vagotomy; Vagus Nerve | 1982 |
Cytoprotection by PGE2, atropine, pirenzepine and vagotomy in rats.
Topics: Animals; Aspirin; Atropine; Benzodiazepinones; Dinoprostone; Female; Gastric Mucosa; Pirenzepine; Prostaglandins E; Rabbits; Rats; Rats, Inbred Strains; Vagotomy | 1982 |
Evaluation of selectivity of two different antimuscarinic substances.
Topics: Animals; Anti-Ulcer Agents; Atropine; Benzodiazepinones; Digestive System; Dose-Response Relationship, Drug; Electric Stimulation; Organ Specificity; Parasympatholytics; Pirenzepine; Rats; Salivation | 1982 |
Subclasses of muscarinic receptors and pirenzepine. Further experimental evidence.
Topics: Atropine; Benzodiazepinones; Gastric Juice; Humans; N-Methylscopolamine; Pirenzepine; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives | 1982 |
Muscarinic acetylcholine receptors on an identified motor neurone in the cockroach, Periplaneta americana.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Arecoline; Atropine; Dose-Response Relationship, Drug; Evoked Potentials; Ganglia, Invertebrate; In Vitro Techniques; Male; Motor Neurons; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Periplaneta; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine; Vertebrates | 1994 |
Cholinergic and VIP-ergic pathways mediate histamine H2 receptor-induced cyclical secretion in the guinea pig colon.
Topics: Acetylcholine; Amiloride; Animals; Atropine; Choline; Colon; Dimaprit; Electric Conductivity; Guinea Pigs; Histamine Release; Intestinal Mucosa; Male; ortho-Aminobenzoates; Piperidines; Pirenzepine; Receptors, Histamine H2; Vasoactive Intestinal Peptide | 1995 |
A snake toxin against muscarinic acetylcholine receptors: amino acid sequence, subtype specificity and effect on guinea-pig ileum.
Topics: Amino Acid Sequence; Animals; Atropine; Elapid Venoms; Freeze Drying; Guinea Pigs; In Vitro Techniques; Iodine Radioisotopes; Ligands; Molecular Sequence Data; Muscarinic Antagonists; Muscle, Smooth, Vascular; Myocardium; Pirenzepine; Radioligand Assay; Receptors, Muscarinic; Swine; Synaptic Membranes; Synaptosomes | 1995 |
Otenzepad shows two populations of binding sites in human gastric smooth muscle.
Topics: Adult; Aged; Atropine; Binding, Competitive; Female; Gastric Mucosa; Humans; In Vitro Techniques; Kinetics; Ligands; Male; Middle Aged; Muscle, Smooth; Parasympatholytics; Pirenzepine; Receptors, Muscarinic | 1995 |
Release of endogenous acetylcholine from a vascularly perfused rat stomach in vitro; inhibition by M3 muscarinic autoreceptors and alpha-2 adrenoceptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Adrenergic alpha-Antagonists; Animals; Atropine; Calcium; Clonidine; Diamines; Drug Interactions; Electric Stimulation; Gastric Mucosa; Hexamethonium; Hexamethonium Compounds; Male; Muscarinic Antagonists; Oxotremorine; Parasympatholytics; Perfusion; Phenylephrine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Stomach; Sympathetic Nervous System; Tetrodotoxin; Vagus Nerve | 1993 |
Functional characterization of a muscarinic receptor stimulating gastrin release from rabbit antral G-cells in primary culture.
Topics: Animals; Arecoline; Atropine; Benzodiazepinones; Carbachol; Cell Adhesion; Cell Separation; Cells, Cultured; Gastrins; Immunohistochemistry; Male; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Pyloric Antrum; Rabbits; Receptors, Muscarinic | 1994 |
Formation of inositol phosphates mediated by M3 muscarinic receptors in type-1 and type-2 astrocytes from neonatal rat cerebral cortex.
Topics: Animals; Animals, Newborn; Astrocytes; Atropine; Carbachol; Cells, Cultured; Cerebral Cortex; Inositol Phosphates; Muscarinic Antagonists; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Signal Transduction; Tubocurarine | 1994 |
Regulation of pancreatic polypeptide release is mediated through M3 muscarinic receptors.
Topics: Animals; Atropine; Cholecystokinin; Dogs; Female; Gastric Acid; Male; Pancreatic Juice; Pancreatic Polypeptide; Parasympatholytics; Piperidines; Pirenzepine; Proglumide; Receptors, Muscarinic; Vagus Nerve | 1994 |
Neurotransmitter and neuropeptide modulation of high affinity choline uptake in Limulus brain.
Topics: Animals; Atropine; Brain; Carbachol; Choline; FMRFamide; Horseshoe Crabs; Neuropeptides; Neurotransmitter Agents; Octopamine; Oligopeptides; Oxotremorine; Pirenzepine; Potassium; Serotonin; Tubocurarine | 1995 |
Hypotensive effect of an M2-selective muscarinic antagonist in anaesthetized guinea-pigs.
Topics: Animals; Atropine; Blood Pressure; Depression, Chemical; Diamines; Guinea Pigs; Heart Rate; Male; Muscarinic Antagonists; Norepinephrine; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic | 1995 |
Antagonists of cholinergic and serotonergic responses of Aplysia buccal muscle.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Aplysia; Atropine; Cholinergic Antagonists; Hexamethonium; In Vitro Techniques; Mecamylamine; Muscle Contraction; Muscle, Smooth; Piperazines; Pirenzepine; Serotonin Antagonists | 1994 |
Pressor effects of acetylcholine injected into the lateral septal area of conscious rats.
Topics: Acetylcholine; Adrenal Glands; Animals; Atropine; Blood Pressure; Ganglionic Blockers; Injections, Intraventricular; Male; Parasympatholytics; Piperidines; Pirenzepine; Pituitary Gland; Rats; Rats, Wistar; Septal Nuclei; Stimulation, Chemical; Vasopressins | 1994 |
Atropine and glycopyrronium show similar binding patterns to M2 (cardiac) and M3 (submandibular gland) muscarinic receptor subtypes in the rat.
Topics: Animals; Atropine; Binding, Competitive; Glycopyrrolate; Heart Ventricles; In Vitro Techniques; Male; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Scopolamine Derivatives; Submandibular Gland | 1995 |
Pertussis toxin-sensitive muscarinic relaxation in the rat iris dilator muscle.
Topics: Acetylcholine; Alkaloids; Animals; Atropine; Diamines; Dose-Response Relationship, Drug; Furans; GTP-Binding Proteins; In Vitro Techniques; Iris; Male; Microinjections; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naphthalenes; Parasympatholytics; Pertussis Toxin; Phentolamine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Virulence Factors, Bordetella | 1995 |
Regional differences in motor responsiveness to antimuscarinic drugs in rabbit isolated small and large intestine.
Topics: Animals; Atropine; Benzodiazepinones; Diamines; Dose-Response Relationship, Drug; Gastrointestinal Motility; Intestine, Large; Intestine, Small; Male; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic | 1995 |
Prejunctional muscarinic autoreceptors on horse airway cholinergic nerves.
Topics: Acetylcholine; Animals; Atropine; Cholinergic Fibers; Electric Stimulation; Horses; In Vitro Techniques; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1995 |
Muscarinic inhibition of cardiac norepinephrine and neuropeptide Y release during ischemia and reperfusion.
Topics: Animals; Atropine; Carbachol; Electric Stimulation; Guinea Pigs; Heart; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Neuropeptide Y; Norepinephrine; Oxotremorine; Parasympatholytics; Pirenzepine; Receptors, Muscarinic | 1994 |
Muscarinic receptors in rat uterus.
Topics: Alkaloids; Animals; Atropine; Binding, Competitive; Computer Simulation; Female; Furans; In Vitro Techniques; Ligands; Muscarinic Antagonists; Naphthalenes; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Uterus | 1994 |
Effects of atropine, pirenzepine, clonidine, and morphine on biphasic response of rat gastric fundus to field stimulation.
Topics: Animals; Atropine; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Gastric Fundus; In Vitro Techniques; Male; Morphine; Muscle Contraction; Pirenzepine; Rats; Rats, Sprague-Dawley | 1994 |
Muscarinic (M1) mediation of carbachol-induced theta in the cat entorhinal cortex in vitro.
Topics: Animals; Atropine; Carbachol; Cats; Entorhinal Cortex; In Vitro Techniques; Male; Muscarinic Agonists; Muscarinic Antagonists; Pirenzepine; Receptors, Muscarinic; Theta Rhythm | 1994 |
Accumulation of 3H-phosphoinositides mediated by muscarinic receptors in the developing chick retina: inhibition of carbachol-induced response by glutamate receptors.
Topics: Animals; Atropine; Carbachol; Chick Embryo; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Phosphatidylinositols; Physostigmine; Pirenzepine; Receptors, Glutamate; Receptors, Muscarinic; Retina | 1995 |
Muscarinic receptors in vagal routes to the biliary system in dogs.
Topics: Animals; Atropine; Biliary Tract; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Gallbladder; Pirenzepine; Receptors, Muscarinic; Sphincter of Oddi; Vagus Nerve | 1994 |
Muscarinic M3 receptor-mediated release of gastrin from canine antral G cells in primary culture.
Topics: Animals; Atropine; Carbachol; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Enterochromaffin Cells; Gastrins; Muscarinic Antagonists; Parasympathetic Nervous System; Parasympatholytics; Piperidines; Pirenzepine; Pyloric Antrum; Receptor, Muscarinic M3; Receptors, Muscarinic; Stimulation, Chemical | 1995 |
Nicotinic and muscarinic modulations of excitatory synaptic transmission in the rat prefrontal cortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Atropine; Bungarotoxins; Cerebral Cortex; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Evoked Potentials; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Male; Mecamylamine; Membrane Potentials; Muscarine; Neurons; Nicotine; Pirenzepine; Pyramidal Tracts; Quinoxalines; Rats; Rats, Sprague-Dawley; Scopolamine; Synaptic Transmission; Tubocurarine | 1993 |
Nicotinic and muscarinic acetylcholine responses in differentiated PC12 cells.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Cell Differentiation; Cell Membrane Permeability; Egtazic Acid; Hexamethonium; Hexamethonium Compounds; Membrane Potentials; Muscarine; Nerve Growth Factors; Nicotine; Nystatin; Parasympatholytics; PC12 Cells; Pirenzepine; Potassium; Receptors, Muscarinic; Receptors, Nicotinic; Tubocurarine | 1994 |
Vitamin D status modulates rat colonic M3 muscarinic receptor characteristics and coupling to guanylate cyclase.
Topics: Animals; Atropine; Colon; Diamines; Enzyme Activation; Guanylate Cyclase; Male; Muscarinic Antagonists; Nutritional Status; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Vitamin D | 1994 |
A physiologically-evoked M1-muscarinic depolarization in guinea-pig inferior mesenteric ganglion neurons.
