atropine has been researched along with ketanserin in 63 studies
| Studies (atropine) | Trials (atropine) | Recent Studies (post-2010) (atropine) | Studies (ketanserin) | Trials (ketanserin) | Recent Studies (post-2010) (ketanserin) |
|---|---|---|---|---|---|
| 26,711 | 1,259 | 1,697 | 3,094 | 335 | 283 |
| Protein | Taxonomy | atropine (IC50) | ketanserin (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0016 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0021 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.015 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 0.015 | |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | 0.265 | |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | 6.5 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.0184 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.0027 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.0016 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.29 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.015 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 1.8 | |
| Synaptic vesicular amine transporter | Homo sapiens (human) | 0.18 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.001 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (14.29) | 18.7374 |
| 1990's | 28 (44.44) | 18.2507 |
| 2000's | 15 (23.81) | 29.6817 |
| 2010's | 11 (17.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Kung, HF; Kung, MP; Zhuang, ZP | 1 |
| Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM | 1 |
| Booth, RG; Brown, RL; Bucholtz, EC; Tropsha, A; Wyrick, SD | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bielenica, A; Caliendo, G; Capasso, R; Ciano, A; Corvino, A; Di Vaio, P; Fiorino, F; Frecentese, F; Izzo, AA; Kędzierska, E; Magli, E; Massarelli, P; Nencini, C; Orzelska-Gòrka, J; Perissutti, E; Rossi, I; Santagada, V; Severino, B | 1 |
| Caliendo, G; Capasso, R; Ciano, A; Corvino, A; Di Vaio, P; Fiorino, F; Frecentese, F; Izzo, AA; Kędzierska, E; Kotlińska, JH; Magli, E; Massarelli, P; Orzelska-Gòrka, J; Perissutti, E; Rossi, I; Saccone, I; Santagada, V; Severino, B | 1 |
| Gretler, DD; Jones, KC; Murphy, MB | 1 |
| Dhasmana, KM; Saxena, PR; Tadipatri, S; Villalón, CM; Zhu, YN | 1 |
| Feniuk, W; Humphrey, PP; Perren, MJ | 1 |
| Pillai, G; Sutter, MC | 1 |
| Adelstein, RS; Corson, MA; Schoenberg, M; Sellers, JR | 1 |
| Sahin-Erdemli, I; Uma, S | 1 |
| Hong, E; Meneses, A | 1 |
| Harf, A; Istin, N; Jarreau, PH; Macquin-Mavier, I | 1 |
| Bianconi, L; Buonanno, G; Caiazza, A; Capretti, L; Cavazzini, U; Chiodera, P; Coiro, V; Marcato, A; Speroni, G; Volpi, R | 1 |
| Gaw, AJ; Humphrey, PP; Wadsworth, RM | 1 |
| Hyman, PE; Jing, J; Ng, WW; Snape, WJ | 1 |
| Claro, E; Wallace, MA | 1 |
| Fitzpatrick, JM; Grant, BJ | 1 |
| Jarrott, B; Louis, WJ; Verberne, AJ; Widdop, RE | 1 |
| Andersson, KE; Forman, A; Funch-Jensen, P; Raundahl, U; Tøttrup, A | 1 |
| Ahlman, H; Dahlström, A; Lidberg, P | 1 |
| Smits, JF; Struyker-Boudier, HA; Tijssen, CM; van Essen, H | 1 |
| Bianconi, L; Caiazza, A; Capretti, L; Chiodera, P; Coiro, V; Fagnoni, F; Schianchi, L; Speroni, G; Volpi, R | 1 |
| Ahlman, H; Dahlström, A; Grönstad, KO; Jaffe, BM | 1 |
