atropine has been researched along with dicyclomine in 30 studies
| Studies (atropine) | Trials (atropine) | Recent Studies (post-2010) (atropine) | Studies (dicyclomine) | Trials (dicyclomine) | Recent Studies (post-2010) (dicyclomine) |
|---|---|---|---|---|---|
| 26,711 | 1,259 | 1,697 | 398 | 41 | 74 |
| Protein | Taxonomy | atropine (IC50) | dicyclomine (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.468 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.046 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.0029 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.0024 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.0035 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 0.0044 | |
| Histamine H2 receptor | Homo sapiens (human) | 1.625 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.24 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.468 | |
| D(3) dopamine receptor | Homo sapiens (human) | 1.21 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 1.301 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 3.065 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.0049 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (43.33) | 18.7374 |
| 1990's | 11 (36.67) | 18.2507 |
| 2000's | 3 (10.00) | 29.6817 |
| 2010's | 3 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DeHaven-Hudkins, DL; Hudkins, RL; Stubbins, JF | 1 |
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Bonner, TI; Brann, MR; Buckley, CM; Buckley, NJ | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Bhattacharjee, AK; Evans, SA; Gordon, RK; Pervitsky, D; Pomponio, JW | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Johns, A; Johnson, CE; Paton, DM; Tasker, JJ; Theman, MA | 1 |
| Barbieri, EJ; DiGregorio, GJ; Khanna, OP; McMichael, R; Ruch, E | 1 |
| Awad, SA; Downie, JW; Twiddy, DA | 1 |
| Aguilar, JS; Ballesta, JJ; Criado, M; Palmero, M; Reig, JA; Viniegra, S | 1 |
| Eltze, M; Kromer, W | 1 |
| Bindslev, N; Winding, B | 1 |
| Cost, M; Majewski, H | 1 |
| Bartolini, A; Ghelardini, C; Giotti, A; Malcangio, M; Malmberg-Aiello, P | 1 |
| Kunysz, EL; Michel, AD; Whiting, RL | 1 |
| Marchi, M; Raiteri, M | 1 |
| Bingham, JR; Cramp, WD; Saiphoo, C | 1 |
| Maggi, CA; Meli, A | 1 |
| Levin, RM; Wein, AJ | 1 |
| Guelfi, M; Subissi, A | 1 |
| Downie, JW; McGuire, RP | 1 |
| Danielson, ND; Holeman, JA | 1 |
| Bartolini, A; Bertucci, C; Dei, S; Ghelardini, C; Giovannini, MG; Gualtieri, F; Pepeu, G; Romanelli, MN; Scapecchi, S; Teodori, E | 1 |
| Kauer, JA; Williams, JH | 1 |
| Wallis, RM | 1 |
| Bernardi, G; Bonci, A; Grillner, P; Mercuri, NB; Svensson, TH | 1 |
| NORTHUP, DW; STICKNEY, JC; VAN LIERE, EJ | 1 |
| Louik, C; Mitchell, AA | 1 |
2 review(s) available for atropine and dicyclomine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Is field (vagal) stimulation of gastric acid secretion mediated by M1 or non-M1 muscarinic receptors? A methodical problem exemplified in the mouse stomach in vitro.
Topics: Animals; Atropine; Bethanechol; Bethanechol Compounds; Dicyclomine; Gastric Acid; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Mice; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Regression Analysis | 1991 |
1 trial(s) available for atropine and dicyclomine
| Article | Year |
|---|---|
Pre-clinical and clinical pharmacology of selective muscarinic M3 receptor antagonists.
Topics: Animals; Atrial Function; Atropine; Colon; Dicyclomine; Dioxoles; Dogs; Drug Evaluation, Preclinical; Gastrointestinal Motility; Guinea Pigs; Heart Atria; Humans; Ileum; Male; Muscarinic Antagonists; Muscle, Smooth; Piperidines; Rabbits; Receptor, Muscarinic M3; Receptors, Muscarinic; Salivary Glands; Trachea; Vas Deferens | 1995 |
27 other study(ies) available for atropine and dicyclomine
| Article | Year |
|---|---|
Muscarinic receptor binding profile of para-substituted caramiphen analogues.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Cyclopentanes; Male; Molecular Structure; Parasympatholytics; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Structure-Activity Relationship | 1991 |
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
Topics: Animals; Cell Line; Cloning, Molecular; Cricetinae; Humans; Kinetics; N-Methylscopolamine; Parasympatholytics; Rats; Receptors, Muscarinic; Scopolamine Derivatives | 1989 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods.