Topics: Action Potentials; Animals; Atropine; Carbachol; Colon; Female; Ganglia, Sympathetic; Gastrointestinal Motility; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; Male; Mechanoreceptors; Pirenzepine; Receptors, Muscarinic; Stress, Mechanical | 1994 |
Muscarinic stimulation promotes cultured Purkinje cell survival: a role for acetylcholine in cerebellar development?
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Cell Survival; Cells, Cultured; Cerebellum; Choline O-Acetyltransferase; Drug Interactions; Nerve Growth Factors; Physostigmine; Pirenzepine; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic | 1994 |
Muscarinic receptor-dependent activation of phospholipase C in the developing human fetal central nervous system.
Topics: Atropine; Brain; Carbachol; Cytidine Diphosphate Diglycerides; Embryonic and Fetal Development; Enzyme Activation; Female; Fetus; Humans; In Vitro Techniques; Inositol Phosphates; Pirenzepine; Pregnancy; Pregnancy Trimester, Second; Receptors, Muscarinic; Second Messenger Systems; Type C Phospholipases | 1994 |
[Intravenous pirenzepine reduces salivary secretion rapidly].
Topics: Adult; Anesthesia, General; Atropine; Depression, Chemical; Heart Rate; Humans; Injections, Intravenous; Middle Aged; Pirenzepine; Preanesthetic Medication; Saliva | 1994 |
Assessment of the muscarinic receptor subtypes involved in pilocarpine-induced seizures in mice.
Topics: Animals; Atropine; Cerebral Ventricles; Injections, Intraventricular; Male; Mice; Parasympatholytics; Pilocarpine; Piperidines; Pirenzepine; Receptors, Muscarinic; Seizures | 1994 |
In vitro pharmacologic characterization of a cholinergic receptor on outer hair cells.
Topics: Acetylcholine; Alkaloids; Animals; Atropine; Azocines; Bungarotoxins; Carbachol; Choline; Cholinergic Antagonists; Curare; Dimethylphenylpiperazinium Iodide; Guinea Pigs; Hair Cells, Auditory, Outer; In Vitro Techniques; Membrane Potentials; Nicotine; Piperidines; Pirenzepine; Quinolizines; Receptors, Cholinergic; Strychnine; Trimethaphan | 1994 |
Diabetes-induced alterations in the properties of muscarinic cholinergic receptors in rat vas deferens.
Topics: Animals; Atropine; Binding, Competitive; Diabetes Mellitus, Experimental; Diamines; Insulin; Male; Parasympatholytics; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Up-Regulation; Vas Deferens | 1994 |
Release of bombesin-like immunoreactivity from synaptosomal membranes isolated from the rat ileum.
Topics: Animals; Atropine; Bombesin; Calcium; Carbachol; Cell Fractionation; Centrifugation, Density Gradient; Ileum; Male; Microscopy, Electron; Pirenzepine; Potassium Chloride; Radioimmunoassay; Rats; Rats, Wistar; Synaptosomes | 1994 |
M3 muscarinic receptors on rat colonocytes are coupled to particulate guanylate cyclase activation.
Topics: Animals; Atropine; Carbachol; Cells, Cultured; Colon; Enzyme Activation; Guanylate Cyclase; Male; Muscarinic Antagonists; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic | 1993 |
Effect of M1- and M2-muscarinic drugs on striatal dopamine release and metabolism: an in vivo microdialysis study comparing normal and 6-hydroxydopamine-lesioned rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Atropine; Carbachol; Corpus Striatum; Diamines; Dopamine; Homovanillic Acid; Male; Microdialysis; Oxidopamine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Reference Values | 1993 |
Characterization of the muscarinic receptors in the mesenteric vascular bed of spontaneously hypertensive rats.
Topics: Animals; Atropine; Benzodiazepinones; Endothelium, Vascular; Hypertension; Male; Mesenteric Artery, Superior; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Muscarinic; Vasodilation | 1993 |
Pharmacological characterization of muscarinic cholinergic receptors in cat pons and cortex. Preliminary study.
Topics: Animals; Atropine; Binding, Competitive; Cats; Cerebral Cortex; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Pons; Receptors, Muscarinic | 1994 |
In vivo characterization of vasodilating muscarinic-receptor subtypes in humans.
Topics: Acetylcholine; Adult; Atropine; Clinical Protocols; Forearm; Humans; Male; Methacholine Chloride; Pirenzepine; Receptors, Muscarinic; Vasodilation | 1994 |
Presynaptic muscarinic receptors modulate acetylcholine release from rat antral mucosal/submucosal nerves.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Cholinergic Fibers; Dose-Response Relationship, Drug; Electric Stimulation; Gastric Mucosa; In Vitro Techniques; Male; Pirenzepine; Pyloric Antrum; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Presynaptic | 1994 |
The vagus nerve and its non-cholinergic mechanism in the modulation of ethanol-induced gastric mucosal damage in rats.
Topics: Animals; Atropine; Blood Circulation; Ethanol; Gastric Acid; Gastric Mucosa; Male; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Vagotomy; Vagus Nerve | 1994 |
Facilitation of memory storage by the acetylcholine M2 muscarinic receptor antagonist AF-DX 116.
Topics: Animals; Atropine; Avoidance Learning; Behavior, Animal; Brain; Drug Synergism; Male; Memory; Mice; Neostigmine; Parasympatholytics; Physostigmine; Pirenzepine; Receptors, Muscarinic | 1993 |
Secretagogue-induced RVD in HSY cells is due to K+ channels activated by Ca2+ and protein kinase C.
Topics: Atropine; Barium; Calcium; Carbachol; Cell Line; Chloride Channels; Egtazic Acid; Humans; Ionomycin; Kinetics; Pirenzepine; Potassium; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Quinidine; Salivary Glands; Scorpion Venoms; Tetradecanoylphorbol Acetate; Valinomycin | 1993 |
Agonist-induced down-regulation and antagonist-induced up-regulation of m2- and m3-muscarinic acetylcholine receptor mRNA and protein in cultured cerebellar granule cells.
Topics: Animals; Atropine; Carbachol; Cells, Cultured; Cerebellum; Down-Regulation; Parasympatholytics; Parasympathomimetics; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; RNA, Messenger; Up-Regulation | 1993 |
Role of M1 muscarinic receptor subtypes in mediating airway smooth muscle contraction.
Topics: Acetylcholine; Atropine; Bronchi; Epithelium; Humans; In Vitro Techniques; Muscarinic Antagonists; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic | 1993 |
[A study of muscarinic cholinergic receptor subtypes in human detrusor muscle using radioligand binding techniques].
Topics: Aged; Atropine; Female; Humans; Male; Mandelic Acids; Muscle, Smooth; Pirenzepine; Radioligand Assay; Receptors, Muscarinic; Urinary Bladder | 1993 |
Stimulation of phosphoinositide hydrolysis by muscarinic receptor activation in the rat olfactory bulb.
Topics: Adenylyl Cyclases; Animals; Atropine; Bucladesine; Carbachol; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Inositol 1,4,5-Trisphosphate; Olfactory Bulb; Phosphatidylinositols; Pirenzepine; Rats; Receptors, Muscarinic; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
Nicotine-induced stimulation of alpha-MSH release in frog pituitary melanotrophs is mediated through a novel type of receptor.
Topics: alpha-MSH; Animals; Atropine; Calcium; Gallamine Triethiodide; In Vitro Techniques; Muscarine; Nicotine; Nifedipine; Pirenzepine; Pituitary Gland, Posterior; Ranidae; Receptors, Muscarinic; Tetrodotoxin | 1993 |
Cholinergic M2 muscarinic receptor-mediated inhibition of endogenous noradrenaline release from the isolated vascularly perfused rat stomach.
Topics: Animals; Arteries; Atrial Function; Atropine; Depression, Chemical; Diamines; Electric Stimulation; Ethylmaleimide; Heart Atria; Male; Myocardial Contraction; Nerve Endings; Norepinephrine; Oxotremorine; Parasympatholytics; Perfusion; Pertussis Toxin; Phentolamine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Stomach; Sympathetic Nervous System; Vagus Nerve; Virulence Factors, Bordetella | 1993 |
Fentanyl attenuates porcine coronary arterial contraction through M3-muscarinic antagonism.
Topics: Acetylcholine; Animals; Atropine; Coronary Vessels; Depression, Chemical; Female; Fentanyl; In Vitro Techniques; Male; Piperidines; Pirenzepine; Receptors, Muscarinic; Swine; Vasoconstriction | 1993 |
Differential effects of antimuscarinic agents on intestinal motility in the conscious dog.
Topics: Animals; Atropine; Dogs; Female; Gastrointestinal Motility; Heart Rate; Male; Parasympatholytics; Piperidines; Pirenzepine; Pupil; Receptors, Muscarinic | 1993 |
Muscarinic M1 receptor agonist actions of muscarinic receptor agonists in rabbit vas deferens.
Topics: Animals; Atropine; Carbachol; Dose-Response Relationship, Drug; Hippocampus; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Pirenzepine; Rabbits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Nicotinic; Vas Deferens | 1993 |
Muscarinic receptors in the aortae of normo- and hypertensive rats: a binding study.
Topics: Acetylcholine; Animals; Aorta; Atropine; Binding, Competitive; Endothelium, Vascular; Guanylyl Imidodiphosphate; Hypertension; In Vitro Techniques; Kinetics; Muscle, Smooth, Vascular; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Muscarinic; Scopolamine; Tropanes | 1993 |
Muscarinic receptor-mediated induction of Fos protein in rat brain.
Topics: Animals; Atropine; Brain; Genes, fos; Immunohistochemistry; Male; Organ Specificity; Pilocarpine; Pirenzepine; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Muscarinic | 1993 |
Subtype of muscarinic receptors mediating relaxation and contraction in the rat iris dilator smooth muscle.
Topics: Alkaloids; Animals; Atropine; Carbachol; Furans; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naphthalenes; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic | 1993 |
Functional characterization of muscarinic receptors in murine airways.
Topics: Administration, Inhalation; Airway Resistance; Animals; Atropine; Bronchi; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Lung Compliance; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1993 |
Constitutive activity of the M1-M4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists.
Topics: Animals; Atropine; Carbachol; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; Humans; Inositol Phosphates; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Transfection; Tritium | 1995 |
Characterization of muscarinic receptors mediating contractions of circular and longitudinal muscle of human isolated colon.
Topics: Alkaloids; Atropine; Carbachol; Carcinoma; Colon; Colonic Neoplasms; Dose-Response Relationship, Drug; Furans; Humans; In Vitro Techniques; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Naphthalenes; Piperidines; Pirenzepine | 1995 |
Endogenous nitric oxide signalling system and the cardiac muscarinic acetylcholine receptor-inotropic response.
