Page last updated: 2024-09-05

atropine and fpl 55712

atropine has been researched along with fpl 55712 in 20 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(fpl 55712)
Trials
(fpl 55712)
Recent Studies (post-2010) (fpl 55712)
26,7111,2591,69739323

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)fpl 55712 (IC50)
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)1.58
Bile salt export pumpHomo sapiens (human)10
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)0.51
Thromboxane-A synthase Homo sapiens (human)10
Cysteinyl leukotriene receptor 2Homo sapiens (human)0.51
Cysteinyl leukotriene receptor 1Homo sapiens (human)2.255

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-199018 (90.00)18.7374
1990's1 (5.00)18.2507
2000's0 (0.00)29.6817
2010's1 (5.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Asakura, K; Kataura, A; Kojima, T; Narita, S; Shirasaki, H1
Regal, JF1
Hosokawa, T; Irinoda, K; Maruyama, Y; Misawa, M; Mizuno, H; Ohno, H; Sugimoto, K; Takahashi, Y; Yanaura, S; Yoshimura, K1
Bánovcin, P; Hanácek, J; Korpás, J; Plank, L; Visnovský, P1
Aizawa, H; Hakoda, H; Hirose, T; Ito, Y; Suzuki, H1
Charette, L; Denis, D; Jones, TR1
Chand, N; Diamantis, W; Nolan, K; Perhach, JL; Sofia, RD1
Benveniste, J; Brink, C; Haye-Legrand, I; Labat, C; Norel, X1
Gobran, LI; Rooney, SA1
Okamoto, M; Terao, M; Tokumura, A; Tsukatani, H; Yoshida, K1
Bell, RL; Regal, JF1
Jones, TR; Masson, P1
Burka, JF; Paterson, NA2
Cade, JF; Clancy, RL; Pain, MC; Walker, SE1
Casey, FB; Chakrin, LW; Hardy, TM; Regal, JF1
Hammerbeck, DM; Swingle, KF1
Alphin, RS; Callaham, EM; Foxwell, MH; Smith, WL; Yanni, JM1
Abraham, WM; King, MM; Oliver, W; Wanner, A; Yerger, L1

Reviews

1 review(s) available for atropine and fpl 55712

ArticleYear
Effects of atropine, acetylsalicylic acid, FPL 55712, and phentolamine on increased histamine responsiveness of cat lung strips under conditions of airway inflammation.
    The European respiratory journal, 1989, Volume: 2, Issue:6

    Topics: Animals; Aspirin; Atropine; Bronchitis; Cats; Chromones; Constriction, Pathologic; Female; Histamine Release; In Vitro Techniques; Lung; Male; Phentolamine

1989

Other Studies

19 other study(ies) available for atropine and fpl 55712

ArticleYear
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Study on the dye leakage response of nasal mucosa following topical, capsaicin challenge in guinea pigs.
    Acta oto-laryngologica, 1992, Volume: 112, Issue:3

    Topics: Administration, Intranasal; Administration, Topical; Animals; Atropine; Benzenesulfonates; Capsaicin; Chromones; Coloring Agents; Diphenhydramine; Exudates and Transudates; Guinea Pigs; Histamine; Histamine Release; Injections, Subcutaneous; Lidocaine; Male; Methacholine Chloride; Nasal Mucosa; Nasal Provocation Tests; Substance P

1992
IgG vs IgE: mediators of antigen-induced guinea pig lung parenchymal contraction.
    Immunopharmacology, 1985, Volume: 10, Issue:3

    Topics: Animals; Antigens; Atropine; Chromones; Guinea Pigs; Histamine Release; Immunoglobulin E; Immunoglobulin G; Indomethacin; Lung; Male; Muscle Contraction; Pyrilamine; SRS-A

1985
[Effects of flutropium bromide, a new antiasthma drug, on mediator release from mast cells and actions of mediators].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1988, Volume: 91, Issue:2

    Topics: Animals; Asthma; Atropine; Atropine Derivatives; Chromones; Dogs; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Male; Mast Cells; Rats; Rats, Inbred Strains; Serotonin Antagonists; SRS-A

1988
The spontaneous electrical and mechanical activity of human bronchial smooth muscle: its modulation by drugs.
    British journal of pharmacology, 1989, Volume: 98, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Atropine; Bronchi; Chromones; Electric Stimulation; Electrophysiology; Female; Humans; In Vitro Techniques; Indomethacin; Isoproterenol; Male; Membrane Potentials; Middle Aged; Muscle Contraction; Muscle, Smooth; Physostigmine

1989
Leukotriene and anti-IgE induced contractions of human isolated trachea: studies with leukotriene receptor antagonists and a novel 5-lipoxygenase inhibitor.
    Canadian journal of physiology and pharmacology, 1988, Volume: 66, Issue:6

    Topics: Animals; Antibodies, Anti-Idiotypic; Arachidonate Lipoxygenases; Atropine; Benzofurans; Chromones; Goats; Humans; In Vitro Techniques; Indomethacin; Keto Acids; Lipoxygenase Inhibitors; Muscle Contraction; Phenylbutyrates; Pyrilamine; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Sulfones; Trachea

1988
Inhibition of leukotriene (SRS-A)-mediated acute lung anaphylaxis by azelastine in guinea pigs.
    Allergy, 1986, Volume: 41, Issue:7

    Topics: Anaphylaxis; Animals; Atropine; Chromones; Cromolyn Sodium; Guinea Pigs; Indomethacin; Ketotifen; Male; Methysergide; Phthalazines; Pyridazines; Pyrilamine; SRS-A

