Compounds > atropine

Page last updated: 2024-09-05

atropine and nomifensine

atropine has been researched along with nomifensine in 15 studies

Compound Research Comparison

Studies (atropine)	Trials (atropine)	Recent Studies (post-2010) (atropine)	Studies (nomifensine)	Trials (nomifensine)	Recent Studies (post-2010) (nomifensine)
26,711	1,259	1,697	1,127	111	65

Protein Interaction Comparison

Protein	Taxonomy	atropine (IC50)	nomifensine (IC50)
D	Rattus norvegicus (Norway rat)		2.724
D(3) dopamine receptor	Rattus norvegicus (Norway rat)		2.724
Sodium-dependent noradrenaline transporter	Homo sapiens (human)		0.631
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)		0.1642
D(1B) dopamine receptor	Rattus norvegicus (Norway rat)		2.724
D(4) dopamine receptor	Rattus norvegicus (Norway rat)		2.724
Sodium-dependent serotonin transporter	Homo sapiens (human)		8.7096
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)		3.115
Cytochrome P450 2C19	Homo sapiens (human)		0.0316
D(2) dopamine receptor	Rattus norvegicus (Norway rat)		2.724
Sodium-dependent dopamine transporter	Homo sapiens (human)		0.0781
Transporter	Rattus norvegicus (Norway rat)		2.7033

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (20.00)	18.7374
1990's	3 (20.00)	18.2507
2000's	3 (20.00)	29.6817
2010's	6 (40.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Damsma, G; de Boer, P; de Vries, JB; Fibiger, HC; Timmerman, W; Westerink, BH	1
Borsini, F; d'Aranno, V; Lecci, A; Mancinelli, A; Meli, A	1
Betti, R; Casanueva, F; Cocchi, D; Motta, T; Müller, EE; Zanardi, P	1
Chang, SS; Cheng, JT	1

Reviews

2 review(s) available for atropine and nomifensine

Article	Year
The role of receptor binding in drug discovery. Journal of natural products, 1993, Volume: 56, Issue:4 Topics: Animals; Drug Design; Humans; Receptors, Drug	1993
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

13 other study(ies) available for atropine and nomifensine

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Dopaminergic-cholinergic interactions in the striatum: the critical significance of calcium concentrations in brain microdialysis. Naunyn-Schmiedeberg's archives of pharmacology, 1990, Volume: 342, Issue:5 Topics: Acetylcholine; Animals; Apomorphine; Atropine; Calcium; Corpus Striatum; Dextroamphetamine; Dialysis Solutions; Dopamine; Haloperidol; Interneurons; Male; Neostigmine; Nomifensine; Perfusion; Rats; Rats, Inbred Strains; Sodium Chloride; Sulpiride; Tetrahydronaphthalenes; Thiophenes	1990
Cholinergic drug effects on antidepressant-induced behaviour in the forced swimming test. European journal of pharmacology, 1988, Dec-13, Volume: 158, Issue:3 Topics: Animals; Antidepressive Agents; Atropine; Behavior, Animal; Desipramine; Drug Synergism; Male; Motor Activity; Nomifensine; Pharmaceutical Vehicles; Physical Exertion; Physostigmine; Rats; Scopolamine; Swimming	1988
A role for dopamine in growth hormone regulation in the dog. Endocrinology, 1981, Volume: 108, Issue:4 Topics: Animals; Apomorphine; Atropine; Benzimidazoles; Dogs; Domperidone; Dopamine; Female; Growth Hormone; Haloperidol; Isoquinolines; Kinetics; Male; Nomifensine; Phentolamine; Pimozide; Piperidines	1981
Inhibitory effect of octopamine on the release of endogenous acetylcholine from isolated myenteric synaptosomes of guinea-pig. Clinical and experimental pharmacology & physiology, 1993, Volume: 20, Issue:11 Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Atropine; Calcium; Dopamine Agents; Female; Guanethidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Myenteric Plexus; Naloxone; Nomifensine; Octopamine; Propranolol; Substance P; Synaptosomes	1993