Compounds > atropine
Page last updated: 2024-09-05

atropine and obidoxime chloride

atropine has been researched along with obidoxime chloride in 98 studies

Compound Research Comparison

Studies
(atropine)		Trials
(atropine)		Recent Studies (post-2010)
(atropine)		Studies
(obidoxime chloride)		Trials
(obidoxime chloride)		Recent Studies (post-2010) (obidoxime chloride)
26,7111,2591,697333657

Research

Studies (98)

TimeframeStudies, this research(%)All Research%
pre-199034 (34.69)18.7374
1990's21 (21.43)18.2507
2000's25 (25.51)29.6817
2010's16 (16.33)24.3611
2020's2 (2.04)2.80

Authors

AuthorsStudies
Wessling, U1
Bertram, U; Kasten, A; Lüllmann, H; Ziegler, A1
Brüner, H; Gandawidjaja, L; Hettwer, H; Oldiges, H1
Jagiełlłlo-Wójtowicz, E; Kleinrok, Z; Sieklucka-Dziuba, M1
Haase, W; Vetterlein, F1
Gidyńska, T; Grudzińska, E; Rump, S1
Grubbauer, HM; Kellerer, K1
Galecka, E; Grudzinska, E; Ilczuk, I; Rabsztyn, T; Rump, S1
Egyed, MN; Eilat, A; Malkinson, M; Shlosberg, A1
Odegaard, S; Torjusen, B1
Bak, W; Borkowska, G; Faff, J; Rump, S; Szymańska, T1
Adler, M; Levy, I; Teitelman, U1
Przezdziak, J; Wisniewska, W1
Bajgar, J; Hrdina, V; Jakl, A; Patocka, J1
Clement, JG2
Malacrida, R; Quadri, F1
Bajgar, J; Fusek, J; Jakl, A; Patocka, J1
Alioth-Streichenberg, CM; Bodmer, DM; Waser, PG1
Galecka, E; Gidynska, T; Raszewski, W; Rump, S1
Hänninen, O; Kaliste-Korhonen, E; Ryhänen, R; Ylitalo, P1
Lund, C; Monteagudo, FS1
König, A; Krügel, M; Oldiges, H; Schoene, K1
Gil, R; Valdés, S; Vukusic, A1
Haavik, TK; Ihlen, H1
Hopmann, G; Wanke, H1
Andersen, RA; Barstad, JA1
Edery, H; Guertzenstein, PG1
Ember, M; Gál, G; Mindszenty, L; Rengei, B1
Inns, RH; Leadbeater, L1
Dierkes-Tizek, U; Glaser, U; Hettwer, H; Oldiges, H1
Ardab'eva, TV; Khramova, EA; Prozorovskiĭ, VB1
Nienartowicz, B; Nowicka, J; Prandota, J1
Rudak-Zakrzewska, A1
Konietzko, H1
Hapke, HJ1
Gajewski, D; Grudzińska, E1
Lüllmann, H; Schmaus, H; Staemmler, C; Ziegler, A1
Kleine, A; Szinicz, L; Worek, F1
Bajgar, J; Kassa, J3
Harpf, M; Pohjola, J1
Kirchner, T; Szinicz, L; Worek, F1
Almog, S; Lifshitz, M; Rotenberg, M; Shahak, E; Sofer, S; Tamiri, T1
Jokanović, M; Maksimović, M1
Bielavský, J; Kassa, J1
Eyer, P; Felgenhauer, N; Hibler, A; Pfab, R; Thiermann, H; Worek, F; Zilker, T1
Kostrzewa, A; Perlik-Gattner, I1
Fjaerli, HO; Jacobsen, D; Kowalczyk, M; Meidel, N; Rolfsjord, LB; Stromme, JH1
Kassa, J2
Kassa, J; Koupilová, M2
Bartelink, AK; Boon, ES; Hens, JJ; Lau, HS; Vos, EM1
Kassa, J; Krejcová, G1
Bentur, Y; Raikhlin-Eisenkraft, B; Singer, P1
Kassa, J; Krejèová, G1
JAQUES, R1
HEILBRONN, E; TOLAGEN, B1
Huang, S; Qiu, Z; Shi, Y; Zhao, D1
Bilsel, G; Bilsel, M; Gören, AC; Karaka, D; Yenisoy-Karaka, S1
Abdi, M; Abdollahi, M; Pajoumand, A; Rezaie, A; Shadnia, S1
Antonijevic, B; Bokonjic, D; Milovanovic, ZA; Nedeljkovic, M; Stefanovic, D; Stojiljkovic, MP1
Karasova, J; Kassa, J2
Karasova, J; Kassa, J; Kuca, K; Musilek, K1
Humlicek, V; Kassa, J1
Klehr, HU; Lewalter, T; Lüderitz, B; Nickenig, G; Rabe, C; Schrickel, JW1
Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F1
Abouzaid, M; Bond, GR; El Guindi, M; El Seddawy, A; Gamaluddin, H; Pièche, S; Sakr, M; Sonicki, Z; Youssef, A1
Bajgar, J; Karasova, J; Kassa, J; Kuca, K; Musilek, K1
Desruelles, D; Lissens, W; Sabbe, MB1
Abdalla, MS; Badawy, SM; El-Naggar, Ael-R; El-Sebaey, AS1
Bajgar, J; Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Tesarova, S1
Dubey, DK; Ganesan, K; Gupta, PK; Mazumder, A; Sharma, R; Vijayaraghavan, R1
Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Pohanka, M1
Filip, R; Raszewski, G1
Eyer, F; Eyer, P; Felgenhauer, N; Haberkorn, M; Thiermann, H; Worek, F; Zilker, T1
Eyer, F; Eyer, P; Felgenhauer, N; Thiermann, H; Worek, F; Zilker, T1
Joosen, MJ; van der Schans, MJ; van Helden, HP1
Fusek, J; Jun, D; Kuca, K; Kumar, UK; Soukup, O; Tobin, G1
Esparza-Ceseña, MJ; Prieto-Miranda, SE1
Joosen, MJ; Smit, AB; van Helden, HP1
Bajgar, J; Capek, L; Fusek, J; Hajek, P; Jun, D; Kassa, J; Krs, O; Kuca, K; Paseka, A; Slizova, D; Zdarova, JK1
Daniels, D; Eisenkraft, A; Gilat, E; Kadar, T; Kapon, J; Krivoy, A; Last, D; Maier, S; Makarovski, I; Mardor, Y; Ramaty, E; Rosman, Y; Salomon, S; Schein, O; Shilderman, EB; Shneor, R; Shrot, S; Tamar, G1
Sanaei-Zadeh, H1
Karasova, JZ; Kassa, J; Misik, J1
Killi, UK; Kuca, K; Soukup, O; Tobin, G; Winder, M; Wsol, V1
Bar-Klein, G; Biala, Y; Daninos, M; Friedman, A; Kamintsky, L; Kassirer, M; Krivoy, A; Lavon, O; Makarovsky, I; Ramaty, E; Rosman, Y; Shrot, S; Statlender, L; Yaari, Y1
Horova, A; Kassa, J; Matouskova, L; Musilek, K; Sepsova, V1
Cohen, Y; Eisenkraft, A; Kadar, T; Kassirer, M; Milk, N; Rosman, Y; Shiyovich, A; Shrot, S; Tauber, M1
Babin, MC; Jett, DA; Platoff, GE; Snider, TH; Yeung, DT1
Bird, M; Green, AC; Kassa, J; Tattersall, JEH; Timperley, CM; Williams, RL1
Cochrane, L; Cornelissen, AS; Joosen, MJA; Klaassen, SD; Shearer, JD; Skiadopoulos, MH; van Groningen, T; Verheij, E1
Bloch-Shilderman, E; Cohen, L; Egoz, I; Gez, R; Gutman, H; Nili, U; Rabinovitz, I; Yacov, G1
Amend, N; John, H; Koller, M; Kranawetvogl, T; Langgartner, J; Mögele-Schmid, C; Pflügler, C; Siegert, M; Thiermann, H; Wille, T; Worek, F1
Barry, J; Bohnert, S; Cochrane, L; Cornelissen, AS; Joosen, MJA; Kentrop, J; Klaassen, SD; Savransky, V; van Groningen, T1

