Page last updated: 2024-09-05

atropine and methylphenidate

atropine has been researched along with methylphenidate in 29 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(methylphenidate)
Trials
(methylphenidate)
Recent Studies (post-2010) (methylphenidate)
26,7111,2591,6977,7831,6982,693

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)methylphenidate (IC50)
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.061
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)0.083
Sodium-dependent serotonin transporterHomo sapiens (human)5.1
Sodium-dependent dopamine transporter Homo sapiens (human)0.079

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199022 (75.86)18.7374
1990's0 (0.00)18.2507
2000's4 (13.79)29.6817
2010's3 (10.34)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Ho, BT; Silverman, PB1
Christensen, AV; Nielsen, IM1
Barry, H; Hanin, I; Khachaturian, ZS; Shih, TM1
Bättig, P; Benz-Lippold, M; Bucher, K1
Baettig, P; Bucher, K; Logara-Kalantzis, A1
Chinn, C; Weber, LJ1
Antonaccio, MJ1
Georgi, H; Gey, KF1
Costall, B; Naylor, RJ2
Caldwell, RW; Goldberg, LI1
Aghajanian, GK; Crowell, EB; Hayes, AH; Ketchum, JS; Sidell, FR1
Laplace, JP; Ruckebusch, Y1
Schroeder, LA; Tang, AH1
Ward, AA1
Maritano, M; Zaffiri, O1
Brenneman, DE; Rutledge, CO1
Preston, KL; Schuster, CR; Seiden, LS; Wagner, GC1
Kabes, J; Kotásková, H1
WHITE, RP1
BOFF, E; SCHECKEL, CL1
RUDOLPH, AS; SEWELL, HH; WHITE, RP1

Reviews

2 review(s) available for atropine and methylphenidate

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Discriminative response control by psychomotor stimulants.
    Psychopharmacology communications, 1976, Volume: 2, Issue:4

    Topics: Animals; Atropine; Central Nervous System Stimulants; Cinanserin; Cocaine; Dextroamphetamine; Discrimination, Psychological; DOM 2,5-Dimethoxy-4-Methylamphetamine; Methylphenidate; p-Hydroxyamphetamine; Phenoxybenzamine; Propranolol; Rats; Time Factors

1976

Other Studies

27 other study(ies) available for atropine and methylphenidate

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Dopaminergic supersensitivity: influence of dopamine agonists, cholinergics, anticholinergics, and drugs used for the treatment of tardive dyskinesia.
    Psychopharmacology, 1979, Apr-11, Volume: 62, Issue:2

    Topics: Animals; Antiparkinson Agents; Apomorphine; Atropine; Dopamine; Drug Synergism; Dyskinesia, Drug-Induced; Flupenthixol; Humans; Male; Methylphenidate; Mice; Muscimol; Parasympatholytics; Parasympathomimetics; Phenobarbital; Physostigmine; Stereotyped Behavior

1979
Cholinergic mediation of the inhibitory effect of methylphenidate on neuronal activity in the reticular formation.
    Neuropharmacology, 1976, Volume: 15, Issue:1

    Topics: Animals; Atropine; Female; Hexamethonium Compounds; Male; Mecamylamine; Methylphenidate; Neurons; Nicotine; Oxotremorine; Parasympathetic Nervous System; Rats; Reticular Formation; Time Factors

1976
Peak-potentialities of inspiratory musculature as disclosed by tracheal occlusion.
    Agents and actions, 1973, Volume: 3, Issue:1

    Topics: Animals; Atropine; Central Nervous System Stimulants; Diaphragm; Female; Hypercapnia; Hypoxia; Male; Methylphenidate; Morphine; Muscles; Nalorphine; Neostigmine; Pneumothorax, Artificial; Rabbits; Stomach; Time Factors; Trachea

1973
Inspiratory versus expiratory efforts in pigeons: a search for selective drug influence.
    Agents and actions, 1973, Volume: 3, Issue:4

    Topics: Anesthesia; Animals; Atropine; Barbiturates; Benzoates; Chloralose; Chlorpromazine; Codeine; Columbidae; Ethanol; Methadone; Methylphenidate; Morphine; Nalorphine; Nikethamide; Noscapine; Pregnanediones; Respiration; Trachea; Urethane

1973
The actions of several psychoactive agents upon the muscarinic mechanisms in the superior cervical ganglion of the cat.
    Neuropharmacology, 1974, Volume: 13, Issue:1