Topics: Analysis of Variance; Animals; Atropine; Binding Sites; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Heart Atria; Male; Myocardial Contraction; Nitric Oxide; Nitric Oxide Synthase; Parasympatholytics; Phosphatidylinositols; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Signal Transduction; Type C Phospholipases | 1995 |
Muscarinic cholinergic receptors in brain and atrial membranes of adult brook trout (Salvelinus fontinalis) measured by radioligand binding techniques.
Topics: Animals; Atropine; Binding, Competitive; Brain Chemistry; Carbachol; Heart Atria; Kinetics; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Oxotremorine; Parasympatholytics; Pirenzepine; Radioligand Assay; Receptors, Muscarinic; Scopolamine; Scopolamine Derivatives; Trout | 1995 |
Two types of functionally different GABAA receptors mediate GABA modulation of cholinergic transmission in cat terminal ileum.
Topics: Animals; Atropine; Bicuculline; Cats; Dose-Response Relationship, Drug; Electric Stimulation; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscimol; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neuromuscular Junction; Pirenzepine; Receptors, GABA-A; Synaptic Transmission; Tetrodotoxin | 1995 |
Effect of selective and non-selective muscarinic blockade on baclofen inhibition of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
Topics: Adenocarcinoma; Animals; Atropine; Baclofen; Bromodeoxyuridine; Carcinogens; GABA Agonists; Male; Methylnitronitrosoguanidine; Muscarinic Antagonists; Neoplasms, Experimental; Pirenzepine; Rats; Rats, Wistar; Stomach Neoplasms | 1996 |
Augmented pharmacologic stimulation of striatal acetylcholine release following developmental hypoxic-ischemic injury.
Topics: Acetylcholine; Analysis of Variance; Animals; Atropine; Basal Metabolism; Brain Ischemia; Corpus Striatum; Female; Hypoxia, Brain; Microdialysis; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1996 |
Effects of selective muscarinic antagonists, pirenzepine and AF-DX 116, on passive avoidance tasks in mice.
Topics: Animals; Atropine; Avoidance Learning; Male; Mice; Muscarinic Antagonists; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Muscarinic | 1996 |
Binding of the labelled muscarinic toxin 125I-MT1 to rat brain muscarinic M1 receptors.
Topics: Alkaloids; Animals; Atropine; Binding, Competitive; Brain; Carbachol; Elapid Venoms; Furans; Gallamine Triethiodide; In Vitro Techniques; Iodine Radioisotopes; Isotope Labeling; Kinetics; Muscarinic Agonists; Muscarinic Antagonists; Naphthalenes; Oxotremorine; Parasympatholytics; Pilocarpine; Piperidines; Pirenzepine; Protein Binding; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic; Synaptic Membranes; Tubocurarine | 1996 |
Mediation of the depolarization-induced [Ca(2+)]i increase in rat sublingual acini by acetylcholine released from nerve terminals.
Topics: Acetylcholine; Animals; Atropine; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Cytosol; Fluorescent Dyes; Fura-2; Gallic Acid; Inositol 1,4,5-Trisphosphate; Male; Muscarinic Antagonists; Nerve Endings; Nicotinic Antagonists; Piperidines; Pirenzepine; Potassium; Rats; Rats, Wistar; Receptors, Nicotinic; Sublingual Gland | 1996 |
Biphasic effect of tacrine on acetylcholine release in rat brain via M1 and M2 receptors.
Topics: Acetylcholine; Alzheimer Disease; Analysis of Variance; Animals; Atropine; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Male; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Synaptosomes; Tacrine | 1996 |
Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae.
Topics: Animals; Artemia; Atropine; Chlorpyrifos; Cholinergic Antagonists; Cholinesterase Reactivators; Cysts; Hexamethonium; Insecticides; Larva; Methyl Parathion; Parasympatholytics; Parathion; Pirenzepine; Poisoning; Pralidoxime Compounds; Species Specificity; Structure-Activity Relationship | 1996 |
The antilesion actions of anticholinergic agents on ethanol-induced injury in rat stomachs: the importance of gastric vascular integrity and tonicity.
Topics: Animals; Anti-Infective Agents, Local; Atropine; Capillary Permeability; Ethanol; Gastric Emptying; Gastric Mucosa; Male; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Sprague-Dawley | 1996 |
Functional partial agonism at cloned human muscarinic acetylcholine receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Atropine; Binding, Competitive; Carbachol; Cells, Cultured; Cloning, Molecular; Dose-Response Relationship, Drug; GTP-Binding Proteins; Humans; Muscarinic Agonists; Muscarinic Antagonists; Nicotinic Agonists; Pirenzepine; Receptors, Muscarinic | 1996 |
Muscarinic receptor subtypes in the submandibular gland and the urinary bladder of the rabbit: in vivo and in vitro functional comparisons of receptor antagonists.
Topics: Animals; Atropine; Carbachol; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Muscarinic Antagonists; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic; Submandibular Gland; Urinary Bladder | 1995 |
The roles of muscarinic receptor subtypes in modulation of nasal ciliary action.
Topics: Atropine; Cilia; Gallamine Triethiodide; Humans; In Vitro Techniques; Methacholine Chloride; Mucociliary Clearance; Muscarinic Agonists; Muscarinic Antagonists; Nasal Mucosa; Piperidines; Pirenzepine; Receptors, Muscarinic | 1996 |
Acetylcholine stimulates growth hormone secretion in the neonatal rat pituitary.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Age Factors; Animals; Animals, Newborn; Atropine; Diamines; Dose-Response Relationship, Drug; Female; Growth Hormone; Male; Muscarinic Agonists; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Pituitary Gland; Rats; Rats, Wistar | 1996 |
Age-dependent changes in cardiac muscarinic receptor function in healthy volunteers.
Topics: Adult; Aging; Atropine; Baroreflex; Blood Pressure; Heart; Heart Rate; Humans; Male; Middle Aged; Muscarinic Antagonists; Myocardium; Phenylephrine; Pirenzepine; Pressoreceptors; Receptors, Muscarinic | 1997 |
Evidence for the presence of regional differences in the subtype specificity of muscarinic receptors in rabbit lower urinary tract.
Topics: Animals; Atropine; Carbachol; Diamines; Female; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pirenzepine; Rabbits; Receptors, Muscarinic; Species Specificity; Urethra; Urinary Bladder | 1997 |
A muscarinic acetylcholine receptor, present in the epithelial cell line from Chironomus tentans.
Topics: Animals; Atropine; Binding Sites; Binding, Competitive; Blotting, Western; Carbachol; Cell Line; Chironomidae; Ecdysterone; Epithelium; Ethylmaleimide; Guanylyl Imidodiphosphate; Kinetics; Oxotremorine; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Cholinergic | 1996 |
Effects of submucosal administration of endothelin-3 on rat gastric mucosa.
Topics: Animals; Anti-Ulcer Agents; Atropine; Dose-Response Relationship, Drug; Endothelin-3; Enzyme Inhibitors; Epinephrine; Gastric Mucosa; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Pirenzepine; Premedication; Ranitidine; Rats; Rats, Sprague-Dawley; Time Factors; Vagotomy | 1997 |
Circulating antibodies against rat parotid gland M3 muscarinic receptors in primary Sjögren's syndrome.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Animals; Antibodies, Blocking; Atropine; Carbachol; Carbamates; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Humans; Immunoglobulin G; Isoproterenol; Muscarinic Antagonists; Parasympatholytics; Parotid Gland; Phenylcarbamates; Phosphatidylinositols; Piperidines; Pirenzepine; Protease Inhibitors; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Sjogren's Syndrome | 1996 |
Involvement of M2 receptor in an enhancement of long-term potentiation by carbachol in Schaffer collateral-CA1 synapses of hippocampal slices.
Topics: Animals; Atropine; Carbachol; Electric Stimulation; Evoked Potentials; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Muscarinic Agonists; Muscarinic Antagonists; Pirenzepine; Receptors, Muscarinic; Synapses | 1997 |
Functional evidence of excitatory M1 receptors in the rabbit airway.
Topics: Acetylcholine; Animals; Atropine; Bronchoconstriction; Female; Gallamine Triethiodide; Male; Mechanoreceptors; Pirenzepine; Propranolol; Rabbits; Receptor, Muscarinic M1; Receptors, Muscarinic; Vagus Nerve | 1997 |
Agonist-independent tonic inhibitory influence of Gi on adenylate cyclase activity in rabbit ventricular myocardium and its removal by pertussis toxin: a role of empty receptor-mediated Gi activation.
Topics: Adenosine Diphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atropine; Cell Membrane; Cells, Cultured; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanylyl Imidodiphosphate; Heart Ventricles; Isoproterenol; Male; Muscarinic Antagonists; Pertussis Toxin; Pirenzepine; Propanolamines; Rabbits; Receptor, Muscarinic M2; Receptors, Adrenergic, beta; Receptors, Muscarinic; Virulence Factors, Bordetella | 1997 |
Expression of muscarinic receptor subtypes in rat gastric smooth muscle: effect of M3 selective antagonist on gastric motility and emptying.
Topics: Animals; Atropine; Butylscopolammonium Bromide; Dioxoles; Gastric Emptying; Gastrointestinal Motility; Glucagon; Male; Muscarinic Antagonists; Muscle, Smooth; Piperidines; Pirenzepine; Polymerase Chain Reaction; Rats; Receptors, Muscarinic; Stomach | 1997 |
Pharmacologic characterization of muscarine receptor subtypes in rat gastric fundus mediating contractile responses.
Topics: Acetylcholine; Animals; Atropine; Diamines; Female; Gastric Fundus; Gastrointestinal Motility; Male; Muscarinic Antagonists; Piperazines; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic | 1997 |
Functional characterization of peripheral muscarinic subtypes in anesthetized cats.
Topics: Animals; Atropine; Blood Pressure; Cats; Gallamine Triethiodide; Galvanic Skin Response; Heart Rate; Methacholine Chloride; Muscarinic Agonists; Muscarinic Antagonists; Piperidines; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Superior Cervical Ganglion; Synaptic Transmission; Vagus Nerve; Vasodilation | 1997 |
Prejunctional regulation by endogenous and exogenous acetylcholine of adrenergic nerve function in isolated canine mesenteric arteries.
Topics: Acetylcholine; Adrenergic Fibers; Animals; Atropine; Cholinesterase Inhibitors; Dogs; Electric Stimulation; Female; Male; Mesenteric Arteries; Muscarinic Antagonists; Norepinephrine; Physostigmine; Pirenzepine; Receptors, Muscarinic; Vasoconstrictor Agents | 1997 |
Cholinergic modulation of electrogenic ion transport in different regions of the rat small intestine.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Analysis of Variance; Animals; Atropine; Bethanechol; Carbachol; Chlorides; Diamines; Duodenum; Ileum; Intestinal Mucosa; Ion Transport; Jejunum; Male; Muscarinic Agonists; Muscarinic Antagonists; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M3; Receptors, Muscarinic; Structure-Activity Relationship; Tetrodotoxin | 1997 |
NG-nitro-L-arginine methyl-ester: a muscarinic receptor antagonist?
