Compounds > atropine
Page last updated: 2024-09-05

atropine and disulfiram

atropine has been researched along with disulfiram in 14 studies

Compound Research Comparison

Studies
(atropine)		Trials
(atropine)		Recent Studies (post-2010)
(atropine)		Studies
(disulfiram)		Trials
(disulfiram)		Recent Studies (post-2010) (disulfiram)
26,7111,2591,6973,776175723

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)disulfiram (IC50)
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonasePlasmodium berghei10.1
Spike glycoproteinBetacoronavirus England 19.35
Replicase polyprotein 1abBetacoronavirus England 19.35
type-1 angiotensin II receptorHomo sapiens (human)6.637
perilipin-5Homo sapiens (human)1.622
perilipin-1Homo sapiens (human)6.959
apelin receptorHomo sapiens (human)2.63
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform aHomo sapiens (human)4.2905
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferaseMycobacterium tuberculosis H37Rv85.03
Transmembrane protease serine 2Homo sapiens (human)9.35
Bile salt export pumpHomo sapiens (human)10
Carbamate kinaseGiardia intestinalis0.6
Retinal dehydrogenase 1Homo sapiens (human)0.13
Aldehyde dehydrogenase, mitochondrialHomo sapiens (human)3.4
Cytochrome P450 1A2Homo sapiens (human)4
Procathepsin LHomo sapiens (human)9.35
Alpha-2A adrenergic receptorHomo sapiens (human)4.904
Fructose-1,6-bisphosphatase 1Homo sapiens (human)1.3756
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus9.35
Replicase polyprotein 1abHuman coronavirus 229E9.35
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus9.35
Adenosine receptor A3Homo sapiens (human)0.356
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 26.9171
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.356
Alpha-2B adrenergic receptorHomo sapiens (human)3.218
D(1A) dopamine receptorHomo sapiens (human)2.158
D(4) dopamine receptorHomo sapiens (human)3.15
C-X-C chemokine receptor type 2Homo sapiens (human)6.013
Mitogen-activated protein kinase 3 Homo sapiens (human)1.51
Protein-lysine 6-oxidaseHomo sapiens (human)0.32
Lysine-specific demethylase 5AHomo sapiens (human)10
Caspase-1Homo sapiens (human)1.8
Mu-type opioid receptorHomo sapiens (human)3.511
D(3) dopamine receptorHomo sapiens (human)1.084
Kappa-type opioid receptorHomo sapiens (human)6.103
C-C chemokine receptor type 2Homo sapiens (human)2.468
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.356
C-C chemokine receptor type 4Homo sapiens (human)8.395
Gasdermin-DHomo sapiens (human)0.4
Lysyl oxidase homolog 3Homo sapiens (human)0.093
Spike glycoproteinSevere acute respiratory syndrome-related coronavirus9.35
Sodium-dependent dopamine transporter Homo sapiens (human)4.637
NACHT, LRR and PYD domains-containing protein 3 Mus musculus (house mouse)3
Lysyl oxidase homolog 4Homo sapiens (human)0.059
Histone-lysine N-methyltransferase EHMT2Homo sapiens (human)0.6
Monoglyceride lipaseHomo sapiens (human)0.8095
Angiotensin-converting enzyme 2 Homo sapiens (human)9.35
Gasdermin-DMus musculus (house mouse)0.4
Histone-lysine N-methyltransferase EHMT1Homo sapiens (human)1.6
Lysyl oxidase homolog 2Homo sapiens (human)0.15
large T antigenBetapolyomavirus macacae10.73

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19906 (42.86)18.7374
1990's0 (0.00)18.2507
2000's1 (7.14)29.6817
2010's7 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Chilian, WM; Lake, DA; Roberts, LA1
Stoliarov, GV1
Day, MD; Hall, JM; Owen, DA1
Koe, BK; Weissman, A1
Rosenblum, G; Rosenblum, I1
Sourkes, TL; Widy-Tyszkiewicz, E1

Reviews

1 review(s) available for atropine and disulfiram

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

13 other study(ies) available for atropine and disulfiram

ArticleYear
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Ethanol increases rate of isolated atria.
    Alcoholism, clinical and experimental research, 1978, Volume: 2, Issue:3

    Topics: Animals; Atropine; Disulfiram; Drug Interactions; Ethanol; Female; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Propranolol; Pyrazoles; Rabbits; Time Factors

1978
[On the course of drug psychoses].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1968, Volume: 68, Issue:3

    Topics: Adrenocorticotropic Hormone; Adult; Atropine; Barbiturates; Chlorpromazine; Disulfiram; Drug Hypersensitivity; Female; Humans; Isoniazid; Male; Prednisolone; Psychoses, Substance-Induced; Quinacrine; Time Factors

1968
Selective inhibition of angiotensin pressor responses in the pithed rat by tetraethylthiuram disulphide (disulfiram) and sodium diethyldithiocarbamate (DDC).
    British journal of pharmacology, 1972, Volume: 44, Issue:2

    Topics: Angiotensin II; Animals; Ascorbic Acid; Atropine; Blood Pressure; Disulfiram; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Heart Rate; Male; Norepinephrine; Penicillamine; Rats; Reserpine; Sympathetic Nervous System; Thiocarbamates; Tubocurarine; Vasopressins

1972
m-Fluorotyrosine convulsions and mortality: relationship to catecholamine and citrate metabolism.
    The Journal of pharmacology and experimental therapeutics, 1967, Volume: 155, Issue:1

    Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anticonvulsants; Atropine; Azoles; Brain; Chlordiazepoxide; Chlorpromazine; Citrates; Dihydroxyphenylalanine; Disulfiram; Drug Antagonism; Drug Synergism; Kidney; Lysergic Acid Diethylamide; Male; Methyldopa; Mice; Morphine; Nialamide; Norepinephrine; Pargyline; Phenobarbital; Phenytoin; Reserpine; Seizures; Serotonin; Strychnine; Tetrabenazine; Trimethadione; Tyrosine; Urea

1967
Effect of drugs and chemicals on subcellular organelles: mitochondrial shrinking and autonomic agents.
    Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 181, Issue:2

    Topics: Adenosine Triphosphate; Animals; Atropine; Disulfiram; Electric Stimulation; Heart; In Vitro Techniques; Iproniazid; Mitochondria; Mitochondria, Muscle; Myocardium; Norepinephrine; Propranolol; Rabbits; Reserpine; Vagus Nerve

1969
n-Pentylamine: effect on motor activity of mice.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 13, Issue:3

    Topics: Amines; Animals; Antipsychotic Agents; Atropine; Disulfiram; Fenclonine; Kinetics; Male; Methyltyrosines; Mice; Motor Activity; Phenoxybenzamine; Reserpine

1980