Trials

2 trial(s) available for atropine and obidoxime chloride

ArticleYear
Benefits of magnesium sulfate in the management of acute human poisoning by organophosphorus insecticides.
    Human & experimental toxicology, 2004, Volume: 23, Issue:12

    Topics: Adolescent; Adult; Aged; Atropine; Cholinesterase Reactivators; Drug Therapy, Combination; Female; Humans; Insecticides; Magnesium Sulfate; Male; Middle Aged; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Pralidoxime Compounds; Single-Blind Method

2004
A clinical decision aid for triage of children younger than 5 years and with organophosphate or carbamate insecticide exposure in developing countries.
    Annals of emergency medicine, 2008, Volume: 52, Issue:6

    Topics: Atropine; Carbamates; Child, Preschool; Cholinesterase Reactivators; Decision Making; Developing Countries; Egypt; Environmental Exposure; Female; Humans; Infant; Insecticides; Male; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Poison Control Centers; Poisoning; Prospective Studies; Triage

2008

Other Studies

96 other study(ies) available for atropine and obidoxime chloride

ArticleYear
[Poisoning with an insecticide].
    Krankenpflege (Frankfurt am Main, Germany), 1979, Volume: 33, Issue:6

    Topics: Adult; Atropine; Humans; Insecticides; Male; Nursing Care; Obidoxime Chloride; Organothiophosphorus Compounds; Suicide, Attempted

1979
Improved treatment of organophosphate intoxication by use of scopolamine or dexetimide.
    Experientia, 1977, Sep-15, Volume: 33, Issue:9

    Topics: Animals; Atropine; Dexetimide; Drug Therapy, Combination; Isoflurophate; Mice; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Piperidines; Rabbits; Scopolamine

1977
[Possible combinations of antidotal therapy in rats following intoxication with phosphoric acid esters (author's transl)].
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:10

    Topics: Actihaemyl; Animals; Antidotes; Atropine; Drug Therapy, Combination; Female; Obidoxime Chloride; Organophosphate Poisoning; Rats

1977
The influence of dfp, atropine and toxogonine on tryptophan pyrolase activity in mouse liver.
    Archivum immunologiae et therapiae experimentalis, 1977, Volume: 25, Issue:6

    Topics: Animals; Atropine; Isoflurophate; Liver; Male; Mice; Obidoxime Chloride; Oximes; Tryptophan Oxygenase

1977
Regional blood flow determinations in the rat during paraoxon-poisoning and treatment with atropine and obidoxime.
    Toxicology, 1979, Volume: 12, Issue:2

    Topics: Animals; Atropine; Blood Circulation; Male; Microspheres; Obidoxime Chloride; Oximes; Paraoxon; Rats; Regional Blood Flow

1979
Therapeutic value of anticonvulsant drugs in poisonings with an organophosphate.
    Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 238, Issue:2

    Topics: Animals; Anticonvulsants; Atropine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Isoflurophate; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Rats

