Page last updated: 2024-09-05

atropine and n-methylscopolamine

atropine has been researched along with n-methylscopolamine in 116 studies

Compound Research Comparison

Studies (atropine)	Trials (atropine)	Recent Studies (post-2010) (atropine)	Studies (n-methylscopolamine)	Trials (n-methylscopolamine)	Recent Studies (post-2010) (n-methylscopolamine)
26,711	1,259	1,697	1,026	12	52

Protein Interaction Comparison

Protein	Taxonomy	n-methylscopolamine (IC50)
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	0.335
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	0.0023
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	0.0023
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	0.0018
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	0.0011

Research

Studies (116)

Timeframe	Studies, this research(%)	All Research%
pre-1990	51 (43.97)	18.7374
1990's	37 (31.90)	18.2507
2000's	19 (16.38)	29.6817
2010's	8 (6.90)	24.3611
2020's	1 (0.86)	2.80

Authors

Authors	Studies
Christopoulos, A; El-Fakahany, EE; Pierce, TL; Sorman, JL	1
Go, ML; Sim, MK; Xu, R	1
Aoki, I; Fujikawa, T; Hasegawa, T; Hirose, H; Kimura, T; Mase, T; Mitsuya, M; Nishikibe, M; Noguchi, K; Numazawa, T; Ohtake, N; Sasaki, K; Sato, A	1
Bodor, N; Browne, CE; Buchwald, P; Farag, HH; Hochhaus, G; Huang, F; Ji, F; Wu, WM	1
Chen, Y; Cheng, K; Kennedy, RH; Khurana, S; Raufman, JP; Zimniak, P	1
Fruchart-Gaillard, C; Marquer, C; Ménez, A; Mourier, G; Servent, D	1
Charlton, SJ; Dowling, MR	1
Bloodworth, LM; Hamdan, FF; Han, SJ; Jacobson, KA; Kim, SK; Li, JH; Wess, J; Zhang, X	1
Bonnet, D; Daval, SB; Galzi, JL; Hibert, M; Ilien, B; Kellenberger, E; Valant, C	1
Bernhardt, G; Gmeiner, P; Hübner, H; Keller, M; Pegoli, A; She, X; Wifling, D	1
Bernhardt, G; Carpenter, J; Chen, M; Gmeiner, P; Gruber, CG; Holliday, ND; Hübner, H; Keller, M; Pegoli, A; She, X; Wan, J; Wifling, D	1
Ally, A; Hara, Y; Murayama, S	1
Akerman, KE; Kukkonen, J	1
Kajimura, M; Reuben, MA; Sachs, G	1
Shainberg, A; Waisberg, M	1
Bellido, I; Garcia, AJ; Gómez, A; Marquez, E; Martos, F; Pavia, J; Sanchez de la Cuesta, F	1
Vanderwolf, CH	1
Musílková, J; Shelkovnikov, SA; Starshinova, LA; Tucek, S	1
Yang, CM	1
Lambert, DG; Nahorski, SR; Wojcikiewicz, RJ	1
Bartfai, T; Grabczewska, E; Maslinski, W; Ryzewski, J	1
Haga, T; Honda, N; Ichiyama, A; Kajimura, M; Kaneko, E	1
Alonso, R; Didier, M; Soubrie, P	1
el-Fakahany, EE; Lee, NH	2
Chiang, PK; Covington, J; Jackson, BW; Leader, H; Newman, AH; Oleshansky, M; Weissman, BA	1
Ackerman, MS; Korc, M; Roeske, WR	1
Hollingsworth, PJ; Smith, CB	1
Ackerman, MS; Heck, RJ; Korc, M; Roeske, WR	1
Palm, D; Pitschner, HF; Schlepper, M; Schulte, B; Wellstein, A	1
Shimizu, H; Watanabe, H	1
Bali, JP; Magous, R; Moummi, C; Strosberg, D	1
Ek, B; Nahorski, S	1
Amrhein, CL; Cioffi, CL; el-Fakahany, EE; McKinney, M; Richelson, E; Stenstrom, S; Surichamorn, W	1
Costa, LG	1
Hsu, CT; Hyman, PE; Jing, J; Snape, WJ; Tomomasa, T	1
Anderson, W; Dickinson, KE; Hirschowitz, BI; Matsumoto, H; Pruitt, RE; Uemura, N	1
Wilkerson, RD	1
Chuang, DM; Xu, J	1
Gillin, JC; Janowsky, D; Risch, SC; Ziegler, M	1
Miranda, HI; Silva, WI; Wolstenholme, WW	1
Auriga, C; Birdsall, NJ; Boer, R; Schudt, C	1
Abdel-Latif, AA; Honkanen, RE	1
Dwyer, TM; Farley, JM; Yang, CM	1
Fisher, SK	1
Davis, LH; Kauffman, FC; Viana, GB	1
Ahmad, A; Chiang, PK; Gordon, RK	1
Bali, JP; Baudiere, B; Giraldo, E; Ladinsky, H; Monferini, E	1
Ban, T; Shingai, R; Usami, K	1
Christophe, J; Gillard, M; Waelbroeck, M	1
Baker, SP; Posner, P	1
Barlow, RB; Dawson, S	1
el-Fakahany, EE; Lee, JH	1
Giraldo, E; Hammer, R; Monferini, E	1
Ehlert, FJ; Jenden, DJ	1
Alatienne, M; Duchene-Marullaz, P; Gueorguiev, G; Kantelip, JP	1
Ellis, J; Lenox, RH	1
El-Fakahany, EE; Feigenbaum, P	1
Harden, TK; Petch, LA; Traynelis, SF; Waldo, GL	1
Eckelman, WC; Francis, B; Gibson, RE; Grissom, MP; Reba, RC	1
Kuhar, MJ; Lepor, H	2
Christophe, J; De Neef, P; Robberecht, P; Waelbroeck, M	1
Moreno-Yanes, JA; Salazar, J	1
Daniotti, S; Del Soldato, P	1
Baissat, J; Chassaing, C; Duchêne-Marullaz, P; Dureng, G	1
Albinus, M; Winne, D	1
Kuhar, MJ; Wamsley, JK; Zarbin, MA	1
Blozovski, D; Hennocq, N	1
Klein, WL; Siman, RG	1
Hammer, R	1
Hirshkowitz, M; Karacan, I; Thornby, JI	1
Hughes, RA	1
Hjälmås, K; Rubenson, A; Sillén, U	1
Glick, SD; Guido, RA	1
Leppik, R; van Giersbergen, PL	1
Christopoulos, A; Mitchelson, F	1
Chowdhury, P; Doi, R; Inoue, K; Kaji, H; Rayford, PL	1
Bellido, I; Gomez, A; Sanchez de la Cuesta, F	1
Proska, J; Tucek, S	1
Butler, T; Dobbie, JW; Duffield, R; Hjelle, JT; Ho, AK; Miller-Hjelle, MA; Reith, M; Steidley, KR	1
Bacáková, L; el-Fakahany, EE; Jakubík, J; Tucek, S	1
Jones, SB; King, LB	1
Brann, MR; Burstein, ES; Spalding, TA	1
Birdsall, NJ; Clementi, F; Court, JA; Griffiths, M; Johnson, M; Kerwin, JM; Morris, CM; Oakley, AE; Perry, EK; Spurden, D	1
Kim, CY; Sohn, UD	1
Christopoulos, A; Lanzafame, A; Mitchelson, F	2
Allal, C; Brefel-Courbon, C; Gharib, C; Lazartigues, E; Montastruc, JL; Rascol, O; Tran, MA	1
Bartoszko-Malik, A; Raufman, JP; Zimniak, P	1
Harbon, S; Lajat, S; Tanfin, Z	1
Maullu, C; Olianas, MC; Onali, P	1
Fu, HM; Fu, ML; Hjalmarson, A; Matsui, S; Wallukat, G	1
Fang, JC; Liu, J; Mittal, RK; Sarosiek, I; Yamamoto, Y	1
Christopoulos, A; El-Fakahany, EE; Parsons, AM	1
Curtis, CA; Hulme, EC; Ward, SD	1
Chang, DJ; Cho, NJ; Hwang, JM; Kaang, BK; Kim, US; Lee, YS; Park, YS	1
De Bruin, VM; De Sousa, FC; Marinho, MM; Viana, GS	1
Janowsky, DS	1
El-Fakahany, EE; Jakubík, J; Tucek, S	1
Corner, B	1
HERXHEIMER, A	1
Azpiazu, I; Gautam, N	1
Barak, D; Pittel, Z; Segall, Y	1
De Lorme, KC; El-Fakahany, EE; Grant, MK; Sikorski, KL	1
Hatanaka, T; Miyata, K; Noguchi, Y; Ohtake, A; Okutsu, H; Saitoh, C; Sasamata, M; Sato, S; Suzuki, M; Ukai, M; Yuyama, H	1
Appadu, BL; Cembala, TM; Forde, SC; Lambert, DG	1
Avlani, VA; Christopoulos, A; McLoughlin, DJ; Sexton, PM	1
Huang, TJ; Ko, WC; Lin, LH; Lin, YL; Wang, SH; Wu, SN	1
El-Fakahany, EE; Grant, MK; Noetzel, MJ	1
Christopoulos, A; Sexton, PM; Stewart, GD	1
Anisuzzaman, AS; Cheng, JT; Lee, KS; Muramatsu, I; Nishimune, A; Suzuki, F; Wang, MH; Yoshiki, H	1
Anisuzzaman, AS; Muramatsu, I; Nishimune, A; Uwada, J; Yoshiki, H	1
Anisuzzaman, AS; Hayashi, H; Ikeuchi, H; Khan, MR; Ma, Y; Maemoto, A; Muramatsu, I; Semba, S; Suzuki, Y; Takano, T; Taniguchi, T; Uchino, M; Ushikubi, F; Uwada, J	1
Catterall, WA; Cheah, CS; Kalume, F; Oakley, JC; Scheuer, T; Westenbroek, RE; Yu, FH	1
Anisuzzaman, ASM; Morishima, S; Muramatsu, I; Uwada, J; Yoshiki, H	1

