Page last updated: 2024-09-05

atropine and orphenadrine

atropine has been researched along with orphenadrine in 23 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(orphenadrine)
Trials
(orphenadrine)
Recent Studies (post-2010) (orphenadrine)
26,7111,2591,6975416159

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)orphenadrine (IC50)
Solute carrier family 22 member 2Homo sapiens (human)2.5
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.534
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.666
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.376
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.125
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.028
Alpha-2A adrenergic receptorHomo sapiens (human)2.156
Cytochrome P450 2D6Homo sapiens (human)0.4
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.148
Alpha-2B adrenergic receptorHomo sapiens (human)1.895
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.175
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.666
Histamine H2 receptorHomo sapiens (human)6.961
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.436
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.534
Sodium-dependent serotonin transporterHomo sapiens (human)0.458
Histamine H1 receptorHomo sapiens (human)1.241
5-hydroxytryptamine receptor 2BHomo sapiens (human)3.391
5-hydroxytryptamine receptor 6Homo sapiens (human)1.121
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.8511

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199017 (73.91)18.7374
1990's1 (4.35)18.2507
2000's2 (8.70)29.6817
2010's3 (13.04)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Mendelson, G1
Bowers, MB; Roth, RH1
Berry, WK; Davies, DR; Gordon, JJ1
Brocklehurst, JC; Killane, JB1
Brocklehurst, JC; Dillane, JB1
Costall, B; Naylor, RJ1
Florio, V; Longo, VG1
Ban, T; Hojo, M1
Boman, K; Meurman, T1
Schnieden, H; Truslove, GM1
Collins, AJ; Horlington, M1
Camarasa, J; Camins, A; Canudas, AM; Escubedo, E; Pallàs, M; Pubill, D; Sureda, FX1
GOLDSTEIN, L; JENNEY, EH; MURPHREE, HB; PFEIFFER, CC1
DRAPER, IT; JOHNS, RJ1
BOISSIER, JR; SIMON, P1
BOSKOVIC, B; CATOVIC, S; STERN, P1
HERZ, A; HOFSTETTER, A; KURZ, H; TESCHEMACHER, H1

Reviews

1 review(s) available for atropine and orphenadrine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

22 other study(ies) available for atropine and orphenadrine

ArticleYear
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Letter: Hallucinogenic plants.
    The Medical journal of Australia, 1975, Jun-28, Volume: 1, Issue:26

    Topics: Acridines; Atropine; Hallucinations; Humans; Orphenadrine; Plant Poisoning; Psychoses, Substance-Induced; Tacrine

1975
Interaction of atropine-like drugs with dopamine-containing neurones in rat brain.
    British journal of pharmacology, 1972, Volume: 44, Issue:2

    Topics: Animals; Atropine; Benztropine; Brain; Chlorpromazine; Dopamine; Homovanillic Acid; Male; Methyltyrosines; Neurons; Orphenadrine; Phenothiazines; Procyclidine; Rats; Time Factors; Trihexyphenidyl

1972
Protection of animals against soman (1,2,2-trimethylpropyl methylphosphono-fluoridate) by pretreatment with some other organophosphorus compounds, followed by oxime and atropine.
    Biochemical pharmacology, 1971, Volume: 20, Issue:1

    Topics: Amitriptyline; Animals; Atropine; Bromides; Carbamates; Cholinesterase Inhibitors; Diphosphates; Drug Antagonism; Female; Fluorine; Guinea Pigs; Hydroxamic Acids; Isoflurophate; Lethal Dose 50; Nitrates; Nitrophenols; Nitroso Compounds; Organophosphonates; Organophosphorus Compounds; Orphenadrine; Oximes; Parasympatholytics; Physostigmine; Poisoning; Pyridinium Compounds; Rabbits; Rats; Salicylates; Scopolamine; Species Specificity; Sulfonic Acids; Sulfuric Acids; Thiazoles; Time Factors

1971
Studies of the female bladder in old age. IV. Drug effects in urinary incontinence.
    Gerontologia clinica, 1967, Volume: 9, Issue:3

    Topics: Aged; Atropine; Ephedrine; Female; Humans; Indenes; Manometry; Muscles; Orphenadrine; Pempidine; Pentolinium Tartrate; Quaternary Ammonium Compounds; Urinary Incontinence

1967
Studies of the female bladder in old age. IV. Drug effects in urinary incontinence.
    Gerontologia clinica, 1967, Volume: 9, Issue:3

    Topics: Aged; Atropine; Ephedrine; Female; Humans; Indenes; Manometry; Muscles; Orphenadrine; Pempidine; Pentolinium Tartrate; Quaternary Ammonium Compounds; Urinary Incontinence

1967
Modification of amphetamine effects by intracerebrally administered anticholinergic agents.
    Life sciences. Pt. 1: Physiology and pharmacology, 1972, Mar-01, Volume: 11, Issue:5

    Topics: Animals; Atropine; Behavior, Animal; Corpus Striatum; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Ethylamines; Globus Pallidus; Humans; Injections; Injections, Intraperitoneal; Male; Motor Activity; Orphenadrine; Parasympatholytics; Pyridones; Rats; Stereotyped Behavior; Time Factors

1972
Effects of amantadine and of some synthetic antiparkinsonian drugs on the behavioral response to L-DOPA in mice.
    Physiology & behavior, 1971, Volume: 6, Issue:4

