Page last updated: 2024-09-05

atropine and fluphenazine

atropine has been researched along with fluphenazine in 16 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(fluphenazine)
Trials
(fluphenazine)
Recent Studies (post-2010) (fluphenazine)
26,7111,2591,6972,494400130
26,7111,2591,697803

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)fluphenazine (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.067
Potassium channel subfamily K member 2Homo sapiens (human)4.7
Tyrosine-protein kinase FynHomo sapiens (human)7.99
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.962
Muscarinic acetylcholine receptor M2Homo sapiens (human)7.481
Muscarinic acetylcholine receptor M4Homo sapiens (human)3.468
ATP-dependent translocase ABCB1Homo sapiens (human)6.1
Alpha-2A adrenergic receptorHomo sapiens (human)0.215
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.683
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)5.7058
D(2) dopamine receptorHomo sapiens (human)0.0016
Alpha-2B adrenergic receptorHomo sapiens (human)0.029
Alpha-2C adrenergic receptorHomo sapiens (human)0.154
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.644
Muscarinic acetylcholine receptor M3Homo sapiens (human)4.728
D(1A) dopamine receptorHomo sapiens (human)0.023
D(4) dopamine receptorHomo sapiens (human)5.877
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.962
Histamine H2 receptorHomo sapiens (human)1.226
Alpha-1D adrenergic receptorHomo sapiens (human)0.033
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.0051
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.067
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)1.644
Sodium-dependent serotonin transporterHomo sapiens (human)1.492
Melanocortin receptor 5Homo sapiens (human)9.518
Pleiotropic ABC efflux transporter of multiple drugsSaccharomyces cerevisiae S288C1.7
Histamine H1 receptorHomo sapiens (human)0.04
D(3) dopamine receptorHomo sapiens (human)0.0006
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.039
5-hydroxytryptamine receptor 6Homo sapiens (human)0.052
Sodium-dependent dopamine transporter Homo sapiens (human)2.053
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)5.7058
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)5.7058
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.02
TPA: protein transporter TIM10Saccharomyces cerevisiae S288C31.3
ubiquitin-conjugating enzyme E2 NHomo sapiens (human)17.4345

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19908 (50.00)18.7374
1990's1 (6.25)18.2507
2000's2 (12.50)29.6817
2010's5 (31.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Rechberger, T; Turski, L; Turski, W; Wójcik, E1
Klimek, V; Maj, J; Rawlów, A; Sarnek, J1
Nymark, M1
Maroske, D; Staib, I1
Da Vanzo, JP; Daugherty, M; Kang, L; Ruckart, R1
Mori, J; Satoh, H; Satoh, Y1
Cawley, TA; Luthin, GR; Ruggieri, MR; Shickley, TJ1
CLARKE, RS; DUNDEE, JW; LOVE, WJ; MOORE, J; NICHOLL, RM1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1

Reviews

1 review(s) available for atropine and fluphenazine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

15 other study(ies) available for atropine and fluphenazine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
[The influence of atropine on the antiamphetaminic action of fluphenazine (author's transl)].
    Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina, 1979, Volume: 34

    Topics: Amphetamine; Animals; Atropine; Conditioning, Classical; Female; Fluphenazine; Humans; Male; Rats; Stereotyped Behavior

1979
On the anticataleptic action of cyproheptadine.
    Pharmacology, biochemistry, and behavior, 1976, Volume: 5, Issue:2

    Topics: Animals; Atropine; Catalepsy; Clomipramine; Cyproheptadine; Desipramine; Female; Fluphenazine; Humans; Imipramine; Male; Methyltyrosines; Pilocarpine; Pimozide; Promethazine; Rats; Reserpine; Spiperone

1976
Apomorphine provoked stereotype in the dog.
    Psychopharmacologia, 1972, Volume: 26, Issue:4

    Topics: Amitriptyline; Animals; Anisoles; Apomorphine; Atropine; Behavior, Animal; Benzamides; Benztropine; Diazepam; Diphenhydramine; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Ethylamines; Female; Fluphenazine; Haloperidol; Humans; Male; Methyltyrosines; Motor Activity; Phenoxybenzamine; Piperazines; Receptors, Drug; Scopolamine; Stereotyped Behavior; Xanthenes

1972
[Circulatory studies following premedication agents and plasma expanders].
    Der Anaesthesist, 1969, Volume: 18, Issue:6

    Topics: Animals; Atropine; Cardiac Output; Dogs; Dye Dilution Technique; Fluphenazine; Indocyanine Green; Plasma Substitutes; Preanesthetic Medication; Triflupromazine

1969
Pharmacological and biochemical studies in isolation-induced fighting mice.
    Psychopharmacologia, 1966, Volume: 9, Issue:3

    Topics: Aggression; Amitriptyline; Amphetamine; Analgesics; Animals; Anticonvulsants; Antidepressive Agents; Atropine; Behavior; Chlorpromazine; Diazepam; Fluphenazine; Humans; Hypnotics and Sedatives; Imipramine; Learning; Male; Meprobamate; Mice; Plants, Medicinal; Rauwolfia; Social Isolation; Tranquilizing Agents

1966
Effect of zotepine and various drugs on apomorphine- and methamphetamine-induced rotational behaviour in rats with unilateral lesions of the substantia nigra.
    Japanese journal of pharmacology, 1983, Volume: 33, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Apomorphine; Atropine; Behavior, Animal; Diazepam; Dibenzothiepins; Fluphenazine; Haloperidol; Male; Methamphetamine; Rats; Rats, Inbred Strains; Substantia Nigra

1983
Effect of chronic neuroleptic treatment on central and peripheral muscarinic receptors.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1

    Topics: Animals; Antipsychotic Agents; Atropine; Cell Membrane; Clozapine; Corpus Striatum; Fluphenazine; Male; Myocardium; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Time Factors; Urinary Bladder

1993
STUDIES OF DRUGS GIVEN BEFORE ANAESTHESIA. VI. THE PHENOTHIAZINE DERIVATIVES.
    British journal of anaesthesia, 1965, Volume: 37

    Topics: Anesthesia; Anesthesia, General; Atropine; Chlorpromazine; Chlorprothixene; Fluphenazine; Humans; Meperidine; Methohexital; Methotrimeprazine; Nitrous Oxide; Oxygen; Perphenazine; Pharmacology; Phenothiazines; Preanesthetic Medication; Prochlorperazine; Promazine; Promethazine; Thiazines; Thiethylperazine; Toxicology; Tranquilizing Agents; Trifluoperazine; Triflupromazine; Trimeprazine

1965
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016