Trials

1 trial(s) available for atropine and n-methylscopolamine

Article	Year
Cholinergic blockade inhibits gastro-oesophageal reflux and transient lower oesophageal sphincter relaxation through a central mechanism. Gut, 1999, Volume: 44, Issue:5 Topics: Adult; Atropine; Cholinergic Antagonists; Esophagogastric Junction; Esophagus; Female; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Male; Manometry; Middle Aged; Muscle Relaxation; N-Methylscopolamine; Parasympatholytics; Peristalsis; Pressure	1999

Article

Year

Cholinergic blockade inhibits gastro-oesophageal reflux and transient lower oesophageal sphincter relaxation through a central mechanism.

Gut, 1999, Volume: 44, Issue:5

Topics: Adult; Atropine; Cholinergic Antagonists; Esophagogastric Junction; Esophagus; Female; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Male; Manometry; Middle Aged; Muscle Relaxation; N-Methylscopolamine; Parasympatholytics; Peristalsis; Pressure

1999

Other Studies

115 other study(ies) available for atropine and n-methylscopolamine

Article	Year
On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor. Molecular pharmacology, 1998, Volume: 53, Issue:6 Topics: Animals; Atropine; Carbachol; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Muscarinic Agonists; N-Methylscopolamine; Nitric Oxide Synthase; Phosphatidylinositols; Pyridines; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiadiazoles; Time Factors	1998
Synthesis and pharmacological characterization of O-alkynyloximes of tropinone and N-methylpiperidinone as muscarinic agonists. Journal of medicinal chemistry, 1998, Aug-13, Volume: 41, Issue:17 Topics: Animals; Aorta; Binding, Competitive; Drug Design; Escape Reaction; In Vitro Techniques; Male; Maze Learning; Mice; Models, Molecular; Molecular Structure; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth, Vascular; N-Methylscopolamine; Nuclear Magnetic Resonance, Biomolecular; Piperidines; Pirenzepine; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Structure-Activity Relationship; Tropanes	1998
Pharmacological properties of (2R)-N-[1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: a novel mucarinic antagonist with M(2)-sparing antagonistic activity. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:2 Topics: Animals; Benzeneacetamides; Brain; Bronchoconstriction; Heart Atria; Heart Rate; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscarinic Antagonists; Muscle, Smooth; Muscle, Smooth, Vascular; Piperidines; Pirenzepine; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptors, Muscarinic; Trachea; Tremor; Vas Deferens	2001
Receptor binding studies of soft anticholinergic agents. AAPS pharmSci, 2001, Volume: 3, Issue:4 Topics: Animals; Cholinergic Antagonists; Dose-Response Relationship, Drug; Drug Stability; Guinea Pigs; Humans; Ileum; Protein Binding; Quantitative Structure-Activity Relationship; Receptors, Muscarinic	2001
Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1 Topics: Acetylcholine; Acetylcholinesterase; Animals; Aorta, Thoracic; Atropine; Carbachol; CHO Cells; Cricetinae; In Vitro Techniques; Inositol Phosphates; Kinetics; Lithocholic Acid; Male; Muscarinic Antagonists; Muscle, Smooth; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Recombinant Proteins; Taurolithocholic Acid	2002
Identification of various allosteric interaction sites on M1 muscarinic receptor using 125I-Met35-oxidized muscarinic toxin 7. Molecular pharmacology, 2006, Volume: 69, Issue:5 Topics: Allosteric Regulation; Binding Sites; Elapid Venoms; Humans; Iodine Radioisotopes; Kinetics; Ligands; Methionine; Oxidation-Reduction; Protein Folding; Receptor, Muscarinic M1; Spectrometry, Mass, Electrospray Ionization	2006
Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M3 receptor. British journal of pharmacology, 2006, Volume: 148, Issue:7 Topics: Algorithms; Animals; Atropine; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Indicators and Reagents; Kinetics; Ligands; Muscarinic Antagonists; N-Methylscopolamine; Radioligand Assay; Receptor, Muscarinic M3; Scopolamine Derivatives; Tiotropium Bromide	2006
Distinct structural changes in a G protein-coupled receptor caused by different classes of agonist ligands. The Journal of biological chemistry, 2007, Sep-07, Volume: 282, Issue:36 Topics: Amino Acid Substitution; Animals; Chlorocebus aethiops; COS Cells; Cysteine; Ligands; Models, Molecular; Mutation, Missense; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Receptor, Muscarinic M3	2007
Fluorescent derivatives of AC-42 to probe bitopic orthosteric/allosteric binding mechanisms on muscarinic M1 receptors. Journal of medicinal chemistry, 2012, Mar-08, Volume: 55, Issue:5 Topics: Allosteric Regulation; Calcium; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Green Fluorescent Proteins; HEK293 Cells; Humans; Models, Molecular; Molecular Probes; Piperidines; Radioligand Assay; Receptor, Muscarinic M1; Recombinant Fusion Proteins; Rhodamines; Solubility; Structure-Activity Relationship	2012
Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M Journal of medicinal chemistry, 2017, 04-27, Volume: 60, Issue:8 Topics: Benzodiazepinones; Binding Sites; Molecular Dynamics Simulation; Muscarinic Antagonists; Radioisotopes; Receptor, Muscarinic M2	2017
Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M Journal of medicinal chemistry, 2020, 04-23, Volume: 63, Issue:8 Topics: Animals; CHO Cells; Cholinergic Agents; Cricetulus; Fluorescent Dyes; Muscarinic Antagonists; Phthalimides; Protein Structure, Secondary; Quaternary Ammonium Compounds; Receptor, Muscarinic M2	2020
Central cardiovascular effects of physostigmine in anesthetized cats. Neuropharmacology, 1992, Volume: 31, Issue:9 Topics: Anesthesia; Animals; Atropine; Blood Pressure; Cats; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Kidney; Male; N-Methylscopolamine; Physostigmine; Receptors, Muscarinic; Scopolamine Derivatives; Sympathetic Nervous System; Vagotomy	1992
Apparent noncompetitive antagonism of muscarinic receptor mediated Ca2+ mobilization by some muscarinic antagonists. Biochemical and biophysical research communications, 1992, Dec-15, Volume: 189, Issue:2 Topics: Atropine; Calcium; Fura-2; Humans; Kinetics; Muscarinic Antagonists; N-Methylscopolamine; Neuroblastoma; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Spectrometry, Fluorescence; Tumor Cells, Cultured	1992
The muscarinic receptor gene expressed in rabbit parietal cells is the m3 subtype. Gastroenterology, 1992, Volume: 103, Issue:3 Topics: Animals; Atropine; Base Sequence; Blotting, Southern; Molecular Sequence Data; N-Methylscopolamine; Parietal Cells, Gastric; Piperidines; Pirenzepine; Polymerase Chain Reaction; Rabbits; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives	1992
Characterization of muscarinic cholinergic receptors in intact myocardial cells in vitro. Biochemical pharmacology, 1992, Jun-09, Volume: 43, Issue:11 Topics: Animals; Atropine; Cells, Cultured; Down-Regulation; Electric Stimulation; Gallopamil; Half-Life; Kinetics; Myocardial Contraction; Myocardium; N-Methylscopolamine; Radioligand Assay; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Thyroid Hormones	1992