    Topics: Amantadine; Amitriptyline; Animals; Antiparkinson Agents; Atropine; Behavior, Animal; Dihydroxyphenylalanine; Diphenhydramine; Drug Synergism; Imipramine; Mice; Orphenadrine; Parasympatholytics; Pargyline; Trihexyphenidyl

1971
Comparison of the electroencephalographic and motor effects of orphenadrine, an antiparkinson agent.
    Japanese journal of pharmacology, 1968, Volume: 18, Issue:4

    Topics: Animals; Arousal; Atropine; Brain; Chlorpromazine; Depression, Chemical; Electric Stimulation; Electroencephalography; Injections, Intravenous; Male; Mephenesin; Motor Activity; Orphenadrine; Pentobarbital; Rabbits; Scopolamine; Stimulation, Chemical; Tectum Mesencephali

1968
Investigations on the effect of some drugs on the Parkinsonian rigidity.
    Acta neurologica Scandinavica, 1970, Volume: 46, Issue:1

    Topics: Adult; Atropine; Biperiden; Female; Humans; Injections, Intravenous; Male; Middle Aged; Muscle Contraction; Orphenadrine; Oscillometry; Parasympatholytics; Parkinson Disease; Procyclidine; Tropanes

1970
The effect of some drugs on genetic tremor in the mouse.
    European journal of pharmacology, 1970, Jul-01, Volume: 11, Issue:1

    Topics: Acetylcholine; Age Factors; Animals; Atropine; Barbiturates; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Dopamine; Female; Genetics; Histocytochemistry; Male; Methyldopa; Mice; Norepinephrine; Orphenadrine; Scopolamine; Serotonin; Tremor

1970
A sequential screning test based on the running component of audiogenic seizures in mice, including reference compound PD50 values.
    British journal of pharmacology, 1969, Volume: 37, Issue:1

    Topics: Acetazolamide; Animals; Anticonvulsants; Atropine; Chloral Hydrate; Chlordiazepoxide; Ethosuximide; Haloperidol; Hydroxybutyrates; Hypnotics and Sedatives; Meprobamate; Methods; Mice; Motor Activity; Orphenadrine; Phenobarbital; Phenytoin; Primidone; Sound

1969
Antiparkinsonism drugs.
    The Medical letter on drugs and therapeutics, 1965, Mar-12, Volume: 7, Issue:6

    Topics: Antidepressive Agents; Atropine; Diphenhydramine; Humans; Orphenadrine; Parasympatholytics; Parkinson Disease; Promethazine; Scopolamine; Trihexyphenidyl

1965
Assessment of the adrenergic effects of orphenadrine in rat vas deferens.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:3

    Topics: Adrenergic Agents; Animals; Atropine; Binding, Competitive; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Epididymis; Fluoxetine; In Vitro Techniques; Ligands; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Norepinephrine; Orphenadrine; Phencyclidine; Prazosin; Rats; Rats, Sprague-Dawley; Vas Deferens

1999
ELECTROENCEPHALOGRAPHIC ASSAY OF ANTI-ANXIETY DRUGS.
    Archives of general psychiatry, 1964, Volume: 10

    Topics: Adolescent; Anti-Anxiety Agents; Atropine; Chlordiazepoxide; Diphenhydramine; Electroencephalography; Meprobamate; Orphenadrine; Pharmacology; Placebos

1964
THE DISORDERED MOVEMENT IN PARKINSONISM AND THE EFFECT OF DRUG TREATMENT.
    Bulletin of the Johns Hopkins Hospital, 1964, Volume: 115

    Topics: Atropine; Dextroamphetamine; Diphenhydramine; Drug Therapy; Geriatrics; Humans; Kinetics; Motor Skills; Movement Disorders; Orphenadrine; Parasympatholytics; Parkinsonian Disorders; Reaction Time; Trihexyphenidyl

1964
[EXPERIMENTAL ANTICATALEPTIC ACTION OF SOME ANTIPARKINSONIAN AGENTS].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1964, Volume: 158

    Topics: Antiparkinson Agents; Atropine; Catalepsy; Nortropanes; Orphenadrine; Parasympatholytics; Pharmacology; Prochlorperazine; Rats; Research; Scopolamine; Toxicology

1964
THE SITE OF ACTION OF ANTIPARKINSONISM DRUGS.
    International journal of neuropharmacology, 1964, Volume: 3

    Topics: Acetylcholine; Animals; Anterior Horn Cells; Anticonvulsants; Atropine; Carbachol; Cell Biology; Heterocyclic Compounds; Mice; Orphenadrine; Research; Scopolamine; Spinal Cord; Tremor; Tubocurarine

1964
THE IMPORTANCE OF LIPID-SOLUBILITY FOR THE CENTRAL ACTION OF CHOLINOLYTIC DRUGS.
    International journal of neuropharmacology, 1965, Volume: 4

    Topics: Atropine; Benactyzine; Blood-Brain Barrier; Brain; Cholinergic Antagonists; Diphenhydramine; Electroencephalography; Lipids; Mice; Morphine; Orphenadrine; Parasympatholytics; Parasympathomimetics; Pharmacology; Pupil; Rabbits; Rats; Research; Scopolamine; Solubility

1965