1979
[Poisoning with phosphorus compounds (chlorphenvinphos)].
    Padiatrie und Padologie, 1975, Volume: 10, Issue:4

    Topics: Atropine; Child, Preschool; Coma; Electric Stimulation Therapy; Humans; Insecticides; Male; Obidoxime Chloride; Organophosphorus Compounds; Oxygen Inhalation Therapy; Poisoning; Pulmonary Edema; Time Factors

1975
New trends in experimental therapy of organophosphate intoxications.
    Environmental quality and safety. Supplement, 1975, Volume: 3

    Topics: Animals; Atropine; Benzoates; Diazepam; Drug Therapy, Combination; Female; Isoflurophate; Lethal Dose 50; Obidoxime Chloride; Phthalimides; Poisoning; Quaternary Ammonium Compounds; Rats; Time Factors

1975
Some considerations in the treatment of diazinon poisoned goslings.
    Clinical toxicology, 1976, Volume: 9, Issue:2

    Topics: Animals; Atropine; Diazinon; Geese; Insecticides; Obidoxime Chloride; Poultry Diseases; Pralidoxime Compounds

1976
[Poisoning by cholinesterase inhibiting insecticides].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Jun-20, Volume: 96, Issue:17-18

    Topics: Atropine; Cholinesterase Inhibitors; Humans; Insecticides; Male; Middle Aged; Obidoxime Chloride; Poisoning; Suicide, Attempted

1976
Efficacy of repeated pharmacotherapy in experimental acute poisonings with fluostigmine.
    Archives of toxicology, 1976, Aug-18, Volume: 35, Issue:4

    Topics: Animals; Antidotes; Atropine; Cyclopentanes; Diazepam; Diethylamines; Isoflurophate; Obidoxime Chloride; Rats

1976
Treatment of massive poisoning by the organophosphate pesticide methidathion.
    Clinical toxicology, 1975, Volume: 8, Issue:3

    Topics: Adult; Atropine; Cephalothin; Gastric Lavage; Humans; Hydrocortisone; Insecticides; Male; Obidoxime Chloride; Organothiophosphorus Compounds; Parenteral Nutrition, Total; Poisoning; Respiration, Artificial; Vitamin K

1975
[Case of acute poisoning with an organophosphate].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1975, Jun-15, Volume: 28, Issue:12

    Topics: Acute Disease; Atropine; Humans; Insecticides; Male; Middle Aged; Obidoxime Chloride; Organophosphorus Compounds; Poisoning

1975
Antidotal therapy and changes of acetylcholinesterase activity following isopropyl methylphosphonofluoridate intoxication in mice.
    Acta biologica et medica Germanica, 1975, Volume: 34, Issue:6

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Sarin; Trimedoxime

1975
Efficacy of various oximes against GF (cyclohexyl methylphosphonofluoridate) poisoning in mice.
    Archives of toxicology, 1992, Volume: 66, Issue:2

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; In Vitro Techniques; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Nervous System Diseases; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds

1992
[Poisoning with cholinesterase inhibitors].
    Schweizerische medizinische Wochenschrift, 1990, Feb-10, Volume: 120, Issue:6

    Topics: Adult; Atropine; Cholinesterase Inhibitors; Drug Therapy, Combination; Female; Fonofos; Gastric Lavage; Humans; Insecticides; Intubation, Intratracheal; Obidoxime Chloride; Respiration, Artificial; Respiratory Insufficiency

1990
Efficacy of various pretreatment and therapy regimens against soman lethality in mice.
    Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove, 1991, Volume: 34, Issue:3

    Topics: Animals; Atropine; Diazepam; Female; Male; Mice; Obidoxime Chloride; Poisoning; Pyridostigmine Bromide; Soman; Trihexyphenidyl; Trimedoxime

1991
Pharmacokinetics and pharmacodynamics of obidoxime in sarin-poisoned rats.
    Toxicology and applied pharmacology, 1991, Volume: 108, Issue:3

    Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Female; Obidoxime Chloride; Rats; Receptors, Cholinergic; Receptors, Nicotinic; Sarin

1991
Effects of CGS 9896 in acute experimental intoxication with fluostigmine.
    Archives of toxicology, 1990, Volume: 64, Issue:5

    Topics: Animals; Atropine; Diazepam; Female; Isoflurophate; Lethal Dose 50; Mice; Obidoxime Chloride; Pyrazoles

1990
Cold exposure decreases the effectiveness of atropine-oxime treatment in organophosphate intoxication in rats and mice.
    General pharmacology, 1989, Volume: 20, Issue:6

    Topics: Animals; Antidotes; Atropine; Carboxylic Ester Hydrolases; Cholinesterase Reactivators; Cold Temperature; Enzyme Reactivators; Isoflurophate; Lethal Dose 50; Mice; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Rats; Rats, Inbred F344

1989
Therapeutic Protocol No. 1. Early management of organophosphate poisoning.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1986, Jan-04, Volume: 69, Issue:1

    Topics: Adult; Atropine; Child; Humans; Ipecac; Obidoxime Chloride; Organophosphate Poisoning

1986
Pharmacokinetics and efficacies of obidoxime and atropine in paraoxon poisoning.
    Archives of toxicology, 1988, Volume: 61, Issue:5

    Topics: Animals; Antidotes; Atropine; Chromatography, High Pressure Liquid; Female; Half-Life; Injections, Intravenous; Lethal Dose 50; Mice; Obidoxime Chloride; Oximes; Paraoxon

1988
[Treatment of acute parathion poisoning with massive doses of atropine].
    Revista medica de Chile, 1985, Volume: 113, Issue:7

