atropine has been researched along with metoprolol in 79 studies
| Studies (atropine) | Trials (atropine) | Recent Studies (post-2010) (atropine) | Studies (metoprolol) | Trials (metoprolol) | Recent Studies (post-2010) (metoprolol) |
|---|---|---|---|---|---|
| 26,711 | 1,259 | 1,697 | 5,821 | 1,743 | 1,304 |
| Protein | Taxonomy | atropine (IC50) | metoprolol (IC50) |
|---|---|---|---|
| Beta-2 adrenergic receptor | Homo sapiens (human) | 2.573 | |
| Beta-1 adrenergic receptor | Homo sapiens (human) | 0.176 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 4.87 | |
| Cytochrome P450 2J2 | Homo sapiens (human) | 4.87 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (32.91) | 18.7374 |
| 1990's | 11 (13.92) | 18.2507 |
| 2000's | 28 (35.44) | 29.6817 |
| 2010's | 14 (17.72) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Lüllmann, H; Timmermans, PB; Weikert, GM; Ziegler, A | 1 |
| Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Bard, B; Carrupt, PA; Martel, S | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Csapo, G | 1 |
| Almeida, AP; Azevedo, AD; Couto, AS; Freire-Maia, L; Moraes-Santos, T | 1 |
| Kirby, DA; Lown, B; Pinto, JM | 1 |
| Edvardsson, N; Hirsch, I; Olsson, SB | 2 |
| Hunt, GB; Ross, DL | 1 |
| Beermann, B; Brandt, R; Jonzon, B; Sylvén, C | 1 |
| Bliss, K; Cornish, KG; Hackley, J; Zucker, IH | 1 |
| Graitzer, HM; Hudson, DL; Raven, PB; Smith, ML | 2 |
| Lang, RE; Ruskoaho, H; Toth, M | 1 |
| Tuttle, RS | 1 |
| Hajdu, MA; Panzenbeck, MJ; Tan, W; Zucker, IH | 1 |
| Curran-Everett, DC; Hong, SK; Krasney, JA; Yoshino, H | 1 |
| al-Rashood, KA; el Tahir, KE; el-Obeid, HA; Ibrahim, ME; Madani, AA; Tilmisani, AK | 1 |
| Dahlöf, C; Franco-Cereceda, A; Lundberg, JM | 1 |
| Barron, KW; Bishop, VS | 1 |
| Caldwell, RW; Nash, CB | 1 |
| Franco-Cereceda, A; Hua, XY; Lundberg, JM | 1 |
| Bonelli, J | 1 |
| Egeblad, H; Lewis, S; Nygaard, E; Saltin, B; Sanchez, J | 1 |
| Barra, M; Bertulla, A; Brignole, M; Menozzi, C; Monducci, I; Sartore, B | 1 |
| Huerta, FI; Sharma, AD; Waxman, MB | 1 |
| Bastian, BC; Blomqvist, CG; Graham, RM; Lewis, SF; Pettinger, WA; Taylor, WF | 1 |
| Areskog, NH; Gad, P; Lewis, SF; Nylander, E | 1 |
| Barber, JM; Boyle, DM; Evans, A; McIlmoyle, EL; Salathia, KS; Shanks, RG | 1 |
| Demura, H; Hotta, M; Imaki, T; Shibasaki, T; Yamada, K; Yamauchi, N | 1 |
| Berntson, GG; Binkley, PF; Cacioppo, JT; Fieldstone, A; Quigley, KS; Uchino, BN | 2 |
| Bellotti, P; Boersma, E; el-Said, ES; Fioretti, PM; Forster, T; McNeill, AJ; Poldermans, D; Roelandt, JR; Salustri, A | 1 |
| Foresman, BH; Raven, PB; Shi, X; Stern, SA; Stevens, GH | 1 |
| Liu, JL; Murakami, H; Zucker, IH | 1 |
| Ogawa, N | 1 |
| Chi, Y; Hatton, DC; Luft, FC; Scrogin, KE | 1 |
| Formes, KJ; Hayes, PM; O-Yurvati, AH; Reese, IP; Shi, X; Wang, HW; Weiss, MS; Wray, DW | 1 |
