atropine has been researched along with darifenacin in 13 studies
| Studies (atropine) | Trials (atropine) | Recent Studies (post-2010) (atropine) | Studies (darifenacin) | Trials (darifenacin) | Recent Studies (post-2010) (darifenacin) |
|---|---|---|---|---|---|
| 26,711 | 1,259 | 1,697 | 165 | 28 | 54 |
| Protein | Taxonomy | atropine (IC50) | darifenacin (IC50) |
|---|---|---|---|
| Beta-1 adrenergic receptor | Homo sapiens (human) | 0.3162 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 0.8322 | |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | 1.5849 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aoki, I; Fujikawa, T; Hasegawa, T; Hirose, H; Kimura, T; Mase, T; Mitsuya, M; Nishikibe, M; Noguchi, K; Numazawa, T; Ohtake, N; Sasaki, K; Sato, A | 1 |
| Fujikawa, T; Kimura, T; Mase, T; Noguchi, K; Numazawa, T; Ohtake, N; Sagara, T; Sagara, Y | 1 |
| Challiss, RA; Nahorski, SR; Nelson, CP | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Hatanaka, T; Ikeda, K; Kobayashi, S; Miyata, K; Ohtake, A; Sasamata, M; Sato, S; Ukai, M | 1 |
| Hein, P; Michel, MC; Michel-Reher, MB; Schneider, T | 1 |
| Hatanaka, T; Miyata, K; Noguchi, Y; Ohtake, A; Okutsu, H; Saitoh, C; Sasamata, M; Sato, S; Suzuki, M; Ukai, M; Yuyama, H | 1 |
| Li, YR; Matsunami, H | 1 |
| Chess-Williams, R; Moro, C; Uchiyama, J | 1 |
| Chancellor, MB; Hirao, Y; Kita, M; Matsumoto, Y; Miyazato, M; Yokoyama, H; Yoshimura, N | 1 |
| Anisuzzaman, AS; Hayashi, H; Ikeuchi, H; Khan, MR; Ma, Y; Maemoto, A; Muramatsu, I; Semba, S; Suzuki, Y; Takano, T; Taniguchi, T; Uchino, M; Ushikubi, F; Uwada, J | 1 |
| Arrighi, N; Bodei, S; Cosciani Cunico, S; Michel, MC; Sigala, S; Simeone, C; Spano, P; Zani, D | 1 |
1 review(s) available for atropine and darifenacin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
12 other study(ies) available for atropine and darifenacin
| Article | Year |
|---|---|
Pharmacological properties of (2R)-N-[1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: a novel mucarinic antagonist with M(2)-sparing antagonistic activity.
Topics: Animals; Benzeneacetamides; Brain; Bronchoconstriction; Heart Atria; Heart Rate; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscarinic Antagonists; Muscle, Smooth; Muscle, Smooth, Vascular; Piperidines; Pirenzepine; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptors, Muscarinic; Trachea; Tremor; Vas Deferens | 2001 |
Cyclohexylmethylpiperidinyltriphenylpropioamide: a selective muscarinic M(3) antagonist discriminating against the other receptor subtypes.
Topics: Acetylcholine; Animals; Bradycardia; Bronchoconstriction; Carbachol; CHO Cells; Cholinergic Agents; Combinatorial Chemistry Techniques; Cricetinae; Dipeptides; Heart Atria; Humans; In Vitro Techniques; Muscarinic Antagonists; Piperidines; Rats; Receptor, Muscarinic M3; Receptors, Muscarinic; Structure-Activity Relationship | 2002 |
Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor.
Topics: Animals; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Immunoblotting; Inositol Phosphates; Ligands; Muscarinic Agonists; Mutagenesis, Site-Directed; Radioligand Assay; Receptor, Muscarinic M2; Transfection | 2006 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
In vitro and in vivo tissue selectivity profile of solifenacin succinate (YM905) for urinary bladder over salivary gland in rats.
