Page last updated: 2024-09-05

atropine and metoprolol

atropine has been researched along with metoprolol in 79 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(metoprolol)
Trials
(metoprolol)
Recent Studies (post-2010) (metoprolol)
26,7111,2591,6975,8211,7431,304

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)metoprolol (IC50)
Beta-2 adrenergic receptorHomo sapiens (human)2.573
Beta-1 adrenergic receptorHomo sapiens (human)0.176
Cytochrome P450 2C9 Homo sapiens (human)4.87
Cytochrome P450 2J2Homo sapiens (human)4.87

Research

Studies (79)

TimeframeStudies, this research(%)All Research%
pre-199026 (32.91)18.7374
1990's11 (13.92)18.2507
2000's28 (35.44)29.6817
2010's14 (17.72)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Lüllmann, H; Timmermans, PB; Weikert, GM; Ziegler, A1
Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Ahman, M; Holmén, AG; Wan, H1
Bard, B; Carrupt, PA; Martel, S1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Csapo, G1
Almeida, AP; Azevedo, AD; Couto, AS; Freire-Maia, L; Moraes-Santos, T1
Kirby, DA; Lown, B; Pinto, JM1
Edvardsson, N; Hirsch, I; Olsson, SB2
Hunt, GB; Ross, DL1
Beermann, B; Brandt, R; Jonzon, B; Sylvén, C1
Bliss, K; Cornish, KG; Hackley, J; Zucker, IH1
Graitzer, HM; Hudson, DL; Raven, PB; Smith, ML2
Lang, RE; Ruskoaho, H; Toth, M1
Tuttle, RS1
Hajdu, MA; Panzenbeck, MJ; Tan, W; Zucker, IH1
Curran-Everett, DC; Hong, SK; Krasney, JA; Yoshino, H1
al-Rashood, KA; el Tahir, KE; el-Obeid, HA; Ibrahim, ME; Madani, AA; Tilmisani, AK1
Dahlöf, C; Franco-Cereceda, A; Lundberg, JM1
Barron, KW; Bishop, VS1
Caldwell, RW; Nash, CB1
Franco-Cereceda, A; Hua, XY; Lundberg, JM1
Bonelli, J1
Egeblad, H; Lewis, S; Nygaard, E; Saltin, B; Sanchez, J1
Barra, M; Bertulla, A; Brignole, M; Menozzi, C; Monducci, I; Sartore, B1
Huerta, FI; Sharma, AD; Waxman, MB1
Bastian, BC; Blomqvist, CG; Graham, RM; Lewis, SF; Pettinger, WA; Taylor, WF1
Areskog, NH; Gad, P; Lewis, SF; Nylander, E1
Barber, JM; Boyle, DM; Evans, A; McIlmoyle, EL; Salathia, KS; Shanks, RG1
Demura, H; Hotta, M; Imaki, T; Shibasaki, T; Yamada, K; Yamauchi, N1
Berntson, GG; Binkley, PF; Cacioppo, JT; Fieldstone, A; Quigley, KS; Uchino, BN2
Bellotti, P; Boersma, E; el-Said, ES; Fioretti, PM; Forster, T; McNeill, AJ; Poldermans, D; Roelandt, JR; Salustri, A1
Foresman, BH; Raven, PB; Shi, X; Stern, SA; Stevens, GH1
Liu, JL; Murakami, H; Zucker, IH1
Ogawa, N1
Chi, Y; Hatton, DC; Luft, FC; Scrogin, KE1
Formes, KJ; Hayes, PM; O-Yurvati, AH; Reese, IP; Shi, X; Wang, HW; Weiss, MS; Wray, DW1
Lei, Z; Liu, Z; Ni, J; Wu, R; Ye, M; Zou, H1
Aoyagi, N; Goldberger, AL; Hidaka, I; Ivanov, PC; Nunes Amaral, LA; Stanley, HE; Tomono, S; Yamamoto, Y1
Camargos, ER; Chiari, E; Fontoura, BF; Freire-Maia, L; Machado, CR; Teixeira, AL; Teixeira, MM1
Hirooka, Y; Ito, K; Kimura, Y; Kishi, T; Sakai, K; Shimokawa, H; Takeshita, A1
Cornish, KG; Pliquett, RU; Zucker, IH1
Andrade, JL; Khandheria, BK; Kowatsch, I; Leal, SM; Lemos, PA; Mathias, W; Ramires, JF; Tsutsui, JM1
Cornish, KG; Liu, XF; Patel, KP; Wang, Y; Zucker, IH1
Blumer, KJ; Diedrich, A; Gross, V; Jordan, J; Luft, FC; Obst, M; Plehm, R; Tank, J2
Formes, KJ; O-Yurvati, AH; Shi, X; Weiss, MS; Wray, DW1
Kettunen, J; Martinmäki, K; Rusko, H; Saalasti, S1
Iijima, T; Murakami, M; Ono, K; Wu, TW1
Sato, S1
De Pauw, M; Drieghe, B; Gheeraert, P; Kersemans, M; Taeymans, Y; Van Heuverswyn, F1
Antolic, B; Jan, M; Pernat, A; Rajković, Z; Rakovec, P; Sinkovec, M1
Boldt, LH; Chaldoupi, SM; DE Bakker, JM; Doevendans, PA; Hauer, RN; Linnenbank, AC; Loh, P; VAN Driel, VJ; VAN Wessel, H; Wittkampf, FH1
Brox, S; Küster, E; Reemtsma, T; Ritter, AP1
Cotie, LM; Ditor, DS; La Fountaine, MF; Sharif, H1
Child, N; Gill, JS; Hanson, B; Orini, M; Rinaldi, CA; Taggart, P; van Duijvenboden, S1
Cesari, M; Dissing Sorensen, HB; Mehlsen, AB; Mehlsen, J1