    Topics: Acute Disease; Adult; Atropine; Cholinesterases; Heart Rate; Humans; Male; Obidoxime Chloride; Parathion; Pralidoxime Compounds

1985
[Alkyl phosphate poisoning. A case of Lebaycid (Fenthion) poisoning].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1974, Jul-10, Volume: 94, Issue:19

    Topics: Adult; Atropine; Fenthion; Humans; Male; Obidoxime Chloride; Poisoning; Pralidoxime Compounds; Suicide

1974
[Maximum dose atropin treatment in severe organophosphate poisoning (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1974, Oct-18, Volume: 99, Issue:42

    Topics: Atropine; Cholinesterases; Gastric Lavage; Heart Arrest; Humans; Male; Middle Aged; Obidoxime Chloride; Organophosphate Poisoning; Poisoning; Pralidoxime Compounds; Reflex, Pupillary; Respiratory Paralysis; Unconsciousness

1974
Passage of tertiary and quaternary nitrogen compounds through the rat placenta.
    Archives internationales de pharmacodynamie et de therapie, 1974, Volume: 210, Issue:2

    Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Inhibitors; Enzyme Activation; Erythrocytes; Female; Fetus; Maternal-Fetal Exchange; Nitrogen; Nitroso Compounds; Obidoxime Chloride; Oximes; Paraoxon; Placenta; Pralidoxime Compounds; Pregnancy; Pyridinium Compounds; Rats

1974
A central vasodepressor effect of Dyflos.
    British journal of pharmacology, 1974, Volume: 50, Issue:4

    Topics: Acetylcholinesterase; Administration, Topical; Animals; Atropine; Blood Pressure; Carbachol; Cats; Depression, Chemical; Enzyme Activation; Heart Rate; Isoflurophate; Male; Medulla Oblongata; Obidoxime Chloride; Oximes; Pilocarpine; Pralidoxime Compounds; Propylamines; Pyridinium Compounds; Respiration; Time Factors

1974
Changes of vitamin A in blood and liver of organophosphorus poisoned suicides.
    Research communications in chemical pathology and pharmacology, 1970, Volume: 1, Issue:4

    Topics: Adolescent; Adult; Aged; Atropine; Cholinesterases; Female; Humans; Liver; Male; Middle Aged; Obidoxime Chloride; Parathion; Poisoning; Pralidoxime Compounds; Renal Dialysis; Vitamin A

1970
The efficacy of bispyridinium derivatives in the treatment of organophosphonate poisoning in the guinea-pig.
    The Journal of pharmacy and pharmacology, 1983, Volume: 35, Issue:7

    Topics: Animals; Atropine; Diazepam; Female; Guinea Pigs; Obidoxime Chloride; Organophosphate Poisoning; Pyridinium Compounds; Pyridostigmine Bromide; Soman

1983
[The effect of organophosphates on heart ATPase in the rat].
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:6

    Topics: Adenosine Triphosphatases; Animals; Antidotes; Atropine; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Electrophysiology; Female; Isoflurophate; Kinetics; Myocardium; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Paraoxon; Parathion; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase

1984
[Trial of cholinesterase reactivators as proserine antagonists].
    Biulleten' eksperimental'noi biologii i meditsiny, 1983, Volume: 96, Issue:10

    Topics: Animals; Antidotes; Atropine; Butanones; Cholinesterase Reactivators; Diphenylacetic Acids; Drug Synergism; Male; Mice; Neostigmine; Obidoxime Chloride; Oximes; Parasympatholytics; Pralidoxime Compounds; Pyridinium Compounds; Trimedoxime

1983
[Dramatic course of poisoning with a organophosphate compound in a 4-year-old boy treated with obidoxime chloride and atropine sulfate].
    Pediatria polska, 1982, Volume: 57, Issue:11

    Topics: Antidotes; Atropine; Child, Preschool; Dimethoate; Drug Therapy, Combination; Humans; Hypokalemia; Male; Obidoxime Chloride; Oximes; Tachycardia, Paroxysmal

1982
[Organophosphate insecticide poisoning--mechanism of action, clinical symptoms and treatment].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1980, Jan-01, Volume: 33, Issue:1

    Topics: Animals; Antidotes; Atropine; Gastric Lavage; Humans; Insecticides; Obidoxime Chloride; Organophosphorus Compounds; Rabbits; Rats

1980
[Pesticide poisoning].
    Intensivmedizinische Praxis, 1980, Issue:2

    Topics: Adult; Aged; Atropine; Charcoal; Gastric Lavage; Humans; Middle Aged; Obidoxime Chloride; Pesticides

1980
[Treatment of intoxications with organophosphates (author's transl)].
    DTW. Deutsche tierarztliche Wochenschrift, 1980, Volume: 87, Issue:7

    Topics: Animal Diseases; Animals; Atropine; Diazepam; Drug Therapy, Combination; Insecticides; Obidoxime Chloride; Organophosphate Poisoning; Pralidoxime Compounds

1980
[Effects of trimethadione on the therapeutic efficiency of atropine and obidoxime in mice poisoned with various phosphoorganic compounds].
    Medycyna pracy, 1981, Volume: 32, Issue:5

    Topics: Animals; Atropine; Blood-Brain Barrier; Drug Synergism; Female; Lethal Dose 50; Mice; Mice, Inbred BALB C; Obidoxime Chloride; Organophosphate Poisoning; Oxazoles; Oximes; Trimethadione

1981
Comparison of atropine and dexetimide in treatment of intoxications by selected organophosphates.
    Acta pharmacologica et toxicologica, 1982, Volume: 50, Issue:3