Topics: Animals; Atropine; Binding, Competitive; Blood Pressure; Enzyme Inhibitors; Female; Heart Rate; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Pirenzepine; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Urinary Bladder | 1997 |
Inhibitory effects of various spasmolytics on the vagal afferent gastric excitatory response in cats.
Topics: Animals; Atropine; Butylscopolammonium Bromide; Cats; Electric Stimulation; Female; Male; Neurons, Afferent; Neurons, Efferent; Parasympatholytics; Pirenzepine; Scopolamine Derivatives; Stomach; Vagus Nerve | 1997 |
Exocytotic release from neuronal cell bodies, dendrites and nerve terminals in sympathetic ganglia of the rat, and its differential regulation.
Topics: Animals; Atropine; Carbachol; Cell Membrane; Dendrites; Exocytosis; Ganglia, Sympathetic; Male; Membrane Potentials; Nerve Endings; Neurons; Nicotine; Oxotremorine; Parasympatholytics; Pirenzepine; Potassium; Rats; Rats, Wistar; Receptors, Muscarinic; Regression Analysis; Synapses | 1997 |
M3 muscarinic receptor-mediated enhancement of NMDA-evoked adenosine release in rat cortical slices in vitro.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atropine; Carbachol; Cerebral Cortex; Diamines; Drug Synergism; In Vitro Techniques; Kinetics; Magnesium; Male; Muscarinic Agonists; Muscarinic Antagonists; N-Methylaspartate; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M3; Receptors, Muscarinic | 1997 |
Differentiation of muscarinic receptors mediating negative chronotropic and vasoconstrictor responses to acetylcholine in isolated rat hearts.
Topics: Acetylcholine; Animals; Atropine; Coronary Vessels; Depression, Chemical; Diamines; Heart Rate; In Vitro Techniques; Male; Pertussis Toxin; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Vasoconstriction; Virulence Factors, Bordetella | 1997 |
Role of acetylcholine and gastrin-releasing peptide (GRP) in gastrin secretion.
Topics: Acetylcholine; Animals; Atropine; Electric Stimulation; Ganglionic Blockers; Gastric Mucosa; Gastrin-Releasing Peptide; Gastrins; Hexamethonium; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Parasympatholytics; Pirenzepine; Rats; Rats, Wistar; Vagus Nerve | 1997 |
Alterations of physostigmine-induced yawning by chronic lithium administration in rats.
Topics: Animals; Antimanic Agents; Atropine; Diamines; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intraperitoneal; Injections, Intraventricular; Lithium Chloride; Male; Muscarinic Antagonists; Parasympatholytics; Physostigmine; Pirenzepine; Rats; Yawning | 1997 |
Properties of carbachol-induced oscillatory activity in rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Atropine; Bicuculline; Carbachol; Dicyclomine; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-B Receptor Antagonists; Hippocampus; In Vitro Techniques; Kinetics; Male; Microelectrodes; Neurons; Nicotine; Oscillometry; Phosphinic Acids; Pirenzepine; Potassium; Propanolamines; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, AMPA; Receptors, GABA-B | 1997 |
Effect of N(G)-nitro-L-arginine methyl ester on functionally characterized muscarinic receptors in anesthetized cats.
Topics: Animals; Atropine; Cats; Enzyme Inhibitors; Gallamine Triethiodide; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic | 1997 |
Muscarinic facilitation of GABA release in substantia gelatinosa of the rat spinal dorsal horn.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Carbachol; Diamines; Evoked Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Muscarinic Agonists; Neostigmine; Neurons; Parasympatholytics; Piperidines; Pirenzepine; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic; Substantia Gelatinosa; Synaptic Transmission; Tetrodotoxin | 1998 |
M2 and M3 muscarinic receptors couple, respectively, with activation of nonselective cationic channels and potassium channels in intestinal smooth muscle cells.
Topics: Animals; Atropine; Calcium; Carbachol; Guinea Pigs; Male; Muscarinic Agonists; Muscle, Smooth; Piperidines; Pirenzepine; Potassium Channels; Receptors, Muscarinic | 1998 |
Postsynaptic integration of cholinergic and dopaminergic signals on medium-sized GABAergic projection neurons in the neostriatum.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Diamines; Electric Stimulation; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Models, Neurological; Muscarinic Agonists; Muscarinic Antagonists; Neostriatum; Neurons; Oxotremorine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Dopamine; Receptors, Muscarinic; Signal Transduction; Sulpiride; Tetrodotoxin | 1998 |
Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Behavior, Animal; Carbachol; Cataplexy; Cholinergic Fibers; Dogs; Feeding Behavior; Female; GABA Agonists; Gallamine Triethiodide; Male; Microdialysis; Muscarinic Agonists; Muscarinic Antagonists; Muscimol; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxotremorine; Piperidines; Pirenzepine; Prosencephalon | 1998 |
Effects of the muscarinic antagonists atropine and pirenzepine on olfactory conditioning in the honeybee.
Topics: Animals; Atropine; Bees; Brain; Conditioning, Classical; Injections; Muscarinic Antagonists; Pirenzepine; Reflex; Smell | 1998 |
Pharmacological profile of CEB-1957 and atropine toward brain muscarinic receptors and comparative study of their efficacy against sarin poisoning.
Topics: Animals; Atropine; Autoradiography; Binding, Competitive; Brain; Cholinesterase Inhibitors; Male; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Poisoning; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Sarin; Thiophenes | 1998 |
Cholinergic regulation of the rat adrenal zona glomerulosa.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Aldosterone; Animals; Atropine; Carbachol; Choline O-Acetyltransferase; Cholinergic Fibers; Histocytochemistry; Immunohistochemistry; Male; Microscopy, Immunoelectron; Muscarinic Agonists; Muscarinic Antagonists; Organ Culture Techniques; Pirenzepine; Rats; Rats, Sprague-Dawley; Zona Glomerulosa | 1998 |
Cellular mechanisms underlying two muscarinic receptor-mediated depolarizing responses in relay cells of the rat lateral geniculate nucleus.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Action Potentials; Animals; Atropine; Cations; Cesium; Geniculate Bodies; Ion Channel Gating; Ion Transport; Methacholine Chloride; Muscarinic Agonists; Muscarinic Antagonists; Nerve Tissue Proteins; Patch-Clamp Techniques; Pirenzepine; Potassium; Potassium Channels; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Tetrodotoxin | 1998 |
Presynaptic muscarinic M1 and M2 receptor modulation of auriculotemporal nerve transmission in the rat.
Topics: Acetylcholine; Animals; Atropine; Diamines; Ear; Electric Stimulation; Male; Muscarinic Antagonists; Parasympathetic Nervous System; Parasympatholytics; Parotid Gland; Pirenzepine; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Regional Blood Flow; Scalp; Synaptic Transmission | 1998 |
Pressor and bradycardic effects of tacrine and other acetylcholinesterase inhibitors in the rat.
Topics: Adrenergic Antagonists; Animals; Antidiuretic Hormone Receptor Antagonists; Atropine; Atropine Derivatives; Blood Pressure; Carbamates; Cardiovascular Agents; Chlorisondamine; Cholinergic Antagonists; Cholinesterase Inhibitors; Diamines; Diastole; Dose-Response Relationship, Drug; Heart Rate; Male; Phenylcarbamates; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Rivastigmine; Systole; Tacrine | 1998 |
Cloning and expression of a G protein-linked acetylcholine receptor from Caenorhabditis elegans.
Topics: Acetylcholine; Animals; Atropine; Base Sequence; Blotting, Southern; Caenorhabditis elegans; Cloning, Molecular; DNA, Complementary; Electrophysiology; Free Radical Scavengers; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; Ion Channel Gating; Isoproterenol; Membrane Potentials; Molecular Sequence Data; Muscarinic Agonists; Muscarinic Antagonists; Oocytes; Oxotremorine; Pirenzepine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Muscarinic; Scopolamine; Sequence Homology, Amino Acid; Serotonin; Sympathomimetics; Vasodilator Agents; Xenopus | 1999 |
3-Alpha-chloro-imperialine, a potent blocker of cholinergic presynaptic modulation of glutamatergic afferents in the rat neostriatum.
Topics: 4-Aminopyridine; Afferent Pathways; Animals; Atropine; Bicuculline; Carbachol; Cevanes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Gallamine Triethiodide; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Neostriatum; Neurons; Pirenzepine; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Muscarinic; Synapses | 1998 |
Rapid eye movement sleep induction by vasoactive intestinal peptide infused into the oral pontine tegmentum of the rat may involve muscarinic receptors.
Topics: Animals; Atropine; Autoradiography; Brain Chemistry; Carbachol; Dose-Response Relationship, Drug; Male; Microinjections; Muscarinic Agonists; Muscarinic Antagonists; Pirenzepine; Pons; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Sleep, REM; Tritium; Vasoactive Intestinal Peptide | 1999 |
Enhancement of GABA-activated current by muscarine in rat dorsal root ganglion neurons.
Topics: Acetylcholine; Action Potentials; Animals; Atropine; Bicuculline; Carbachol; Carbolines; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Female; GABA Agonists; GABA Modulators; Gallamine Triethiodide; gamma-Aminobutyric Acid; Ganglia, Spinal; Ion Channel Gating; Ion Channels; Male; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Nerve Tissue Proteins; Nicotinic Antagonists; Patch-Clamp Techniques; Pentobarbital; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Muscarinic | 1999 |
Subtypes of muscarinic receptors regulating gallbladder cholinergic contractions.
Topics: Acetylcholine; Animals; Atropine; Diamines; Electric Stimulation; Gallbladder; Guinea Pigs; Hexamethonium; Muscarinic Antagonists; Muscle Contraction; Parasympatholytics; Piperidines; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Tetrodotoxin; Tropicamide | 1999 |
Muscarinic blockade of methacholine induced airway and parenchymal lung responses in anaesthetised rats.
Topics: Animals; Atropine; Bronchoconstrictor Agents; Injections, Intravenous; Lung; Lung Compliance; Male; Methacholine Chloride; Muscarinic Antagonists; Pirenzepine; Rats; Receptors, Muscarinic | 1999 |
Pharmacological analysis of the novel mode of interaction between xanomeline and the M1 muscarinic acetylcholine receptor.