Reviews

3 review(s) available for atropine and metoprolol

ArticleYear
The role of receptor binding in drug discovery.
    Journal of natural products, 1993, Volume: 56, Issue:4

    Topics: Animals; Drug Design; Humans; Receptors, Drug

1993
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Analysis and characterization of ligand-receptor binding systems].
    Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55 Suppl 2

    Topics: Alprenolol; Animals; Atropine; Binding, Competitive; Carbachol; Dihydroalprenolol; Humans; Ligands; Metoprolol; Receptors, Cell Surface; Receptors, Neurotransmitter

1997

Trials

7 trial(s) available for atropine and metoprolol

ArticleYear
Adenosine receptor mediated stimulation of ventilation in man.
    European journal of clinical investigation, 1989, Volume: 19, Issue:1

    Topics: Adenosine; Adult; Afferent Pathways; Atropine; Chemoreceptor Cells; Cromolyn Sodium; Dipyridamole; Female; Heart Block; Humans; Hyperventilation; Male; Metoprolol; Middle Aged; Receptors, Purinergic; Respiration; Theophylline

1989
Haemodynamic responses to static and dynamic handgrip before and after autonomic blockade.
    Clinical science (London, England : 1979), 1983, Volume: 64, Issue:6

    Topics: Adult; Atropine; Autonomic Nerve Block; Epinephrine; Hand; Hemodynamics; Humans; Male; Metoprolol; Muscle Contraction; Norepinephrine; Physical Exertion

1983
Metoprolol and atropine in acute myocardial infarction.
    Irish medical journal, 1980, Volume: 73, Issue:12

    Topics: Atropine; Drug Therapy, Combination; Humans; Metoprolol; Myocardial Infarction; Propanolamines

1980
Autonomic cardiac control. II. Noninvasive indices and basal response as revealed by autonomic blockades.
    Psychophysiology, 1994, Volume: 31, Issue:6

    Topics: Adult; Arousal; Atropine; Autonomic Nervous System; Blood Pressure; Cardiography, Impedance; Double-Blind Method; Female; Heart; Humans; Infusions, Intravenous; Metoprolol; Stroke Volume

