Page last updated: 2024-09-05

atropine and diclofenac

atropine has been researched along with diclofenac in 31 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(diclofenac)
Trials
(diclofenac)
Recent Studies (post-2010) (diclofenac)
26,7111,2591,6978,8741,8743,616

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)diclofenac (IC50)
Aldo-keto reductase family 1 member B10Homo sapiens (human)1.9
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.003
Prostaglandin G/H synthase 1Ovis aries (sheep)1.3376
Interleukin-8Homo sapiens (human)0.008
Prostaglandin G/H synthase 1Homo sapiens (human)0.0415
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.5
C-X-C chemokine receptor type 1Homo sapiens (human)0.012
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.5
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.5
Prostaglandin G/H synthase 2Homo sapiens (human)0.4165
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.5
Prostaglandin G/H synthase 2Ovis aries (sheep)1.6867
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.0502
Solute carrier family 22 member 6Homo sapiens (human)4
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.02

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19902 (6.45)18.7374
1990's5 (16.13)18.2507
2000's14 (45.16)29.6817
2010's10 (32.26)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andrews, PR; Craik, DJ; Martin, JL1
Topliss, JG; Yoshida, F1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Glen, RC; Lowe, R; Mitchell, JB1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bellucci, R; Bonomi, L; De Franco, I; Massa, F; Perfetti, S1
Czaja, JM; McCaffrey, TV; Schlosser, RJ; Yang, B1
Bhalotra, AR; Saksena, R1
Kume, H; Nasa, Y; Takeo, S1
Cervin, A; Lindberg, S; Runer, T; Uddman, R1
Aguado, L; Ariño, P; Baltasar, M; Cortada, V; Puig, MM1
Goble, RR; Kirkby, GR; Kulshrestha, MK; Rauz, S; Stavrakas, IA1
Bevin, TH; Fuller, JR; Molteno, AC; Vote, B1
Roy, A1
David, SU; Dinu, D; Grigorescu, A1
Reanmongkol, W; Subhadhirasakul, S; Thaina, P; Tungcharoen, P; Wongnawa, M1
Agahan, AL; Lim, RB; Valenton, MJ1
Berna, C; Edwards, RR; Jensen, KB; Kaptchuk, TJ; Kirsch, I; Lee, YC; Sadler, P; Zion, SR1

Reviews

2 review(s) available for atropine and diclofenac

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Systemic anti-inflammatory fibrosis suppression in threatened trabeculectomy failure.
    Clinical & experimental ophthalmology, 2004, Volume: 32, Issue:1

    Topics: Anti-Inflammatory Agents; Atropine; Blister; Colchicine; Conjunctiva; Diclofenac; Drug Therapy, Combination; Epinephrine; Fibrosis; Glaucoma; Humans; Ophthalmic Solutions; Postoperative Complications; Prednisone; Trabeculectomy; Treatment Failure

2004

Trials

4 trial(s) available for atropine and diclofenac

ArticleYear
Evaluation of diclofenac sodium as a perioperative analgesic.
    Indian journal of medical sciences, 1994, Volume: 48, Issue:12

    Topics: Adult; Atropine; Diclofenac; Female; Humans; Male; Meperidine; Middle Aged; Monitoring, Physiologic; Pain Measurement; Pain, Postoperative; Premedication; Promethazine; Respiratory Function Tests

1994
The role of preoperative subconjunctival mydricaine and topical diclofenac sodium 0.1% in maintaining mydriasis during vitrectomy.
    Retina (Philadelphia, Pa.), 2000, Volume: 20, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Atropine; Cyclooxygenase Inhibitors; Diclofenac; Drug Combinations; Epinephrine; Female; Humans; Injections; Iris; Male; Middle Aged; Mydriatics; Ophthalmic Solutions; Preoperative Care; Procaine; Pupil; Treatment Outcome; Vitrectomy

2000
A 22-year experience with quinacrine sterilization in a rural private clinic in Midnapore, India: a report on 5 protocols and 1838 cases.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2003, Volume: 83 Suppl 2

    Topics: Adult; Ambulatory Care Facilities; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Butylscopolammonium Bromide; Contraceptives, Oral, Synthetic; Diclofenac; Female; Follow-Up Studies; Humans; India; Medroxyprogesterone; Parasympatholytics; Pregnancy; Quinacrine; Reproductive Control Agents; Rural Health Services; Sterilization, Tubal; Time Factors