| Lei, Z; Liu, Z; Ni, J; Wu, R; Ye, M; Zou, H | 1 |
| Aoyagi, N; Goldberger, AL; Hidaka, I; Ivanov, PC; Nunes Amaral, LA; Stanley, HE; Tomono, S; Yamamoto, Y | 1 |
| Camargos, ER; Chiari, E; Fontoura, BF; Freire-Maia, L; Machado, CR; Teixeira, AL; Teixeira, MM | 1 |
| Hirooka, Y; Ito, K; Kimura, Y; Kishi, T; Sakai, K; Shimokawa, H; Takeshita, A | 1 |
| Cornish, KG; Pliquett, RU; Zucker, IH | 1 |
| Andrade, JL; Khandheria, BK; Kowatsch, I; Leal, SM; Lemos, PA; Mathias, W; Ramires, JF; Tsutsui, JM | 1 |
| Cornish, KG; Liu, XF; Patel, KP; Wang, Y; Zucker, IH | 1 |
| Blumer, KJ; Diedrich, A; Gross, V; Jordan, J; Luft, FC; Obst, M; Plehm, R; Tank, J | 2 |
| Formes, KJ; O-Yurvati, AH; Shi, X; Weiss, MS; Wray, DW | 1 |
| Kettunen, J; Martinmäki, K; Rusko, H; Saalasti, S | 1 |
| Iijima, T; Murakami, M; Ono, K; Wu, TW | 1 |
| Sato, S | 1 |
| De Pauw, M; Drieghe, B; Gheeraert, P; Kersemans, M; Taeymans, Y; Van Heuverswyn, F | 1 |
| Antolic, B; Jan, M; Pernat, A; Rajković, Z; Rakovec, P; Sinkovec, M | 1 |
| Boldt, LH; Chaldoupi, SM; DE Bakker, JM; Doevendans, PA; Hauer, RN; Linnenbank, AC; Loh, P; VAN Driel, VJ; VAN Wessel, H; Wittkampf, FH | 1 |
| Brox, S; Küster, E; Reemtsma, T; Ritter, AP | 1 |
| Cotie, LM; Ditor, DS; La Fountaine, MF; Sharif, H | 1 |
| Child, N; Gill, JS; Hanson, B; Orini, M; Rinaldi, CA; Taggart, P; van Duijvenboden, S | 1 |
| Cesari, M; Dissing Sorensen, HB; Mehlsen, AB; Mehlsen, J | 1 |
3 review(s) available for atropine and metoprolol
| Article | Year |
|---|---|
The role of receptor binding in drug discovery.
Topics: Animals; Drug Design; Humans; Receptors, Drug | 1993 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Analysis and characterization of ligand-receptor binding systems].
Topics: Alprenolol; Animals; Atropine; Binding, Competitive; Carbachol; Dihydroalprenolol; Humans; Ligands; Metoprolol; Receptors, Cell Surface; Receptors, Neurotransmitter | 1997 |
7 trial(s) available for atropine and metoprolol
| Article | Year |
|---|---|
Adenosine receptor mediated stimulation of ventilation in man.
Topics: Adenosine; Adult; Afferent Pathways; Atropine; Chemoreceptor Cells; Cromolyn Sodium; Dipyridamole; Female; Heart Block; Humans; Hyperventilation; Male; Metoprolol; Middle Aged; Receptors, Purinergic; Respiration; Theophylline | 1989 |
Haemodynamic responses to static and dynamic handgrip before and after autonomic blockade.
Topics: Adult; Atropine; Autonomic Nerve Block; Epinephrine; Hand; Hemodynamics; Humans; Male; Metoprolol; Muscle Contraction; Norepinephrine; Physical Exertion | 1983 |
Metoprolol and atropine in acute myocardial infarction.
Topics: Atropine; Drug Therapy, Combination; Humans; Metoprolol; Myocardial Infarction; Propanolamines | 1980 |
Autonomic cardiac control. II. Noninvasive indices and basal response as revealed by autonomic blockades.
