Page last updated: 2024-09-05

atropine and methyldopa

atropine has been researched along with methyldopa in 35 studies

Compound Research Comparison

Studies (atropine)	Trials (atropine)	Recent Studies (post-2010) (atropine)	Studies (methyldopa)	Trials (methyldopa)	Recent Studies (post-2010) (methyldopa)
26,711	1,259	1,697	3,719	420	143

Protein Interaction Comparison

Protein	Taxonomy	methyldopa (IC50)
Epidermal growth factor receptor	Homo sapiens (human)	5.228
Tyrosine-protein kinase Fyn	Homo sapiens (human)	5.176
Polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus (rabbit)	2.126

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (51.43)	18.7374
1990's	2 (5.71)	18.2507
2000's	6 (17.14)	29.6817
2010's	9 (25.71)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bissett, JK; de Soyza, ND; Kane, JJ; Murphy, ML	1
Gaul, SL; Sweet, CS	1
Sjoerdsma, A	1
Carlsson, A; Carlsson, M; Svensson, A	1
Mehta, VL; Prabhu, S; Valecha, N	1
Fox, GR; Virgo, BB	1
Bivens, LW; Ray, OS	1
Antonaccio, MJ; Burrell, R; Robson, RD	1
Bartholini, G; Pletscher, A	1
Juvancz, P; Káldor, A	1
Bencosme, SA; Berger, JM	1
Walker, JL; Weetman, DF	1
Koe, BK; Weissman, A	1
Schnieden, H; Truslove, GM	1
Gunnar, RM; Loeb, HS; Rahimtoola, SH; Rosen, KM; Sinno, MZ	1
Alberti, PW; Black, JI	1
de Angelis, J	1
SCHNIEDEN, H	1
BARRNETT, RJ; LENTZ, TL	1
APPENZELLER, O; SCHNIEDEN, H	1
Aboul-Enein, HY; Alizadeh, R; Ghassempour, A; Karami, A; Najafi, NM; Römpp, A; Spengler, B	1

Reviews

3 review(s) available for atropine and methyldopa

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drugs affecting monoamines in the basal ganglia. Advances in biochemical psychopharmacology, 1972, Volume: 6 Topics: Amines; Animals; Atropine; Barbiturates; Basal Ganglia; Biogenic Amines; Carbon Isotopes; Chlorpromazine; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Haloperidol; Hydroxyindoleacetic Acid; Methyldopa; Norepinephrine; Phenylacetates; Rabbits; Rats; Tranquilizing Agents; Tritium	1972
Specific granules in mammalian and non-mammalian vertebrate cardiocytes. Methods and achievements in experimental pathology, 1971, Volume: 5 Topics: Animals; Atropine; Bethanechol Compounds; Catecholamines; Cats; Cattle; Cytoplasmic Granules; Dihydroxyphenylalanine; Fishes; Heart Atria; Heart Ventricles; Hemicholinium 3; Histocytochemistry; Humans; Isoproterenol; Lysosomes; Methyldopa; Microscopy, Electron; Myocardium; Nialamide; Norepinephrine; Propranolol; Rabbits; Rats; Reserpine; Sympatholytics; Sympathomimetics	1971

Trials

1 trial(s) available for atropine and methyldopa

Article	Year
Effect of antihypertensive drugs on the "intrinsic" heart rate. British medical journal, 1969, May-24, Volume: 2, Issue:5655 Topics: Amidines; Antihypertensive Agents; Atropine; Clinical Trials as Topic; Depression, Chemical; Heart Rate; Humans; Methyldopa; Propranolol; Quinolines; Reserpine	1969