Topics: Animals; Atropine; Binding, Competitive; Carbachol; CHO Cells; Citrulline; Cricetinae; Humans; Kinetics; Muscarinic Agonists; N-Methylscopolamine; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pirenzepine; Pyridines; Radioligand Assay; Receptor, Muscarinic M1; Receptors, Muscarinic; Recombinant Proteins; Thiadiazoles; Transfection; Tritium | 1999 |
[Effects of propiverine hydrochloride (propiverine) on the muscarinic receptor binding affinity in guinea pig tissues and on salivation in conscious dogs].
Topics: Animals; Atropine; Benzilates; Binding, Competitive; Butylamines; Cerebral Cortex; Dogs; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart; Ileum; Male; Mandelic Acids; Muscarinic Agonists; Muscarinic Antagonists; Parasympatholytics; Pilocarpine; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Salivary Glands; Salivation; Urinary Bladder; Urination Disorders | 1999 |
Presynaptic muscarinic (M3) receptors reduce excitatory transmission in dopamine neurons of the rat mesencephalon.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Atropine; Carbachol; Diamines; Dicyclomine; Dopamine; Electric Stimulation; Excitatory Postsynaptic Potentials; Mesencephalon; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Parasympatholytics; Physostigmine; Piperidines; Pirenzepine; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reaction Time; Receptor, Muscarinic M3; Receptors, Muscarinic; Synaptic Transmission; Tetrodotoxin | 1999 |
Comparison of anti-M2-muscarinic effect of AF-DX 116 on atrioventricular nodal conduction with those of pirenzepine and atropine as antibradyarrhythmic drugs.
Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Atropine; Cardiac Surgical Procedures; Dogs; Female; In Vitro Techniques; Male; Parasympatholytics; Perfusion; Pirenzepine | 1999 |
Muscarinic receptor modulation of GABA-mediated giant depolarizing potentials in the neonatal rat hippocampus.
Topics: Animals; Animals, Newborn; Atropine; Cholinesterase Inhibitors; Edrophonium; Electric Stimulation; Electrophysiology; gamma-Aminobutyric Acid; Guanosine Diphosphate; Hippocampus; In Vitro Techniques; Membrane Potentials; Muscarinic Antagonists; Nerve Fibers; Parasympathetic Nervous System; Patch-Clamp Techniques; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic | 1999 |
Muscarinic cholinoceptor subtypes mediating tracheal smooth muscle contraction and inositol phosphate generation in guinea pig and rat.
Topics: Animals; Atropine; Diamines; Guinea Pigs; In Vitro Techniques; Inositol Phosphates; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Trachea | 1999 |
Effects of muscarinic cholinergic receptor antagonists on postnatal eye growth of rhesus monkeys.
Topics: Animals; Animals, Newborn; Atropine; Drug Therapy, Combination; Eye; Macaca mulatta; Muscarinic Antagonists; Myopia; Ophthalmic Solutions; Pirenzepine; Precipitin Tests; Rabbits; Receptors, Muscarinic; Refraction, Ocular; Sensory Deprivation; Treatment Outcome | 1999 |
Functional characterization and potential applications for enhanced green fluorescent protein- and epitope-fused human M1 muscarinic receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Atropine; Binding, Competitive; Calcium; Cells, Cultured; DNA Primers; Epitopes; Flow Cytometry; Gene Expression; Green Fluorescent Proteins; Histidine; Humans; Indicators and Reagents; Kidney; Luminescent Proteins; Microscopy, Confocal; Muscarinic Antagonists; Mutagenesis, Site-Directed; Piperidines; Pirenzepine; Radioligand Assay; Receptor, Muscarinic M1; Receptors, Muscarinic; Recombinant Fusion Proteins; Tritium | 1999 |
Radioligand binding assay of M1-M5 muscarinic cholinergic receptor subtypes in human peripheral blood lymphocytes.
Topics: Adult; Animals; Atropine; Autoradiography; Brain Chemistry; Humans; Intercellular Signaling Peptides and Proteins; Kinetics; Lymphocytes; Male; Muscarinic Antagonists; Peptides; Pirenzepine; Protein Binding; Radioligand Assay; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptor, Muscarinic M4; Receptor, Muscarinic M5; Receptors, Muscarinic; Tritium | 1999 |
Effect of cholinergic drugs on the concentration of intracellular free calcium of rat pituitary intermediate lobe cells.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Age Factors; Animals; Atropine; Calcium; Carbachol; Cells, Cultured; Cholinergic Agonists; Cytosol; Female; Male; Melanocytes; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Piperidines; Pirenzepine; Pituitary Gland; Rats; Rats, Wistar; Vasodilator Agents | 1999 |
Muscarinic control of intracortical connections to layer II in rat entorhinal cortex slice.
Topics: Animals; Atropine; Carbachol; Cholinergic Agonists; Entorhinal Cortex; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptors, Muscarinic; Synaptic Transmission | 1999 |
The assessment of antagonist potency under conditions of transient response kinetics.
Topics: Animals; Artifacts; Atropine; Binding, Competitive; Calcium; Carbachol; CHO Cells; Cricetinae; Drug Antagonism; Humans; Intracellular Fluid; Kinetics; Models, Biological; Monte Carlo Method; Muscarinic Agonists; Muscarinic Antagonists; Pirenzepine; Pyridines; Radioligand Assay; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiadiazoles; Time Factors | 1999 |
Isolation of a muscarinic alkaloid with ocular hypotensive action from Trophis racemosa.
Topics: Acetylcholine; Alkaloids; Animals; Antihypertensive Agents; Atropine; Carbachol; Dogs; Female; Gallamine Triethiodide; Guinea Pigs; Hexamethonium; Ileum; Intraocular Pressure; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Ocular Hypotension; Pentolinium Tartrate; Pilocarpine; Pirenzepine; Plant Extracts; Plants, Medicinal; Trachea | 1999 |
Muscarinic-induced modulation of potassium conductances is unchanged in mouse hippocampal pyramidal cells that lack functional M1 receptors.
Topics: Action Potentials; Animals; Atropine; Carbachol; Elapid Venoms; Hippocampus; Ion Channel Gating; Ion Transport; Mice; Mice, Knockout; Muscarinic Agonists; Muscarinic Antagonists; Patch-Clamp Techniques; Pirenzepine; Potassium; Potassium Channels; Pyramidal Cells; Receptor, Muscarinic M1; Receptors, Muscarinic | 2000 |
Selective restoration of calcium coupling to muscarinic M(3) receptors in contractile cultured airway myocytes.
Topics: Acetylcholine; Animals; Atropine; Blood Proteins; Blotting, Western; Bradykinin; Calcium; Calcium Channels; Cells, Cultured; Diamines; Dogs; Dose-Response Relationship, Drug; Fluorescent Dyes; Fura-2; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Muscarinic Antagonists; Muscle, Smooth; Oxazoles; Parasympatholytics; Phenotype; Piperidines; Pirenzepine; Receptor, Muscarinic M3; Receptors, Bradykinin; Receptors, Cytoplasmic and Nuclear; Receptors, Muscarinic; Trachea; Vasodilator Agents | 2000 |
Acetylcholine is released from in vitro cat carotid bodies during hypoxic stimulation.
Topics: Acetylcholine; Animals; Atropine; Carotid Body; Cats; Gallamine Triethiodide; Hypoxia; In Vitro Techniques; Mecamylamine; Parasympatholytics; Pirenzepine; Receptor, Muscarinic M2; Receptors, Muscarinic | 2000 |
M(2)/M(4)-muscarinic receptors mediate automodulation of acetylcholine outflow from mouse cortex.
Topics: Acetylcholine; Alkaloids; Animals; Atropine; Autoreceptors; Binding, Competitive; Cerebral Cortex; Furans; Male; Mice; Muscarinic Antagonists; Naphthalenes; Neostigmine; Parasympatholytics; Parasympathomimetics; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Receptors, Muscarinic | 2000 |
Carbachol and acetylcholine delay the early postdenervation depolarization of muscle fibres through M1-cholinergic receptors.
Topics: Acetylcholine; Animals; Arecoline; Atropine; Carbachol; Culture Techniques; Diaphragm; Male; Membrane Potentials; Muscarinic Agonists; Muscarinic Antagonists; Muscle Denervation; Muscle Fibers, Skeletal; Oxotremorine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptors, Muscarinic | 2000 |
Secretion and gene expression of secretory leukocyte protease inhibitor by human airway submucosal glands.
Topics: Adult; Aged; Aged, 80 and over; Atropine; Bronchi; Dexamethasone; Dose-Response Relationship, Drug; Exocrine Glands; Female; Gene Expression; Glucocorticoids; Humans; Leukocyte Elastase; Male; Methacholine Chloride; Middle Aged; Muscarinic Agonists; Muscarinic Antagonists; Piperidines; Pirenzepine; Proteinase Inhibitory Proteins, Secretory; Proteins; Respiratory Mucosa; RNA, Messenger; Secretory Leukocyte Peptidase Inhibitor; Trachea | 2001 |
Modulation by muscarinic receptor antagonists on negative chronotropic effects of tetrandrine.
Topics: Action Potentials; Alkaloids; Animals; Anti-Arrhythmia Agents; Atropine; Benzylisoquinolines; Calcium Channels; Depression, Chemical; Guinea Pigs; Heart Rate; Male; Muscarinic Antagonists; Myocardial Contraction; Pirenzepine; Rabbits; Rats; Sinoatrial Node | 1999 |
Mechanisms of acetylcholine-induced vasorelaxation in high K+-stimulated rabbit renal arteries.
Topics: Acetylcholine; Animals; Atropine; Calcium; Calcium Channel Blockers; Cations, Monovalent; Endothelium, Vascular; Gadolinium; Imidazoles; In Vitro Techniques; Lanthanum; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Parasympatholytics; Piperidines; Pirenzepine; Potassium; Rabbits; Renal Artery; Tropicamide; Vasoconstriction; Vasodilation | 2001 |
Functional characterization of rat submaxillary gland muscarinic receptors using microphysiometry.
Topics: Alkaloids; Animals; Atropine; Benzhydryl Compounds; Benzodiazepinones; Binding, Competitive; Biosensing Techniques; Carbachol; Cholinergic Agonists; Cresols; Diamines; Dose-Response Relationship, Drug; Furans; Male; Mandelic Acids; Muscarinic Antagonists; Naphthalenes; Phenethylamines; Phenylpropanolamine; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Submandibular Gland; Tolterodine Tartrate | 2001 |
The allosteric interaction of otenzepad (AF-DX 116) at muscarinic M2 receptors in guinea pig atria.