Muscarinic receptor subtypes in human and rat colon smooth muscle. Biochemical pharmacology, 1992, Jun-09, Volume: 43, Issue:11 Topics: Animals; Atropine; Binding, Competitive; Colon; Humans; Infant, Newborn; Male; Muscle, Smooth; N-Methylscopolamine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives	1992
Anti-muscarinic drug effects in a swim-to-platform test: dose-response relations. Behavioural brain research, 1991, Aug-29, Volume: 44, Issue:2 Topics: Animals; Atropine; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Subcutaneous; Male; N-Methylscopolamine; Parasympatholytics; Rats; Scopolamine; Scopolamine Derivatives; Swimming	1991
Interaction of the neuromuscular blocking drug atracurium with muscarinic acetylcholine receptors. Physiological research, 1991, Volume: 40, Issue:3 Topics: Animals; Atracurium; Atropine; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Female; Heart Atria; Male; Muscarine; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Parasympathomimetics; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Scopolamine Derivatives; Tritium	1991
Characterization of muscarinic receptors in dog tracheal smooth muscle cells. Journal of autonomic pharmacology, 1991, Volume: 11, Issue:1 Topics: Animals; Atropine; Carbachol; Diamines; Dogs; In Vitro Techniques; Kinetics; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Trachea	1991
Regulation of muscarinic agonist-induced activation of phosphoinositidase C in electrically permeabilized SH-SY5Y human neuroblastoma cells by guanine nucleotides. Journal of neurochemistry, 1990, Volume: 54, Issue:2 Topics: Atropine; Calcium; Cell Membrane Permeability; Electric Stimulation; Guanine Nucleotides; Humans; N-Methylscopolamine; Neuroblastoma; Parasympatholytics; Parasympathomimetics; Phosphoric Diester Hydrolases; Scopolamine Derivatives; Tumor Cells, Cultured	1990
Muscarinic antagonist binding to intact rat thymocytes. Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1990, Volume: 44, Issue:2 Topics: Animals; Atropine; Benzilates; Kinetics; Male; Muscarine; N-Methylscopolamine; Piperidines; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Thymus Gland	1990
Carbachol-induced potentiation and inhibition of acid secretion by guinea pig gastric gland. European journal of pharmacology, 1990, Mar-13, Volume: 178, Issue:1 Topics: Aminopyrine; Animals; Atropine; Binding, Competitive; Carbachol; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Guinea Pigs; Histamine; In Vitro Techniques; Male; N-Methylscopolamine; Parasympathomimetics; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives	1990
[3H]N-methylscopolamine binding studies reveal M2 and M3 muscarinic receptor subtypes on cerebellar granule cells in primary culture. Journal of neurochemistry, 1990, Volume: 55, Issue:1 Topics: Animals; Atropine; Binding, Competitive; Cell Survival; Cells, Cultured; Cerebellum; Diamines; Granulocytes; N-Methylscopolamine; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Tritium	1990
The allosteric binding profile of himbacine: a comparison with other cardioselective muscarinic antagonists. European journal of pharmacology, 1990, Apr-10, Volume: 179, Issue:1-2 Topics: Alkaloids; Allosteric Regulation; Animals; Atropine; Binding, Competitive; Diamines; Dose-Response Relationship, Drug; Furans; Gallamine Triethiodide; Male; Myocardium; N-Methylscopolamine; Naphthalenes; Piperidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives	1990
Aprophit: an irreversible antagonist for muscarinic receptors. Biochemical pharmacology, 1990, Sep-15, Volume: 40, Issue:6 Topics: Adrenal Glands; Animals; Atropine; Binding, Competitive; Brain; Catecholamines; Guinea Pigs; Male; N-Methylscopolamine; Parasympatholytics; Phenylpropionates; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Thiocyanates	1990
A cholinergic antagonist identifies a subclass of muscarinic receptors in isolated rat pancreatic acini. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:1 Topics: Amylases; Animals; Atropine; Carbachol; Cerebral Cortex; Dose-Response Relationship, Drug; Kinetics; Male; Myocardium; N-Methylscopolamine; Pancreas; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives	1987
Effects of muscarinic receptor agonists and antagonists on alpha 2-adrenoceptors in rat brain. European journal of pharmacology, 1989, Sep-13, Volume: 168, Issue:2 Topics: Animals; Atropine; Atropine Derivatives; Brain; Clonidine; Male; N-Methylscopolamine; Neurons; Oxotremorine; Parasympatholytics; Pilocarpine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Scopolamine; Scopolamine Derivatives; Time Factors	1989
Identification and characterization of muscarinic receptors in cultured human pancreatic carcinoma cells. Pancreas, 1989, Volume: 4, Issue:3 Topics: Atropine; Carbachol; Cell Line; Humans; Inositol Phosphates; Kinetics; N-Methylscopolamine; Pancreatic Neoplasms; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Tumor Cells, Cultured	1989
AF-DX 116 discriminates heart from gland M2-cholinoceptors in man. Life sciences, 1989, Volume: 45, Issue:6 Topics: Adult; Animals; Atropine; Blood Pressure; Cattle; Cell Membrane; Cerebral Cortex; Heart Rate; Humans; Kinetics; Male; Myocardium; N-Methylscopolamine; Organ Specificity; Pirenzepine; Propranolol; Receptors, Cholinergic; Reference Values; Saliva; Salivary Glands; Scopolamine Derivatives; Swine	1989
Effect of anticholinergic drugs on striatal acetylcholine release and motor activity in freely moving rats studied by brain microdialysis. Japanese journal of pharmacology, 1989, Volume: 51, Issue:1 Topics: Acetylcholine; Animals; Atropine; Brain Chemistry; Corpus Striatum; Dialysis; Male; Motor Activity; N-Methylscopolamine; Parasympatholytics; Rats; Rats, Inbred Strains; Scopolamine; Scopolamine Derivatives; Tissue Distribution	1989
Muscarinic receptors in isolated smooth muscle cells from gastric antrum. Biochemical pharmacology, 1988, Apr-01, Volume: 37, Issue:7 Topics: Acetylcholine; Animals; Antibodies, Monoclonal; Atropine; Cyclic AMP; Dose-Response Relationship, Drug; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Pyloric Antrum; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives	1988
Muscarinic receptor coupling to inositol phospholipid metabolism in guinea-pig cerebral cortex, parotid gland and ileal smooth muscle. Biochemical pharmacology, 1988, Dec-01, Volume: 37, Issue:23 Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Guanosine Triphosphate; Guinea Pigs; Ileum; Muscle, Smooth; N-Methylscopolamine; Oxotremorine; Parotid Gland; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives	1988
Pseudo-noncompetitive antagonism of muscarinic receptor-mediated cyclic GMP formation and phosphoinositide hydrolysis by pirenzepine. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3 Topics: Animals; Atropine; Carbachol; Cyclic GMP; Hydrolysis; Mice; N-Methylscopolamine; Phosphatidylinositols; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives	1988
Specific binding of [3H]methylscopolamine to glass fibre filters. The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:3 Topics: Animals; Aplysia; Atropine; Atropine Derivatives; Chemical Phenomena; Chemistry, Physical; Filtration; gamma-Aminobutyric Acid; Glass; N-Methylscopolamine; Norepinephrine; Receptors, Muscarinic; Scopolamine; Scopolamine Derivatives	1987