1994
Autonomic cardiac control. III. Psychological stress and cardiac response in autonomic space as revealed by pharmacological blockades.
    Psychophysiology, 1994, Volume: 31, Issue:6

    Topics: Adult; Arousal; Atropine; Autonomic Nervous System; Double-Blind Method; Female; Heart; Humans; Metoprolol; Problem Solving; Reaction Time; Stress, Psychological

1994
Atropine increases the accuracy of dobutamine stress echocardiography in patients taking beta-blockers.
    European heart journal, 1994, Volume: 15, Issue:3

    Topics: Aged; Angina Pectoris; Atropine; Dobutamine; Drug Synergism; Echocardiography; Electrocardiography; Exercise Test; Female; Heart Rate; Hemodynamics; Humans; Male; Metoprolol; Middle Aged; Myocardial Ischemia; Prospective Studies

1994
Sympathetic cardiac influence and arterial blood pressure instability.
    Autonomic neuroscience : basic & clinical, 2005, Mar-31, Volume: 118, Issue:1-2

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Atropine; Blood Pressure; Blood Pressure Determination; Drug Interactions; Female; Heart Rate; Hemodynamics; Humans; Lower Body Negative Pressure; Male; Metoprolol; Muscarinic Antagonists; Norepinephrine; Phenylephrine; Reference Values; Renin; Spectrum Analysis; Sympathetic Nervous System; Time Factors; Valsalva Maneuver

2005

Other Studies

69 other study(ies) available for atropine and metoprolol

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Accumulation of drugs by guinea pig isolated atria. Quantitative correlations.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:5

    Topics: Animals; Chemistry, Pharmaceutical; Electric Stimulation; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Myocardium; Pharmaceutical Preparations; Protein Binding; Serum Albumin; Solubility; Time Factors

1980
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water

2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Lipophilicity of basic drugs measured by hydrophilic interaction chromatography.
    Journal of medicinal chemistry, 2009, May-28, Volume: 52, Issue:10

    Topics: Chemistry, Pharmaceutical; Chromatography; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Pharmaceutical Preparations; Solubility; Technology, Pharmaceutical

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Paroxysmal nonreentrant tachycardias due to simultaneous conduction in dual atrioventricular nodal pathways.
    The American journal of cardiology, 1979, Volume: 43, Issue:5

    Topics: Adult; Ajmaline; Atrial Fibrillation; Atrioventricular Node; Atropine; Bundle of His; Cardiac Pacing, Artificial; Electrocardiography; Heart Block; Heart Conduction System; Humans; Lidocaine; Male; Metoprolol; Models, Biological; Tachycardia, Paroxysmal; Verapamil

1979
Effects of toxin Ts-gamma, purified from Tityus serrulatus scorpion venom, on the isolated rat atria.
    Toxicon : official journal of the International Society on Toxinology, 1992, Volume: 30, Issue:3

    Topics: Acetylcholine; Animals; Atropine; Electrocardiography; Heart; Heart Atria; In Vitro Techniques; Metoprolol; Myocardial Contraction; Physostigmine; Rats; Scorpion Venoms; Sodium Channels; Tetrodotoxin

1992
Changes in ventricular fibrillation threshold during the development of perinephritic hypertension.
    American journal of hypertension, 1990, Volume: 3, Issue:10

    Topics: Animals; Atropine; Blood Pressure; Cardiac Pacing, Artificial; Cardiomegaly; Dogs; Electrophysiology; Female; Heart Rate; Hypertension, Renal; Male; Metoprolol; Nephrectomy; Time Factors; Ventricular Fibrillation

1990
Effects of lidocaine, procainamide, metoprolol, digoxin and atropine on the conduction of premature ventricular beats in man.
    European heart journal, 1985, Volume: 6, Issue:1

    Topics: Action Potentials; Adult; Anti-Arrhythmia Agents; Atropine; Cardiac Complexes, Premature; Digoxin; Electric Stimulation; Electrophysiology; Humans; Lidocaine; Male; Metoprolol; Procainamide

