Compounds > atropine
Page last updated: 2024-09-05

atropine and milrinone

atropine has been researched along with milrinone in 8 studies

Compound Research Comparison

Studies
(atropine)		Trials
(atropine)		Recent Studies (post-2010)
(atropine)		Studies
(milrinone)		Trials
(milrinone)		Recent Studies (post-2010) (milrinone)
26,7111,2591,6971,605235452

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)milrinone (IC50)
Phosphodiesterase Bos taurus (cattle)1
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.3
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)0.3
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.52
Prostaglandin G/H synthase 1Homo sapiens (human)4.7
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)6
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)6
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)6
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)3.15
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)1.8674
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)1.8177
cGMP-specific 3',5'-cyclic phosphodiesteraseBos taurus (cattle)5
Phosphodiesterase Sus scrofa (pig)0.843

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's2 (25.00)18.2507
2000's3 (37.50)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Forde, MD; Wilson, TD1
Brown, L; Erdmann, E; Näbauer, M1
Lundberg, JM; Modin, A; Weitzberg, E1

Reviews

1 review(s) available for atropine and milrinone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

7 other study(ies) available for atropine and milrinone

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Stability of milrinone and epinephrine, atropine sulfate, lidocaine hydrochloride, or morphine sulfate injection.
    American journal of hospital pharmacy, 1990, Volume: 47, Issue:11

    Topics: Atropine; Chromatography, High Pressure Liquid; Drug Combinations; Drug Stability; Epinephrine; Indicators and Reagents; Lidocaine; Milrinone; Morphine; Pyridones

1990
The positive inotropic response to milrinone in isolated human and guinea pig myocardium.
    Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 334, Issue:2

    Topics: Adult; Animals; Atropine; Calcium; Carbachol; Female; Guinea Pigs; Humans; In Vitro Techniques; Male; Middle Aged; Milrinone; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors; Practolol; Pyridones; Sodium-Potassium-Exchanging ATPase; Stimulation, Chemical

1986
Nitric oxide regulates peptide release from parasympathetic nerves and vascular reactivity to vasoactive intestinal polypeptide in vivo.
    European journal of pharmacology, 1994, Aug-11, Volume: 261, Issue:1-2

    Topics: Animals; Arginine; Atropine; Blood Pressure; Cyclic GMP; Electric Stimulation; Female; Male; Milrinone; Neuropeptides; Nitric Oxide; Nitroarginine; Nitroprusside; Parasympathetic Nervous System; Phosphodiesterase Inhibitors; Pyridones; Regional Blood Flow; Submandibular Gland; Swine; Vascular Resistance; Vasoactive Intestinal Peptide; Vasodilation

1994