Compounds > atropine
Page last updated: 2024-09-05

atropine and mibefradil

atropine has been researched along with mibefradil in 5 studies

Compound Research Comparison

Studies
(atropine)		Trials
(atropine)		Recent Studies (post-2010)
(atropine)		Studies
(mibefradil)		Trials
(mibefradil)		Recent Studies (post-2010) (mibefradil)
26,7111,2591,69766769143

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)mibefradil (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.156
Voltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)1.0476
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.333
Voltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)0.4122
Sodium channel protein type 2 subunit alphaRattus norvegicus (Norway rat)0.5
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
ATP-dependent translocase ABCB1Homo sapiens (human)1.58
Cytochrome P450 3A4Homo sapiens (human)0.2575
Cytochrome P450 2D6Homo sapiens (human)0.063
Cytochrome P450 2C9 Homo sapiens (human)2.14
Sodium channel protein type 4 subunit alphaRattus norvegicus (Norway rat)0.5
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.34
ATP-dependent translocase ABCB1Mus musculus (house mouse)7.4
Sodium channel protein type 1 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 4 subunit alphaHomo sapiens (human)0.98
Cytochrome P450 2J2Homo sapiens (human)2.14
Voltage-dependent L-type calcium channel subunit beta-3Rattus norvegicus (Norway rat)1
Voltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)0.878
Sodium channel protein type 7 subunit alphaHomo sapiens (human)0.98
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.333
Voltage-dependent N-type calcium channel subunit alpha-1BRattus norvegicus (Norway rat)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.4543
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.333
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.2795
Sodium channel protein type 5 subunit alphaHomo sapiens (human)0.74
Sodium channel protein type 9 subunit alphaHomo sapiens (human)0.74
Sodium channel protein type 2 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 3 subunit alphaHomo sapiens (human)0.98
Voltage-dependent T-type calcium channel subunit alpha-1IHomo sapiens (human)0.4187
Sodium channel protein type 11 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 8 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 10 subunit alphaHomo sapiens (human)0.98

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Lombardo, F; Obach, RS; Waters, NJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1

Other Studies

5 other study(ies) available for atropine and mibefradil

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011