atropine has been researched along with nortriptyline in 29 studies
| Studies (atropine) | Trials (atropine) | Recent Studies (post-2010) (atropine) | Studies (nortriptyline) | Trials (nortriptyline) | Recent Studies (post-2010) (nortriptyline) |
|---|---|---|---|---|---|
| 26,711 | 1,259 | 1,697 | 2,289 | 517 | 327 |
| Protein | Taxonomy | atropine (IC50) | nortriptyline (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.016 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.0032 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.347 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.095 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.17 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.027 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.366 | |
| Cytochrome P450 2D26 | Rattus norvegicus (Norway rat) | 1.9 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 1.95 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.082 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.17 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.047 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.1015 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 1.019 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 0.171 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 0.539 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.0032 | |
| Histamine H2 receptor | Homo sapiens (human) | 2.334 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.273 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.051 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.016 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 1.019 | |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | 0.17 | |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | 0.17 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.17 | |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | 0.17 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.013 | |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | 0.17 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 3 | |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | 0.17 | |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | 0.17 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.05 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.179 | |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | 0.17 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.136 | |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | 7 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 0.554 | |
| Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens (human) | 10 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 1.678 | |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | 0.17 | |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | 0.17 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (37.93) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 7 (24.14) | 29.6817 |
| 2010's | 10 (34.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Booth, RG; Brown, RL; Bucholtz, EC; Tropsha, A; Wyrick, SD | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Richelson, E | 1 |
| Bye, CE; Clubley, M; Henson, T; Peck, AW; Smith, SA; Smith, SE | 1 |
| Banaszkiewicz, W; Grzymislawska, I; Mrozikiewica, A | 1 |
| Andre, C; Guillet, JG; Hoebeke, J; Marullo, S; Strosberg, AD | 1 |
| Perel, JM; Somogyi, GT | 1 |
| Chinn, C; Weber, LJ | 1 |
| Brittain, RT | 1 |
| Garattini, S; Jori, A; Paglialunga, S | 1 |
| Jones, BJ; Roberts, DJ; Tolman, BD | 1 |
| Capitanucci, P; Fioretti, MC | 1 |
1 review(s) available for atropine and nortriptyline
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for atropine and nortriptyline
| Article | Year |
|---|---|
Changes in the human light reflex as a measure of the anticholinergic effects of drugs. A comparison with other measures.
Topics: Adolescent; Adult; Atropine; Female; Humans; Male; Nortriptyline; Parasympatholytics; Procyclidine; Pulse; Reflex, Pupillary; Salivation; Sweating; Vision, Ocular | 1979 |
27 other study(ies) available for atropine and nortriptyline
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ligands; Models, Molecular; Pyrilamine; Radioligand Assay; Structure-Activity Relationship; Tetrahydronaphthalenes | 1999 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Tricyclic antidepressants and histamine H1 receptors.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Atropine; Benztropine; Cells, Cultured; Clozapine; Cyproheptadine; Desipramine; Doxepin; Haloperidol; Histamine H1 Antagonists; Hydroxyzine; Imipramine; Mice; Neoplasms, Experimental; Neuroblastoma; Nortriptyline; Protriptyline; Receptors, Histamine; Receptors, Histamine H1; Receptors, Muscarinic | 1979 |
Influence of some antidepressant drugs on the circulatory system: II. Action of amitriptyline and nortriptyline on basic circulatory parameters.
Topics: Amitriptyline; Animals; Atropine; Cats; Dihydroergotamine; Hemodynamics; In Vitro Techniques; Muscle, Smooth; Myocardial Contraction; Norepinephrine; Nortriptyline; Propranolol; Quaternary Ammonium Compounds; Rabbits; Respiration | 1975 |
Immunologic mimicry by a monoclonal antibody of the tricyclic anti-depressants' binding site on muscarinic acetylcholine receptors.
Topics: Animals; Antibodies, Monoclonal; Antidepressive Agents, Tricyclic; Atropine; Binding Sites; Binding, Competitive; Carbachol; Cattle; Epitopes; Nortriptyline; Receptors, Muscarinic | 1987 |
Antagonism by tricyclic antidepressants of the muscarinic receptors located on the adrenergic nerve endings in rabbit heart atrium.
Topics: Animals; Antidepressive Agents, Tricyclic; Atropine; Desipramine; Electric Stimulation; Heart; Imipramine; Male; Norepinephrine; Nortriptyline; Oxotremorine; Parasympatholytics; Rabbits; Receptors, Muscarinic; Sympathetic Nervous System | 1989 |
The actions of several psychoactive agents upon the muscarinic mechanisms in the superior cervical ganglion of the cat.
Topics: Alkynes; Animals; Atropine; Carbamates; Cats; Desipramine; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Female; Ganglia, Autonomic; Ganglia, Spinal; Heart Rate; Hexamethonium Compounds; Hydrazines; Injections, Intra-Arterial; Male; Methylphenidate; Muscle Contraction; Nictitating Membrane; Nortriptyline; Parasympathetic Nervous System; Parasympathomimetics; Pargyline; Piperidines; Quaternary Ammonium Compounds | 1974 |
The intracerebral effects of noradrenaline and its modification by drugs in the mouse.
Topics: Amitriptyline; Animals; Antidepressive Agents; Ataxia; Atropine; Body Temperature; Brain; Central Nervous System; Chlordiazepoxide; Chlorpheniramine; Chlorpromazine; Diazepam; Drug Antagonism; Haloperidol; Histamine H1 Antagonists; Imipramine; Male; Mice; Norepinephrine; Nortriptyline; Pentobarbital; Phenytoin; Piperazines; Trihexyphenidyl | 1966 |
Effect of antidepressant and adrenergic blocking drugs on hyperthermia induced by reserpine.
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Body Temperature; Chlorisondamine; Chlorpromazine; Desipramine; Ethanolamines; Female; Fever; Hydrazines; Imipramine; Monoamine Oxidase Inhibitors; Norepinephrine; Nortriptyline; Phenoxybenzamine; Phentolamine; Propranolol; Rats; Reserpine; Sympatholytics; Tetrabenazine | 1967 |
Studies on interactions involving antidepressive and other drugs with tetrabenazine and noradnamine on locomotor activity in mice, including details of the experimental design and statistical analysis.
Topics: Amitriptyline; Analysis of Variance; Animals; Atropine; Bretylium Compounds; Chlorpromazine; Cycloheptanes; Depression, Chemical; Dextroamphetamine; Dibenzocycloheptenes; Drug Antagonism; Ketones; Male; Mice; Motor Activity; Nialamide; Nortriptyline; Phentolamine; Tetrabenazine | 1970 |
[Research on the mechanisms of the protective activity against gastric ulcer of psychoactive drugs: effects of nortriptyline, imipramine and chlorpromazine on gastric secretion].
Topics: Animals; Atropine; Chlorpromazine; Gastric Juice; Imipramine; Nortriptyline; Rats; Stomach Ulcer | 1965 |