Development of the muscarinic receptor in rabbit gastric smooth muscle. The American journal of physiology, 1988, Volume: 254, Issue:5 Pt 1 Topics: Animals; Animals, Newborn; Atropine; Bethanechol; Bethanechol Compounds; Dose-Response Relationship, Drug; Kinetics; Muscle Contraction; Muscle Development; Muscle, Smooth; N-Methylscopolamine; Phenethylamines; Piperidines; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives; Stomach	1988
Muscarinic cholinergic receptor subtype on frog esophageal peptic cells: binding and secretion studies. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:3 Topics: Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Carbachol; Esophagus; Imipramine; Kinetics; N-Methylscopolamine; Oxotremorine; Pepsinogens; Pirenzepine; Propranolol; Radioligand Assay; Rana catesbeiana; Receptors, Muscarinic; Scopolamine Derivatives	1988
Cardiovascular effects of cocaine: enhancement by yohimbine and atropine. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:1 Topics: Animals; Atropine; Blood Pressure; Cardiovascular System; Cocaine; Coronary Circulation; Dogs; Heart Rate; Myocardial Contraction; N-Methylscopolamine; Norepinephrine; Oxygen Consumption; Scopolamine Derivatives; Yohimbine	1989
Muscarinic acetylcholine receptor-mediated phosphoinositide turnover in cultured cerebellar granule cells: desensitization by receptor agonists. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:1 Topics: Animals; Atropine; Carbachol; Cells, Cultured; Cerebellum; Kinetics; Male; N-Methylscopolamine; Oxotremorine; Phorbol Esters; Phosphatidylinositols; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Virulence Factors, Bordetella	1987
Antagonistic effects of scopolamine and atropine on the physostigmine response in man. Military medicine, 1987, Volume: 152, Issue:11 Topics: Adult; Affect; Atropine; Cardiovascular System; Double-Blind Method; Drug Evaluation; Humans; Male; N-Methylscopolamine; Neurosecretory Systems; Parasympatholytics; Physostigmine; Scopolamine; Scopolamine Derivatives	1987
Pre- and post-synaptic muscarinic receptors of the rat vas deferens: an update. Puerto Rico health sciences journal, 1988, Volume: 7, Issue:2 Topics: Animals; Atropine; Binding, Competitive; Male; Membrane Potentials; Muscle, Smooth; N-Methylscopolamine; Neuromuscular Junction; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives; Synapses; Terminology as Topic; Vas Deferens	1988
Does the prolonged occupancy of M1 receptors by telenzepine protect them against the action of vagally released acetylcholine? Pharmacology, 1988, Volume: 37 Suppl 1 Topics: Acetylcholine; Animals; Atropine; Binding, Competitive; Brain; Cattle; In Vitro Techniques; Kinetics; N-Methylscopolamine; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Vagus Nerve	1988
Characterization of cholinergic muscarinic receptors in the rabbit iris. Biochemical pharmacology, 1988, Jul-01, Volume: 37, Issue:13 Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Ileum; Iris; Kinetics; Methacholine Chloride; Methacholine Compounds; Microsomes; N-Methylscopolamine; Oxotremorine; Pirenzepine; Quinuclidinyl Benzilate; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives	1988
Muscarinic stimulation of submucosal glands in swine trachea. Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 64, Issue:1 Topics: Animals; Atropine; Binding, Competitive; Carbachol; Exocrine Glands; Isoflurophate; Male; Mucus; N-Methylscopolamine; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Scopolamine Derivatives; Swine; Trachea	1988
Recognition of muscarinic cholinergic receptors in human SK-N-SH neuroblastoma cells by quaternary and tertiary ligands is dependent upon temperature, cell integrity, and the presence of agonists. Molecular pharmacology, 1988, Volume: 33, Issue:4 Topics: Atropine; Binding, Competitive; Carbachol; Humans; Kinetics; Ligands; N-Methylscopolamine; Neuroblastoma; Quinuclidinyl Benzilate; Receptors, Muscarinic; Scopolamine; Scopolamine Derivatives; Temperature; Tumor Cells, Cultured	1988
Effects of organophosphates and nerve growth factor on muscarinic receptor binding number in rat pheochromocytoma PC12 cells. Toxicology and applied pharmacology, 1988, Volume: 93, Issue:2 Topics: Animals; Atropine; Cholinesterases; Dose-Response Relationship, Drug; N-Methylscopolamine; Nerve Growth Factors; Organophosphorus Compounds; Pheochromocytoma; Phosphorylation; Physostigmine; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Soman; Tumor Cells, Cultured	1988
Influence of ligand choice on the apparent binding profile of gallamine to cardiac muscarinic receptors. Identification of three main types of gallamine-muscarinic receptor interactions. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:3 Topics: Algorithms; Alkylation; Animals; Atropine; Binding Sites; Gallamine Triethiodide; Male; Myocardium; N-Methylscopolamine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives	1988
A microtechnique for quantification of detergent-solubilized muscarinic and nicotinic acetylcholine receptors using a semi-automated cell harvestor. FEBS letters, 1987, Apr-20, Volume: 214, Issue:2 Topics: Animals; Atropine; Bungarotoxins; Digitonin; In Vitro Techniques; Microchemistry; N-Methylscopolamine; Neuroblastoma; Polyethylene Glycols; Quinuclidinyl Benzilate; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine Derivatives; Solubility	1987
Characterization of the muscarinic receptor subtype in isolated gastric fundic cells of the rabbit. Biochemical pharmacology, 1987, Sep-15, Volume: 36, Issue:18 Topics: Aminopyrine; Animals; Atropine; Carbachol; Gastric Fundus; Kinetics; Male; N-Methylscopolamine; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives	1987
Muscarinic cholinergic receptor binding and electrophysiological response to acetylcholine in cultured rat caudate putamen nucleus neurons. Brain research, 1987, Sep-08, Volume: 420, Issue:1 Topics: Acetylcholine; Action Potentials; Animals; Atropine; Caudate Nucleus; Cells, Cultured; N-Methylscopolamine; Putamen; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives	1987
In vitro effects of gallamine on dissociation kinetics of (3H)N-methylscopolamine and (3H)pirenzepine from rat brain muscarinic receptors. Journal of receptor research, 1986, Volume: 6, Issue:1 Topics: Animals; Atropine; Benzodiazepinones; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Gallamine Triethiodide; Hippocampus; Kinetics; Male; Myocardium; N-Methylscopolamine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Substrate Specificity	1986
Irreversible binding of acetylethylcholine mustard to cardiac cholinergic muscarinic receptors. Molecular pharmacology, 1986, Volume: 30, Issue:5 Topics: Acetylcholine; Animals; Atropine; Carbachol; Cell Membrane; Guanylyl Imidodiphosphate; Heart Rate; Male; Myocardium; N-Methylscopolamine; Oxotremorine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives	1986
The selectivity of the (-)-and (+)-forms of hyoscine methiodide and of hyoscyamine camphorsulphonate for muscarinic (M2) receptors. British journal of pharmacology, 1986, Volume: 89, Issue:2 Topics: Animals; Atropine; Guinea Pigs; Heart; Ileum; In Vitro Techniques; Muscle, Smooth; Myocardial Contraction; N-Methylscopolamine; Receptors, Muscarinic; Scopolamine; Scopolamine Derivatives; Stereoisomerism	1986