Topics: Atropine; Computer Simulation; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Receptor, Muscarinic M1; Structure-Activity Relationship | 2013 |
The mechanism of action of dicyclomine hydrochloride on rabbit detrusor muscle and vas deferens.
Topics: Acetylcholine; Anesthetics, Local; Animals; Atropine; Calcium; Cyclohexanecarboxylic Acids; Dicyclomine; Electric Stimulation; Female; In Vitro Techniques; Lidocaine; Male; Muscle Contraction; Muscle, Smooth; Potassium; Rabbits; Synaptic Transmission | 1976 |
In vitro study of antispasmodic effects of dicyclomine hydrochloride on vesicourethral smooth muscle of guinea pig and rabbit.
Topics: Acetylcholine; Animals; Atropine; Barium; Chlorides; Cyclohexanecarboxylic Acids; Dicyclomine; Dose-Response Relationship, Drug; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Propantheline; Rabbits; Urethra; Urinary Bladder | 1979 |
Antimuscarinic and noncompetitive antagonist properties of dicyclomine hydrochloride in isolated human and rabbit bladder muscle.
Topics: Animals; Atropine; Carbachol; Cyclohexanecarboxylic Acids; Dicyclomine; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Rabbits; Urinary Bladder | 1977 |
Muscarinic receptor subtypes in bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Atropine; Binding Sites; Binding, Competitive; Cattle; Cell Membrane; Dicyclomine; Muscarine; Piperidines; Pirenzepine; Quinuclidinyl Benzilate; Receptors, Muscarinic | 1992 |
Characterization of a muscarinic receptor controlling Cl- secretion in hen trachea.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Bumetanide; Calcium Channels; Chickens; Chlorides; Dicyclomine; Female; In Vitro Techniques; Ion Channels; Kinetics; Mucous Membrane; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea | 1990 |
Evidence for facilitatory and inhibitory muscarinic receptors on postganglionic sympathetic nerves in mouse isolated atria.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Carbachol; Cocaine; Diamines; Dicyclomine; Female; Heart; Hexamethonium Compounds; In Vitro Techniques; Mice; Myocardium; Nerve Endings; Neurons; Norepinephrine; Parasympatholytics; Pirenzepine; Receptors, Muscarinic; Sympathetic Nervous System; Synaptic Transmission | 1991 |
Investigation into atropine-induced antinociception.
Topics: Analgesics; Animals; Atropine; Dicyclomine; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Muscle, Smooth; Naloxone; Oxotremorine; Pain; Parasympatholytics; Pirenzepine; Postural Balance; Rats; Rats, Inbred F344; Rats, Inbred Strains; Reaction Time; Sensory Thresholds | 1990 |
Functional and direct binding studies using subtype selective muscarinic receptor antagonists.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Dicyclomine; Diphenylacetic Acids; Gallamine Triethiodide; Guinea Pigs; In Vitro Techniques; Inositol Phosphates; Myocardium; Phenethylamines; Phenylacetates; Pirenzepine; Receptors, Muscarinic | 1988 |
On the presence in the cerebral cortex of muscarinic receptor subtypes which differ in neuronal localization, function and pharmacological properties.
Topics: Acetylcholine; Animals; Atropine; Benzodiazepinones; Carbachol; Cerebral Cortex; Dicyclomine; Dopamine; Drug Synergism; Neurons; Phenethylamines; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Synaptosomes | 1985 |
Gastric secretion and gastric emptying: a comparative study of the effects of dicyclomine, glycopyrrolate and atropine, using a new testing technique.
Topics: Atropine; Cyclohexanecarboxylic Acids; Dicyclomine; Female; Gastric Acid; Gastric Emptying; Glycopyrrolate; Humans; Male; Pyrrolidines | 1968 |
Eserine-induced hypertone of guinea pig distal colon in vivo: a new pharmacological procedure for testing smooth muscle relaxants.