| Ferrara, A; Jaffe, BM; Sherlock, DJ | 1 |
| Heiligers, J; Mylecharane, EJ; Saxena, PR; Tio, R | 1 |
| Ahlman, H; Björck, S; Dahlström, A; Kelly, KA; Phillips, SF | 1 |
| Beubler, E; Bukhave, K; Rask-Madsen, J | 1 |
| Glusa, E | 1 |
| Bingham, S; Gaster, L; King, BF; Rushant, B; Sanger, GJ; Smith, MI | 1 |
| Frossard, N; Tavakoli, R | 1 |
| Blackshaw, LA; Dent, J; Nisyrios, V | 1 |
| Cazzola, M; D'Agostino, B; De Santis, D; Matera, MG; Pallotta, M; Rossi, F; Vacca, C | 1 |
| Camilleri, M; Kost, LJ; Oosterbosch, L; Phillips, SF; Valdovinos, MA; von der Ohe, M | 1 |
| Iino, T; Katsura, M; Kuriyama, K | 1 |
| Gidener, S; Güven, H; Kirkali, Z | 1 |
| Itoh, Z; Mizumoto, A; Nakajima, M; Sakai, T; Sano, I; Shiba, Y; Shiihara, Y | 1 |
| Kaibara, M; Mameya, S; Takada, K; Takemura, K; Taniyama, K | 1 |
| Kollias-Baker, C; Nieto, JE; Snyder, JR; Stanley, S | 1 |
| Naylor, RJ; Tuladhar, BR; Womack, MD | 1 |
| Castro-Souza, C; Coimbra, NC; Garcia-Cairasco, N; Herrero, CF; Nora, JE; Segato, EN; Tedeschi-Filho, W | 1 |
| Chang, TM; Chey, WY; Li, JP | 1 |
| Fozard, JR; Hannon, JP; Mazzoni, L; Tigani, B; Williams, I | 1 |
| Cocks, TM; Moffatt, JD; Page, CP | 1 |
| Angers, P; Dalbó, S; Jürgensen, S; Ribeiro-do-Valle, RM; Santos, AR | 1 |
| Karaki, S; Kuwahara, A; Mitsui, R; Ono, S | 1 |
| Betancourt, A; Freerksen, N; Garfield, R; Günter, HH; Maul, H; Orise, P; Saade, G; Sohn, C; Vedernikov, Y; Wentz, M | 1 |
| Kitazawa, T; Komori, S; Taneike, T; Ukai, H | 1 |
| Hiyama, Y; Ishimura, M; Kataoka, S; Maeda, T; Suda, M | 1 |
| Komada, T; Yano, S | 1 |
| Meeker, S; Myers, AC; Undem, BJ; Weigand, LA | 1 |
| Del Bel, EA; Dias, QM; Prado, WA; Silveira, JW | 1 |
| Fedin, AN; Kirilina, VM; Krivchenko, AI; Postnikova, TIu | 1 |
| Hattori, T; Kanno-Saito, S; Katano, Y; Okada, T; Sakai-Saito, A; Takanashi, A | 1 |
1 review(s) available for atropine and ketanserin
| Article | Year |
|---|---|
The role of receptor binding in drug discovery.
Topics: Animals; Drug Design; Humans; Receptors, Drug | 1993 |
1 trial(s) available for atropine and ketanserin
| Article | Year |
|---|---|
5-HT1-, but not 5-HT2-serotonergic, M1-, M2-muscarinic cholinergic or dopaminergic receptors mediate the ACTH/cortisol response to metoclopramide in man.
Topics: Adrenocorticotropic Hormone; Adult; Atropine; Bromocriptine; Dose-Response Relationship, Drug; Humans; Hydrocortisone; Ketanserin; Male; Metergoline; Metoclopramide; Pirenzepine; Receptors, Adrenergic; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Muscarinic; Receptors, Serotonin | 1990 |
61 other study(ies) available for atropine and ketanserin
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Synthesis of (R,S)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetral in (trans-8-OH-PIPAT): a new 5-HT1A receptor ligand.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Iodine Radioisotopes; Ligands; Rats; Receptors, Serotonin; Stereoisomerism; Tetrahydronaphthalenes; Tritium | 1993 |
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ligands; Models, Molecular; Pyrilamine; Radioligand Assay; Structure-Activity Relationship; Tetrahydronaphthalenes | 1999 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus.