    Topics: Alkynes; Animals; Atropine; Carbamates; Cats; Desipramine; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Female; Ganglia, Autonomic; Ganglia, Spinal; Heart Rate; Hexamethonium Compounds; Hydrazines; Injections, Intra-Arterial; Male; Methylphenidate; Muscle Contraction; Nictitating Membrane; Nortriptyline; Parasympathetic Nervous System; Parasympathomimetics; Pargyline; Piperidines; Quaternary Ammonium Compounds

1974
Paradoxical vagal tachycardia in ganglion-blocked anesthetized dogs.
    European journal of pharmacology, 1974, Volume: 28, Issue:1

    Topics: Adrenergic beta-Antagonists; Anesthesia; Animals; Atropine; Blood Pressure; Bretylium Compounds; Chlorisondamine; Debrisoquin; Desipramine; Dogs; Drug Interactions; Electric Stimulation; Female; Ganglionic Blockers; Guanethidine; Heart Rate; Hexamethonium Compounds; Male; Mecamylamine; Methylphenidate; Oxprenolol; Reserpine; Vagus Nerve

1974
Effect of neurotropic agents on total pyridoxal phosphate and on the activity of the decarboxylose of aromatic amino acids as well as of other pyridoxal phosphate-dependent enzymes in rat brains.
    Journal of neurochemistry, 1974, Volume: 23, Issue:4

    Topics: Acetates; Amphetamine; Animals; Anti-Anxiety Agents; Atropine; Benzodiazepines; Brain; Carbon Radioisotopes; Carboxy-Lyases; Chloroform; Chlorpromazine; Cocaine; Dihydroxyphenylalanine; Ether; Female; Glutamates; Haloperidol; Hydroxylamines; Methylphenidate; Oxotremorine; Pentobarbital; Pentylenetetrazole; Pyridoxal Phosphate; Quinolines; Rats; Reserpine; Scopolamine; Semicarbazides; Theophylline; Tranylcypromine; Tyrosine Transaminase

1974
Dopamine agonist and antagonist activities of piribedil (ET495)and its metabolites.
    Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 285, Issue:1

    Topics: Amantadine; Amphetamine; Animals; Apomorphine; Atropine; Behavior, Animal; Caudate Nucleus; Dextroamphetamine; Dioxoles; Dopamine; Dopamine Antagonists; Drug Synergism; Haloperidol; Humans; Injections; Male; Methylphenidate; Motor Activity; Nialamide; Piperazines; Pyrimidines; Rats; Stereotyped Behavior; Sulfites

1974
An evaluation of the vasodilation produced by mephentermine and certain other sympathomimetic amines.
    The Journal of pharmacology and experimental therapeutics, 1970, Volume: 172, Issue:2

    Topics: Animals; Arteries; Atropine; Blood Flow Velocity; Chemical Phenomena; Chemistry; Dextroamphetamine; Dogs; Ephedrine; Femoral Artery; Histamine H1 Antagonists; Isoproterenol; Mephentermine; Mesenteric Arteries; Metaraminol; Methamphetamine; Methylphenidate; Muscle Contraction; Nitroglycerin; Phenoxybenzamine; Portal Vein; Propranolol; Regional Blood Flow; Renal Artery; Reserpine; Sympathomimetics; Vascular Resistance; Vasodilator Agents

1970
Stereotyped and circling behaviour induced by dopaminergic agonists after lesions of the midbrain raphe nuclei.
    European journal of pharmacology, 1974, Volume: 29, Issue:2

    Topics: Amphetamine; Animals; Apomorphine; Atropine; Behavior; Caudate Nucleus; Cyproheptadine; Dextroamphetamine; Dibenzothiepins; Dioxoles; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Haloperidol; Humans; Locomotion; Male; Mesencephalon; Methylphenidate; Piperazines; Putamen; Pyrimidines; Rats; Rats, Inbred Strains; Stereotaxic Techniques; Stereotyped Behavior; Stimulation, Chemical; Substantia Nigra; Sulfides; Time Factors

1974
Atropine, scopolamine, and ditran: comparative pharmacology and antagonists in man.
    Psychopharmacologia, 1973, Jan-01, Volume: 28, Issue:2

    Topics: Acridines; Adult; Atropine; Behavior; Blood Pressure; Central Nervous System; Delirium; Glycolates; Heart Rate; Human Experimentation; Humans; Isoflurophate; Male; Memory; Methylphenidate; Neostigmine; Parasympatholytics; Physostigmine; Piperidines; Respiration; Sarin; Scopolamine