1985
Reassessment of AV and VA conduction and AV junctional reentry in the normal dog heart: the role of altered autonomic tone.
    Pacing and clinical electrophysiology : PACE, 1988, Volume: 11, Issue:5

    Topics: Animals; Atrioventricular Node; Atropine; Autonomic Agents; Cardiac Pacing, Artificial; Dogs; Electric Conductivity; Electrocardiography; Heart Conduction System; Isoproterenol; Metoprolol

1988
Effects of left ventricular receptor stimulation on coronary blood flow in conscious dogs.
    Circulation research, 1987, Volume: 61, Issue:5 Pt 2

    Topics: Animals; Atropine; Autonomic Nervous System; Blood Flow Velocity; Blood Pressure; Coronary Circulation; Denervation; Dogs; Heart Ventricles; Metoprolol; Phentolamine; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Cholinergic; Sinus of Valsalva; Vascular Resistance; Veratridine; Veratrine

1987
Blood pressure regulation during cardiac autonomic blockade: effect of fitness.
    Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:4

    Topics: Adult; Atropine; Autonomic Nervous System; Blood Pressure; Cardiac Output; Heart; Heart Rate; Homeostasis; Humans; Male; Metoprolol; Oxygen Consumption; Parasympathetic Nervous System; Physical Fitness; Receptors, Adrenergic, beta; Regional Blood Flow; Stroke Volume; Vascular Resistance

1988
Exercise training bradycardia: the role of autonomic balance.
    Medicine and science in sports and exercise, 1989, Volume: 21, Issue:1

    Topics: Adult; Atropine; Autonomic Nervous System; Exercise; Heart Rate; Humans; Male; Metoprolol; Models, Cardiovascular; Parasympathetic Nervous System; Physical Education and Training; Sympathetic Nervous System

1989
Regulation of atrial natriuretic peptide secretion.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1986, Volume: 4, Issue:6

    Topics: Acetylcholine; Animals; Atrial Natriuretic Factor; Atropine; Epinephrine; In Vitro Techniques; Metoprolol; Perfusion; Phentolamine; Pressure; Rats

1986
Cephalic carotid pressure as a measure of transmission through cervical ganglion.
    The American journal of physiology, 1985, Volume: 248, Issue:6 Pt 2

    Topics: Action Potentials; Animals; Atropine; Blood Pressure; Carotid Sinus; Cats; Electric Stimulation; Ganglia, Sympathetic; Heart Rate; Intracranial Pressure; Metoprolol; Norepinephrine; Synaptic Transmission; Time Factors

1985
Intracoronary infusion of prostaglandin I2 attenuates arterial baroreflex control of heart rate in conscious dogs.
    Circulation research, 1988, Volume: 63, Issue:5

    Topics: Animals; Atropine; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Epoprostenol; Female; Heart Rate; Infusions, Intra-Arterial; Male; Metoprolol; Pressoreceptors; Reflex

1988
Altered heart rate-arterial pressure relation during head-out water immersion in conscious dog.
    The American journal of physiology, 1988, Volume: 254, Issue:4 Pt 2

    Topics: Animals; Atropine; Blood Pressure; Dogs; Female; Head; Heart Rate; Immersion; Metoprolol; Reference Values; Systole

1988
Synthesis and pharmacological activity of N-alkyl-1,2-diphenylethanolamines.
    Pharmaceutical research, 1987, Volume: 4, Issue:2

    Topics: Animals; Antihypertensive Agents; Atropine; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Ethanolamines; Jejunum; Male; Metoprolol; Muscle, Smooth, Vascular; Myocardial Contraction; Propranolol; Rabbits; Rats; Vas Deferens

1987
Neuropeptide Y and sympathetic control of heart contractility and coronary vascular tone.
    Acta physiologica Scandinavica, 1985, Volume: 124, Issue:3