Topics: Animals; Body Temperature; Humans; Ligands; Locomotion; Male; Mice; Niacinamide; Piperazine; Piperazines; Protein Binding; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A | 2016 |
New 5-HT
Topics: Animals; Binding Sites; Biological Assay; Ileum; Ligands; Maze Learning; Molecular Structure; Picolines; Protein Binding; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin Receptor Agonists | 2017 |
5-Hydroxytryptamine receptor activity of the dopamine receptor agonist fenoldopam in canine tracheal smooth muscle.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Atropine; Benzazepines; Dogs; Dopamine Agents; Drug Interactions; Fenoldopam; In Vitro Techniques; Indomethacin; Ketanserin; Methysergide; Muscle, Smooth; Receptors, Serotonin; Serotonin; Trachea; Vasodilator Agents | 1992 |
Role of 5-HT1-like receptors in the increase in intragastric pressure induced by 5-hydroxytryptamine in the rat.
Topics: Animals; Atropine; Catecholamines; Female; Indoles; Ketanserin; Male; Methiothepin; Methysergide; Pressure; Pyrilamine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Stomach; Tropisetron | 1992 |
Vascular 5-HT1-like receptors that mediate contraction of the dog isolated saphenous vein and carotid arterial vasoconstriction in anaesthetized dogs are not of the 5-HT1A or 5-HT1D subtype.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Atropine; Carotid Arteries; Dogs; Ganglionic Blockers; In Vitro Techniques; Indoles; Ketanserin; Methiothepin; Muscle, Smooth, Vascular; Pyrilamine; Receptors, Serotonin; Saphenous Vein; Spiperone; Sulfonamides; Sumatriptan; Tetrahydronaphthalenes; Vasoconstriction; Vasoconstrictor Agents | 1991 |
Effect of human plasma proteins on spontaneous contractile activity of rat mesenteric portal vein.
Topics: Alpha-Globulins; Animals; Atropine; Beta-Globulins; Blood Proteins; Chlorpheniramine; gamma-Globulins; Humans; Immunoglobulin G; Ketanserin; Male; Mesenteric Veins; Muscle Contraction; Muscle, Smooth, Vascular; Ouabain; Phentolamine; Portal Vein; Rats; Rats, Inbred Strains; Saralasin; Serum Albumin; Verapamil | 1990 |
Substance P contracts bovine tracheal smooth muscle via activation of myosin light chain kinase.
Topics: Animals; Atropine; Calcium; Cattle; Enzyme Activation; Glycopeptides; In Vitro Techniques; Indomethacin; Ketanserin; Kinetics; Masoprocol; Muscle Contraction; Muscle, Smooth; Myosin Subfragments; Myosin-Light-Chain Kinase; Peptide Mapping; Phosphorylation; Potassium Chloride; Prazosin; Propranolol; Pyrilamine; Substance P; Trachea | 1990 |
Receptors mediating the contractile effect of serotonin (5-HT) in the isolated common bile duct of guinea-pig.
Topics: Animals; Atropine; Common Bile Duct; Dose-Response Relationship, Drug; Female; Guinea Pigs; Ketanserin; Male; Methysergide; Muscle Contraction; Receptors, Serotonin; Serotonin | 1991 |
Effects of serotonergic compounds on associative learning.
Topics: Animals; Atropine; Buspirone; Conditioning, Operant; Ketanserin; Learning; Male; Quinazolines; Rats; Rats, Inbred Strains; Ritanserin; Serotonin; Serotonin Antagonists | 1991 |
5-Hydroxytryptamine-induced bronchoconstriction in the guinea-pig: effect of 5-HT2 receptor activation on acetylcholine release.
Topics: Acetylcholine; alpha-Methyltyrosine; Animals; Atropine; Bronchoconstriction; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Indoles; Ketanserin; Male; Methyltyrosines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tropisetron; Vagotomy | 1991 |
Neurotransmission in the sheep middle cerebral artery: modulation of responses by 5-HT and haemolysate.
Topics: Animals; Atropine; Blood Physiological Phenomena; Cerebral Arteries; Erythrocytes; Hemoglobins; Hemolysis; Ketanserin; Neurotransmitter Agents; Prazosin; Serotonin; Sheep; Vasoconstriction | 1990 |
Effect of 5-hydroxytryptamine and its antagonists on colonic smooth muscle of the rabbit.