Topics: Adult; Arousal; Atropine; Autonomic Nervous System; Blood Pressure; Cardiography, Impedance; Double-Blind Method; Female; Heart; Humans; Infusions, Intravenous; Metoprolol; Stroke Volume | 1994 |
Autonomic cardiac control. III. Psychological stress and cardiac response in autonomic space as revealed by pharmacological blockades.
Topics: Adult; Arousal; Atropine; Autonomic Nervous System; Double-Blind Method; Female; Heart; Humans; Metoprolol; Problem Solving; Reaction Time; Stress, Psychological | 1994 |
Atropine increases the accuracy of dobutamine stress echocardiography in patients taking beta-blockers.
Topics: Aged; Angina Pectoris; Atropine; Dobutamine; Drug Synergism; Echocardiography; Electrocardiography; Exercise Test; Female; Heart Rate; Hemodynamics; Humans; Male; Metoprolol; Middle Aged; Myocardial Ischemia; Prospective Studies | 1994 |
Sympathetic cardiac influence and arterial blood pressure instability.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Atropine; Blood Pressure; Blood Pressure Determination; Drug Interactions; Female; Heart Rate; Hemodynamics; Humans; Lower Body Negative Pressure; Male; Metoprolol; Muscarinic Antagonists; Norepinephrine; Phenylephrine; Reference Values; Renin; Spectrum Analysis; Sympathetic Nervous System; Time Factors; Valsalva Maneuver | 2005 |
69 other study(ies) available for atropine and metoprolol
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Accumulation of drugs by guinea pig isolated atria. Quantitative correlations.
Topics: Animals; Chemistry, Pharmaceutical; Electric Stimulation; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Myocardium; Pharmaceutical Preparations; Protein Binding; Serum Albumin; Solubility; Time Factors | 1980 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Lipophilicity of basic drugs measured by hydrophilic interaction chromatography.
Topics: Chemistry, Pharmaceutical; Chromatography; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Pharmaceutical Preparations; Solubility; Technology, Pharmaceutical | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Paroxysmal nonreentrant tachycardias due to simultaneous conduction in dual atrioventricular nodal pathways.
Topics: Adult; Ajmaline; Atrial Fibrillation; Atrioventricular Node; Atropine; Bundle of His; Cardiac Pacing, Artificial; Electrocardiography; Heart Block; Heart Conduction System; Humans; Lidocaine; Male; Metoprolol; Models, Biological; Tachycardia, Paroxysmal; Verapamil | 1979 |
Effects of toxin Ts-gamma, purified from Tityus serrulatus scorpion venom, on the isolated rat atria.
Topics: Acetylcholine; Animals; Atropine; Electrocardiography; Heart; Heart Atria; In Vitro Techniques; Metoprolol; Myocardial Contraction; Physostigmine; Rats; Scorpion Venoms; Sodium Channels; Tetrodotoxin | 1992 |
Changes in ventricular fibrillation threshold during the development of perinephritic hypertension.
Topics: Animals; Atropine; Blood Pressure; Cardiac Pacing, Artificial; Cardiomegaly; Dogs; Electrophysiology; Female; Heart Rate; Hypertension, Renal; Male; Metoprolol; Nephrectomy; Time Factors; Ventricular Fibrillation | 1990 |
Effects of lidocaine, procainamide, metoprolol, digoxin and atropine on the conduction of premature ventricular beats in man.
Topics: Action Potentials; Adult; Anti-Arrhythmia Agents; Atropine; Cardiac Complexes, Premature; Digoxin; Electric Stimulation; Electrophysiology; Humans; Lidocaine; Male; Metoprolol; Procainamide | 1985 |
Reassessment of AV and VA conduction and AV junctional reentry in the normal dog heart: the role of altered autonomic tone.
Topics: Animals; Atrioventricular Node; Atropine; Autonomic Agents; Cardiac Pacing, Artificial; Dogs; Electric Conductivity; Electrocardiography; Heart Conduction System; Isoproterenol; Metoprolol | 1988 |
Effects of left ventricular receptor stimulation on coronary blood flow in conscious dogs.
Topics: Animals; Atropine; Autonomic Nervous System; Blood Flow Velocity; Blood Pressure; Coronary Circulation; Denervation; Dogs; Heart Ventricles; Metoprolol; Phentolamine; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Cholinergic; Sinus of Valsalva; Vascular Resistance; Veratridine; Veratrine | 1987 |
Blood pressure regulation during cardiac autonomic blockade: effect of fitness.