Agonist-induced muscarinic acetylcholine receptor down-regulation in intact rat brain cells. European journal of pharmacology, 1986, Dec-02, Volume: 132, Issue:1 Topics: Animals; Atropine; Brain; Carbachol; Female; In Vitro Techniques; Male; N-Methylscopolamine; Parasympathomimetics; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives	1986
Selective labelling of M1-receptors in autonomic ganglia with 3H-pirenzepine. Arzneimittel-Forschung, 1985, Volume: 35, Issue:1A Topics: Animals; Atropine; Benzodiazepinones; Binding, Competitive; Cattle; Ganglia, Autonomic; Ganglia, Sympathetic; In Vitro Techniques; N-Methylscopolamine; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Muscarinic; Scopolamine Derivatives; Synaptosomes	1985
The binding of a 2-chloroethylamine derivative of oxotremorine (BM 123) to muscarinic receptors in the rat cerebral cortex. Molecular pharmacology, 1985, Volume: 28, Issue:2 Topics: Alkylation; Animals; Atropine; Benzodiazepinones; Binding Sites; Binding, Competitive; Cerebral Cortex; Gallamine Triethiodide; Kinetics; N-Methylscopolamine; Oxotremorine; Pirenzepine; Pyrrolidinones; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Structure-Activity Relationship; Thiosulfates	1985
Chronotropic and dromotropic effects of atropine and hyoscine methobromide in unanaesthetized dogs. British journal of anaesthesia, 1985, Volume: 57, Issue:2 Topics: Animals; Atropine; Autonomic Nervous System; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Heart Conduction System; Heart Rate; N-Methylscopolamine; Parasympatholytics; Propranolol; Scopolamine Derivatives; Stimulation, Chemical; Time Factors	1985
Quaternary forms of classical muscarinic antagonists distinguish subpopulations of muscarinic receptors: correlation with gallamine-defined subpopulations. Biochemical and biophysical research communications, 1985, Feb-15, Volume: 126, Issue:3 Topics: Allosteric Site; Animals; Atropine; Atropine Derivatives; Binding, Competitive; Brain; Gallamine Triethiodide; In Vitro Techniques; Male; N-Methylscopolamine; Parasympatholytics; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine; Scopolamine Derivatives	1985
Regulation of muscarinic cholinergic receptor density in neuroblastoma cells by brief exposure to agonist: possible involvement in desensitization of receptor function. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 233, Issue:1 Topics: Animals; Atropine; Carbachol; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Mice; N-Methylscopolamine; Neuroblastoma; Parasympathomimetics; Receptors, Muscarinic; Scopolamine Derivatives; Temperature	1985
Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors. The Journal of biological chemistry, 1985, Oct-25, Volume: 260, Issue:24 Topics: Astrocytoma; Atropine; Carbachol; Cell Fractionation; Cell Line; Cell Membrane; Centrifugation, Density Gradient; Guanosine Triphosphate; Humans; Kinetics; N-Methylscopolamine; Quinuclidinyl Benzilate; Receptors, Muscarinic; Scopolamine Derivatives	1985
The use of tritium labeled compounds to develop gamma-emitting receptor-binding radiotracers. International journal of nuclear medicine and biology, 1982, Volume: 9, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Dihydroalprenolol; Dioxanes; Dogs; Guinea Pigs; Heart; Humans; Male; N-Methylscopolamine; Parasympatholytics; Pindolol; Prazosin; Propanolamines; Quinuclidinyl Benzilate; Rabbits; Radionuclide Imaging; Rats; Scopolamine Derivatives; Tritium	1982
Characterization and localization of the muscarinic cholinergic receptor in human prostatic tissue. The Journal of urology, 1984, Volume: 132, Issue:2 Topics: Animals; Atropine; Autoradiography; Binding, Competitive; Dogs; Humans; In Vitro Techniques; Male; N-Methylscopolamine; Prostate; Prostatic Hyperplasia; Rabbits; Radioligand Assay; Receptors, Muscarinic; Scopolamine Derivatives; Swine	1984
Inhibitory effects of quinidine on rat heart muscarinic receptors. Life sciences, 1984, Sep-03, Volume: 35, Issue:10 Topics: Animals; Atropine; Binding, Competitive; Heart; Kinetics; Mathematics; Myocardium; N-Methylscopolamine; Oxotremorine; Quinidine; Rats; Receptors, Muscarinic; Scopolamine Derivatives	1984
[Biochemical studies on muscarinic cholinergic receptors of the rat brain: specific labeling of this protein using the photoaffinity method]. Acta cientifica venezolana, 1984, Volume: 35, Issue:1 Topics: Affinity Labels; Animals; Atropine; Binding Sites; Brain Chemistry; Cell Membrane; Male; N-Methylscopolamine; Parasympatholytics; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives	1984
Comparative studies of the effects of some antimuscarinic agents on gastric damage and pupillary reflex in the rat. British journal of pharmacology, 1984, Volume: 82, Issue:2 Topics: Animals; Atropine; Benzodiazepinones; Female; N-Methylscopolamine; Oxotremorine; Parasympatholytics; Pirenzepine; Propantheline; Rats; Rats, Inbred Strains; Reflex, Pupillary; Scopolamine Derivatives; Stomach Diseases	1984
Pharmacological evidence for cardiac muscarinic receptor subtypes. Life sciences, 1984, Oct-22, Volume: 35, Issue:17 Topics: Acetylcholine; Animals; Arecoline; Atropine; Benzodiazepinones; Binding Sites; Butylscopolammonium Bromide; Carbachol; Female; Guinea Pigs; Heart Rate; Male; Myocardial Contraction; Myocardium; N-Methylscopolamine; Pirenzepine; Quaternary Ammonium Compounds; Receptors, Muscarinic; Scopolamine Derivatives	1984
Subclasses of muscarinic receptors in isolated gastric mucosal cells: receptor characterization and parietal cell function. European journal of pharmacology, 1983, Oct-28, Volume: 94, Issue:3-4 Topics: Animals; Atropine; Benzodiazepinones; Binding, Competitive; Carbachol; Dogs; Gastric Mucosa; Guanine Nucleotides; Guinea Pigs; In Vitro Techniques; Male; Models, Biological; N-Methylscopolamine; Pilocarpine; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives	1983
Distribution of muscarinic cholinergic high and low affinity agonist binding sites: a light microscopic autoradiographic study. Brain research bulletin, 1984, Volume: 12, Issue:3 Topics: Animals; Atropine; Autoradiography; Brain; Brain Stem; Carbachol; Kinetics; Male; N-Methylscopolamine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Spinal Cord	1984
Characterization of muscarinic cholinergic receptor binding in the vas deferens, bladder, prostate and penis of the rabbit. The Journal of urology, 1984, Volume: 132, Issue:2 Topics: Animals; Atropine; Binding, Competitive; Diazoxide; Haloperidol; In Vitro Techniques; Male; N-Methylscopolamine; Oxotremorine; Parasympathomimetics; Penis; Phentolamine; Propranolol; Prostate; Rabbits; Radioligand Assay; Receptors, Muscarinic; Scopolamine Derivatives; Urinary Bladder; Vas Deferens	1984
Effects of antimuscarinic cholinergic drugs injected systemically or into the hippocampo-entorhinal area upon passive avoidance learning in young rats. Psychopharmacology, 1982, Volume: 76, Issue:4 Topics: Age Factors; Animals; Atropine; Atropine Derivatives; Avoidance Learning; Extinction, Psychological; Female; Hippocampus; Limbic System; Male; N-Methylscopolamine; Rats; Receptors, Muscarinic; Retention, Psychology; Scopolamine; Scopolamine Derivatives	1982
