Page last updated: 2024-09-05

atropine and memantine

atropine has been researched along with memantine in 16 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(memantine)
Trials
(memantine)
Recent Studies (post-2010) (memantine)
26,7111,2591,6972,6843411,425

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)memantine (IC50)
Neuronal acetylcholine receptor subunit alpha-3Rattus norvegicus (Norway rat)6
Neuronal acetylcholine receptor subunit beta-4Rattus norvegicus (Norway rat)6
AcetylcholinesteraseHomo sapiens (human)0.0049
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)1.4167
Neuronal acetylcholine receptor subunit alpha-6Rattus norvegicus (Norway rat)6
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)1.4167
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)1.5
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)1.5
Glutamate receptor ionotropic, NMDA 1Homo sapiens (human)4.3212
Glutamate receptor ionotropic, NMDA 2AHomo sapiens (human)3.662
Glutamate receptor ionotropic, NMDA 2BHomo sapiens (human)5.31
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)1.5
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)1.5
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)1.5

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.25)18.7374
1990's3 (18.75)18.2507
2000's6 (37.50)29.6817
2010's5 (31.25)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Glen, RC; Lowe, R; Mitchell, JB1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Dettbarn, WD; Gupta, RC1
Dettbarn, WD; Gupta, RC; McLean, MJ; Wamil, AW1
Gupta, RC; Kadel, WL1
Gupta, RC1
Goad, JT; Gupta, RC1
Dettbarn, WD; Gupta, RC; Milatovic, D1
Dekundy, A; Dettbarn, WD; Gupta, RC; Milatovic, D; Montine, TJ1
Brito, GA; Cavalheiro, EA; da Costa, MA; da Cruz, GM; da Graça Naffah-Mazzacoratti, M; de Andrade, GM; de Barros Viana, GS; Felipe, CF; Leal, LK; Menezes, ML; Scorza, FA; Tavares, AF1
Bokonjić, D; Jokanović, M; Kilibarda, V; Škrbić, R; Stojiljković, MP; Vulović, M1
Kassa, J; Zdarova Karasova, J1

Reviews

2 review(s) available for atropine and memantine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Carbofuran toxicity.
    Journal of toxicology and environmental health, 1994, Volume: 43, Issue:4

    Topics: Agricultural Workers' Diseases; Animals; Atropine; Brain; Carbofuran; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Female; Humans; L-Lactate Dehydrogenase; Lethal Dose 50; Maternal-Fetal Exchange; Memantine; Mutagens; Pregnancy; Soil Pollutants; Water Pollutants, Chemical

1994

Other Studies

14 other study(ies) available for atropine and memantine

ArticleYear
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Potential of memantine, D-tubocurarine, and atropine in preventing acute toxic myopathy induced by organophosphate nerve agents: soman, sarin, tabun and VX.
    Neurotoxicology, 1992,Fall, Volume: 13, Issue:3

    Topics: Acetylcholinesterase; Acute Disease; Animals; Atropine; Cholinesterase Inhibitors; Male; Memantine; Muscular Diseases; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman; Tubocurarine

1992
Prophylactic and therapeutic efficacy of memantine against seizures produced by soman in the rat.
    Toxicology and applied pharmacology, 1992, Volume: 112, Issue:1

    Topics: Animals; Atropine; Brain; Cells, Cultured; Cholinesterase Inhibitors; Male; Memantine; Mice; Neurons; Rats; Rats, Inbred Strains; Seizures; Soman; Time Factors

1992
Prevention and antagonism of acute carbofuran intoxication by memantine and atropine.
    Journal of toxicology and environmental health, 1989, Volume: 28, Issue:1

    Topics: Acetylcholinesterase; Amantadine; Animals; Atropine; Carbofuran; Carboxylesterase; Carboxylic Ester Hydrolases; Chemical Phenomena; Chemistry; Cholinesterase Inhibitors; Drug Antagonism; Drug Synergism; Insecticides; Male; Memantine; Rats; Rats, Inbred Strains

1989
Role of high-energy phosphates and their metabolites in protection of carbofuran-induced biochemical changes in diaphragm muscle by memantine.
    Archives of toxicology, 2000, Volume: 74, Issue:1

    Topics: Acetylcholinesterase; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Atropine; Carbofuran; Cholinesterase Inhibitors; Creatine Kinase; Excitatory Amino Acid Antagonists; Injections, Subcutaneous; L-Lactate Dehydrogenase; Male; Memantine; Muscarinic Antagonists; Muscle, Skeletal; Phosphates; Phosphocreatine; Rats; Rats, Sprague-Dawley

2000
Involvement of nitric oxide in myotoxicity produced by diisopropylphosphorofluoridate (DFP)-induced muscle hyperactivity.
    Archives of toxicology, 2002, Volume: 76, Issue:12

    Topics: Acetylcholinesterase; Adenosine Triphosphate; Animals; Atropine; Behavior, Animal; Cholinesterase Inhibitors; Citrulline; Drug Therapy, Combination; Hyperkinesis; Injections, Subcutaneous; Isoflurophate; Male; Memantine; Muscle, Skeletal; Nitric Oxide; Phosphocreatine; Rats; Rats, Sprague-Dawley; Time Factors

2002
Carbofuran-induced oxidative stress in slow and fast skeletal muscles: prevention by memantine and atropine.
    Toxicology, 2005, Mar-01, Volume: 208, Issue:1

    Topics: Adenosine Triphosphate; Animals; Antidotes; Atropine; Biomarkers; Carbofuran; Cholinesterase Inhibitors; Citrulline; F2-Isoprostanes; Male; Memantine; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Oxidative Stress; Phosphocreatine; Rats; Rats, Sprague-Dawley; Time Factors

2005
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
    Pharmacology, biochemistry, and behavior, 2013, Volume: 104

    Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Monoamines; Brain; Diazepam; Disease Models, Animal; Epilepsy; Flumazenil; gamma-Aminobutyric Acid; Humans; Male; Memantine; Mice; Nimodipine; Nitrites; Pilocarpine; Piperidines; Polyunsaturated Alkamides; Seizures; Tumor Necrosis Factor-alpha

2013
Prophylactic potential of memantine against soman poisoning in rats.
    Toxicology, 2019, 03-15, Volume: 416

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Behavior, Animal; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; GPI-Linked Proteins; Male; Memantine; Neuromuscular Junction; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Soman; Synaptic Transmission

2019
Combination of acetylcholinesterase inhibitors and NMDA receptor antagonists increases survival rate in soman-poisoned mice.
    Toxicology mechanisms and methods, 2023, Volume: 33, Issue:7

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Memantine; Mice; Oximes; Poisons; Procyclidine; Pyridinium Compounds; Receptors, N-Methyl-D-Aspartate; Soman; Survival Rate

2023