Compounds > atropine
Page last updated: 2024-09-05

atropine and doxapram

atropine has been researched along with doxapram in 11 studies

Compound Research Comparison

Studies
(atropine)		Trials
(atropine)		Recent Studies (post-2010)
(atropine)		Studies
(doxapram)		Trials
(doxapram)		Recent Studies (post-2010) (doxapram)
26,7111,2591,6975969572

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)doxapram (IC50)
Potassium channel subfamily K member 3Rattus norvegicus (Norway rat)0.41
Cytochrome P450 2D6Homo sapiens (human)0.1

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19907 (63.64)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's3 (27.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Glen, RC; Lowe, R; Mitchell, JB1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Lipp, JA1
Hembrough, FB; Hsu, WH; Lu, ZX1
Kuga, T; Naito, J1
Collins, VJ; Winnie, AP1
Jensen, EC; Klemm, WR1
Azuma, H; Naito, J; Onozato, M; Sasaki, T; Tamaoki, H1
Hatch, RC1

Reviews

1 review(s) available for atropine and doxapram

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

10 other study(ies) available for atropine and doxapram

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Effect of atropine upon the cardiovascular system during soman-induced respiratory depression.
    Archives internationales de pharmacodynamie et de therapie, 1976, Volume: 220, Issue:1

    Topics: Animals; Atropine; Blood Pressure; Clonazepam; Depression, Chemical; Doxapram; Electroencephalography; Female; Haplorhini; Heart Rate; Hemodynamics; Intracranial Pressure; Isoproterenol; Macaca mulatta; Male; Organophosphorus Compounds; Respiration; Soman

1976
Effect of xylazine on heart rate and arterial blood pressure in conscious dogs, as influenced by atropine, 4-aminopyridine, doxapram, and yohimbine.
    Journal of the American Veterinary Medical Association, 1985, Jan-15, Volume: 186, Issue:2

    Topics: 4-Aminopyridine; Aminopyridines; Animals; Atropine; Blood Pressure; Central Nervous System Stimulants; Dogs; Doxapram; Drug Interactions; Heart Rate; Male; Thiazines; Xylazine; Yohimbine

1985
[Pharmacological action of 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrolinone hydrochloride (doxapram). 1. The action on the central nervous system].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1973, Volume: 69, Issue:5

    Topics: Amides; Animals; Atropine; Blood Pressure; Central Nervous System; Central Nervous System Stimulants; Dogs; Doxapram; Electrocardiography; Ethylenediamines; Hexamethonium Compounds; Male; Mice; Morpholines; Pentobarbital; Phentolamine; Rabbits; Rats; Reserpine; Respiration; Seizures; Sympathetic Nervous System; Vagotomy

1973
Clinical management of the patient in shock. Pharmacologic adjuncts to the management of shock.
    Clinical anesthesia, 1965, Volume: 2

    Topics: Aged; Atropine; Central Nervous System Stimulants; Chlorpromazine; Dextrans; Doxapram; Female; Humans; Mannitol; Promethazine; Shock, Hemorrhagic

1965
Clinical evaluation of the analeptic, doxapram, in dogs and cats.
    Journal of the American Veterinary Medical Association, 1967, Mar-01, Volume: 150, Issue:5

    Topics: Anesthesia; Animals; Atropine; Cats; Central Nervous System Stimulants; Dogs; Doxapram; Electrocardiography; Fentanyl; Heart Rate; Morphine; Preanesthetic Medication; Promazine; Spirometry

1967
[Pharmacological studies of doxapram].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1973, Volume: 69, Issue:5

    Topics: Acetylcholine; Amides; Amobarbital; Animals; Atropine; Blood Pressure; Body Temperature; Coronary Circulation; Diaphragm; Dogs; Doxapram; Ethylenediamines; Female; Gastric Juice; Guinea Pigs; Heart; Heparin; In Vitro Techniques; Male; Morpholines; Norepinephrine; Oxygen Consumption; Papaverine; Pentobarbital; Rabbits; Rats; Respiration; Trachea

1973
Effects of doxapram in dogs given atropine and xylazine.
    Journal of the American Veterinary Medical Association, 1983, Nov-01, Volume: 183, Issue:9

    Topics: 4-Aminopyridine; Adjuvants, Anesthesia; Animals; Atropine; Central Nervous System Stimulants; Dogs; Dose-Response Relationship, Drug; Doxapram; Treatment Outcome; Xylazine; Yohimbine

1983