Topics: Animals; Atropine; Benzodiazepinones; Colon; Dicyclomine; Dose-Response Relationship, Drug; Guinea Pigs; Male; Methods; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Physostigmine; Pirenzepine; Quaternary Ammonium Compounds; Verapamil | 1984 |
Direct measurement of the anticholinergic activity of a series of pharmacological compounds on the canine and rabbit urinary bladder.
Topics: Animals; Atropine; Binding, Competitive; Dicyclomine; Dogs; Female; Glycopyrrolate; Imipramine; In Vitro Techniques; Mandelic Acids; Parasympatholytics; Propantheline; Rabbits; Radioligand Assay; Receptors, Cholinergic; Receptors, Muscarinic; Urinary Bladder | 1982 |
Effects of rociverine and other spasmolytic agents on caerulein-induced delay in gastric emptying in the conscious rat.
Topics: Animals; Atropine; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Butylscopolammonium Bromide; Ceruletide; Cyclohexanecarboxylic Acids; Dicyclomine; Drug Interactions; Female; Food; Gastric Emptying; Parasympatholytics; Rats; Rats, Inbred Strains | 1982 |
Antagonism of calcium-induced contraction in potassium-depolarized rabbit detrusor muscle strips by dicyclomine hydrochloride and rociverine.
Topics: Animals; Atropine; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Dicyclomine; In Vitro Techniques; Lidocaine; Male; Muscle Contraction; Muscle, Smooth; Potassium; Rabbits; Urinary Bladder | 1981 |
Microbore liquid chromatography of tertiary amine anticholinergic pharmaceuticals with tris(2,2'-bipyridine)ruthenium(III) chemiluminescence detection.
Topics: 2,2'-Dipyridyl; Amines; Amitriptyline; Atropine; Butanones; Cholinergic Antagonists; Chromatography, High Pressure Liquid; Cyclopentolate; Dicyclomine; Hydrogen-Ion Concentration; Indicators and Reagents; Luminescent Measurements; Organometallic Compounds; Procyclidine; Scopolamine | 1995 |
Synthesis and enantioselectivity of the enantiomers of PG9 and SM21, new potent analgesic and cognition-enhancing drugs.
Topics: Acetylcholine; Analgesics; Animals; Atropine; Atropine Derivatives; Avoidance Learning; Brain Chemistry; Dicyclomine; Male; Mice; Microdialysis; Nootropic Agents; Pain Measurement; Parasympatholytics; Rats; Rats, Wistar; Stereoisomerism | 1996 |
Properties of carbachol-induced oscillatory activity in rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Atropine; Bicuculline; Carbachol; Dicyclomine; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-B Receptor Antagonists; Hippocampus; In Vitro Techniques; Kinetics; Male; Microelectrodes; Neurons; Nicotine; Oscillometry; Phosphinic Acids; Pirenzepine; Potassium; Propanolamines; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, AMPA; Receptors, GABA-B | 1997 |
Presynaptic muscarinic (M3) receptors reduce excitatory transmission in dopamine neurons of the rat mesencephalon.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Atropine; Carbachol; Diamines; Dicyclomine; Dopamine; Electric Stimulation; Excitatory Postsynaptic Potentials; Mesencephalon; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Parasympatholytics; Physostigmine; Piperidines; Pirenzepine; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reaction Time; Receptor, Muscarinic M3; Receptors, Muscarinic; Synaptic Transmission; Tetrodotoxin | 1999 |
Effect of atropine, tetraethylammonium, banthine and bentyl on motility of the small intestine.
Topics: Atropine; Dicyclomine; Humans; Intestine, Small; Intestines; Methantheline; Muscle Relaxants, Central; Parasympatholytics; Quaternary Ammonium Compounds; Tetraethylammonium | 1952 |
Post-marketing surveillance using pharmacy-based cohorts: results of a pilot study.
Topics: Adolescent; Adult; Aged; Atropine; Cohort Studies; Community Pharmacy Services; Dicyclomine; Feasibility Studies; Female; Follow-Up Studies; Humans; Male; Medical Records Systems, Computerized; Middle Aged; Parasympatholytics; Patient Selection; Pilot Projects; Product Surveillance, Postmarketing; Surveys and Questionnaires | 2005 |