atropine has been researched along with doxepin in 20 studies
| Studies (atropine) | Trials (atropine) | Recent Studies (post-2010) (atropine) | Studies (doxepin) | Trials (doxepin) | Recent Studies (post-2010) (doxepin) |
|---|---|---|---|---|---|
| 26,711 | 1,259 | 1,697 | 885 | 207 | 129 |
| Protein | Taxonomy | atropine (IC50) | doxepin (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.046 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.029 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.258 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.042 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.2 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.026 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.6675 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.077 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.2 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0355 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.5145 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.8595 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 0.069 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 0.688 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.029 | |
| Histamine H2 receptor | Homo sapiens (human) | 1.867 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.118 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.038 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.046 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.8595 | |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | 0.2 | |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | 0.2 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.2 | |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | 0.2 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.042 | |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | 0.2 | |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | 0.2 | |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | 0.2 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.0006 | |
| D(3) dopamine receptor | Homo sapiens (human) | 1.393 | |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | 0.2 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.089 | |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | 1.6 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 0.32 | |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | 0.2 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.631 | |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | 0.2 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (40.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Booth, RG; Brown, RL; Bucholtz, EC; Tropsha, A; Wyrick, SD | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Richelson, E | 1 |
| Elonen, E | 1 |
| Almeida, L; Figueiredo, A; Gonçalo, M; Poiares-Baptista, A; Ribeiro, CA; Teixeira, F | 1 |
| Gupta, A; Misra, NP; Rao, S; Saifi, AQ; Sharma, KN; Singh, R; Tripathi, BM | 1 |
| Aaltonen, L; Iisalo, E; Peltomäki, T; Syvälahti, E | 1 |
| Barth, N; Muscholl, E | 1 |
| Chung, C; Cook, P; Pendleton, RG; Risley, E; Williams, M | 1 |
1 review(s) available for atropine and doxepin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
19 other study(ies) available for atropine and doxepin
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ligands; Models, Molecular; Pyrilamine; Radioligand Assay; Structure-Activity Relationship; Tetrahydronaphthalenes | 1999 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Tricyclic antidepressants and histamine H1 receptors.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Atropine; Benztropine; Cells, Cultured; Clozapine; Cyproheptadine; Desipramine; Doxepin; Haloperidol; Histamine H1 Antagonists; Hydroxyzine; Imipramine; Mice; Neoplasms, Experimental; Neuroblastoma; Nortriptyline; Protriptyline; Receptors, Histamine; Receptors, Histamine H1; Receptors, Muscarinic | 1979 |
Effect of beta-adrenoceptor blocking drugs, physostigmine, and atropine on the toxicity of doxepin in mice.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Atropine; Doxepin; Drug Interactions; Electrocardiography; Heart Rate; Male; Mice; Physostigmine; Practolol; Propanolamines; Propranolol | 1975 |
Mechanism of action of doxepin in the treatment of chronic urticaria.
Topics: Adult; Aged; Animals; Atropine; Carbachol; Chronic Disease; Dimaprit; Doxepin; Female; Gastric Juice; Guinea Pigs; Heart; Histamine; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Pylorus; Pyrilamine; Rats; Thiourea; Urticaria | 1990 |
An experimental assessment of actions of cimetidine and tricyclic anti-depressants in peptic ulcer.
Topics: Animals; Anti-Ulcer Agents; Atropine; Cimetidine; Doxepin; Female; Male; Rats; Rats, Inbred Strains; Stomach Ulcer; Trimipramine | 1986 |
Anticholinergic activity in the serum of patients receiving maintenance amitriptyline or doxepin therapy.
Topics: Adult; Amitriptyline; Atropine; Binding Sites; Depression; Doxepin; Female; Humans; Kinetics; Male; Parasympatholytics; Radioligand Assay | 1985 |
The effects of the tricyclic antidepressants desipramine, doxepin and iprindole on the isolated perfused rabbit heart.
Topics: Animals; Antidepressive Agents; Arrhythmias, Cardiac; Atropine; Autonomic Fibers, Postganglionic; Cocaine; Desipramine; Doxepin; Drug Antagonism; Electric Stimulation; Female; Heart; Heart Rate; Iprindole; Male; Perfusion; Propranolol; Quinidine; Rabbits; Sympathetic Nervous System; Time Factors | 1974 |
Comparison of central gastric antisecretory effects of desmethylimipramine, doxepin and pirenzepine in rats.
Topics: Animals; Anti-Ulcer Agents; Atropine; Benzodiazepinones; Brain; Chlorpromazine; Desipramine; Doxepin; Gastric Acid; Male; Pirenzepine; Rats; Rats, Inbred Strains | 1984 |