Topics: Adult; Atropine; Autonomic Nervous System; Blood Pressure; Cardiac Output; Heart; Heart Rate; Homeostasis; Humans; Male; Metoprolol; Oxygen Consumption; Parasympathetic Nervous System; Physical Fitness; Receptors, Adrenergic, beta; Regional Blood Flow; Stroke Volume; Vascular Resistance | 1988 |
Exercise training bradycardia: the role of autonomic balance.
Topics: Adult; Atropine; Autonomic Nervous System; Exercise; Heart Rate; Humans; Male; Metoprolol; Models, Cardiovascular; Parasympathetic Nervous System; Physical Education and Training; Sympathetic Nervous System | 1989 |
Regulation of atrial natriuretic peptide secretion.
Topics: Acetylcholine; Animals; Atrial Natriuretic Factor; Atropine; Epinephrine; In Vitro Techniques; Metoprolol; Perfusion; Phentolamine; Pressure; Rats | 1986 |
Cephalic carotid pressure as a measure of transmission through cervical ganglion.
Topics: Action Potentials; Animals; Atropine; Blood Pressure; Carotid Sinus; Cats; Electric Stimulation; Ganglia, Sympathetic; Heart Rate; Intracranial Pressure; Metoprolol; Norepinephrine; Synaptic Transmission; Time Factors | 1985 |
Intracoronary infusion of prostaglandin I2 attenuates arterial baroreflex control of heart rate in conscious dogs.
Topics: Animals; Atropine; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Epoprostenol; Female; Heart Rate; Infusions, Intra-Arterial; Male; Metoprolol; Pressoreceptors; Reflex | 1988 |
Altered heart rate-arterial pressure relation during head-out water immersion in conscious dog.
Topics: Animals; Atropine; Blood Pressure; Dogs; Female; Head; Heart Rate; Immersion; Metoprolol; Reference Values; Systole | 1988 |
Synthesis and pharmacological activity of N-alkyl-1,2-diphenylethanolamines.
Topics: Animals; Antihypertensive Agents; Atropine; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Ethanolamines; Jejunum; Male; Metoprolol; Muscle, Smooth, Vascular; Myocardial Contraction; Propranolol; Rabbits; Rats; Vas Deferens | 1987 |
Neuropeptide Y and sympathetic control of heart contractility and coronary vascular tone.
Topics: Animals; Arginine Vasopressin; Atropine; Coronary Vessels; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Metoprolol; Muscle, Smooth, Vascular; Myocardial Contraction; Nerve Tissue Proteins; Neuropeptide Y; Nifedipine; Norepinephrine; Phentolamine; Tetrodotoxin | 1985 |
Reflex cardiovascular effects of intracoronary acetylstrophanthidin in the conscious dog.
Topics: Animals; Atropine; Blood Pressure; Calcium Gluconate; Cardiovascular System; Carotid Arteries; Dogs; Heart Rate; Injections, Intra-Arterial; Metoprolol; Myocardial Contraction; Nerve Block; Reflex; Stimulation, Chemical; Strophanthidin; Vagus Nerve; Vascular Resistance | 1985 |
Effect of an aminocardenolide and digoxin upon atrioventricular refractory period in the dog.
Topics: Animals; Atrioventricular Node; Atropine; Digitoxigenin; Digoxin; Dogs; Female; Heart Conduction System; Male; Metoprolol; Neural Conduction; Pressoreceptors; Refractory Period, Electrophysiological; Sympathectomy | 1985 |
Effects of neuropeptide Y (NPY) on mechanical activity and neurotransmission in the heart, vas deferens and urinary bladder of the guinea-pig.
Topics: Animals; Atropine; Electric Stimulation; Guanethidine; Guinea Pigs; Heart Atria; Male; Metoprolol; Muscle Contraction; Muscle Tonus; Nerve Tissue Proteins; Neuropeptide Y; Portal Vein; Propranolol; Synaptic Transmission; Trachea; Urinary Bladder; Vas Deferens | 1984 |
Relevance of selectivity and non-selectivity in beta-adrenoceptor blocking drugs.