Topics: Animals; Atropine; Colon; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Indoles; Ketanserin; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Rabbits; Serotonin; Serotonin Antagonists; Tetrodotoxin; Tropisetron | 1991 |
Comparison of serotoninergic to muscarinic cholinergic stimulation of phosphoinositide-specific phospholipase C in rat brain cortical membranes.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Dopamine; Dose-Response Relationship, Drug; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Ketanserin; Membranes; Parasympathomimetics; Phosphatidylinositols; Rats; Serotonin; Synaptic Transmission; Tryptamines; Type C Phospholipases | 1990 |
Effects of pulmonary vascular obstruction on right ventricular afterload.
Topics: Animals; Atropine; Biomechanical Phenomena; Compliance; Constriction; Dogs; Ketanserin; Meclofenamic Acid; Models, Cardiovascular; Positive-Pressure Respiration; Pulmonary Artery; Pulmonary Circulation; Pulmonary Embolism; Pulsatile Flow; Vagotomy; Vascular Resistance; Ventricular Function | 1990 |
The effect of ketanserin on cardiovascular reflexes in conscious normotensive and spontaneously hypertensive rats.
Topics: Animals; Atropine; Biguanides; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Electric Stimulation; Female; Heart Rate; Hypoglycemic Agents; Ketanserin; Nitroprusside; Pressoreceptors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reflex; Tropanes; Vagus Nerve | 1990 |
Effects of transmural field stimulation in isolated muscle strips from human esophagus.
Topics: Atropine; Carbachol; Electric Stimulation; Esophagus; Humans; In Vitro Techniques; Ketanserin; Muscle Contraction; Muscle, Smooth; Nicotine; Phentolamine; Prazosin; Propranolol; Stomach; Tetrodotoxin; Yohimbine | 1990 |
On the nature of the contractile motor responses of the rat stomach elicited by serotonin or substance P in vitro.
Topics: Animals; Atropine; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Stomach; Substance P; Tachyphylaxis; Tetrodotoxin | 1985 |
Effects of ketanserin on hemodynamics and baroreflex effects in conscious spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Atropine; Hemodynamics; Hypertension; Ketanserin; Nitroprusside; Pressoreceptors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reflex | 1987 |
Muscarinic cholinergic, but not serotoninergic mediation of arginine vasopressin response to metoclopramide in man.
Topics: Adult; Arginine Vasopressin; Atropine; Dose-Response Relationship, Drug; Humans; Ketanserin; Kinetics; Male; Metergoline; Metoclopramide; Pirenzepine; Receptors, Muscarinic; Receptors, Serotonin | 1989 |
Regional and selective changes in blood flow of the feline small intestine induced by endoluminal serotonin.
Topics: Animals; Atropine; Cats; Intestinal Mucosa; Jejunum; Ketanserin; Male; Microspheres; Perfusion; Piperidines; Receptors, Muscarinic; Receptors, Serotonin; Regional Blood Flow; Serotonin | 1986 |
Comparative effects of ketanserin, atropine and methysergide on the gastrointestinal effects of hyperserotoninemia in the awake dog.
Topics: Animals; Atropine; Digestive System; Dogs; Gastrointestinal Motility; Ketanserin; Methysergide; Piperidines; Receptors, Serotonin; Serotonin; Water-Electrolyte Balance | 1986 |
Excitatory 5-hydroxytryptamine receptors in the cat urinary bladder are of the M- and 5-HT2-type.
Topics: Animals; Atropine; Cats; Cyproheptadine; Dimethylphenylpiperazinium Iodide; Drug Interactions; Female; Guanethidine; Ketanserin; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Piperidines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tropanes; Urinary Bladder | 1985 |
Serotonergic regulation of canine enteric motility (measured as electrical activity) and absorption: physiologic and morphologic evidence.
Topics: Animals; Atropine; Dogs; Female; Gastrointestinal Motility; Gastrointestinal Transit; Immunohistochemistry; Intestinal Absorption; Intestinal Mucosa; Ketanserin; Serotonin | 1988 |
Colonic secretion mediated by prostaglandin E2 and 5-hydroxytryptamine may contribute to diarrhea due to morphine withdrawal in the rat.