Other Studies

31 other study(ies) available for atropine and methyldopa

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Electrophysiology of atropine. Cardiovascular research, 1975, Volume: 9, Issue:1 Topics: Adult; Aged; Atrioventricular Node; Atropine; Bundle of His; Bundle-Branch Block; Cardiac Catheterization; Electrocardiography; Electrophysiology; Heart; Heart Atria; Heart Conduction System; Heart Diseases; Humans; Hydrochlorothiazide; Hypertension; Methyldopa; Middle Aged; Neural Conduction; Nitroglycerin; Purkinje Fibers; Refractory Period, Electrophysiological; Rheumatic Heart Disease; Tachycardia	1975
Antagonism of conditioned salivation in conscious dogs by antihypertensive drugs. Canadian journal of physiology and pharmacology, 1977, Volume: 55, Issue:4 Topics: Animals; Antihypertensive Agents; Atropine; Carbidopa; Clonidine; Conditioning, Classical; Dogs; Drug Interactions; Female; Male; Methyldopa; Pilocarpine; Salivation	1977
Central action as a key to past and future therapy of hypertension. Progress in brain research, 1977, Volume: 47 Topics: Atropine; Brain; Humans; Hypertension; Methyldopa; Pargyline; Phenobarbital; Propranolol; Receptors, Adrenergic; Research Design	1977
Synergistic interactions between muscarinic antagonists, adrenergic agonists and NMDA antagonists with respect to locomotor stimulatory effects in monoamine-depleted mice. Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 343, Issue:6 Topics: Adrenergic alpha-Agonists; Animals; Atropine; Biperiden; Clonidine; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism; Ketamine; Male; Methyldopa; Mice; Mice, Neurologic Mutants; Motor Activity; N-Methylaspartate; Parasympatholytics; Parkinson Disease; Piperazines	1991
Influence of clonidine, methyldopa and propranolol on acute toxicity of fenitrothion in mice. Indian journal of physiology and pharmacology, 1990, Volume: 34, Issue:1 Topics: Animals; Atropine; Clonidine; Drug Interactions; Fenitrothion; Male; Methyldopa; Mice; Propranolol	1990
The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicology and applied pharmacology, 1985, Volume: 78, Issue:3 Topics: Administration, Oral; Animals; Atropine; Blood Glucose; Central Nervous System; Dieldrin; Drug Interactions; Gluconeogenesis; Hypoglycemia; Lethal Dose 50; Liver; Male; Methyldopa; Phenobarbital; Phosphoenolpyruvate Carboxykinase (GTP); Propranolol; Rats; Rats, Inbred Strains	1985
Drug alteration of autonomic function and electroconvulsive shock mortality in rats. The American journal of physiology, 1966, Volume: 210, Issue:6 Topics: Animals; Atropine; Autonomic Nervous System; Chlorpromazine; Dibenzylchlorethamine; Electroconvulsive Therapy; Ethanolamines; Heart Rate; Hexamethonium Compounds; Methyldopa; Mortality; Rats; Scopolamine	1966
The effects of L-dopa and alpha-methyldopa on reflexes and sympathetic nerve function. European journal of pharmacology, 1974, Volume: 25, Issue:1 Topics: Animals; Atropine; Barbiturates; Benserazide; Blood Pressure; Carbidopa; Carotid Arteries; Dogs; Electric Stimulation; Heart Rate; Hindlimb; Levodopa; Methyldopa; Monoamine Oxidase Inhibitors; Neurons; Perfusion; Posture; Reflex; Regional Blood Flow; Sympathetic Nervous System; Vagotomy; Vagus Nerve	1974
Oxotremorine-induced hypertension in the anaesthetized rat. British journal of pharmacology, 1970, Volume: 39, Issue:3 Topics: Adrenal Glands; Animals; Atropine; Blood Pressure; Central Nervous System; Cordotomy; Female; Guanethidine; Heart Rate; Hypertension; Male; Methyldopa; Pentolinium Tartrate; Phentolamine; Pyrrolidinones; Rats; Reserpine; Stimulation, Chemical; Sympathetic Nervous System; Vagotomy	1970