Topics: Acetylcholine; Allosteric Regulation; Animals; Atropine; Carbachol; Cardiotonic Agents; Dexetimide; Electric Stimulation; Female; Gallamine Triethiodide; Guinea Pigs; Heart Atria; In Vitro Techniques; Kinetics; Male; Muscarinic Antagonists; N-Methylscopolamine; Nicotinic Antagonists; Parasympatholytics; Phthalimides; Pirenzepine; Quaternary Ammonium Compounds; Radioligand Assay; Receptor, Muscarinic M2; Receptors, Muscarinic | 2001 |
Nitric oxide modulates cardiac performance in the heart of Anguilla anguilla.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Anguilla; Animals; Arginine; Atropine; Detergents; Enzyme Inhibitors; Female; Free Radical Scavengers; Heart; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Molsidomine; Muscarinic Antagonists; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Octoxynol; omega-N-Methylarginine; Ornithine; Oxadiazoles; Parasympatholytics; Pirenzepine; Quinoxalines; Superoxide Dismutase | 2001 |
Blood pressure and heart rate are increased by AF-DX 116, a selective M2 antagonist, in autonomic imbalanced and hypotensive rats caused by repeated cold stress.
Topics: Animals; Atropine; Blood Pressure; Cold Temperature; Heart Rate; Hypotension; Male; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Muscarinic; Stress, Physiological | 2001 |
Effects of cholinergic agents on the vasopressin-mediated water transport in the isolated toad bladder.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Arginine Vasopressin; Atropine; Biological Transport; Bufo marinus; Calcium; Calcium Channel Blockers; Carbachol; Cholinergic Agonists; Cholinergic Antagonists; In Vitro Techniques; Isotonic Solutions; Lanthanum; Osmolar Concentration; Piperidines; Pirenzepine; Urinary Bladder; Vasoconstrictor Agents; Water | 2001 |
Involvement of the cholinergic pathway in the pathogenesis of pituitary Cushing's syndrome.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenocorticotropic Hormone; Atropine; Choline; Cushing Syndrome; Dexamethasone; Female; Humans; Hydrocortisone; Metyrapone; Middle Aged; Muscarinic Antagonists; Petrosal Sinus Sampling; Pirenzepine; Pituitary Neoplasms | 2001 |
Muscarinic receptors control K+ secretion in inner ear strial marginal cells.
Topics: Adrenergic beta-Agonists; Animals; Atropine; Calcium; Carbachol; Cholinergic Agonists; Cloning, Molecular; Cyclic AMP; Diamines; Dose-Response Relationship, Drug; Gerbillinae; Isoproterenol; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Potassium; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; Stria Vascularis | 2001 |
Characterization of muscarinic acetylcholine receptors in the rat epididymis.
Topics: Animals; Atropine; Cell Membrane; Diamines; Epididymis; Male; Muscarinic Antagonists; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tritium | 2001 |
Muscarinic receptor subtypes mediating vasorelaxation of the perforating branch of the human internal mammary artery.
Topics: Acetylcholine; Adult; Aged; Atropine; Diamines; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Mammary Arteries; Middle Aged; Muscarinic Antagonists; Piperidines; Pirenzepine; Receptors, Muscarinic; Vasodilation; Vasodilator Agents | 2001 |
Coupling of M(2) muscarinic receptors to Src activation in cultured canine colonic smooth muscle cells.
Topics: Animals; Atropine; Cells, Cultured; Colon; Dogs; Female; Gene Expression Regulation, Enzymologic; Genistein; Male; Mitogen-Activated Protein Kinases; Muscarinic Antagonists; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Pyrazoles; Pyrimidines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; src-Family Kinases; Teprotide | 2002 |
Acetylcholine-induced contractions in the perforating branch of the human internal mammary artery: protective role of the vascular endothelium.
Topics: Acetylcholine; Atropine; Diamines; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Indomethacin; Mammary Arteries; Middle Aged; Muscarinic Antagonists; Nitric Oxide Synthase; omega-N-Methylarginine; Phenylephrine; Piperidines; Pirenzepine; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2002 |
The nature of the acetylcholine and 5-hydroxytryptamine receptors in buccal smooth muscle of the pest slug Deroceras reticulatum.
Topics: Acetylcholine; Animals; Atropine; Choline; Esters; Gallamine Triethiodide; Hexamethonium; Mollusca; Mouth; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pirenzepine; Receptors, Muscarinic; Receptors, Nicotinic; Receptors, Serotonin; Scopolamine; Serotonin; Serotonin Antagonists; Succinylcholine; Tubocurarine | 2002 |
Activation of nitric oxide synthase through muscarinic receptors in rat parotid gland.
Topics: Amylases; Animals; Atropine; Binding, Competitive; Carbachol; Cell Membrane; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Male; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Parotid Gland; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Specific Pathogen-Free Organisms | 2002 |
Muscarinic receptor knockout mice: role of muscarinic acetylcholine receptors M(2), M(3), and M(4) in carbamylcholine-induced gallbladder contractility.
Topics: Animals; Anti-Arrhythmia Agents; Atropine; Carbachol; Cardiovascular Agents; Cholinesterase Inhibitors; Drug Interactions; Gallbladder; Indomethacin; Mice; Mice, Knockout; Muscarinic Antagonists; Muscle Contraction; Neostigmine; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptor, Muscarinic M4; Receptors, Muscarinic | 2002 |
[The effects of the antagonists of muscarinic acetylcholine receptor subtypes in rat brain on urinary bladder contraction].
Topics: Animals; Atropine; Brain; Female; Muscarine; Muscarinic Antagonists; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Urinary Bladder; Urination | 2002 |
Interaction of a new potent anticholinesterasic compound (+/-)huprine X with muscarinic receptors in rat brain.
Topics: Acetylcholine; Aminoquinolines; Animals; Atropine; Binding, Competitive; Cerebral Cortex; Cholinesterase Inhibitors; Dopamine; Heterocyclic Compounds, 4 or More Rings; Hippocampus; In Vitro Techniques; Male; Mecamylamine; Muscarinic Antagonists; Nicotinic Antagonists; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Muscarinic; Synaptosomes | 2002 |
The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts.
Topics: Acetylcholine; Animals; Atropine; Calcium; Calcium Signaling; CHO Cells; Colon; Cricetinae; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Quaternary Ammonium Compounds; Receptor, Muscarinic M3; Receptors, Muscarinic; Time Factors; Vasodilator Agents | 2002 |
PMA decreases the proliferation of retinal cells in vitro: the involvement of acetylcholine and BDNF.
Topics: Acetylcholine; Alkaloids; Amacrine Cells; Animals; Atropine; Benzophenanthridines; Brain-Derived Neurotrophic Factor; Calcium; Carbachol; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Eye Proteins; Growth Inhibitors; Isoenzymes; MAP Kinase Signaling System; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Phenanthridines; Pirenzepine; Protein Kinase C; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic; Retina; Signal Transduction; Tetradecanoylphorbol Acetate | 2003 |
Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the central nervous system: involvement of muscarinic receptors.
Topics: Animals; Atropine; Central Nervous System; Cholinesterase Inhibitors; Cholinesterases; Electric Stimulation; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; Muscarinic Antagonists; Neurons; Patch-Clamp Techniques; Piperidines; Pirenzepine; Pyramidal Cells; Pyridostigmine Bromide; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Receptors, Nicotinic; Soman; Synaptic Transmission | 2003 |
Scintillation proximity assay of inositol phosphates in cell extracts: high-throughput measurement of G-protein-coupled receptor activation.
Topics: Animals; Atropine; Carbachol; Cell Extracts; Cell Line; CHO Cells; Chromatography, Ion Exchange; Cricetinae; GTP-Binding Proteins; Humans; Inositol; Inositol Phosphates; Lithium Chloride; Muscarinic Antagonists; Pirenzepine; Receptors, Muscarinic; Recombinant Proteins; Scintillation Counting; Silicates; Tritium; Yttrium; Yttrium Radioisotopes | 2003 |
Change in muscarinic modulation of transmitter release in the rat urinary bladder after spinal cord injury.
Topics: Animals; Atropine; Electric Stimulation; Female; Muscarinic Antagonists; Neurotransmitter Agents; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M3; Receptors, Muscarinic; Spinal Cord Injuries; Urinary Bladder; Urinary Bladder, Neurogenic | 2003 |
The M4 muscarinic receptor-selective effects on keratinocyte crawling locomotion.
Topics: Animals; Atropine; Cell Movement; Humans; Infant, Newborn; Keratinocytes; Mice; Mice, Knockout; Muscarine; Muscarinic Agonists; Piperidines; Pirenzepine; Receptor, Muscarinic M4; Receptors, Muscarinic; Stimulation, Chemical | 2003 |
Brain muscarinic receptor subtypes mediating water intake and Fos following cerebroventricular administration of bethanecol in rats.
Topics: Animals; Atropine; Bethanechol; Dose-Response Relationship, Drug; Drinking Behavior; Injections, Intraventricular; Male; Muscarinic Agonists; Muscarinic Antagonists; Piperidines; Pirenzepine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Water | 2003 |
The rebound excitation triggered by anticholinergic drugs from ovine pyloric antrum, small bowel and gallbladder.
Topics: Animals; Atropine; Electrodes, Implanted; Electromyography; Fasting; Gallbladder; Gastrointestinal Motility; Hexamethonium; Intestine, Small; Muscarinic Antagonists; Muscle Contraction; Nicotinic Agonists; Pirenzepine; Pyloric Antrum; Receptors, Muscarinic; Receptors, Nicotinic; Sheep | 2003 |
Characterization of muscarinic receptor subtypes in the rostral ventrolateral medulla and effects on morphine-induced antinociception in rats.
Topics: Analgesics, Opioid; Animals; Atropine; Diamines; Male; Mecamylamine; Medulla Oblongata; Microinjections; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Time Factors | 2003 |
6beta-acetoxy nortropane regulated processing of amyloid precursor protein in CHOm1 cells and rat brain.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Atropine; Carbachol; Cerebral Cortex; CHO Cells; Cricetinae; Hippocampus; Immunoblotting; In Vitro Techniques; Male; Muscarinic Agonists; Muscarinic Antagonists; Nortropanes; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptors, Muscarinic | 2003 |
Involvement of cholinoceptors in cadmium-induced endothelial dysfunction.
Topics: Acetylcholine; Administration, Oral; Animals; Aorta, Thoracic; Atropine; Cadmium; Calcimycin; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Gallamine Triethiodide; Glomerular Filtration Rate; Hypertension; Indomethacin; Kidney Cortex; Kidney Diseases; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroprusside; Peripheral Vascular Diseases; Phenylephrine; Pirenzepine; Prostaglandins; Rats; Rats, Wistar; Receptor, Muscarinic M1; Vasodilation | 2003 |
Miniaturization of fluorescence polarization receptor-binding assays using CyDye-labeled ligands.