Topics: Animals; Atropine; Clonidine; Colon; Cyclic AMP; Diarrhea; Dinoprostone; Female; Humans; Indomethacin; Ketanserin; Morphine Dependence; Naloxone; Piperidines; Prostaglandins E; Rats; Rats, Inbred Strains; Serotonin; Substance Withdrawal Syndrome | 1984 |
Desulfated hirugen (hirudin 54-65) induces endothelium-dependent relaxation of porcine pulmonary arteries.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Arginine; Atropine; Bradykinin; Calcium; Captopril; Cyclic GMP; Dinoprost; Endothelium, Vascular; Hirudins; Histamine; Indomethacin; Ketanserin; Methiothepin; Molecular Sequence Data; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Peptide Fragments; Phentolamine; Pulmonary Artery; Swine; Vasodilation | 1994 |
Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an in-vivo model of 5-HT4 receptor function.
Topics: 4-Aminobenzoic Acid; Animals; Atropine; Dioxanes; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Gastric Mucosa; Gastrointestinal Motility; Granisetron; Injections, Intravenous; Ketanserin; Male; Methiothepin; Methysergide; Muscle Contraction; Muscle, Smooth; para-Aminobenzoates; Piperidines; Random Allocation; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Stomach | 1995 |
5-HT2-mediated bronchial responses after syngeneic lung transplantation in the rat.
Topics: Animals; Atropine; Bronchi; Dose-Response Relationship, Drug; Ketanserin; Lung Transplantation; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Lew; Serotonin | 1995 |
Responses of ferret lower esophageal sphincter to 5-hydroxytryptamine: pathways and receptor subtypes.
Topics: Animals; Atropine; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Esophagus; Female; Ferrets; Granisetron; Guanethidine; Indoles; Ketanserin; Male; Muscle, Smooth; Receptors, Serotonin; Reference Values; Serotonin; Serotonin Antagonists; Splanchnic Nerves; Time Factors; Vagotomy; Vagus Nerve | 1995 |
Role of 5-hydroxytryptamine in mediating adenosine-induced airway contraction.
Topics: Analysis of Variance; Animals; Atropine; Diphenhydramine; Dose-Response Relationship, Drug; Epithelium; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Indomethacin; Ketanserin; Male; Muscle Contraction; Muscle, Smooth; Phenylisopropyladenosine; Serotonin; Trachea; Xanthines | 1995 |
Effects of serotonin on rat ileocolonic transit and fluid transfer in vivo: possible mechanisms of action.
Topics: Animals; Atropine; Benzamides; Bethanechol; Bethanechol Compounds; Biological Transport; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Colon; Gastrointestinal Transit; Heterocyclic Compounds; Ileum; Ketanserin; Male; Methysergide; Models, Biological; Pyrroles; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists | 1993 |
(+-)-Methyl-2,3,3a,4-tetrahydro-1H-indolo [3,2,1-de] [1,5] naphthyridine-6-carboxylate monohydrochloride facilitates phosphatidylinositol hydrolysis: possible involvement of muscarinic and nonmuscarinic mechanisms.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Guanosine Triphosphate; Hypoxia; In Vitro Techniques; Inositol Phosphates; Ketanserin; Male; Phentolamine; Phosphatidylinositols; Potassium; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Synaptic Membranes; Vinca Alkaloids | 1993 |
Influence of serotonin on the human ureter: an in vitro pharmacological study.
Topics: Adult; Aged; Atropine; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Indoles; Ketanserin; Male; Methysergide; Middle Aged; Muscle Contraction; Serotonin; Serotonin Antagonists; Tropisetron; Ureter | 1995 |
Effect of 5-hydroxytryptamine on gastrointestinal motility in conscious guinea-pigs.
Topics: Animals; Atropine; Consciousness; Duodenum; Eating; Fasting; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; Infusions, Intravenous; Ketanserin; Methysergide; Muscle Contraction; Muscle, Smooth; Ondansetron; Pyloric Antrum; Serotonin; Serotonin Antagonists | 1997 |
Regional and functional differences of 5-hydroxytryptamine-receptor subtypes in guinea pig stomach.