Topics: Adrenergic beta-Antagonists; Adult; Atropine; Dose-Response Relationship, Drug; Heart Rate; Humans; Isoproterenol; Male; Metoprolol; Norepinephrine; Organ Specificity; Propranolol | 1982 |
Acute effects of lignocaine, procainamide, metoprolol, digoxin and atropine on human myocardial refractoriness.
Topics: Action Potentials; Adult; Anti-Arrhythmia Agents; Atropine; Digoxin; Heart; Heart Rate; Heart Ventricles; Humans; Lidocaine; Male; Metoprolol; Procainamide; Time Factors; Ventricular Function | 1984 |
Static contraction of the quadriceps muscle in man: cardiovascular control and responses to one-legged strength training.
Topics: Adaptation, Physiological; Adult; Atropine; Blood Pressure; Echocardiography; Energy Metabolism; Heart Rate; Hemodynamics; Humans; Knee; Male; Metoprolol; Muscle Contraction; Muscles; Physical Education and Training; Physical Endurance | 1984 |
[Influence of beta block and autonomic nerve block on the recovery time of the sinus node in sick sinus syndrome and carotid sinus syndrome].
Topics: Adult; Aged; Atropine; Autonomic Nerve Block; Carotid Sinus; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Sick Sinus Syndrome; Sinoatrial Node; Syncope; Syndrome | 1984 |
Effect of adrenergic stimulation and blockade on ventricular defibrillation in the rat.
Topics: Albuterol; Animals; Atropine; Isoproterenol; Male; Metoprolol; Norepinephrine; Phenoxybenzamine; Phenylephrine; Propranolol; Rats; Rats, Inbred Strains; Sympathomimetics; Time Factors; Ventricular Fibrillation | 1983 |
Non-autonomic component in bradycardia of endurance trained men at rest and during exercise.
Topics: Adult; Atropine; Autonomic Nerve Block; Blood Pressure; Heart Rate; Humans; Male; Metoprolol; Oxygen Consumption; Physical Endurance; Physical Exertion; Propranolol | 1980 |
Beta 1-adrenergic mechanism is involved in stress-induced increase in arousal.
Topics: Animals; Arousal; Atropine; Butoxamine; Corticotropin-Releasing Hormone; Hypothalamus; Male; Metoprolol; Pentobarbital; Phentolamine; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, beta-1; Restraint, Physical; Sleep; Sleep Initiation and Maintenance Disorders; Stress, Physiological | 1994 |
Autonomic nervous system control of the heart: endurance exercise training.
Topics: Adult; Atropine; Autonomic Nervous System; Blood Volume; Bradycardia; Cholinergic Antagonists; Drug Combinations; Exercise; Follow-Up Studies; Heart; Heart Rate; Humans; Lower Body Negative Pressure; Male; Metoprolol; Muscarinic Antagonists; Oxygen Consumption; Parasympathetic Nervous System; Parasympatholytics; Physical Education and Training; Physical Endurance; Receptors, Adrenergic, beta-1; Receptors, Cholinergic; Receptors, Muscarinic; Reflex; Sympathetic Nervous System; Sympatholytics; Tachycardia; Vagus Nerve | 1995 |
Blockade of AT1 receptors enhances baroreflex control of heart rate in conscious rabbits with heart failure.
Topics: Angiotensin Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Atropine; Autonomic Nerve Block; Baroreflex; Cardiac Output, Low; Cardiac Pacing, Artificial; Heart Rate; Hemodynamics; Imidazoles; Male; Metoprolol; Rabbits; Reference Values; Tetrazoles | 1996 |
Chronic nitric oxide inhibition with L-NAME: effects on autonomic control of the cardiovascular system.
Topics: Adrenergic beta-Antagonists; Animals; Atropine; Baroreflex; Blood Pressure; Diuresis; Drinking; Enzyme Inhibitors; Heart Rate; Male; Methoxamine; Metoprolol; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Sprague-Dawley | 1998 |
Orthostatic hypotension in aging humans.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Atropine; Blood Pressure; Female; Glycopyrrolate; Heart Conduction System; Heart Rate; Humans; Hypotension; Hypotension, Orthostatic; Lower Body Negative Pressure; Male; Metoprolol; Middle Aged; Nerve Block; Parasympathetic Nervous System; Tachycardia | 2000 |
Enantiomer separation by strong anion-exchange capillary electrochromatography with dynamically modified sulfated beta-cyclodextrin.
