Compounds > atropine
Page last updated: 2024-09-05

atropine and ici 204,219

atropine has been researched along with ici 204,219 in 7 studies

Compound Research Comparison

Studies
(atropine)		Trials
(atropine)		Recent Studies (post-2010)
(atropine)		Studies
(ici 204,219)		Trials
(ici 204,219)		Recent Studies (post-2010) (ici 204,219)
26,7111,2591,69746310191

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)ici 204,219 (IC50)
Solute carrier family 22 member 2Homo sapiens (human)9.7
Epidermal growth factor receptorHomo sapiens (human)5.751
Adenosine receptor A3Homo sapiens (human)1.363
Cytochrome P450 2C9 Homo sapiens (human)2.2575
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)1.363
Thromboxane-A synthase Homo sapiens (human)3.81
Mitogen-activated protein kinase 3 Homo sapiens (human)4.376
Mitogen-activated protein kinase 1Homo sapiens (human)0.538
Bifunctional epoxide hydrolase 2Homo sapiens (human)2
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)1.363
Sodium/bile acid cotransporterHomo sapiens (human)6.5
Mitogen-activated protein kinase 14Homo sapiens (human)0.353
Cysteinyl leukotriene receptor 1Cavia porcellus (domestic guinea pig)0.002
Multidrug and toxin extrusion protein 2Homo sapiens (human)7.6
Multidrug and toxin extrusion protein 1Homo sapiens (human)1.3
Cysteinyl leukotriene receptor 2Homo sapiens (human)7.397
Cysteinyl leukotriene receptor 1Homo sapiens (human)0.0039

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Hiyama, Y; Ishimura, M; Kataoka, S; Maeda, T; Suda, M1
Chang, BS; Chang, JC; Huang, SC; Wang, YS1

Reviews

1 review(s) available for atropine and ici 204,219

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

6 other study(ies) available for atropine and ici 204,219

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea.
    Allergology international : official journal of the Japanese Society of Allergology, 2006, Volume: 55, Issue:4

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetates; Acetylcholine; Albuterol; Animals; Atropine; Benzoquinones; Carbachol; Chromones; Cyclopropanes; Dinoprost; Drug Evaluation, Preclinical; Guinea Pigs; Heptanoic Acids; Histamine; In Vitro Techniques; Indoles; Indomethacin; Ketanserin; Ketotifen; Leukotriene Antagonists; Leukotriene D4; Male; Muscle Contraction; Muscle, Smooth; Phenylcarbamates; Powders; Procaterol; Prostaglandin Antagonists; Prostaglandin D2; Quinolines; Receptors, Thromboxane A2, Prostaglandin H2; Serotonin; Substance P; Sulfides; Sulfonamides; Tosyl Compounds; Trachea; Tryptophan

2006
Cysteinyl leucotriene receptor type 1 mediates contraction in human and guinea-pig oesophagus.
    Neurogastroenterology and motility, 2008, Volume: 20, Issue:10

    Topics: Acetates; Animals; Atropine; Capsaicin; Carbachol; Cholinergic Agonists; Cyclopropanes; Esophagus; Guinea Pigs; Humans; Indoles; Leukotriene Antagonists; Leukotrienes; Male; Muscarinic Antagonists; Muscle Contraction; Phenylcarbamates; Quinolines; Receptors, Leukotriene; Sensory System Agents; Sodium Channel Blockers; SRS-A; Sulfides; Sulfonamides; Tetrodotoxin; Tosyl Compounds

2008