    Topics: Animals; Atropine; Dexetimide; Diet; Guinea Pigs; Insecticides; Isoflurophate; Lethal Dose 50; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Paraoxon; Piperidines

1982
Effect of pyridostigmine pretreatment on cardiorespiratory function in tabun poisoning.
    Human & experimental toxicology, 1995, Volume: 14, Issue:8

    Topics: Animals; Atropine; Blood Pressure; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Heart Rate; Hemodynamics; Injections, Intravenous; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Pyridostigmine Bromide; Respiration

1995
Treatment of the stressogenic effect of dichlorvos.
    Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove, 1994, Volume: 37, Issue:1

    Topics: Animals; Antidotes; Atropine; Corticosterone; Diazepam; Dichlorvos; Liver; Male; Obidoxime Chloride; Poisoning; Rats; Rats, Wistar; Tyrosine Transaminase

1994
Determination of atropine and obidoxime in automatic injection devices used as antidotes against nerve agent intoxication.
    Journal of chromatography. A, 1994, Dec-02, Volume: 686, Issue:2

    Topics: Atropine; Chemical Warfare; Chromatography, Gas; Chromatography, High Pressure Liquid; Humans; Neurotoxins; Obidoxime Chloride; Poisoning

1994
Treatment of tabun poisoned guinea-pigs with atropine, HLö 7 or HI 6: effect on respiratory and circulatory function.
    Archives of toxicology, 1994, Volume: 68, Issue:4

    Topics: Animals; Atropine; Blood Circulation; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Respiration

1994
Carbamate poisoning and oxime treatment in children: a clinical and laboratory study.
    Pediatrics, 1994, Volume: 93, Issue:4

    Topics: Aldicarb; Antidotes; Atropine; Carbamates; Child; Child, Preschool; Cholinesterases; Drug Therapy, Combination; Female; Humans; Infant; Male; Methomyl; Obidoxime Chloride; Oximes; Paraoxon; Poisoning; Pralidoxime Compounds; Retrospective Studies

1994
Pharmacological nature of soman-induced hypothermia in mice.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:3

    Topics: Acetylcholinesterase; Animals; Atropine; Body Temperature; Cholinesterase Inhibitors; Cholinesterase Reactivators; Hypothalamus; Hypothermia; Male; Mecamylamine; Mice; Nicotine; Obidoxime Chloride; Oximes; Oxotremorine; Physostigmine; Pyridinium Compounds; Soman

1993
Comparison of the efficacy of HI-6 and obidoxime against cyclohexyl methylphosphonofluoridate (GF) in rats.
    Human & experimental toxicology, 1995, Volume: 14, Issue:11

    Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Corticosterone; Diaphragm; Drug Interactions; Liver; Male; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Tyrosine Transaminase

1995
[Comparison of the therapeutic effectiveness of selected cholinesterase reactivators with atropine in acute fosdrine poisoning in mice].
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 1996, Volume: 45, Issue:1

    Topics: Acute Disease; Animals; Atropine; Cholinesterase Reactivators; Insecticides; Male; Mevinphos; Mice; Obidoxime Chloride; Oximes; Poisoning; Pyridinium Compounds

1996
A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat.
    Archives of toxicology, 1995, Volume: 70, Issue:2

    Topics: Administration, Oral; Animals; Antidotes; Atropine; Diazepam; Dose-Response Relationship, Drug; Insecticides; Male; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Rats; Rats, Wistar; Trimedoxime

1995
The efficacy of monopyridinium (2-PAAM, 2-PAEM) and bispyridinium (obidoxime, HI-6) oximes against mevinphos in mice.
    Pharmacology & toxicology, 1997, Volume: 81, Issue:3

    Topics: Animals; Atropine; Cholinesterase Reactivators; Insecticides; Lethal Dose 50; Male; Mevinphos; Mice; Muscarinic Antagonists; Obidoxime Chloride; Oximes; Pyridinium Compounds; Structure-Activity Relationship

1997
Factors influencing the efficacy of obidoxime in organophosphate pesticides poisoning.
    Przeglad lekarski, 1997, Volume: 54, Issue:10

    Topics: Adult; Atropine; Cholinesterase Reactivators; Cholinesterases; Drug Administration Schedule; Female; Humans; Insecticides; Male; Middle Aged; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphates; Parathion; Poisoning; Premedication

1997
Acute, severe cholinesterase inhibitors poisonings in the material of occupational diseases and toxicology ward in Poznań.
    Przeglad lekarski, 1997, Volume: 54, Issue:10

    Topics: Atropine; Female; Gastric Lavage; Humans; Incidence; Insecticides; Middle Aged; Obidoxime Chloride; Occupational Diseases; Organophosphorus Compounds; Poison Control Centers; Poisoning; Poland

1997
Severe organophosphate (demeton-S-methyl) poisoning in a two-year-old child.
    Veterinary and human toxicology, 1998, Volume: 40, Issue:4

    Topics: Antidotes; Atropine; Child, Preschool; Cholinesterase Reactivators; Humans; Insecticides; Male; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphates; Poisoning

1998
A comparison of the efficacy of new asymmetric bispyridinium oxime BI-6 with other oximes (obidoxime, HI-6) against soman in rats.
    Human & experimental toxicology, 1998, Volume: 17, Issue:6

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Diaphragm; Drug Therapy, Combination; Liver; Male; Obidoxime Chloride; Oximes; Poisoning; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Tyrosine Transaminase

1998
[Comparison of the effects of BI-6, a new asymmetric bipyridine oxime, with HI-6 oxime and obidoxime in combination with atropine on soman and fosdrine toxicity in mice].
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 1999, Volume: 48, Issue:1