Topics: Animals; Atropine; Binding, Competitive; Carbocyanines; CHO Cells; Cricetinae; Fluorescence Polarization; Fluorescent Dyes; Humans; Kinetics; Miniaturization; Neurokinin A; Peptides; Pirenzepine; Receptors, Cell Surface; Receptors, Muscarinic; Receptors, Neurokinin-1; Sensitivity and Specificity; Substance P | 2003 |
Aging-related alterations in the contractile responses to acetylcholine, muscarinic cholinoceptors and cholinesterase activities in jejunum and colon of the male Fischer 344 rats.
Topics: Acetylcholine; Aging; Animals; Atropine; Cholinesterases; Colon; Diamines; Dose-Response Relationship, Drug; Gastrointestinal Motility; In Vitro Techniques; Intestine, Large; Jejunum; Male; Muscarinic Antagonists; Muscle, Smooth; Piperidines; Pirenzepine; Rats; Rats, Inbred F344 | 2004 |
Contractile effect of acetylcholine on isolated isthmic segment of fallopian tubes.
Topics: Acetylcholine; Adult; Aged; Atropine; Diamines; Dose-Response Relationship, Drug; Fallopian Tubes; Female; Follicular Phase; Humans; Lidocaine; Luteal Phase; Mecamylamine; Middle Aged; Muscle Contraction; Muscle, Smooth; Nifedipine; Piperidines; Pirenzepine; Postmenopause; Receptors, Muscarinic | 2004 |
Does the cholinergic system modulate gastrointestinal slow waves during less active phases of migrating myoelectric complex in healthy rams?
Topics: Acetylcholine; Animals; Atropine; Carbachol; Cholinergic Agents; Electrodes, Implanted; Electromyography; Fasting; Hexamethonium; Intestine, Small; Male; Myoelectric Complex, Migrating; Pirenzepine; Pyloric Antrum; Receptors, Cholinergic; Sheep; Time Factors | 2003 |
Activation of muscarinic acetylcholine receptors elicits pigment granule dispersion in retinal pigment epithelium isolated from bluegill.
Topics: Adenylyl Cyclase Inhibitors; Animals; Arecoline; Atropine; Carbachol; Colforsin; Cyclic AMP; Cytoplasmic Granules; Light; Muscarinic Agonists; Muscarinic Antagonists; Perciformes; Pigment Epithelium of Eye; Piperidines; Pirenzepine; Quaternary Ammonium Compounds; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Receptors, Muscarinic; Retinal Pigments; Second Messenger Systems; Tropicamide | 2004 |
Intrathecal clonidine inhibits mechanical allodynia via activation of the spinal muscarinic M1 receptor in streptozotocin-induced diabetic mice.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Analgesics; Animals; Atropine; Blood Glucose; Clonidine; Diabetes Mellitus, Experimental; Diamines; Injections, Spinal; Male; Mice; Motor Activity; Muscarinic Agonists; Muscarinic Antagonists; Pain; Pain Threshold; Piperidines; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Spinal Cord; Streptozocin; Stress, Mechanical; Time Factors | 2004 |
Evaluation of drug-muscarinic receptor affinities using cell membrane chromatography and radioligand binding assay in guinea pig jejunum membrane.
Topics: Animals; Atropine; Binding, Competitive; Cell Membrane; Chromatography, Affinity; Drug Interactions; Female; Guinea Pigs; In Vitro Techniques; Jejunum; Male; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Muscarinic | 2005 |
Effects of AF-DX116 and other muscarinic receptor antagonists on orthostatic hypotension in autonomic imbalanced (SART-stressed) rats.
Topics: Animals; Atropine; Atropine Derivatives; Blood Pressure; Cold Temperature; Diamines; Heart Rate; Hypotension, Orthostatic; Male; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Stress, Physiological | 2005 |
The anti-inflammatory effect of peripheral bee venom stimulation is mediated by central muscarinic type 2 receptors and activation of sympathetic preganglionic neurons.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Atropine; Autonomic Fibers, Preganglionic; Bee Venoms; Catecholamines; Cell Count; Choline O-Acetyltransferase; Disease Models, Animal; Drug Interactions; Exudates and Transudates; Hexamethonium; Immunohistochemistry; Inflammation; Leukocytes; Male; Mice; Mice, Inbred ICR; Muscarinic Antagonists; Neurons; Nicotinic Antagonists; Oncogene Proteins v-fos; Oxidopamine; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Spinal Cord; Sympathectomy, Chemical | 2005 |
Expression and localization of muscarinic acetylcholine receptor subtypes in rat efferent ductules and epididymis.
Topics: Animals; Atropine; Carbachol; Cell Membrane; Diamines; Ejaculatory Ducts; Epididymis; Immunohistochemistry; In Vitro Techniques; Male; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic | 2006 |
Cooperative glutamatergic and cholinergic mechanisms generate short-term modifications of synaptic effectiveness in prepositus hypoglossi neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Animals; Animals, Newborn; Atropine; Brain Stem; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoglossal Nerve; In Vitro Techniques; Membrane Potentials; Muscarinic Antagonists; Nerve Net; Neurons; Patch-Clamp Techniques; Pirenzepine; Rats; Synaptic Transmission; Time Factors; Valine | 2005 |
Distribution and function of muscarinic receptor subtypes in the ovine submandibular gland.
Topics: Animals; Atropine; Chorda Tympani Nerve; Electric Stimulation; Female; Immunohistochemistry; Muscarinic Antagonists; Piperidines; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Receptor, Muscarinic M5; Salivation; Sheep; Submandibular Gland; Time Factors; Vasodilation | 2006 |
Pharmacological characterization of muscarinic receptor subtypes mediating vasoconstriction of human umbilical vein.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Atropine; Diamines; Humans; In Vitro Techniques; Piperidines; Pirenzepine; Receptors, Muscarinic; Umbilical Veins; Vasoconstriction | 2006 |
Effects of atropine and pirenzepine on heart rate turbulence.
Topics: Analysis of Variance; Anti-Arrhythmia Agents; Atropine; Female; Heart Conduction System; Heart Rate; Humans; Injections, Intravenous; Male; Middle Aged; Muscarinic Antagonists; Pirenzepine; Statistics, Nonparametric; Ventricular Premature Complexes | 2006 |
Agonist and antagonist sensitivity of non-selective cation channel currents evoked by muscarinic receptor stimulation in bovine ciliary muscle cells.
Topics: Animals; Atropine; Barium; Carbachol; Cattle; Cells, Cultured; Ciliary Body; Dose-Response Relationship, Drug; Membrane Potentials; Microscopy, Fluorescence; Muscarinic Agonists; Muscarinic Antagonists; Muscle Cells; Patch-Clamp Techniques; Piperidines; Pirenzepine; Receptor, Muscarinic M3; TRPC Cation Channels | 2006 |
Muscarinic cholinoceptor activation modulates DNA synthesis and CD40 expression in fibroblast cells.
Topics: Atropine; Calmodulin; Carbachol; CD40 Antigens; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Fibroblasts; Flow Cytometry; Humans; Inositol Phosphates; Muscarinic Agonists; Muscarinic Antagonists; Pirenzepine; Pyrrolidinones; Quinuclidinyl Benzilate; Radioligand Assay; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Receptors, Muscarinic; Trifluoperazine; Type C Phospholipases | 2006 |
Vitamin A deficiency increases airway resistance following C-fiber stimulation.
Topics: Airway Resistance; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Atropine; Capsaicin; Disease Models, Animal; Drug Interactions; Female; Lung; Lung Compliance; Lung Volume Measurements; Nerve Fibers, Unmyelinated; Pirenzepine; Positive-Pressure Respiration; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Sulfur Dioxide; Vitamin A Deficiency | 2007 |
Muscarinic receptor-independent activation of cyclic adenosine monophosphate-dependent protein kinase in rostral ventrolateral medulla underlies the sympathoexcitatory phase of cardiovascular responses during mevinphos intoxication in the rat.
Topics: Animals; Atropine; Blotting, Western; Cardiovascular System; Cholinesterase Inhibitors; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Intracellular Signaling Peptides and Proteins; Male; Medulla Oblongata; Mevinphos; Muscarinic Antagonists; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Time Factors; Tropicamide | 2007 |
Functional expression of M3, a muscarinic acetylcholine receptor subtype, in taste bud cells of mouse fungiform papillae.
Topics: Acetylcholine; Animals; Atropine; Calcium Signaling; Cells, Cultured; Diamines; Electrophysiology; Gene Expression; Inositol 1,4,5-Trisphosphate Receptors; Mice; Mice, Inbred Strains; Muscarinic Antagonists; Patch-Clamp Techniques; Phospholipase C beta; Piperidines; Pirenzepine; Receptor, Muscarinic M3; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; Synaptosomal-Associated Protein 25; Taste Buds; Tropicamide; Vesicular Acetylcholine Transport Proteins | 2008 |
Muscarinic receptors involved in airway vascular leakage induced by experimental gastro-oesophageal reflux.
Topics: Animals; Atropine; Capillary Permeability; Diamines; Female; Ganglionic Blockers; Gastroesophageal Reflux; Guinea Pigs; Hexamethonium; In Vitro Techniques; Male; Muscarinic Antagonists; Nicotinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Receptors, Muscarinic; Receptors, Nicotinic; Regional Blood Flow; Respiratory System | 2008 |
Development of a homogeneous high-throughput live-cell G-protein-coupled receptor binding assay.
Topics: Animals; Atropine; Benzenesulfonates; Biological Assay; Carbocyanines; CHO Cells; Cricetinae; Cricetulus; Fluorescent Dyes; Ligands; Miniaturization; Muscarinic Antagonists; Parasympatholytics; Pirenzepine; Quinuclidinyl Benzilate; Receptor, Muscarinic M1; Receptors, G-Protein-Coupled | 2008 |
Functional characterization of the muscarinic receptors involved in endothelium-dependent relaxation in isolated canine uterine artery.
Topics: Acetylcholine; Animals; Arteries; Atropine; Cholinergic Agents; Diamines; Dogs; Endothelium, Vascular; Female; Hysterectomy; In Vitro Techniques; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Uterus | 2009 |
Spinal cholinergic mechanism of the relieving effects of electroacupuncture on cold and warm allodynia in a rat model of neuropathic pain.
Topics: Animals; Atropine; Cholinergic Agents; Cholinergic Fibers; Cold Temperature; Diamines; Disease Models, Animal; Electroacupuncture; Hot Temperature; Hyperesthesia; Male; Mecamylamine; Neuralgia; Pain Threshold; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Spinal Nerves | 2009 |
Detection of novel functional selectivity at M3 muscarinic acetylcholine receptors using a Saccharomyces cerevisiae platform.
Topics: 3T3 Cells; Animals; Atropine; Gene Expression; Genes, Reporter; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Mice; Muscarinic Antagonists; N-Methylscopolamine; Pirenzepine; Receptor, Muscarinic M3; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2010 |
Role of curcumin in the prevention of cholinergic mediated cortical dysfunctions in streptozotocin-induced diabetic rats.