Differential regulation of muscarinic and nicotinic receptors by cholinergic stimulation in cultured avian retina cells. Brain research, 1983, Feb-28, Volume: 262, Issue:1 Topics: Animals; Atropine; Carbachol; Cells, Cultured; Chick Embryo; N-Methylscopolamine; Neurons; Nicotine; Oxotremorine; Quinuclidinyl Benzilate; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, Nicotinic; Retina; Scopolamine Derivatives; Tubocurarine	1983
Subclasses of muscarinic receptors and pirenzepine. Further experimental evidence. Scandinavian journal of gastroenterology. Supplement, 1982, Volume: 72 Topics: Atropine; Benzodiazepinones; Gastric Juice; Humans; N-Methylscopolamine; Pirenzepine; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine Derivatives	1982
Sleep spindles: pharmacological effects in humans. Sleep, 1982, Volume: 5, Issue:1 Topics: Atropine; Azepines; Caffeine; Cerebral Cortex; Computers; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Evoked Potentials; Flurazepam; Haloperidol; Humans; N-Methylscopolamine; Phenobarbital; Scopolamine; Scopolamine Derivatives; Sleep Stages; Thalidomide; Tryptophan	1982
Anticholinergic drugs, blood-brain-barrier and tonic immobility in chickens. Physiology & behavior, 1982, Volume: 29, Issue:1 Topics: Aging; Animals; Atropine; Atropine Derivatives; Blood-Brain Barrier; Chickens; Dose-Response Relationship, Drug; Fear; Motor Activity; N-Methylscopolamine; Parasympatholytics; Scopolamine; Scopolamine Derivatives	1982
Central cholinergic mechanisms in L-DOPA induced hyperactive urinary bladder of the rat. Urological research, 1982, Volume: 10, Issue:5 Topics: Animals; Atropine; Brain; Calcium; Hexamethonium Compounds; Levodopa; Male; N-Methylscopolamine; Oxotremorine; Phentolamine; Rats; Receptors, Adrenergic; Receptors, Cholinergic; Reserpine; Scopolamine Derivatives; Sotalol; Urinary Bladder	1982
Scopolamine self-administration: cholinergic involvement in reward mechanisms. Life sciences, 1982, Aug-30, Volume: 31, Issue:9 Topics: Animals; Arecoline; Atropine; Behavior, Animal; Female; Mecamylamine; N-Methylscopolamine; Oxotremorine; Parasympathetic Nervous System; Physostigmine; Pilocarpine; Rats; Rats, Inbred Strains; Reinforcement, Psychology; Reward; Scopolamine; Scopolamine Derivatives; Self Administration	1982
Modulation of agonist binding by guanine nucleotides in CHO cells expressing muscarinic m1-m5 receptors. Naunyn-Schmiedeberg's archives of pharmacology, 1995, Volume: 352, Issue:2 Topics: Animals; Atropine; Carbachol; CHO Cells; Cricetinae; Guanine Nucleotides; Guanylyl Imidodiphosphate; Humans; Kinetics; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Parasympatholytics; Radioligand Assay; Receptors, Muscarinic; Scopolamine Derivatives	1995
[3H]N-methylscopolamine dissociation from muscarine receptors affected by low concentrations of allosteric modulators. European journal of pharmacology, 1995, Aug-15, Volume: 290, Issue:3 Topics: Allosteric Regulation; Animals; Atropine; Binding, Competitive; Gallamine Triethiodide; Guinea Pigs; In Vitro Techniques; Kinetics; Ligands; Muscarinic Antagonists; N-Methylscopolamine; Nicotinic Antagonists; Parasympatholytics; Receptors, Muscarinic; Scopolamine Derivatives	1995
Structural and functional changes of exocrine pancreas induced by FK506 in rats. Gastroenterology, 1993, Volume: 104, Issue:4 Topics: Amylases; Analysis of Variance; Animals; Atropine; Body Weight; Calcimycin; Calcium; Carbachol; Cholecystokinin; Colforsin; Cytosol; Dose-Response Relationship, Drug; Feeding Behavior; Kinetics; Male; N-Methylscopolamine; Pancreas; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Reference Values; Scopolamine; Scopolamine Derivatives; Secretin; Sincalide; Tacrolimus; Tetradecanoylphorbol Acetate; Time Factors; Trypsinogen; Vasoactive Intestinal Peptide	1993
Atropine and glycopyrronium show similar binding patterns to M2 (cardiac) and M3 (submandibular gland) muscarinic receptor subtypes in the rat. British journal of anaesthesia, 1995, Volume: 74, Issue:5 Topics: Animals; Atropine; Binding, Competitive; Glycopyrrolate; Heart Ventricles; In Vitro Techniques; Male; N-Methylscopolamine; Parasympatholytics; Pirenzepine; Rats; Rats, Wistar; Receptors, Muscarinic; Scopolamine Derivatives; Submandibular Gland	1995
Mechanisms of steric and cooperative actions of alcuronium on cardiac muscarinic acetylcholine receptors. Molecular pharmacology, 1994, Volume: 45, Issue:4 Topics: Alcuronium; Animals; Atropine; Heart; Kinetics; Male; N-Methylscopolamine; Rats; Rats, Wistar; Receptors, Muscarinic; Scopolamine Derivatives	1994
Multiple drug classes and hyperosmolarity alter binding of muscarinic drugs to mesothelial cells in vitro. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, 1995, Volume: 11 Topics: Animals; Atropine; Cells, Cultured; Cocaine; Cycloheximide; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Epithelium; Mannitol; Muscarinic Antagonists; N-Methylscopolamine; Osmolar Concentration; Parasympatholytics; Peritoneum; Piperazines; Quinuclidinyl Benzilate; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives; Sodium Chloride	1995
Constitutive activity of the M1-M4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists. FEBS letters, 1995, Dec-18, Volume: 377, Issue:2 Topics: Animals; Atropine; Carbachol; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; Humans; Inositol Phosphates; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Transfection; Tritium	1995
Muscarinic cholinergic receptors in brain and atrial membranes of adult brook trout (Salvelinus fontinalis) measured by radioligand binding techniques. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1995, Volume: 112, Issue:1 Topics: Animals; Atropine; Binding, Competitive; Brain Chemistry; Carbachol; Heart Atria; Kinetics; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Oxotremorine; Parasympatholytics; Pirenzepine; Radioligand Assay; Receptors, Muscarinic; Scopolamine; Scopolamine Derivatives; Trout	1995
Constitutive activation of chimeric m2/m5 muscarinic receptors and delineation of G-protein coupling selectivity domains. Biochemical pharmacology, 1996, Feb-23, Volume: 51, Issue:4 Topics: 3T3 Cells; Adenylyl Cyclases; Animals; Atropine; beta-Galactosidase; Binding, Competitive; Carbachol; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chlorocebus aethiops; GTP-Binding Proteins; Humans; Kinetics; Mice; N-Methylscopolamine; Phosphatidylinositols; Receptors, Muscarinic; Recombinant Fusion Proteins; Scopolamine Derivatives; Signal Transduction; Transfection	1996
The role of the cholinergic system in the development of the human cerebellum. Brain research. Developmental brain research, 1995, Dec-21, Volume: 90, Issue:1-2 Topics: Acetylcholine; Atropine; Autoradiography; Binding, Competitive; Cerebellum; Choline O-Acetyltransferase; Embryonic and Fetal Development; Gestational Age; Humans; Immunohistochemistry; N-Methylscopolamine; Receptor, Nerve Growth Factor; Receptors, Muscarinic; Receptors, Nerve Growth Factor; Receptors, Nicotinic; Scopolamine Derivatives	1995