m-Fluorotyrosine convulsions and mortality: relationship to catecholamine and citrate metabolism. The Journal of pharmacology and experimental therapeutics, 1967, Volume: 155, Issue:1 Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anticonvulsants; Atropine; Azoles; Brain; Chlordiazepoxide; Chlorpromazine; Citrates; Dihydroxyphenylalanine; Disulfiram; Drug Antagonism; Drug Synergism; Kidney; Lysergic Acid Diethylamide; Male; Methyldopa; Mice; Morphine; Nialamide; Norepinephrine; Pargyline; Phenobarbital; Phenytoin; Reserpine; Seizures; Serotonin; Strychnine; Tetrabenazine; Trimethadione; Tyrosine; Urea	1967
The effect of some drugs on genetic tremor in the mouse. European journal of pharmacology, 1970, Jul-01, Volume: 11, Issue:1 Topics: Acetylcholine; Age Factors; Animals; Atropine; Barbiturates; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Dopamine; Female; Genetics; Histocytochemistry; Male; Methyldopa; Mice; Norepinephrine; Orphenadrine; Scopolamine; Serotonin; Tremor	1970
Cardiac conduction in patients with symptomatic sinus node disease. Circulation, 1971, Volume: 43, Issue:6 Topics: Aged; Arrhythmia, Sinus; Atropine; Bundle-Branch Block; Digoxin; Electrocardiography; Female; Heart Block; Heart Conduction System; Heart Rate; Humans; Male; Methyldopa; Middle Aged; Pacemaker, Artificial; Sinoatrial Node	1971
Iatrogenic symptoms in otolaryngology. The Journal of laryngology and otology, 1968, Volume: 82, Issue:8 Topics: Adult; Aged; Anti-Bacterial Agents; Anticonvulsants; Antidepressive Agents; Antihypertensive Agents; Atropine; Contraceptives, Oral; Deafness; Drug-Related Side Effects and Adverse Reactions; Epistaxis; Female; Glutethimide; Humans; Iatrogenic Disease; Male; Methyldopa; Middle Aged; Monoamine Oxidase Inhibitors; Nose Diseases; Otorhinolaryngologic Diseases; Pharyngitis; Salivary Gland Diseases; Sinusitis; Tinnitus; Vertigo	1968
Hemodynamic monitoring in the operating room. Resuscitation, 1984, Volume: 11, Issue:3-4 Topics: Atropine; Cardiac Catheterization; Ephedrine; Hemodynamics; Homeostasis; Humans; Intraoperative Care; Intraoperative Complications; Methyldopa; Monitoring, Physiologic; Nitroglycerin; Nitroprusside; Operating Rooms; Phenylephrine; Positive-Pressure Respiration; Propranolol	1984
EFFECT OF ALPHA METHYL DOPA ON EXPERIMENTAL TREMOR. Journal of neurology, neurosurgery, and psychiatry, 1963, Volume: 26 Topics: 5-Hydroxytryptophan; Atropine; Electrophysiological Phenomena; Electrophysiology; Equipment and Supplies; Heterocyclic Compounds; Hypnotics and Sedatives; Indoles; Methamphetamine; Methyldopa; Mice; Nicotine; Parasympatholytics; Research; Toxicology; Tremor	1963
THE ROLE OF THE NERVOUS SYSTEM IN REGENERATING HYDRA: THE EFFECT OF NEUROPHARMACOLOGICAL AGENTS. The Journal of experimental zoology, 1963, Volume: 154 Topics: Amphetamine; Amphetamines; Animals; Atropine; Autonomic Agents; Biphenyl Compounds; Chlorpromazine; Cnidaria; Decamethonium Compounds; Dihydroxyphenylalanine; Enzyme Inhibitors; Ergotamine; Hexamethonium Compounds; Histocytochemistry; Histology; Hydra; Isoflurophate; Lidocaine; Methyldopa; Nervous System; Pharmacology; Physostigmine; Regeneration; Research; Reserpine; Tubocurarine	1963
EFFECT OF SOME DRUGS ON REFLEX VASODILATATION OF HAND PRODUCED BY RADIANT HEATING OF TRUNK. Journal of applied physiology, 1964, Volume: 19 Topics: Atropine; Bretylium Compounds; Hand; Heating; Hot Temperature; Humans; Methyldopa; Pharmacology; Phenoxybenzamine; Reflex; Sensory Receptor Cells; Sympatholytics; Vasodilation; Vasomotor System	1964
Crystalline degradation products of vancomycin as chiral stationary phase in microcolumn liquid chromatography. Journal of separation science, 2008, Volume: 31, Issue:13 Topics: Alanine; Atropine; Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Liquid; Crystallization; Methyldopa; Microchemistry; Particle Size; Phenylalanine; Propranolol; Silicon Dioxide; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Vancomycin	2008