Topics: Acetylcholinesterase; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antibodies; Atropine; Cerebral Cortex; Choline O-Acetyltransferase; Curcumin; Diabetes Mellitus, Experimental; Diphenylacetic Acids; Gene Expression Regulation; Glucose Transporter Type 3; Male; Maze Learning; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Insulin; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Receptors, Cholinergic; Receptors, Nicotinic; Superoxide Dismutase | 2011 |
The interaction between tropomyosin-related kinase B receptors and presynaptic muscarinic receptors modulates transmitter release in adult rodent motor nerve terminals.
Topics: Acetylcholine; Animals; Atropine; Brain-Derived Neurotrophic Factor; Bungarotoxins; Carbazoles; Diamines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indole Alkaloids; Male; Mice; Motor Neurons; Muscarinic Antagonists; Nerve Growth Factors; Neuromuscular Junction; Neurotransmitter Agents; Pirenzepine; Qa-SNARE Proteins; Receptor, Nerve Growth Factor; Receptor, trkB; Receptors, Muscarinic | 2010 |
An evidence-based update on myopia and interventions to retard its progression.
Topics: Animals; Atropine; Disease Models, Animal; Disease Progression; Female; Humans; Male; Muscarinic Antagonists; Myopia; Orthokeratologic Procedures; Pirenzepine; Prevalence; Risk Factors; Sensory Deprivation | 2011 |
Intracellular distribution of functional M(1) -muscarinic acetylcholine receptors in N1E-115 neuroblastoma cells.
Topics: Animals; Atropine; Blotting, Western; Calcium; Carbachol; Cell Line, Tumor; Elapid Venoms; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Immunohistochemistry; Inositol Phosphates; Kinetics; Mice; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Neuroblastoma; Peptides, Cyclic; Pirenzepine; Protein Kinase Inhibitors; Quinuclidinyl Benzilate; Receptor, Muscarinic M1; Receptors, Cell Surface | 2011 |
Role of M1 receptor in regulation of gastric fundus smooth muscle contraction.
Topics: Animals; Atropine; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Gastric Fundus; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Statistics as Topic | 2011 |
Urothelial/lamina propria spontaneous activity and the role of M3 muscarinic receptors in mediating rate responses to stretch and carbachol.
Topics: Animals; Atropine; Benzhydryl Compounds; Benzofurans; Carbachol; Cresols; Diamines; Mandelic Acids; Mucous Membrane; Muscarinic Antagonists; Muscle Contraction; Phenylpropanolamine; Piperidines; Pirenzepine; Pyrrolidines; Quinuclidines; Receptor, Muscarinic M3; Solifenacin Succinate; Stress, Mechanical; Swine; Tetrahydroisoquinolines; Tolterodine Tartrate; Urinary Bladder; Urothelium | 2011 |
Activation of muscarinic receptors increases the activity of the granule neurones of the rat dorsal cochlear nucleus--a calcium imaging study.
Topics: Acetylcholine; Action Potentials; Animals; Atropine; Calcium; Carbachol; Cochlear Nucleus; Female; Male; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Patch-Clamp Techniques; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic | 2012 |
Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus.
Topics: Action Potentials; Animals; Atropine; CA1 Region, Hippocampal; Calcium; Calcium Channels, L-Type; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Models, Neurological; Muscarinic Antagonists; Neural Inhibition; Neuronal Plasticity; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Potentials | 2012 |
An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action.
Topics: Animals; Antidotes; Atropine; Cell Line, Tumor; Cholinergic Antagonists; Cholinesterase Reactivators; Drug Evaluation, Preclinical; Emetine; Glycopyrrolate; High-Throughput Screening Assays; Humans; Lethal Dose 50; Metoclopramide; Neostigmine; Organophosphates; Parathion; Pirenzepine; Pralidoxime Compounds; Zebrafish | 2013 |
Different muscarinic receptor subtypes modulate proliferation of primary human detrusor smooth muscle cells via Akt/PI3K and map kinases.
Topics: Aged; Atropine; Benzofurans; Carbachol; Cell Proliferation; Cells, Cultured; Cholinergic Agonists; Gene Expression; Humans; Male; Mitogen-Activated Protein Kinases; Muscarinic Antagonists; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Piperidines; Pirenzepine; Proto-Oncogene Proteins c-akt; Pyrrolidines; Receptors, Muscarinic; RNA, Messenger; Urinary Bladder | 2013 |
Comparison of subcellular distribution and functions between exogenous and endogenous M1 muscarinic acetylcholine receptors.
Topics: Analysis of Variance; Animals; Atropine; Blotting, Western; Calcium; CHO Cells; Cricetinae; Cricetulus; Mice; Microscopy, Confocal; N-Methylscopolamine; Organelles; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Receptor, Muscarinic M1; Recombinant Proteins; Tritium | 2013 |
Activation of M1 mAChRs by lesatropane rescues glutamate neurotoxicity in PC12 cells via PKC-mediated phosphorylation of ERK1/2.
Topics: Animals; Atropine; Cell Survival; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Neurons; Neuroprotective Agents; PC12 Cells; Phosphorylation; Pirenzepine; Protein Kinase C; Rats; Receptor, Muscarinic M1; Tropanes | 2013 |
Paradoxical neostigmine-induced TOFfade: on the role of presynaptic cholinergic and adenosine receptors.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Diamines; Diaphragm; In Vitro Techniques; Male; Muscarinic Antagonists; Neostigmine; Phrenic Nerve; Pirenzepine; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Cholinergic; Receptors, Presynaptic; Receptors, Purinergic P1; Synaptic Transmission; Triazines; Triazoles | 2014 |
Muscarinic M1 receptors regulate propofol modulation of GABAergic transmission in rat ventrolateral preoptic neurons.
Topics: Anesthetics, Intravenous; Animals; Atropine; GABAergic Neurons; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Miniature Postsynaptic Potentials; Muscarinic Antagonists; Pirenzepine; Preoptic Area; Propofol; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1 | 2015 |
In vitro effects of the organophosphorus pesticide malathion on the reactivity of rat aorta.
Topics: Animals; Aorta, Thoracic; Atropine; Endothelium, Vascular; Epoprostenol; Gallamine Triethiodide; In Vitro Techniques; Indomethacin; Malathion; Male; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pesticides; Phenylephrine; Piperidines; Pirenzepine; Rats, Wistar; Vasodilator Agents | 2014 |
Muscarinic presynaptic modulation in GABAergic pallidal synapses of the rat.
Topics: Animals; Atropine; Cholinergic Neurons; Globus Pallidus; Inhibitory Postsynaptic Potentials; Intercellular Signaling Peptides and Proteins; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Peptides; Pirenzepine; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Muscarinic M1; Synapses | 2015 |
Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs.
Topics: Atropine; Cell Line; Humans; Muscarinic Antagonists; Pirenzepine; Protein Multimerization; Receptor, Muscarinic M1 | 2016 |
Early changes in M2 muscarinic acetylcholine receptors (mAChRs) induced by sarin intoxication may be linked to long lasting neurological effects.
Topics: Animals; Atropine; Cerebral Cortex; Female; Male; Pirenzepine; Radioligand Assay; Rats; Receptor, Muscarinic M2; Sarin; Sex Characteristics; Time Factors; Trimedoxime; Tritium | 2018 |
The Screening of Anticholinergic Accumulation by Traditional Chinese Medicine.
Topics: Animals; Atropine; Cimetidine; Drugs, Chinese Herbal; Ephedra sinica; Humans; Male; Medicine, Chinese Traditional; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Inbred WKY; Receptors, Cholinergic; Risperidone; Theophylline | 2017 |
Cholinergic regulation of proliferation of the urothelium in response to E. coli lipopolysaccharide exposition.
Topics: Animals; Apoptosis; Atropine; Caspase 3; Cell Line; Cell Proliferation; Cholinergic Agents; Diamines; Escherichia coli; Female; Humans; Immunity, Innate; Lipopolysaccharides; Pirenzepine; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, Muscarinic; Toll-Like Receptor 4; Urothelium | 2018 |
Role of rho-kinase (ROCK) in tonic but not phasic contraction in the frog stomach smooth muscle.
Topics: Amides; Animals; Atropine; Carbachol; Gastric Mucosa; Muscle Contraction; Muscle, Smooth; Nifedipine; Organ Culture Techniques; Pirenzepine; Pyridines; Ranidae; rho-Associated Kinases | 2018 |
Effects of time-of-day on inhibition of lens-induced myopia by quinpirole, pirenzepine and atropine in chicks.
Topics: Animals; Animals, Newborn; Atropine; Chickens; Circadian Rhythm; Dopamine Agonists; Drug Administration Schedule; Eye; Intravitreal Injections; Muscarinic Antagonists; Myopia; Pirenzepine; Quinpirole; Sensory Deprivation | 2019 |
Novel choline analog 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol produces sympathoinhibition, hypotension, and antihypertensive effects.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Atropine; Blood Pressure; Heart Rate; Hypertension; Hypotension; Male; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperazines; Piperidines; Pirenzepine; Pyrazoles; Rats, Inbred SHR; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M3 | 2019 |
Practice patterns to decrease myopia progression differ among paediatric ophthalmologists around the world.
Topics: Atropine; Behavior Therapy; Child, Preschool; Disease Progression; Eyeglasses; Female; Global Health; Humans; Male; Mydriatics; Myopia; Ophthalmologists; Pediatrics; Pirenzepine; Practice Patterns, Physicians'; Surveys and Questionnaires | 2020 |
Muscarinic M1 and M2 receptor subtypes play opposite roles in LPS-induced septic shock.
Topics: Animals; Atropine; Cytokines; Lipopolysaccharides; Liver; Lung; Macrophages; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Shock, Septic; Tumor Necrosis Factor-alpha | 2019 |
Transcriptome-based insights into gene networks controlling myopia prevention.
Topics: Alternative Splicing; Animals; Atropine; Chickens; Circadian Rhythm; Early Growth Response Protein 1; Eye; Gene Expression Regulation; Gene Regulatory Networks; Humans; Janus Kinases; Male; Models, Biological; Myopia; Phosphinic Acids; Pirenzepine; Pyridines; Reproducibility of Results; Retina; STAT Transcription Factors; Tetrahydronaphthalenes; Time Factors; Transcriptome | 2021 |
Balanced modulation of neuromuscular synaptic transmission via M1 and M2 muscarinic receptors during inhibition of cholinesterases.
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterases; Diamines; Diaphragm; Disease Models, Animal; Mice; Muscarinic Antagonists; Muscle Contraction; Muscle Weakness; Paraoxon; Parasympatholytics; Pirenzepine; Protective Agents; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Signal Transduction; Synaptic Transmission; Treatment Outcome | 2022 |