    Topics: Animals; Arginine Vasopressin; Atropine; Coronary Vessels; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Metoprolol; Muscle, Smooth, Vascular; Myocardial Contraction; Nerve Tissue Proteins; Neuropeptide Y; Nifedipine; Norepinephrine; Phentolamine; Tetrodotoxin

1985
Reflex cardiovascular effects of intracoronary acetylstrophanthidin in the conscious dog.
    The American journal of physiology, 1985, Volume: 248, Issue:6 Pt 2

    Topics: Animals; Atropine; Blood Pressure; Calcium Gluconate; Cardiovascular System; Carotid Arteries; Dogs; Heart Rate; Injections, Intra-Arterial; Metoprolol; Myocardial Contraction; Nerve Block; Reflex; Stimulation, Chemical; Strophanthidin; Vagus Nerve; Vascular Resistance

1985
Effect of an aminocardenolide and digoxin upon atrioventricular refractory period in the dog.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:3

    Topics: Animals; Atrioventricular Node; Atropine; Digitoxigenin; Digoxin; Dogs; Female; Heart Conduction System; Male; Metoprolol; Neural Conduction; Pressoreceptors; Refractory Period, Electrophysiological; Sympathectomy

1985
Effects of neuropeptide Y (NPY) on mechanical activity and neurotransmission in the heart, vas deferens and urinary bladder of the guinea-pig.
    Acta physiologica Scandinavica, 1984, Volume: 121, Issue:4

    Topics: Animals; Atropine; Electric Stimulation; Guanethidine; Guinea Pigs; Heart Atria; Male; Metoprolol; Muscle Contraction; Muscle Tonus; Nerve Tissue Proteins; Neuropeptide Y; Portal Vein; Propranolol; Synaptic Transmission; Trachea; Urinary Bladder; Vas Deferens

1984
Relevance of selectivity and non-selectivity in beta-adrenoceptor blocking drugs.
    British journal of clinical pharmacology, 1982, Volume: 13, Issue:Suppl 2

    Topics: Adrenergic beta-Antagonists; Adult; Atropine; Dose-Response Relationship, Drug; Heart Rate; Humans; Isoproterenol; Male; Metoprolol; Norepinephrine; Organ Specificity; Propranolol

1982
Acute effects of lignocaine, procainamide, metoprolol, digoxin and atropine on human myocardial refractoriness.
    Cardiovascular research, 1984, Volume: 18, Issue:8

    Topics: Action Potentials; Adult; Anti-Arrhythmia Agents; Atropine; Digoxin; Heart; Heart Rate; Heart Ventricles; Humans; Lidocaine; Male; Metoprolol; Procainamide; Time Factors; Ventricular Function

1984
Static contraction of the quadriceps muscle in man: cardiovascular control and responses to one-legged strength training.
    Acta physiologica Scandinavica, 1984, Volume: 122, Issue:3

    Topics: Adaptation, Physiological; Adult; Atropine; Blood Pressure; Echocardiography; Energy Metabolism; Heart Rate; Hemodynamics; Humans; Knee; Male; Metoprolol; Muscle Contraction; Muscles; Physical Education and Training; Physical Endurance

1984
[Influence of beta block and autonomic nerve block on the recovery time of the sinus node in sick sinus syndrome and carotid sinus syndrome].
    Giornale italiano di cardiologia, 1984, Volume: 14, Issue:10

    Topics: Adult; Aged; Atropine; Autonomic Nerve Block; Carotid Sinus; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Sick Sinus Syndrome; Sinoatrial Node; Syncope; Syndrome

1984
Effect of adrenergic stimulation and blockade on ventricular defibrillation in the rat.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 227, Issue:3

    Topics: Albuterol; Animals; Atropine; Isoproterenol; Male; Metoprolol; Norepinephrine; Phenoxybenzamine; Phenylephrine; Propranolol; Rats; Rats, Inbred Strains; Sympathomimetics; Time Factors; Ventricular Fibrillation