1986
Antigenic contraction of guinea pig tracheal preparations passively sensitized with monoclonal IgE: pharmacological modulation.
    International archives of allergy and applied immunology, 1988, Volume: 87, Issue:4

    Topics: Animals; Antibodies, Monoclonal; Antigens; Atropine; Chromones; Dinitrophenols; Dose-Response Relationship, Immunologic; Guinea Pigs; Immunization, Passive; Immunoglobulin E; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Phenothiazines; Serum Albumin, Bovine; Trachea; Tripelennamine

1988
Adenosine and leukotrienes have a regulatory role in lung surfactant secretion in the newborn rabbit.
    Biochimica et biophysica acta, 1988, May-02, Volume: 960, Issue:1

    Topics: Adenosine; Animals; Animals, Newborn; Atropine; Chromones; Phospholipids; Pilocarpine; Pulmonary Surfactants; Rabbits; Receptors, Purinergic; SRS-A; Theophylline

1988
Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis.
    European journal of pharmacology, 1988, Apr-13, Volume: 148, Issue:3

    Topics: Animals; Atropine; Chlorpheniramine; Chromones; Colon; In Vitro Techniques; Indomethacin; Male; Methysergide; Muscle Contraction; Platelet Activating Factor; Rats; Rats, Inbred Strains; Serum Albumin; SRS-A; Tachyphylaxis

1988
Mediators of C5a-induced bronchoconstriction in the guinea pig.
    International archives of allergy and applied immunology, 1987, Volume: 84, Issue:4

    Topics: Acetylcholine; Animals; Atropine; Bronchi; Bronchial Spasm; Chromones; Complement C5; Guinea Pigs; Histamine; Indomethacin; Male; Phenylbutyrates; Pyrilamine; SRS-A

1987
Comparative study of the pulmonary effects of intravenous leukotrienes and other bronchoconstrictors in anaesthetized guinea pigs.
    Prostaglandins, 1985, Volume: 29, Issue:5

    Topics: Airway Resistance; Anesthesia; Animals; Arachidonic Acid; Arachidonic Acids; Atropine; Blood Pressure; Bronchi; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; Hexamethonium Compounds; Histamine; Indomethacin; Lung; Male; Methysergide; Prostaglandin Endoperoxides, Synthetic; Pyrilamine; SRS-A; Timolol; Vagotomy

1985
Inhibition of antigen-induced release of prostaglandin-like material from guinea-pig trachea by antihistamines FPL55712 and atropine.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:12

    Topics: Animals; Antigens; Atropine; Chromones; Ethers; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Male; Prostaglandins E; SRS-A; Trachea

1980
The effects of SRS-A and histamine antagonists on antigen-induced contraction of guinea pig trachea.
    European journal of pharmacology, 1981, Apr-09, Volume: 70, Issue:4

    Topics: Airway Resistance; Animals; Antigens; Atropine; Autacoids; Chromones; Drug Interactions; Ethers; Guinea Pigs; Histamine H1 Antagonists; Histamine H2 Antagonists; Indomethacin; Male; Muscle Contraction; Trachea

1981
Slow-reacting substance from alveolar macrophages--a mechanism of asthma?
    The Australian journal of experimental biology and medical science, 1981, Volume: 59, Issue:4

    Topics: Animals; Asthma; Atropine; Autacoids; Chromones; Cimetidine; Ethers; Guinea Pigs; Indomethacin; Macrophages; Methysergide; Muscle Contraction; Muscle, Smooth; Pyrilamine; Trachea

1981
Effects of C5a on guinea pig lung: histamine release and mechanism of contraction.
    Immunopharmacology, 1983, Volume: 5, Issue:4

    Topics: Animals; Aspirin; Atropine; Chromones; Complement C5; Complement C5a; Dose-Response Relationship, Immunologic; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Indomethacin; Lung; Male; Muscle Contraction; Muscle, Smooth

1983
Use of a simple in vivo technique to investigate components of the immediate hypersensitivity reaction in conscious guinea pigs.
    International archives of allergy and applied immunology, 1984, Volume: 74, Issue:1

    Topics: Aerosols; Anaphylaxis; Animals; Atropine; Bronchial Spasm; Chlorpheniramine; Chromones; Guinea Pigs; Hypersensitivity, Immediate; Indomethacin; Lipoxygenase; Male; Premedication; Prostaglandin-Endoperoxide Synthases

1984
A method for measuring changes in tracheal mucus gel layer thickness as an indication of an immediate hypersensitivity response.
    International archives of allergy and applied immunology, 1984, Volume: 74, Issue:4

    Topics: Acetylcysteine; Aluminum Hydroxide; Animals; Atropine; Chromones; Cimetidine; Cromolyn Sodium; Dose-Response Relationship, Immunologic; Expectorants; Hypersensitivity, Immediate; Immune Sera; Methods; Methysergide; Mucus; Ovalbumin; Pyrilamine; Rats; Rats, Inbred Strains; Trachea

1984
Effect of pharmacologic agents on antigen-induced decreases in specific lung conductance in sheep.
    The American review of respiratory disease, 1981, Volume: 124, Issue:5

    Topics: Airway Resistance; Animals; Antigens; Ascaris; Atropine; Bronchial Spasm; Chlorpheniramine; Chromones; Cromolyn Sodium; Ethers; Indomethacin; Metiamide; Respiratory Hypersensitivity; Sheep

1981