1973
[Pharmacologic changes in feeding behavior: food intake and rumination in sheep].
    Psychopharmacologia, 1968, Volume: 12, Issue:2

    Topics: Amphetamine; Animals; Apomorphine; Atropine; Behavior, Animal; Cerebral Cortex; Chlorpromazine; Digestion; Digitalis Glycosides; Eating; Imipramine; Iproniazid; Lanatosides; Mescaline; Methylphenidate; Morphine; Ouabain; Pentobarbital; Psychopharmacology; Reticulum; Rumen; Sheep; Theophylline

1968
Anticholinergic activities of imipramine and methylphenidate.
    Journal of pharmaceutical sciences, 1969, Volume: 58, Issue:2

    Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Carbamates; Cats; Cocaine; Female; Imipramine; Male; Methylphenidate; Quaternary Ammonium Compounds; Salivation

1969
The physiology of concussion.
    Clinical neurosurgery, 1964, Volume: 12

    Topics: Atropine; Blood Pressure; Brain Concussion; Cerebrospinal Fluid; Craniocerebral Trauma; Electroencephalography; Humans; Methylphenidate; Pressure; Scopolamine

1964
[Apropos of neuroleptoanalgesia: the extrapyramidal symptomatology of neuroleptics and drugs that modify such symptoms].
    Acta anaesthesiologica, 1965, Volume: 16

    Topics: Anesthesia; Animals; Atropine; Humans; Methylphenidate; Monoamine Oxidase Inhibitors; Movement Disorders; Neuroleptanalgesia; Tranquilizing Agents

1965
Effect of dietary lipid on locomotor activity and response to psychomotor stimulants.
    Psychopharmacology, 1982, Volume: 76, Issue:3

    Topics: Animals; Atropine; Central Nervous System Stimulants; Dextroamphetamine; Dietary Fats; Female; Gestational Age; Methylphenidate; Motor Activity; Pregnancy; Rats

1982
Effects of methamphetamine on atropine-induced conditioned gustatory avoidance.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:4

    Topics: Animals; Atropine; Avoidance Learning; Brain; Conditioning, Psychological; Dopamine; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Methamphetamine; Methylphenidate; Rats; Rats, Inbred Strains; Serotonin; Taste

1984
[A contribution to differential diagnostics of functional psychoses with the use of pharmacological tests (author's transl)].
    Ceskoslovenska psychiatrie, 1981, Volume: 77, Issue:6

    Topics: Adult; Atropine; Depressive Disorder; Diagnosis, Differential; Female; Humans; Male; Methylphenidate; Middle Aged; Schizophrenia

1981
RELATIONSHIP BETWEEN CHOLINERGIC DRUGS AND EEG ACTIVATION.
    Archives internationales de pharmacodynamie et de therapie, 1963, Sep-01, Volume: 145

    Topics: Atropine; Bemegride; Caffeine; Chlordiazepoxide; Chlorpromazine; Cholinergic Agents; Dextroamphetamine; Electroencephalography; Lysergic Acid Diethylamide; Methylphenidate; Morphine; Parasympathomimetics; Pentobarbital; Pentylenetetrazole; Pharmacology; Phenoxybenzamine; Physostigmine; Rabbits; Research

1963
BEHAVIORAL EFFECTS OF INTERACTING IMIPRAMINE AND OTHER DRUGS WITH D-AMPHETAMINE, COCAINE, AND TETRABENAZINE.
    Psychopharmacologia, 1964, Feb-12, Volume: 5

    Topics: Amitriptyline; Atropine; Avoidance Learning; Chlorpromazine; Cocaine; Desipramine; Dextroamphetamine; Guanethidine; Imipramine; Iproniazid; Isocarboxazid; Methylphenidate; Parasympatholytics; Pharmacology; Piperidines; Promazine; Promethazine; Rats; Research; Scopolamine; Tetrabenazine; Trihexyphenidyl; Tyramine

1964
DRUG-INDUCED DISSOCIATION BETWEEN EVOKED RETICULAR POTENTIALS AND THE EEG.
    Electroencephalography and clinical neurophysiology, 1965, Volume: 19

    Topics: Amphetamine; Amphetamines; Animals; Antidepressive Agents; Atropine; Brain; Caffeine; Catechols; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Electroencephalography; Electrophysiology; Hallucinogens; Humans; Imipramine; Methamphetamine; Methylphenidate; Paraldehyde; Pentobarbital; Pentylenetetrazole; Phenoxybenzamine; Rabbits; Research; Reticular Formation; Scopolamine; Thioridazine; Tranquilizing Agents

1965