Topics: Animals; Atropine; Benzhydryl Compounds; Benzofurans; Calcium; Cresols; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Mandelic Acids; Muscarinic Antagonists; Myocytes, Smooth Muscle; Organ Specificity; Phenylpropanolamine; Pyrrolidines; Quinuclidines; Rats; Rats, Wistar; Solifenacin Succinate; Submandibular Gland; Tetrahydroisoquinolines; Tolterodine Tartrate; Urinary Bladder | 2004 |
Effects of ageing on muscarinic receptor subtypes and function in rat urinary bladder.
Topics: Aging; Animals; Atropine; Benzofurans; Carbachol; Cholinergic Agonists; Cholinergic Antagonists; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Pyrrolidines; Rats; Rats, Wistar; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Submandibular Gland; Urinary Bladder | 2005 |
Pharmacological characterization of a new antimuscarinic agent, solifenacin succinate, in comparison with other antimuscarinic agents.
Topics: Animals; Atropine; Benzhydryl Compounds; Benzilates; Benzofurans; Binding, Competitive; Carbachol; CHO Cells; Cholinergic Agonists; Cresols; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mandelic Acids; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Phenylpropanolamine; Pyrrolidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Muscarinic; Solifenacin Succinate; Tetrahydroisoquinolines; Tolterodine Tartrate; Transfection; Urinary Bladder; Urinary Bladder, Overactive; Urination | 2007 |
Activation state of the M3 muscarinic acetylcholine receptor modulates mammalian odorant receptor signaling.
Topics: Atropine; Benzofurans; Carbachol; Cholinergic Agonists; Colforsin; Cyclic AMP; HEK293 Cells; Humans; Immunohistochemistry; Ionomycin; Ionophores; Membrane Transport Proteins; Muscarinic Antagonists; Olfactory Receptor Neurons; Protein Binding; Pyrrolidines; Receptor, Muscarinic M3; Receptors, G-Protein-Coupled; Receptors, Odorant; Signal Transduction; Transfection | 2011 |
Urothelial/lamina propria spontaneous activity and the role of M3 muscarinic receptors in mediating rate responses to stretch and carbachol.
Topics: Animals; Atropine; Benzhydryl Compounds; Benzofurans; Carbachol; Cresols; Diamines; Mandelic Acids; Mucous Membrane; Muscarinic Antagonists; Muscle Contraction; Phenylpropanolamine; Piperidines; Pirenzepine; Pyrrolidines; Quinuclidines; Receptor, Muscarinic M3; Solifenacin Succinate; Stress, Mechanical; Swine; Tetrahydroisoquinolines; Tolterodine Tartrate; Urinary Bladder; Urothelium | 2011 |
Role of M2 and M3 muscarinic acetylcholine receptor subtypes in activation of bladder afferent pathways in spinal cord injured rats.
Topics: Afferent Pathways; Animals; Atropine; Benzofurans; Diamines; Female; Mucous Membrane; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Parasympatholytics; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; RNA, Messenger; Spinal Cord Injuries; Thoracic Vertebrae; Urinary Bladder; Urinary Bladder, Overactive | 2012 |
M1 is a major subtype of muscarinic acetylcholine receptors on mouse colonic epithelial cells.
Topics: Animals; Atropine; Benzofurans; Colitis; Colon; Elapid Venoms; Epithelial Cells; Inflammation; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; N-Methylscopolamine; Parasympatholytics; Pyrrolidines; Radioligand Assay; Receptor, Muscarinic M1; Receptor, Muscarinic M3 | 2013 |
Different muscarinic receptor subtypes modulate proliferation of primary human detrusor smooth muscle cells via Akt/PI3K and map kinases.
Topics: Aged; Atropine; Benzofurans; Carbachol; Cell Proliferation; Cells, Cultured; Cholinergic Agonists; Gene Expression; Humans; Male; Mitogen-Activated Protein Kinases; Muscarinic Antagonists; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Piperidines; Pirenzepine; Proto-Oncogene Proteins c-akt; Pyrrolidines; Receptors, Muscarinic; RNA, Messenger; Urinary Bladder | 2013 |