    Topics: Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Insecticides; Male; Mevinphos; Mice; Mice, Inbred Strains; Obidoxime Chloride; Oximes; Pyridinium Compounds; Soman

1999
Neuroprotective effects of antidotes in soman-poisoned rats.
    Acta medica (Hradec Kralove), 1999, Volume: 42, Issue:4

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Male; Nervous System; Obidoxime Chloride; Poisoning; Rats; Rats, Wistar; Soman

1999
Neuroprotective effects of currently used antidotes in soman-poisoned rats.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:3

    Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Motor Activity; Muscarinic Antagonists; Neuroprotective Agents; Obidoxime Chloride; Rats; Rats, Wistar; Soman

2000
[Poisoning with organophosphate compounds].
    Nederlands tijdschrift voor geneeskunde, 2002, Jan-05, Volume: 146, Issue:1

    Topics: Acetylcholine; Atropine; Bradycardia; Cholinesterase Inhibitors; Cholinesterase Reactivators; Critical Care; Fasciculation; Humans; Hypotension; Insecticides; Male; Middle Aged; Miosis; Muscarinic Antagonists; Obidoxime Chloride; Organophosphorus Compounds; Suicide, Attempted; Treatment Outcome; Vomiting

2002
Neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in tabun-poisoned rats.
    Toxicology, 2003, Mar-14, Volume: 185, Issue:1-2

    Topics: Animals; Antidotes; Atropine; Behavior, Animal; Benactyzine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Combinations; Drug Therapy, Combination; Lethal Dose 50; Male; Motor Activity; Nervous System Diseases; Neuroprotective Agents; Neuropsychological Tests; Obidoxime Chloride; Organophosphates; Pyridostigmine Bromide; Rats; Rats, Wistar; Trihexyphenidyl

2003
Beneficial late administration of obidoxime in malathion poisoning.
    Veterinary and human toxicology, 2003, Volume: 45, Issue:1

    Topics: Adult; Atropine; Cholinesterase Reactivators; Diagnosis, Differential; Emergency Treatment; Female; Humans; Infusions, Intravenous; Insecticides; Malathion; Obidoxime Chloride; Poisoning; Respiration, Artificial; Suicide, Attempted

2003
Neuroprotective effects of currently used antidotes in tabun-poisoned rats.
    Pharmacology & toxicology, 2003, Volume: 92, Issue:6

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Motor Activity; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar

2003
THE PROTECTIVE EFFECT OF PYRIDINE-2-ALDOXIME METHIODIDE (P2AM), BIS-(4-HYDROXYIMINO-METHYL-PYRIDINIUM-1-METHYL)-ETHER DICHLORIDE (TOXOGONIN) AND ATROPINE IN EXPERIMENTAL DDVP POISONING.
    Helvetica physiologica et pharmacologica acta, 1964, Volume: 22

    Topics: Animals; Antidotes; Atropine; Blood; Brain; Cholinesterase Inhibitors; Cholinesterases; Dichlorvos; Ethers; Horses; Insecticides; Mice; Obidoxime Chloride; Phosphates; Pralidoxime Compounds; Pyridines; Rats; Research; Succinylcholine; Toxicology

1964
TOXOGONIN IN SARIN, SOMAN AND TABUN POISONING.
    Biochemical pharmacology, 1965, Jan-01, Volume: 14

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterases; Erythrocytes; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pharmacology; Phosphates; Research; Sarin; Soman; Toxicology

1965
[Study on the therapeutic effect of combined use of obidoxime and atropine with respiratory machine on respiratory muscle paralysis caused by omethoate poisoning of rats].
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2002, Volume: 20, Issue:5

    Topics: Animals; Atropine; Dimethoate; Drug Therapy, Combination; Obidoxime Chloride; Rats; Respiration, Artificial; Respiratory Paralysis

2002
Simple high-performance liquid chromatographic method for determination of atropine and obidoxime in a parenteral injection device.
    Journal of chromatography. A, 2004, Nov-19, Volume: 1057, Issue:1-2

    Topics: Atropine; Calibration; Chromatography, High Pressure Liquid; Injections, Intraperitoneal; Obidoxime Chloride; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet

2004
Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos.
    Basic & clinical pharmacology & toxicology, 2006, Volume: 98, Issue:2

    Topics: Acidosis; Animals; Antidotes; Atropine; Blood Gas Analysis; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dichlorvos; Drug Synergism; Male; Obidoxime Chloride; Rats; Rats, Wistar; Sodium Bicarbonate; Trimedoxime

2006
A comparison of the potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, HI-6) to counteract tabun-induced neurotoxicity in rats.
    Toxicology, 2007, Jan-05, Volume: 229, Issue:1-2

    Topics: Animals; Antidotes; Atropine; Behavior, Animal; Butanes; Chemical Warfare Agents; Cholinergic Antagonists; Dose-Response Relationship, Drug; Injections, Intramuscular; Lacrimal Apparatus; Male; Miosis; Molecular Structure; Muscle Tonus; Neurotoxicity Syndromes; Obidoxime Chloride; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Tears; Time Factors; Toxicity Tests; Treatment Outcome

2007
A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) to counteract soman-induced neurotoxicity in rats.
    Drug and chemical toxicology, 2007, Volume: 30, Issue:2

    Topics: Animals; Antidotes; Atropine; Autonomic Nervous System; Behavior, Animal; Butanes; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Motor Activity; Neuroprotective Agents; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Structure-Activity Relationship

2007
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
    Toxicology, 2008, Jan-20, Volume: 243, Issue:3

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Injections, Intramuscular; Lethal Dose 50; Male; Mice; Molecular Structure; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Species Specificity; Toxicity Tests, Acute; Trimedoxime