Suppression of the rat micturition reflex by imipramine. Journal of autonomic pharmacology, 1997, Volume: 17, Issue:1 Topics: Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Antidepressive Agents, Tricyclic; Atropine; Cholinergic Agents; Dose-Response Relationship, Drug; Drug Interactions; Enuresis; Enzyme Inhibitors; Female; Fenclonine; Hemicholinium 3; Imipramine; Injections, Intraperitoneal; Injections, Intravenous; Injections, Intraventricular; Methyltyrosines; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Rats; Rats, Sprague-Dawley; Scopolamine Derivatives; Serotonin Agents; Urination	1997
Three allosteric modulators act at a common site, distinct from that of competitive antagonists, at muscarinic acetylcholine M2 receptors. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:1 Topics: Alcuronium; Allosteric Regulation; Animals; Atropine; Female; Gallamine Triethiodide; Guinea Pigs; Male; Muscarinic Antagonists; N-Methylscopolamine; Receptor, Muscarinic M2; Receptors, Muscarinic; Scopolamine Derivatives	1997
Central cardiovascular effects of tacrine in the conscious dog: a role for catecholamines and vasopressin release. European journal of pharmacology, 1998, May-08, Volume: 348, Issue:2-3 Topics: Animals; Atropine; Blood Pressure; Bradycardia; Cholinesterase Inhibitors; Dogs; Dose-Response Relationship, Drug; Epinephrine; Female; Injections, Intravenous; Male; Muscarinic Antagonists; N-Methylscopolamine; Norepinephrine; Parasympathomimetics; Receptors, Muscarinic; Tacrine; Vasopressins	1998
Lithocholyltaurine interacts with cholinergic receptors on dispersed chief cells from guinea pig stomach. The American journal of physiology, 1998, Volume: 274, Issue:6 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Atropine; Carbachol; Chief Cells, Gastric; Cholagogues and Choleretics; Cholecystokinin; Guinea Pigs; Male; N-Methylscopolamine; Parasympatholytics; Pepsinogens; Receptors, Cholinergic; Sincalide; Taurolithocholic Acid	1998
Carbachol-induced desensitization of PLC-beta pathway in rat myometrium: downregulation of Gqalpha/G11alpha. The American journal of physiology, 1998, Volume: 275, Issue:3 Topics: Aluminum Compounds; Animals; Atropine; Carbachol; Enzyme Inhibitors; Female; Fluorides; GTP-Binding Proteins; In Vitro Techniques; Indoles; Inositol; Inositol Phosphates; Isoenzymes; Kinetics; Membrane Potentials; Myometrium; N-Methylscopolamine; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Phospholipase C beta; Radioligand Assay; Rats; Rats, Wistar; Receptors, Muscarinic; Signal Transduction; Type C Phospholipases	1998
Mixed agonist-antagonist properties of clozapine at different human cloned muscarinic receptor subtypes expressed in Chinese hamster ovary cells. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 20, Issue:3 Topics: Animals; Antipsychotic Agents; Atropine; Binding Sites; Cell Membrane; CHO Cells; Cloning, Molecular; Clozapine; Cricetinae; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Sulfur Radioisotopes	1999
Autoantibodies against M2 muscarinic receptors in patients with cardiomyopathy display non-desensitized agonist-like effects. Life sciences, 1999, Volume: 64, Issue:6-7 Topics: Animals; Atropine; Autoantibodies; Binding Sites; Carbachol; Cardiomyopathy, Dilated; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Down-Regulation; Heart Rate; Humans; Muscarinic Agonists; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Rats; Rats, Wistar; Receptor, Muscarinic M2; Receptors, Muscarinic; Time Factors	1999
Pharmacological analysis of the novel mode of interaction between xanomeline and the M1 muscarinic acetylcholine receptor. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:3 Topics: Animals; Atropine; Binding, Competitive; Carbachol; CHO Cells; Citrulline; Cricetinae; Humans; Kinetics; Muscarinic Agonists; N-Methylscopolamine; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pirenzepine; Pyridines; Radioligand Assay; Receptor, Muscarinic M1; Receptors, Muscarinic; Recombinant Proteins; Thiadiazoles; Transfection; Tritium	1999
Alanine-scanning mutagenesis of transmembrane domain 6 of the M(1) muscarinic acetylcholine receptor suggests that Tyr381 plays key roles in receptor function. Molecular pharmacology, 1999, Volume: 56, Issue:5 Topics: Acetylcholine; Alanine; Animals; Atropine; Binding, Competitive; COS Cells; Immunohistochemistry; Ligands; Muscarinic Agonists; Muscarinic Antagonists; Mutagenesis, Site-Directed; N-Methylscopolamine; Oxotremorine; Phosphatidylinositols; Pilocarpine; Protein Structure, Tertiary; Quinuclidinyl Benzilate; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic; Tyrosine	1999
Cloning and functional characterization of a Caenorhabditis elegans muscarinic acetylcholine receptor. Receptors & channels, 1999, Volume: 6, Issue:6 Topics: Acetylcholine; Amino Acid Sequence; Animals; Atropine; Base Sequence; Binding, Competitive; Caenorhabditis elegans; Chloride Channels; CHO Cells; Cloning, Molecular; Cricetinae; Gene Expression; Ion Channel Gating; Ligands; Molecular Sequence Data; N-Methylscopolamine; Oxotremorine; Receptors, Muscarinic; Recombinant Proteins; Scopolamine; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Xenopus	1999
Behavioral and neurochemical alterations after lithium-pilocarpine administration in young and adult rats: a comparative study. Pharmacology, biochemistry, and behavior, 2000, Volume: 65, Issue:3 Topics: Age Factors; Animals; Atropine; Behavior, Animal; Brain; Lithium; Male; N-Methylscopolamine; Pilocarpine; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Muscarinic; Spiperone	2000
The allosteric interaction of otenzepad (AF-DX 116) at muscarinic M2 receptors in guinea pig atria. European journal of pharmacology, 2001, Mar-30, Volume: 416, Issue:3 Topics: Acetylcholine; Allosteric Regulation; Animals; Atropine; Carbachol; Cardiotonic Agents; Dexetimide; Electric Stimulation; Female; Gallamine Triethiodide; Guinea Pigs; Heart Atria; In Vitro Techniques; Kinetics; Male; Muscarinic Antagonists; N-Methylscopolamine; Nicotinic Antagonists; Parasympatholytics; Phthalimides; Pirenzepine; Quaternary Ammonium Compounds; Radioligand Assay; Receptor, Muscarinic M2; Receptors, Muscarinic	2001
Central anticholinergics to treat nerve-agent poisoning. Lancet (London, England), 2002, Jan-19, Volume: 359, Issue:9302 Topics: Animals; Antidotes; Atropine; Central Nervous System Agents; Chemical Warfare Agents; Cholinergic Antagonists; Cholinesterase Inhibitors; Mice; N-Methylscopolamine; Physostigmine; Scopolamine	2002
Allosteric modulation by persistent binding of xanomeline of the interaction of competitive ligands with the M1 muscarinic acetylcholine receptor. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:3 Topics: Allosteric Regulation; Animals; Atropine; Binding, Competitive; Buffers; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Kinetics; Ligands; Muscarinic Agonists; N-Methylscopolamine; Pyridines; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiadiazoles; Tritium	2002
Intravenous atropine treatment in infantile hypertrophic pyloric stenosis. Archives of disease in childhood, 2003, Volume: 88, Issue:1 Topics: Atropine; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Muscarinic Antagonists; N-Methylscopolamine; Pyloric Stenosis	2003
