Compounds > atropine
Page last updated: 2024-09-05

atropine and huperzine a

atropine has been researched along with huperzine a in 7 studies

Compound Research Comparison

Studies
(atropine)		Trials
(atropine)		Recent Studies (post-2010)
(atropine)		Studies
(huperzine a)		Trials
(huperzine a)		Recent Studies (post-2010) (huperzine a)
26,7111,2591,69746815198
26,7111,2591,69724021

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)huperzine a (IC50)
CholinesteraseHomo sapiens (human)0.2504
AcetylcholinesteraseHomo sapiens (human)2.1226
AcetylcholinesteraseRattus norvegicus (Norway rat)0.0955
AcetylcholinesteraseElectrophorus electricus (electric eel)5.17
Cytochrome P450 3A4Homo sapiens (human)0.12
Acetylcholinesterase Bos taurus (cattle)0.1

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's2 (28.57)24.3611
2020's2 (28.57)2.80

Authors

AuthorsStudies
Chen, XP; Han, YF; Tang, XC; Zhu, XD1
Badia, A; Camps, P; Clos, MV; Muñoz-Torrero, D; Roman, S1
Adler, M; Albuquerque, EX; Aracava, Y; Fawcett, WP; Hamilton, TA; Kan, RK; Oliveira, M; Pereira, EF; Randall, WR; Romano, JA1
Park, P; Schachter, S; Yaksh, T1
Feng, ZH; Li, XY; Liu, L; Mei, SH; Wang, M; Wang, Y; Wang, YJ; Zuo, ZX1
Kassa, J; Zdarova Karasova, J1
Curtis, MA; Lin, SX; Sperry, J1

Reviews

1 review(s) available for atropine and huperzine a

ArticleYear
Pyridine alkaloids with activity in the central nervous system.
    Bioorganic & medicinal chemistry, 2020, 12-15, Volume: 28, Issue:24

    Topics: Alkaloids; Amphibians; Animals; Bacteria; Central Nervous System Diseases; Fungi; Nicotine; Plants; Pyridines; Receptors, Nicotinic

2020

Other Studies

6 other study(ies) available for atropine and huperzine a

ArticleYear
[Effects of huperzine A on learning and the retrieval process of discrimination performance in rats].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1986, Volume: 7, Issue:6

    Topics: Alkaloids; Animals; Atropine; Discrimination Learning; Hemicholinium 3; Male; Memory; Physostigmine; Rats; Scopolamine; Sesquiterpenes

1986
Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors.
    Brain research, 2005, Nov-09, Volume: 1061, Issue:2

    Topics: Acetylcholine; Alkaloids; Aminoquinolines; Animals; Atropine; Cholinesterase Inhibitors; Dopamine Antagonists; Dose-Response Relationship, Drug; Galantamine; Haloperidol; Heterocyclic Compounds, 4 or More Rings; In Vitro Techniques; Mecamylamine; Nicotinic Agonists; Nicotinic Antagonists; Parasympatholytics; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sesquiterpenes

2005
Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Aug-29, Volume: 103, Issue:35

    Topics: Acetylcholinesterase; Alkaloids; Animals; Atropine; Behavior, Animal; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Lethal Dose 50; Neurons; Organophosphate Poisoning; Organophosphorus Compounds; Paraoxon; Poisoning; Pyridostigmine Bromide; Sarin; Sesquiterpenes; Soman; Time Factors

2006
Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats.
    Neuroscience letters, 2010, Feb-05, Volume: 470, Issue:1

    Topics: Alkaloids; Analgesics; Animals; Atropine; Behavior, Animal; Catheterization; Dose-Response Relationship, Drug; Hot Temperature; Injections, Spinal; Male; Muscarinic Antagonists; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Time Factors

2010
Huperzine A Alleviates Mechanical Allodynia but Not Spontaneous Pain via Muscarinic Acetylcholine Receptors in Mice.
    Neural plasticity, 2015, Volume: 2015

    Topics: Acetylcholinesterase; Alkaloids; Ambenonium Chloride; Analgesics; Animals; Atropine; Behavior, Animal; Cholinesterase Inhibitors; Chronic Pain; Clonidine; Gyrus Cinguli; Hyperalgesia; Inflammation; Learning; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Muscarinic Antagonists; Neuralgia; Pain Threshold; Peroneal Nerve; Receptors, Muscarinic; Sesquiterpenes

2015
Combination of acetylcholinesterase inhibitors and NMDA receptor antagonists increases survival rate in soman-poisoned mice.
    Toxicology mechanisms and methods, 2023, Volume: 33, Issue:7

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Memantine; Mice; Oximes; Poisons; Procyclidine; Pyridinium Compounds; Receptors, N-Methyl-D-Aspartate; Soman; Survival Rate

2023