Topics: Anions; Atropine; beta-Cyclodextrins; Cyclodextrins; Electrophoresis, Capillary; Metoprolol; Molecular Structure; Praziquantel; Tryptophan; Verapamil | 2001 |
Behavioral-independent features of complex heartbeat dynamics.
Topics: Activities of Daily Living; Adrenergic beta-Antagonists; Adult; Atropine; Female; Fractals; Heart; Humans; Male; Metoprolol; Parasympathetic Nervous System; Parasympatholytics; Sympathetic Nervous System | 2001 |
Cardiac autonomic denervation and functional response to neurotoxins during acute experimental Chagas' disease in rats.
Topics: Acetylcholine; Animals; Atropine; Bradycardia; Chagas Cardiomyopathy; Denervation; Heart; Heart Rate; Male; Metoprolol; Parasympathetic Nervous System; Parasympatholytics; Rats; Rats, Sprague-Dawley; Scorpion Venoms; Sympathetic Nervous System; Sympatholytics; Tachycardia; Vasodilator Agents | 2001 |
Overexpression of eNOS in RVLM improves impaired baroreflex control of heart rate in SHRSP. Rostral ventrolateral medulla. Stroke-prone spontaneously hypertensive rats.
Topics: Animals; Atropine; Autonomic Agents; Baroreflex; beta-Galactosidase; Blood Pressure; Gene Expression Regulation, Enzymologic; Heart Rate; Hypertension; Male; Medulla Oblongata; Metoprolol; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Solitary Nucleus; Transfection | 2003 |
Statin therapy restores sympathovagal balance in experimental heart failure.
Topics: Animals; Atropine; Baroreflex; Cardiac Output, Low; Chronic Disease; Heart Rate; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Metoprolol; Rabbits; Simvastatin; Sympathetic Nervous System; Sympatholytics; Vagus Nerve | 2003 |
Value of rapid beta-blocker injection at peak dobutamine-atropine stress echocardiography for detection of coronary artery disease.
Topics: Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Atropine; Coronary Artery Disease; Echocardiography, Stress; Female; Humans; Injections, Intravenous; Male; Metoprolol; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Time Factors | 2003 |
Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Blood Pressure; Blotting, Northern; Cardiac Output, Low; Chronic Disease; Heart Rate; Hemodynamics; Immunohistochemistry; Male; Metoprolol; Microinjections; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Oligonucleotides, Antisense; omega-N-Methylarginine; Paraventricular Hypothalamic Nucleus; Phentolamine; Rats; Rats, Sprague-Dawley | 2005 |
Autonomic nervous system and blood pressure regulation in RGS2-deficient mice.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Autonomic Nervous System; Blood Pressure; Circadian Rhythm; Epinephrine; Heart Rate; Male; Metoprolol; Mice; Mice, Knockout; Norepinephrine; Parasympatholytics; Prazosin; RGS Proteins; Stress, Physiological | 2005 |
NO-dependent blood pressure regulation in RGS2-deficient mice.
Topics: Animals; Arteries; Atropine; Baroreflex; Blood Pressure; Epinephrine; Heart Rate; Metoprolol; Mice; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Prazosin; RGS Proteins; Vasoconstriction | 2006 |
Ability of short-time Fourier transform method to detect transient changes in vagal effects on hearts: a pharmacological blocking study.
Topics: Adrenergic beta-Antagonists; Adult; Atropine; Autonomic Agents; Blood Pressure; Dizziness; Fourier Analysis; Heart; Humans; Male; Metoprolol; Muscarinic Antagonists; Posture; Sympathetic Nervous System; Vagus Nerve | 2006 |
Involvement of voltage-dependent Ca(2+) channel beta(3) subunit in the autonomic control of heart rate variability.
