Page last updated: 2024-09-05

atropine and mianserin

atropine has been researched along with mianserin in 17 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(mianserin)
Trials
(mianserin)
Recent Studies (post-2010) (mianserin)
26,7111,2591,6972,624539488

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)mianserin (IC50)
5-hydroxytryptamine receptor 3EHomo sapiens (human)1.4125
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.0012
5-hydroxytryptamine receptor 3BHomo sapiens (human)1.4125
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.163
Muscarinic acetylcholine receptor M2Homo sapiens (human)1.078
Muscarinic acetylcholine receptor M4Homo sapiens (human)2.066
5-hydroxytryptamine receptor 1AHomo sapiens (human)0.3981
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)1.9
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.32
Alpha-2A adrenergic receptorHomo sapiens (human)0.0213
Muscarinic acetylcholine receptor M1Homo sapiens (human)1.423
D(2) dopamine receptorHomo sapiens (human)7.0795
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.38
Alpha-2B adrenergic receptorHomo sapiens (human)0.026
Alpha-2C adrenergic receptorHomo sapiens (human)0.0661
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.872
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.21
Muscarinic acetylcholine receptor M3Homo sapiens (human)1.405
D(1A) dopamine receptorHomo sapiens (human)0.543
D(4) dopamine receptorHomo sapiens (human)3.3113
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.21
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.21
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.38
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.163
5-hydroxytryptamine receptor 3AMus musculus (house mouse)1.4125
Histamine H2 receptorHomo sapiens (human)1.008
Alpha-1D adrenergic receptorHomo sapiens (human)0.083
Endothelin-1 receptorHomo sapiens (human)0.1148
5-hydroxytryptamine receptor 1DHomo sapiens (human)0.3802
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.011
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.0043
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.872
Sodium-dependent serotonin transporterHomo sapiens (human)2.068
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)2.9
5-hydroxytryptamine receptor 7Homo sapiens (human)0.1148
Alpha-1A adrenergic receptorHomo sapiens (human)0.4074
Type-2 angiotensin II receptorRattus norvegicus (Norway rat)0.21
Histamine H1 receptorHomo sapiens (human)0.0024
D(3) dopamine receptorHomo sapiens (human)3.8905
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.0073
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.19
5-hydroxytryptamine receptor 3AHomo sapiens (human)1.4125
Histamine H2 receptorCavia porcellus (domestic guinea pig)0.88
5-hydroxytryptamine receptor 6Homo sapiens (human)0.085
D(2) dopamine receptorRattus norvegicus (Norway rat)3.5481
5-hydroxytryptamine receptor 3DHomo sapiens (human)1.4125
5-hydroxytryptamine receptor 3CHomo sapiens (human)1.4125
5-hydroxytryptamine receptor 3BMus musculus (house mouse)1.4125
TransporterRattus norvegicus (Norway rat)0.022

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19905 (29.41)18.7374
1990's2 (11.76)18.2507
2000's4 (23.53)29.6817
2010's6 (35.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Andrews, PR; Craik, DJ; Martin, JL1
Booth, RG; Brown, RL; Bucholtz, EC; Tropsha, A; Wyrick, SD1
Topliss, JG; Yoshida, F1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Glen, RC; Lowe, R; Mitchell, JB1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Schönbaum, E; Van Proosdij, J; Van Riezen, H1
Enna, SJ; Mann, E1
Kwok, YH; Mitchelson, F1
Katayama, S; Kohno, H; Ohkubo, Y; Ohuchi, Y1
Oliveira, EE; Schmidt, J; Westmark, S1
Kara, B; Koseoglu, Z; Satar, S1

Other Studies

17 other study(ies) available for atropine and mianserin

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.
    Journal of medicinal chemistry, 1999, Aug-12, Volume: 42, Issue:16

    Topics: Animals; Binding Sites; Binding, Competitive; Brain; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ligands; Models, Molecular; Pyrilamine; Radioligand Assay; Structure-Activity Relationship; Tetrahydronaphthalenes

1999
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Effects of various drugs supposed to interact with serotonin on PGO frequency changes induced by reserpine and 5-hydroxytryptophan.
    Monographs in neural sciences, 1976, Volume: 3

    Topics: 5-Hydroxytryptophan; Animals; Atropine; Cats; Drug Interactions; Electrodes, Implanted; Electroencephalography; Imipramine; Male; Methiothepin; Mianserin; Reserpine; Serotonin; Time Factors

1976
Neurochemical and behavioral correlates of antidepressant drug action.
    Life sciences, 1982, May-10, Volume: 30, Issue:19

    Topics: Aggression; Animals; Antidepressive Agents, Tricyclic; Atropine; Cerebral Cortex; Humans; Imipramine; Male; Mianserin; Mice; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, beta; Receptors, Serotonin; Time Factors

1982
The effect of amitriptyline, mianserin, and viloxazine at pre- and post-junctional muscarinic receptors in guinea-pig ileal longitudinal muscle.
    Canadian journal of physiology and pharmacology, 1982, Volume: 60, Issue:2

    Topics: Acetylcholine; Amitriptyline; Animals; Antidepressive Agents; Atropine; Carbachol; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mianserin; Muscle, Smooth; Oxotremorine; Receptors, Cholinergic; Receptors, Muscarinic; Viloxazine

1982
Possible neural mechanisms involved in footshock stress-induced enhancement of exploratory behavior in mice.
    Biological & pharmaceutical bulletin, 1999, Volume: 22, Issue:4

    Topics: Animals; Atropine; Central Nervous System; Diazepam; Dizocilpine Maleate; Electric Stimulation; Exploratory Behavior; Haloperidol; Male; Mianserin; Mice; Naltrexone; Phentolamine; Propranolol; Stress, Physiological

1999
Pharmacological analysis of tonic activity in motoneurons during stick insect walking.
    Journal of neurophysiology, 2009, Volume: 102, Issue:2

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Adrenergic alpha-Agonists; Animals; Atropine; Calcium; Cells, Cultured; Cholinergic Agents; Egtazic Acid; Female; Ganglia, Invertebrate; In Vitro Techniques; Insecta; Membrane Potentials; Mianserin; Motor Neurons; Muscarinic Antagonists; Octopamine; Patch-Clamp Techniques; Serotonin Antagonists; Walking

2009
Bradycardia and hypotension in mianserin intoxication.
    Human & experimental toxicology, 2010, Volume: 29, Issue:10

    Topics: Adult; Anti-Arrhythmia Agents; Antidepressive Agents, Second-Generation; Atropine; Bradycardia; Female; Humans; Hypotension; Mianserin; Neurotoxicity Syndromes; Suicide, Attempted; Theophylline; Treatment Outcome; Vasodilator Agents

2010