2008
A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, trimedoxime, HI-6) to counteract acute toxic effects of tabun and cyclosarin in mice.
    Drug and chemical toxicology, 2008, Volume: 31, Issue:1

    Topics: Animals; Antidotes; Atropine; Butanes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Poisoning; Pyridinium Compounds; Trimedoxime

2008
Recovery from ultra-high dose organophosphate poisoning after "in-the-field" antidote treatment: potential lessons for civil defense.
    The Journal of emergency medicine, 2009, Volume: 37, Issue:3

    Topics: Adult; Atropine; Cholinesterase Reactivators; Emergency Medical Services; Gastric Lavage; Hemoperfusion; Humans; Intensive Care Units; Male; Middle Aged; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Polyneuropathies

2009
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
    Toxicology and applied pharmacology, 2008, Sep-01, Volume: 231, Issue:2

    Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2008
An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice.
    Clinical toxicology (Philadelphia, Pa.), 2009, Volume: 47, Issue:1

    Topics: Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Diaphragm; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Molecular Structure; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Treatment Outcome

2009
Is beta-glucuronidase a clinical useful biomarker for an acute organophosphorus poisoning?
    Human & experimental toxicology, 2008, Volume: 27, Issue:5

    Topics: Acetylcholinesterase; Atropine; Biomarkers; Cholinesterase Inhibitors; Drug Therapy, Combination; Fluid Therapy; Glucuronidase; Humans; Male; Middle Aged; Obidoxime Chloride; Parathion; Poisoning; Propofol; Suicide, Attempted; Vasoconstrictor Agents

2008
Clinical findings and cholinesterase levels in children of organophosphates and carbamates poisoning.
    European journal of pediatrics, 2009, Volume: 168, Issue:8

    Topics: Adolescent; Atropine; Biomarkers; Carbamates; Child; Child, Preschool; Cholinesterase Reactivators; Cholinesterases; Early Diagnosis; Egypt; Female; Humans; Infant; Insecticides; Male; Obidoxime Chloride; Organophosphate Poisoning; Poisoning; Predictive Value of Tests; Respiration, Artificial; Retrospective Studies

2009
Evaluation of the neuroprotective efficacy of newly developed oximes (K206, K269) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 104, Issue:3

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Muscarinic Antagonists; Neuroprotective Agents; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar

2009
A quantitative NMR protocol for the simultaneous analysis of atropine and obidoxime in parenteral injection devices.
    Journal of pharmaceutical and biomedical analysis, 2009, May-01, Volume: 49, Issue:4

    Topics: Algorithms; Alkanesulfonic Acids; Atropine; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Infusions, Parenteral; Magnetic Resonance Spectroscopy; Molecular Weight; Muscarinic Antagonists; Obidoxime Chloride; Pharmaceutical Solutions; Reproducibility of Results; Spectrophotometry, Ultraviolet; Trimethylsilyl Compounds

2009
Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: induction of oxidative stress versus reactivation efficacy.
    Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:6

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Injections, Intramuscular; Lethal Dose 50; Male; Molecular Structure; Molecular Weight; Obidoxime Chloride; Organophosphates; Oxidative Stress; Pyridinium Compounds; Rats; Rats, Wistar; Toxicity Tests, Acute; Trimedoxime

2009
Correlation of therapeutic effect of obidoxime and dosing time in the acute intoxication by chlorfenvinphos in rats.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:1

    Topics: Acetylcholinesterase; Animals; Anticonvulsants; Antidotes; Atropine; Brain; Chlorfenvinphos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Diazepam; Drug Interactions; Drug Therapy, Combination; Injections, Intraperitoneal; Injections, Subcutaneous; Intercostal Muscles; Male; Medulla Oblongata; Obidoxime Chloride; Random Allocation; Rats; Rats, Wistar; Time Factors

2009
Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness.
    Clinical toxicology (Philadelphia, Pa.), 2009, Volume: 47, Issue:8

    Topics: Acetylcholinesterase; Acute Disease; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Critical Care; Dimethoate; Drug Administration Schedule; Drug Overdose; Erythrocytes; Germany; Humans; Neuromuscular Junction; Obidoxime Chloride; Organothiophosphorus Compounds; Parathion; Suicide; Time Factors; Treatment Outcome

2009
Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships.
    Clinical toxicology (Philadelphia, Pa.), 2009, Volume: 47, Issue:8

    Topics: Acetylcholinesterase; Acute Disease; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Critical Care; Dimethoate; Drug Administration Schedule; Drug Monitoring; Drug Overdose; Erythrocytes; Germany; Humans; Neuromuscular Junction; Obidoxime Chloride; Organothiophosphorus Compounds; Parathion; Suicide; Treatment Outcome

2009
Percutaneous exposure to the nerve agent VX: Efficacy of combined atropine, obidoxime and diazepam treatment.
    Chemico-biological interactions, 2010, Oct-06, Volume: 188, Issue:1

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Diazepam; Guinea Pigs; Obidoxime Chloride; Organothiophosphorus Compounds; Skin

2010
Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder.
    Toxicology mechanisms and methods, 2010, Volume: 20, Issue:7

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Heart Atria; Heart Rate; Male; Molecular Structure; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Rats; Urinary Bladder

2010
The efficacy of obidoxime 72 hours after intoxication by organophosphates.
    The American journal of emergency medicine, 2011, Volume: 29, Issue:2

    Topics: Adult; Atropine; Cholinesterase Reactivators; Humans; Male; Mexico; Obidoxime Chloride; Organophosphate Poisoning; Poisoning; Suicide, Attempted; Time Factors