Topics: Animals; Atropine; Dioxanes; Enzyme Inhibitors; Female; Gastric Fundus; Granisetron; Guinea Pigs; In Vitro Techniques; Ketanserin; Male; Methysergide; Muscarinic Antagonists; Muscle Relaxation; Muscle Tonus; Nitroarginine; Piperidines; Pyloric Antrum; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Stomach; Tetrodotoxin | 1999 |
In vitro effects of 5-hydroxytryptamine and cisapride on the circular smooth muscle of the jejunum of horses.
Topics: Animals; Atropine; Cisapride; Drug Synergism; Horses; In Vitro Techniques; Indoles; Isometric Contraction; Jejunum; Ketanserin; Muscle, Smooth; Serotonin; Serotonin Antagonists; Tetrodotoxin; Tropisetron | 2000 |
Pharmacological characterization of the 5-HT receptor-mediated contraction in the mouse isolated ileum.
Topics: Animals; Atropine; Dioxanes; Dose-Response Relationship, Drug; Female; Granisetron; Ileum; In Vitro Techniques; Indoles; Ketanserin; Male; Mice; Muscle Contraction; Ondansetron; Piperidines; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tetrodotoxin; Tropanes; Tropisetron | 2000 |
Post-ictal analgesia: involvement of opioid, serotoninergic and cholinergic mechanisms.
Topics: Analgesia; Animals; Atropine; Convulsants; Disease Models, Animal; Injections, Intraperitoneal; Ketanserin; Methysergide; Motor Activity; Muscarinic Antagonists; Naloxone; Narcotic Antagonists; Pain Measurement; Pentylenetetrazole; Rats; Rats, Wistar; Reaction Time; Reflex; Seizures; Serotonin Antagonists | 2001 |
Roles of 5-HT receptors in the release and action of secretin on pancreatic secretion in rats.
Topics: Animals; Atropine; Duodenum; Ketanserin; Male; Muscarinic Antagonists; Ondansetron; Pancreas; Pancreatic Juice; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Secretin; Serotonin Antagonists | 2001 |
Mechanism of airway hyperresponsiveness to adenosine induced by allergen challenge in actively sensitized Brown Norway rats.
Topics: Adenosine; Allergens; Animals; Atropine; Bradykinin; Bronchoconstriction; Bronchoconstrictor Agents; Capsaicin; Cardiovascular System; Cell Degranulation; Cromolyn Sodium; Dose-Response Relationship, Drug; Histamine; In Vitro Techniques; Ketanserin; Lung; Male; Mast Cells; Methacholine Chloride; Methysergide; Ovalbumin; p-Methoxy-N-methylphenethylamine; Rats; Rats, Inbred BN; Respiratory Hypersensitivity; Serotonin; Serotonin Antagonists; Time Factors; Vagotomy; Vasoconstrictor Agents | 2001 |
Role of the epithelium and acetylcholine in mediating the contraction to 5-hydroxytryptamine in the mouse isolated trachea.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Atropine; Boron Compounds; Botulinum Toxins, Type A; Calcium Channel Blockers; Calcium Channels; Cartilage; Electric Stimulation; Epithelial Cells; Epithelium; Female; Ganglia, Parasympathetic; Inositol 1,4,5-Trisphosphate Receptors; Ketanserin; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; omega-Conotoxin GVIA; Receptors, Cytoplasmic and Nuclear; Serotonin; Surface-Active Agents; Tetrodotoxin; Trachea | 2004 |
Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Behavior, Animal; Capsaicin; Cat's Claw; Dose-Response Relationship, Drug; Formaldehyde; Ketanserin; Male; Mice; Motor Activity; Naltrexone; Pain; Pain Measurement; Phytotherapy; Plant Preparations; Prazosin; Receptors, Serotonin, 5-HT2; Reserpine; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Yohimbine | 2005 |
Propionate modulates spontaneous contractions via enteric nerves and prostaglandin release in the rat distal colon.