A comparison of some atropine-like drugs in man, with particular reference to their end-organ specificity. British journal of pharmacology and chemotherapy, 1958, Volume: 13, Issue:2 Topics: Accommodation, Ocular; Atropine; Heart Rate; Humans; Male; Methantheline; N-Methylscopolamine; Organ Specificity; Parasympatholytics; Propantheline; Pupil; Quaternary Ammonium Compounds; Salivation; Scopolamine; Sweating	1958
A G protein gamma subunit peptide stabilizes a novel muscarinic receptor state. Biochemical and biophysical research communications, 2006, Mar-24, Volume: 341, Issue:4 Topics: Acetylcholine; Animals; Atropine; Carbachol; CHO Cells; Cricetinae; Cricetulus; GTP-Binding Protein alpha Subunit, Gi2; N-Methylscopolamine; Peptide Fragments; Protein Prenylation; Quinuclidinyl Benzilate; Receptor, Muscarinic M2	2006
Function-specific blockage of M(1) and M(3) muscarinic acetylcholine receptors by VX and echothiophate. Brain research, 2006, Apr-26, Volume: 1085, Issue:1 Topics: Animals; Atropine; CHO Cells; Cholinesterase Inhibitors; Colforsin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Echothiophate Iodide; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Organothiophosphorus Compounds; Oxotremorine; Phosphatidylinositols; Protein Binding; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Transfection; Tritium	2006
Long-term wash-resistant effects of brief interaction of xanomeline at the M1 muscarinic receptor. Neuroscience letters, 2006, Dec-13, Volume: 410, Issue:1 Topics: Animals; Atropine; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Drug Interactions; Humans; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Pyridines; Receptor, Muscarinic M1; Thiadiazoles; Time Factors; Transfection; Tritium	2006
Pharmacological characterization of a new antimuscarinic agent, solifenacin succinate, in comparison with other antimuscarinic agents. Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:1 Topics: Animals; Atropine; Benzhydryl Compounds; Benzilates; Benzofurans; Binding, Competitive; Carbachol; CHO Cells; Cholinergic Agonists; Cresols; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mandelic Acids; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Phenylpropanolamine; Pyrrolidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Muscarinic; Solifenacin Succinate; Tetrahydroisoquinolines; Tolterodine Tartrate; Transfection; Urinary Bladder; Urinary Bladder, Overactive; Urination	2007
Allosteric interaction of the neuromuscular blockers vecuronium and pancuronium with recombinant human muscarinic M2 receptors. European journal of pharmacology, 2007, Aug-13, Volume: 569, Issue:1-2 Topics: Allosteric Regulation; Animals; Atropine; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Gallamine Triethiodide; Humans; Kinetics; Muscarinic Antagonists; N-Methylscopolamine; Neuromuscular Blocking Agents; Pancuronium; Radioligand Assay; Receptor, Muscarinic M2; Recombinant Proteins; Tritium; Vecuronium Bromide	2007
The impact of orthosteric radioligand depletion on the quantification of allosteric modulator interactions. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 325, Issue:3 Topics: Alcuronium; Allosteric Regulation; Animals; Atropine; Carbachol; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Gallamine Triethiodide; Ligands; Models, Biological; N-Methylscopolamine; Radioligand Assay; Receptor, Muscarinic M2; Tritium	2008
Bronchodilatory effects of S-isopetasin, an antimuscarinic sesquiterpene of Petasites formosanus, on obstructive airway hyperresponsiveness. European journal of pharmacology, 2008, Apr-28, Volume: 584, Issue:2-3 Topics: Acetylcholine; Animals; Atropine; Binding, Competitive; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Cells, Cultured; Cholinesterase Inhibitors; Diamines; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Ipratropium; Male; Muscarinic Antagonists; Muscle, Smooth; N-Methylscopolamine; Neostigmine; Petasites; Piperidines; Protein Binding; Receptor, Muscarinic M3; Sesquiterpenes; Time Factors; Trachea	2008
Mechanisms of M3 muscarinic receptor regulation by wash-resistant xanomeline binding. Pharmacology, 2009, Volume: 83, Issue:5 Topics: Animals; Atropine; Binding Sites; Carbachol; Cell Line, Transformed; Cricetinae; Drug Interactions; Female; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Muscarinic Agonists; N-Methylscopolamine; Phosphatidylinositols; Pilocarpine; Pyridines; Quinuclidinyl Benzilate; Receptor, Muscarinic M3; Thiadiazoles; Time Factors; Transfection	2009
Detection of novel functional selectivity at M3 muscarinic acetylcholine receptors using a Saccharomyces cerevisiae platform. ACS chemical biology, 2010, Apr-16, Volume: 5, Issue:4 Topics: 3T3 Cells; Animals; Atropine; Gene Expression; Genes, Reporter; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Mice; Muscarinic Antagonists; N-Methylscopolamine; Pirenzepine; Receptor, Muscarinic M3; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins	2010
Assessment of novel muscarinic acetylcholine receptors in rat cerebral cortex by a tissue segment binding method. Journal of pharmacological sciences, 2010, Volume: 112, Issue:4 Topics: Acetylcholine; Animals; Atropine; Cerebral Cortex; In Vitro Techniques; Male; N-Methylscopolamine; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Wistar; Receptors, Muscarinic	2010
Intracellular distribution of functional M(1) -muscarinic acetylcholine receptors in N1E-115 neuroblastoma cells. Journal of neurochemistry, 2011, Volume: 118, Issue:6 Topics: Animals; Atropine; Blotting, Western; Calcium; Carbachol; Cell Line, Tumor; Elapid Venoms; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Immunohistochemistry; Inositol Phosphates; Kinetics; Mice; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Neuroblastoma; Peptides, Cyclic; Pirenzepine; Protein Kinase Inhibitors; Quinuclidinyl Benzilate; Receptor, Muscarinic M1; Receptors, Cell Surface	2011
M1 is a major subtype of muscarinic acetylcholine receptors on mouse colonic epithelial cells. Journal of gastroenterology, 2013, Volume: 48, Issue:8 Topics: Animals; Atropine; Benzofurans; Colitis; Colon; Elapid Venoms; Epithelial Cells; Inflammation; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; N-Methylscopolamine; Parasympatholytics; Pyrrolidines; Radioligand Assay; Receptor, Muscarinic M1; Receptor, Muscarinic M3	2013
Sudden unexpected death in a mouse model of Dravet syndrome. The Journal of clinical investigation, 2013, Volume: 123, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrioventricular Block; Atropine; Bradycardia; Disease Models, Animal; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Heart Rate; Humans; Mice; Mice, Knockout; N-Methylscopolamine; NAV1.1 Voltage-Gated Sodium Channel; Parasympatholytics	2013
Comparison of subcellular distribution and functions between exogenous and endogenous M1 muscarinic acetylcholine receptors. Life sciences, 2013, Jul-19, Volume: 93, Issue:1 Topics: Analysis of Variance; Animals; Atropine; Blotting, Western; Calcium; CHO Cells; Cricetinae; Cricetulus; Mice; Microscopy, Confocal; N-Methylscopolamine; Organelles; Pirenzepine; Quinuclidinyl Benzilate; Radioligand Assay; Receptor, Muscarinic M1; Recombinant Proteins; Tritium	2013