2011
Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine?
    Archives of toxicology, 2011, Volume: 85, Issue:3

    Topics: Animals; Atropine; Brain; Carbamates; Chemical Warfare Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Electroencephalography; Guinea Pigs; Male; Models, Animal; Obidoxime Chloride; Parasympatholytics; Physostigmine; Seizures; Soman; Time Factors; Treatment Outcome

2011
A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques.
    Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:6

    Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Frontal Lobe; GPI-Linked Proteins; Lethal Dose 50; Obidoxime Chloride; Organ Specificity; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Reticular Formation

2010
Using MRI for the assessment of paraoxon-induced brain damage and efficacy of antidotal treatment.
    Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:6

    Topics: Animals; Antidotes; Atropine; Brain; Brain Diseases; Cholinergic Antagonists; Cholinesterase Inhibitors; Cholinesterase Reactivators; GABA Modulators; Magnetic Resonance Imaging; Male; Midazolam; Obidoxime Chloride; Paraoxon; Rats; Rats, Sprague-Dawley; Scopolamine

2012
Atropine dosage in patients with severe organophosphate pesticide poisoning.
    The American journal of emergency medicine, 2012, Volume: 30, Issue:4

    Topics: Atropine; Humans; Male; Obidoxime Chloride; Organophosphate Poisoning

2012
A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats.
    Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:5

    Topics: Animals; Antidotes; Atropine; Autonomic Nervous System; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Czech Republic; Drug Therapy, Combination; Lethal Dose 50; Male; Muscarinic Antagonists; Neurons; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Psychomotor Performance; Pyridinium Compounds; Rats; Rats, Wistar; Sarin

2012
In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat.
    Clinical and experimental pharmacology & physiology, 2014, Volume: 41, Issue:2

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Diamines; Dose-Response Relationship, Drug; Heart Atria; In Vitro Techniques; Male; Methacholine Chloride; Muscarinic Antagonists; Muscle Contraction; Obidoxime Chloride; Physostigmine; Rats; Receptor Cross-Talk; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Urinary Bladder

2014
Prevention of organophosphate-induced chronic epilepsy by early benzodiazepine treatment.
    Toxicology, 2014, Sep-02, Volume: 323

    Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chronic Disease; Epilepsy; Midazolam; Muscarinic Agonists; Obidoxime Chloride; Paraoxon; Pesticides; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus

2014
A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice.
    Toxicology mechanisms and methods, 2015, Volume: 25, Issue:3

    Topics: Acetylcholinesterase; Animals; Animals, Outbred Strains; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Mice; Muscarinic Antagonists; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats, Wistar; Sarin

2015
Early brain magnetic resonance imaging can predict short and long-term outcomes after organophosphate poisoning in a rat model.
    Neurotoxicology, 2015, Volume: 48

    Topics: Animals; Aspartic Acid; Atropine; Behavior, Animal; Brain; Brain Edema; Choline; Cholinesterase Reactivators; Cognition; Creatine; Disease Models, Animal; Drug Therapy, Combination; Early Diagnosis; Magnetic Resonance Imaging; Male; Maze Learning; Midazolam; Neuroprotective Agents; Obidoxime Chloride; Organophosphate Poisoning; Paraoxon; Predictive Value of Tests; Proton Magnetic Resonance Spectroscopy; Rats, Sprague-Dawley; Scopolamine; Time Factors; Weight Loss

2015
Toxicity and median effective doses of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig.
    The Journal of toxicological sciences, 2016, Volume: 41, Issue:4

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Guinea Pigs; Lethal Dose 50; Male; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pesticides; Pralidoxime Compounds; Pyridinium Compounds; Time Factors

2016
Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice.
    Toxicology, 2018, 09-01, Volume: 408

    Topics: Animals; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Time Factors

2018
Efficacy of atropine sulfate/obidoxime chloride co-formulation against sarin exposure in guinea pigs.
    Chemico-biological interactions, 2018, Dec-25, Volume: 296

    Topics: Animals; Atropine; Cholinesterase Reactivators; Cholinesterases; Dose-Response Relationship, Drug; Drug Compounding; Electroencephalography; Guinea Pigs; Injections, Subcutaneous; Male; Obidoxime Chloride; Sarin; Structure-Activity Relationship; Survival Rate

2018
Repetitive antidotal treatment is crucial in eliminating eye pathology, respiratory toxicity and death following whole-body VX vapor exposure in freely moving rats.
    Archives of toxicology, 2019, Volume: 93, Issue:5

    Topics: Animals; Antidotes; Atropine; Benactyzine; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Administration Schedule; Drug Combinations; Environmental Exposure; Eye Diseases; Male; Obidoxime Chloride; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Respiratory Tract Diseases; Trimedoxime

2019
A case report of cholinesterase inhibitor poisoning: cholinesterase activities and analytical methods for diagnosis and clinical decision making.
    Archives of toxicology, 2020, Volume: 94, Issue:6

    Topics: Acetylcholinesterase; Aged, 80 and over; Antidotes; Atropine; Biomarkers; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Clinical Decision-Making; Clinical Enzyme Tests; Diagnosis, Differential; GPI-Linked Proteins; Humans; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Predictive Value of Tests; Suicide, Attempted; Treatment Outcome

2020
Pharmacokinetics and efficacy of atropine sulfate/obidoxime chloride co-formulation against VX in a guinea pig model.
    Regulatory toxicology and pharmacology : RTP, 2021, Volume: 119

    Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Drug Combinations; Guinea Pigs; Male; Muscarinic Antagonists; Obidoxime Chloride; Organothiophosphorus Compounds; Treatment Outcome

2021