Topics: Acetates; Animals; Atropine; Cholinergic Fibers; Colon, Descending; Cyclooxygenase Inhibitors; Enteric Nervous System; Gastrointestinal Motility; Granisetron; Hexamethonium; Ketanserin; Male; Motor Neurons; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nicotinic Antagonists; Piroxicam; Propionates; Prostaglandins; Rats; Rats, Wistar; Serotonin Antagonists; Tetrodotoxin | 2005 |
PAR-2 activating peptide-induced stimulation of pregnant rat myometrium contractile activity partly involves the other membrane receptors.
Topics: Animals; Atropine; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Hydrazines; Ibuprofen; In Vitro Techniques; Ketanserin; Ketotifen; Metabolic Networks and Pathways; Myometrium; Oligopeptides; Platelet Membrane Glycoproteins; Pregnancy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Receptors, G-Protein-Coupled; Receptors, Histamine H1; Receptors, Serotonin; Receptors, Thromboxane A2, Prostaglandin H2; Uterine Contraction | 2007 |
Pharmacological characterization of 5-hydroxytryptamine-induced contraction in the chicken gastrointestinal tract.
Topics: Anesthetics, Local; Animals; Atropine; Chickens; Dose-Response Relationship, Drug; Electric Stimulation; Ileum; In Vitro Techniques; Ketanserin; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Proventriculus; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin Agents; Spiro Compounds; Sulfonamides; Tetrodotoxin | 2006 |
Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetates; Acetylcholine; Albuterol; Animals; Atropine; Benzoquinones; Carbachol; Chromones; Cyclopropanes; Dinoprost; Drug Evaluation, Preclinical; Guinea Pigs; Heptanoic Acids; Histamine; In Vitro Techniques; Indoles; Indomethacin; Ketanserin; Ketotifen; Leukotriene Antagonists; Leukotriene D4; Male; Muscle Contraction; Muscle, Smooth; Phenylcarbamates; Powders; Procaterol; Prostaglandin Antagonists; Prostaglandin D2; Quinolines; Receptors, Thromboxane A2, Prostaglandin H2; Serotonin; Substance P; Sulfides; Sulfonamides; Tosyl Compounds; Trachea; Tryptophan | 2006 |
Pharmacological characterization of 5-Hydroxytryptamine-receptor subtypes in circular muscle from the rat stomach.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Drug Synergism; Gastric Emptying; Gastric Fundus; In Vitro Techniques; Indoles; Ketanserin; Methysergide; Muscle Contraction; Muscle, Smooth; Ondansetron; Oxadiazoles; Phenols; Piperazines; Piperidines; Protein Isoforms; Pyloric Antrum; Pyridines; Pyrimidines; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Stomach; Sulfonamides; Tetrodotoxin | 2007 |
Mast cell-cholinergic nerve interaction in mouse airways.
Topics: Animals; Atropine; Bronchoconstriction; Cholinergic Fibers; Electrophysiological Phenomena; Histamine Release; In Vitro Techniques; Ketanserin; Male; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Antagonists; Muscle Contraction; Ovalbumin; Serotonin; Serotonin Antagonists; Trachea | 2009 |
Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats.
Topics: Animals; Atropine; Cholinergic Antagonists; Immunohistochemistry; Ketanserin; Male; Methiothepin; Methysergide; Neurons; Norepinephrine; Pain; Pain Measurement; Pain, Postoperative; Phenoxybenzamine; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Spinal Cord | 2010 |
[Heterogeneity of the rat respiratory way responses to serotonin].
Topics: Animals; Atropine; Bronchi; Electric Stimulation; Hexamethonium; Isometric Contraction; Ketanserin; Male; Methysergide; Muscle, Smooth; Nerve Fibers; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Tissue Culture Techniques; Trachea | 2011 |
Differences between young and aged rats in voiding frequency and detrusor muscle serotonergic contraction.
Topics: Adrenergic alpha-Antagonists; Animals; Atropine; Ketanserin; Male; Muscle Contraction; Naphthalenes; Piperazines; Rats; Rats, Inbred F344; Receptors, Serotonin, 5-HT2; Serotonin; Serotonin Receptor Agonists; Tetrodotoxin; Urinary Bladder | 2019 |