1983
Non-autonomic component in bradycardia of endurance trained men at rest and during exercise.
    Acta physiologica Scandinavica, 1980, Volume: 109, Issue:3

    Topics: Adult; Atropine; Autonomic Nerve Block; Blood Pressure; Heart Rate; Humans; Male; Metoprolol; Oxygen Consumption; Physical Endurance; Physical Exertion; Propranolol

1980
Beta 1-adrenergic mechanism is involved in stress-induced increase in arousal.
    Neuroscience letters, 1994, Oct-24, Volume: 180, Issue:2

    Topics: Animals; Arousal; Atropine; Butoxamine; Corticotropin-Releasing Hormone; Hypothalamus; Male; Metoprolol; Pentobarbital; Phentolamine; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, beta-1; Restraint, Physical; Sleep; Sleep Initiation and Maintenance Disorders; Stress, Physiological

1994
Autonomic nervous system control of the heart: endurance exercise training.
    Medicine and science in sports and exercise, 1995, Volume: 27, Issue:10

    Topics: Adult; Atropine; Autonomic Nervous System; Blood Volume; Bradycardia; Cholinergic Antagonists; Drug Combinations; Exercise; Follow-Up Studies; Heart; Heart Rate; Humans; Lower Body Negative Pressure; Male; Metoprolol; Muscarinic Antagonists; Oxygen Consumption; Parasympathetic Nervous System; Parasympatholytics; Physical Education and Training; Physical Endurance; Receptors, Adrenergic, beta-1; Receptors, Cholinergic; Receptors, Muscarinic; Reflex; Sympathetic Nervous System; Sympatholytics; Tachycardia; Vagus Nerve

1995
Blockade of AT1 receptors enhances baroreflex control of heart rate in conscious rabbits with heart failure.
    The American journal of physiology, 1996, Volume: 271, Issue:1 Pt 2

    Topics: Angiotensin Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Atropine; Autonomic Nerve Block; Baroreflex; Cardiac Output, Low; Cardiac Pacing, Artificial; Heart Rate; Hemodynamics; Imidazoles; Male; Metoprolol; Rabbits; Reference Values; Tetrazoles

1996
Chronic nitric oxide inhibition with L-NAME: effects on autonomic control of the cardiovascular system.
    The American journal of physiology, 1998, Volume: 274, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Atropine; Baroreflex; Blood Pressure; Diuresis; Drinking; Enzyme Inhibitors; Heart Rate; Male; Methoxamine; Metoprolol; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Sprague-Dawley

1998
Orthostatic hypotension in aging humans.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:4

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Atropine; Blood Pressure; Female; Glycopyrrolate; Heart Conduction System; Heart Rate; Humans; Hypotension; Hypotension, Orthostatic; Lower Body Negative Pressure; Male; Metoprolol; Middle Aged; Nerve Block; Parasympathetic Nervous System; Tachycardia

2000
Enantiomer separation by strong anion-exchange capillary electrochromatography with dynamically modified sulfated beta-cyclodextrin.
    Electrophoresis, 2001, Volume: 22, Issue:3

    Topics: Anions; Atropine; beta-Cyclodextrins; Cyclodextrins; Electrophoresis, Capillary; Metoprolol; Molecular Structure; Praziquantel; Tryptophan; Verapamil

2001
Behavioral-independent features of complex heartbeat dynamics.
    Physical review letters, 2001, Jun-25, Volume: 86, Issue:26 Pt 1

    Topics: Activities of Daily Living; Adrenergic beta-Antagonists; Adult; Atropine; Female; Fractals; Heart; Humans; Male; Metoprolol; Parasympathetic Nervous System; Parasympatholytics; Sympathetic Nervous System

2001
Cardiac autonomic denervation and functional response to neurotoxins during acute experimental Chagas' disease in rats.
    Autonomic neuroscience : basic & clinical, 2001, Jun-20, Volume: 89, Issue:1-2