Topics: Adrenergic alpha-Antagonists; Animals; Atropine; Calcium Channels, N-Type; Electrocardiography; Genotype; Heart Rate; Metoprolol; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Parasympatholytics; Phentolamine; Protein Subunits; Sympathetic Nervous System; Sympatholytics | 2006 |
Quantitative evaluation of ontogenetic change in heart rate and its autonomic regulation in newborn mice with the use of a noninvasive piezoelectric sensor.
Topics: Age Factors; Animals; Animals, Newborn; Atropine; Autonomic Nervous System; Baroreflex; Biosensing Techniques; Bradycardia; Electrocardiography; Equipment Design; Heart; Heart Rate; Metoprolol; Mice; Mice, Inbred C57BL; Monitoring, Ambulatory; Parasympatholytics; Reproducibility of Results; Restraint, Physical; Stress, Psychological; Sympathetic Nervous System; Sympatholytics; Transducers; Vagus Nerve | 2008 |
Hemodynamic effect of myocardial bridging.
Topics: Adenosine; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Angina Pectoris; Atropine; Bicycling; Coronary Angiography; Dobutamine; Exercise; Exercise Test; Hemodynamics; Humans; Hyperemia; Infusions, Intravenous; Male; Metoprolol; Myocardial Bridging; Young Adult | 2009 |
Electrophysiology of anterograde right-atrial and left-atrial inputs to the atrioventricular node in patients with atrioventricular nodal re-entrant tachycardia.
Topics: Adult; Anti-Arrhythmia Agents; Atrioventricular Node; Atropine; Autonomic Nervous System; Bundle of His; Case-Control Studies; Electrophysiologic Techniques, Cardiac; Electrophysiological Phenomena; Female; Heart Atria; Humans; Male; Metoprolol; Middle Aged; Tachycardia, Atrioventricular Nodal Reentry | 2011 |
Complex fractionated electrograms in the right atrial free wall and the superior/posterior wall of the left atrium are affected by activity of the autonomic nervous system.
Topics: Adult; Analysis of Variance; Atrial Fibrillation; Atropine; Autonomic Nervous System; Chi-Square Distribution; Electrophysiologic Techniques, Cardiac; Female; Heart Atria; Humans; Male; Metoprolol; Middle Aged; Parasympatholytics; Pilot Projects; Predictive Value of Tests; Prospective Studies; Sympatholytics; Time Factors | 2012 |
A quantitative HPLC-MS/MS method for studying internal concentrations and toxicokinetics of 34 polar analytes in zebrafish (Danio rerio) embryos.
Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Atropine; Chromatography, High Pressure Liquid; Cimetidine; Embryo, Nonmammalian; Metoprolol; Pesticides; Pharmaceutical Preparations; Phenytoin; Tandem Mass Spectrometry; Toxicokinetics; Water Pollutants, Chemical; Zebrafish | 2014 |
The influence of cardiac autonomic activity on the QT-variability index in able-bodied and incomplete spinal cord injured individuals.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Anti-Arrhythmia Agents; Atropine; Autonomic Nervous System; Cross-Sectional Studies; Electrocardiography; Female; Heart Rate; Humans; Male; Metoprolol; Rest; Spinal Cord Injuries; Stress, Physiological; Supine Position; Vagus Nerve | 2015 |
Effect of autonomic blocking agents on the respiratory-related oscillations of ventricular action potential duration in humans.
Topics: Action Potentials; Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Atropine; Autonomic Nerve Block; Blood Pressure; Electrocardiography; Female; Heart Rate; Heart Ventricles; Humans; Male; Metoprolol; Middle Aged; Muscarinic Antagonists; Parasympatholytics; Respiratory Mechanics; Tachycardia, Supraventricular; Ventricular Function, Left; Ventricular Function, Right | 2015 |
Application of a new robust ECG T-wave delineation algorithm for the evaluation of the autonomic innervation of the myocardium.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Algorithms; Atropine; Autonomic Nervous System; Databases, Factual; Electrocardiography; Heart; Heart Conduction System; Humans; Male; Metoprolol; Myocardium; Sensitivity and Specificity; Signal Processing, Computer-Assisted; Signal-To-Noise Ratio; Wavelet Analysis | 2016 |