2003
Side effects can enhance treatment response through expectancy effects: an experimental analgesic randomized controlled trial.
    Pain, 2017, Volume: 158, Issue:6

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticipation, Psychological; Atropine; Diclofenac; Double-Blind Method; Female; Humans; Male; Pain; Pain Measurement; Placebo Effect; Treatment Outcome; Xerostomia; Young Adult

2017

Other Studies

25 other study(ies) available for atropine and diclofenac

ArticleYear
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Determination of log D via automated microfluidic liquid-liquid extraction.
    Journal of medicinal chemistry, 2008, Aug-28, Volume: 51, Issue:16

    Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Prevention of surgically induced miosis by diclofenac eye drops.
    Annals of ophthalmology, 1987, Volume: 19, Issue:4

    Topics: Animals; Atropine; Diclofenac; Female; Intraoperative Complications; Male; Mydriatics; Ophthalmologic Surgical Procedures; Pupil; Rabbits

1987
Signal transduction mechanisms in substance P-mediated ciliostimulation.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1995, Volume: 113, Issue:5

    Topics: Adenoids; Atropine; Awards and Prizes; Cilia; Cyclooxygenase Inhibitors; Diclofenac; Humans; In Vitro Techniques; Mucociliary Clearance; Muscarinic Antagonists; Nitric Oxide; Prostaglandin Antagonists; Prostaglandins; Second Messenger Systems; Signal Transduction; Substance P

1995
Acetylcholine-induced vasoconstrictor response of coronary vessels in rats: a possible contribution of M2 muscarinic receptor activation.
    Heart and vessels, 1997, Volume: 12, Issue:4

    Topics: Acetylcholine; Animals; Atropine; Coronary Vessels; Cyclooxygenase Inhibitors; Diclofenac; Endothelium, Vascular; In Vitro Techniques; Male; Muscarinic Antagonists; Myocardial Contraction; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Saponins; Vasoconstriction

1997
Nitric oxide is a regulator of mucociliary activity in the upper respiratory tract.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1998, Volume: 119, Issue:3

    Topics: Animals; Arginine; Atropine; Calcium Channel Blockers; Cholinergic Antagonists; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Ganglia, Parasympathetic; Immunohistochemistry; Maxillary Sinus; Mucociliary Clearance; NADP; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Rabbits

1998
Cold urticaria associated with intraoperative hypotension and facial edema.
    Anesthesiology, 1999, Volume: 90, Issue:3

    Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anesthetics, General; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Atracurium; Atropine; Diclofenac; Down Syndrome; Drug Therapy, Combination; Face; Fentanyl; Hip; Humans; Hypotension; Intraoperative Complications; Legg-Calve-Perthes Disease; Male; Midazolam; Thiopental

1999
[Sympathetic ophthalmia, case report].
    Oftalmologia (Bucharest, Romania : 1990), 2006, Volume: 50, Issue:3

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Diclofenac; Drug Therapy, Combination; Eye Enucleation; Eye Injuries, Penetrating; Humans; Male; Methylprednisolone; Middle Aged; Mydriatics; Ophthalmia, Sympathetic; Ophthalmic Solutions; Recurrence; Treatment Outcome

2006
Uterine relaxant effects of Curcuma aeruginosa Roxb. rhizome extracts.
    Journal of ethnopharmacology, 2009, Jan-30, Volume: 121, Issue:3

    Topics: Acetylcholine; Animals; Atropine; Calcium Channel Blockers; Curcuma; Diclofenac; Dinoprost; Female; Isoproterenol; Oxytocics; Oxytocin; Parasympatholytics; Plant Extracts; Propranolol; Rats; Rats, Wistar; Rhizome; Uterine Contraction; Uterus; Vasodilator Agents; Verapamil

2009
Successful treatment of Acanthamoeba keratitis without anti-amoebic agents.
    Annals of the Academy of Medicine, Singapore, 2009, Volume: 38, Issue:2

    Topics: Acanthamoeba Keratitis; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Cornea; Diagnosis, Differential; Diclofenac; Drug Administration Schedule; Drug Therapy, Combination; Follow-Up Studies; Humans; Mydriatics; Ophthalmic Solutions; Retrospective Studies

2009