    Topics: Acetylcholine; Animals; Atropine; Bradycardia; Chagas Cardiomyopathy; Denervation; Heart; Heart Rate; Male; Metoprolol; Parasympathetic Nervous System; Parasympatholytics; Rats; Rats, Sprague-Dawley; Scorpion Venoms; Sympathetic Nervous System; Sympatholytics; Tachycardia; Vasodilator Agents

2001
Overexpression of eNOS in RVLM improves impaired baroreflex control of heart rate in SHRSP. Rostral ventrolateral medulla. Stroke-prone spontaneously hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 41, Issue:2

    Topics: Animals; Atropine; Autonomic Agents; Baroreflex; beta-Galactosidase; Blood Pressure; Gene Expression Regulation, Enzymologic; Heart Rate; Hypertension; Male; Medulla Oblongata; Metoprolol; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Solitary Nucleus; Transfection

2003
Statin therapy restores sympathovagal balance in experimental heart failure.
    Journal of applied physiology (Bethesda, Md. : 1985), 2003, Volume: 95, Issue:2

    Topics: Animals; Atropine; Baroreflex; Cardiac Output, Low; Chronic Disease; Heart Rate; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Metoprolol; Rabbits; Simvastatin; Sympathetic Nervous System; Sympatholytics; Vagus Nerve

2003
Value of rapid beta-blocker injection at peak dobutamine-atropine stress echocardiography for detection of coronary artery disease.
    Journal of the American College of Cardiology, 2003, May-07, Volume: 41, Issue:9

    Topics: Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Atropine; Coronary Artery Disease; Echocardiography, Stress; Female; Humans; Injections, Intravenous; Male; Metoprolol; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Time Factors

2003
Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Blood Pressure; Blotting, Northern; Cardiac Output, Low; Chronic Disease; Heart Rate; Hemodynamics; Immunohistochemistry; Male; Metoprolol; Microinjections; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Oligonucleotides, Antisense; omega-N-Methylarginine; Paraventricular Hypothalamic Nucleus; Phentolamine; Rats; Rats, Sprague-Dawley

2005
Autonomic nervous system and blood pressure regulation in RGS2-deficient mice.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2005, Volume: 288, Issue:5

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Autonomic Nervous System; Blood Pressure; Circadian Rhythm; Epinephrine; Heart Rate; Male; Metoprolol; Mice; Mice, Knockout; Norepinephrine; Parasympatholytics; Prazosin; RGS Proteins; Stress, Physiological

2005
NO-dependent blood pressure regulation in RGS2-deficient mice.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 290, Issue:4

    Topics: Animals; Arteries; Atropine; Baroreflex; Blood Pressure; Epinephrine; Heart Rate; Metoprolol; Mice; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Prazosin; RGS Proteins; Vasoconstriction

2006
Ability of short-time Fourier transform method to detect transient changes in vagal effects on hearts: a pharmacological blocking study.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 290, Issue:6

    Topics: Adrenergic beta-Antagonists; Adult; Atropine; Autonomic Agents; Blood Pressure; Dizziness; Fourier Analysis; Heart; Humans; Male; Metoprolol; Muscarinic Antagonists; Posture; Sympathetic Nervous System; Vagus Nerve

2006
Involvement of voltage-dependent Ca(2+) channel beta(3) subunit in the autonomic control of heart rate variability.
    Pharmacology, 2006, Volume: 76, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Atropine; Calcium Channels, N-Type; Electrocardiography; Genotype; Heart Rate; Metoprolol; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Parasympatholytics; Phentolamine; Protein Subunits; Sympathetic Nervous System; Sympatholytics

2006
Quantitative evaluation of ontogenetic change in heart rate and its autonomic regulation in newborn mice with the use of a noninvasive piezoelectric sensor.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:4

    Topics: Age Factors; Animals; Animals, Newborn; Atropine; Autonomic Nervous System; Baroreflex; Biosensing Techniques; Bradycardia; Electrocardiography; Equipment Design; Heart; Heart Rate; Metoprolol; Mice; Mice, Inbred C57BL; Monitoring, Ambulatory; Parasympatholytics; Reproducibility of Results; Restraint, Physical; Stress, Psychological; Sympathetic Nervous System; Sympatholytics; Transducers; Vagus Nerve

2008
Hemodynamic effect of myocardial bridging.
    Circulation. Cardiovascular interventions, 2009, Volume: 2, Issue:4

    Topics: Adenosine; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Angina Pectoris; Atropine; Bicycling; Coronary Angiography; Dobutamine; Exercise; Exercise Test; Hemodynamics; Humans; Hyperemia; Infusions, Intravenous; Male; Metoprolol; Myocardial Bridging; Young Adult

2009
Electrophysiology of anterograde right-atrial and left-atrial inputs to the atrioventricular node in patients with atrioventricular nodal re-entrant tachycardia.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2011, Volume: 13, Issue:6

    Topics: Adult; Anti-Arrhythmia Agents; Atrioventricular Node; Atropine; Autonomic Nervous System; Bundle of His; Case-Control Studies; Electrophysiologic Techniques, Cardiac; Electrophysiological Phenomena; Female; Heart Atria; Humans; Male; Metoprolol; Middle Aged; Tachycardia, Atrioventricular Nodal Reentry

2011
Complex fractionated electrograms in the right atrial free wall and the superior/posterior wall of the left atrium are affected by activity of the autonomic nervous system.
    Journal of cardiovascular electrophysiology, 2012, Volume: 23, Issue:1

    Topics: Adult; Analysis of Variance; Atrial Fibrillation; Atropine; Autonomic Nervous System; Chi-Square Distribution; Electrophysiologic Techniques, Cardiac; Female; Heart Atria; Humans; Male; Metoprolol; Middle Aged; Parasympatholytics; Pilot Projects; Predictive Value of Tests; Prospective Studies; Sympatholytics; Time Factors

2012
A quantitative HPLC-MS/MS method for studying internal concentrations and toxicokinetics of 34 polar analytes in zebrafish (Danio rerio) embryos.
    Analytical and bioanalytical chemistry, 2014, Volume: 406, Issue:20

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Atropine; Chromatography, High Pressure Liquid; Cimetidine; Embryo, Nonmammalian; Metoprolol; Pesticides; Pharmaceutical Preparations; Phenytoin; Tandem Mass Spectrometry; Toxicokinetics; Water Pollutants, Chemical; Zebrafish

2014
The influence of cardiac autonomic activity on the QT-variability index in able-bodied and incomplete spinal cord injured individuals.
    Autonomic neuroscience : basic & clinical, 2015, Volume: 190

    Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Anti-Arrhythmia Agents; Atropine; Autonomic Nervous System; Cross-Sectional Studies; Electrocardiography; Female; Heart Rate; Humans; Male; Metoprolol; Rest; Spinal Cord Injuries; Stress, Physiological; Supine Position; Vagus Nerve

2015
Effect of autonomic blocking agents on the respiratory-related oscillations of ventricular action potential duration in humans.
    American journal of physiology. Heart and circulatory physiology, 2015, Dec-15, Volume: 309, Issue:12

    Topics: Action Potentials; Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Atropine; Autonomic Nerve Block; Blood Pressure; Electrocardiography; Female; Heart Rate; Heart Ventricles; Humans; Male; Metoprolol; Middle Aged; Muscarinic Antagonists; Parasympatholytics; Respiratory Mechanics; Tachycardia, Supraventricular; Ventricular Function, Left; Ventricular Function, Right

2015
Application of a new robust ECG T-wave delineation algorithm for the evaluation of the autonomic innervation of the myocardium.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2016, Volume: 2016

    Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Algorithms; Atropine; Autonomic Nervous System; Databases, Factual; Electrocardiography; Heart; Heart Conduction System; Humans; Male; Metoprolol; Myocardium; Sensitivity and Specificity; Signal Processing, Computer-Assisted; Signal-To-Noise Ratio; Wavelet Analysis

2016