Page last updated: 2024-09-05

atropine and colchicine

atropine has been researched along with colchicine in 29 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(colchicine)
Trials
(colchicine)
Recent Studies (post-2010) (colchicine)
26,7111,2591,69715,4724042,974

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)colchicine (IC50)
Tubulin alpha-1A chainSus scrofa (pig)3.7639
Tubulin beta chainSus scrofa (pig)3.8663
Tubulin beta-4A chainHomo sapiens (human)2.4334
Tubulin beta chainHomo sapiens (human)2.7244
Tubulin alpha-3C chainHomo sapiens (human)2.4334
Serine/threonine-protein kinase pim-1Homo sapiens (human)4.3
Tubulin alpha-1B chainHomo sapiens (human)2.4334
Tubulin alpha-4A chainHomo sapiens (human)2.4334
Tubulin beta-4B chainHomo sapiens (human)2.4334
Vesicular acetylcholine transporterTetronarce californica (Pacific electric ray)2.62
Tubulin beta-3 chainHomo sapiens (human)2.4334
Tubulin beta-2A chainHomo sapiens (human)2.4334
Tubulin beta-8 chainHomo sapiens (human)2.4334
Tubulin beta-2B chainBos taurus (cattle)2.8255
Tubulin alpha-3E chainHomo sapiens (human)2.4334
Tubulin alpha-1A chainHomo sapiens (human)2.4334
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)3.0611
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)3.1553
Tubulin alpha-1C chainHomo sapiens (human)2.4334
Tubulin beta-6 chainHomo sapiens (human)2.4334
Tubulin beta-2B chainHomo sapiens (human)2.4334
Tubulin beta-1 chainHomo sapiens (human)2.4334

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199012 (41.38)18.7374
1990's1 (3.45)18.2507
2000's7 (24.14)29.6817
2010's9 (31.03)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Schreiner, GF; Unanue, ER1
Cole, RD; Furtner, R; Steinhaus, N; Wiche, G1
Blackard, WG; Kikuchi, M; Rabinovitch, A; Renold, AE1
Massaro, D1
Fozard, JR; Mwaluko, GM1
Hoffstein, S; Kammerman, S; Tai, HH; Weissmann, G; Zurier, RB1
Hoffstein, S; Weissmann, G; Zurier, RB1
Gray, GM1
Pert, CB; Snyder, SH1
Hui, F; Smith, A1
Levin, SL1
Chang, TM; Chey, WY; Kwon, HY; Lee, KY1
KUUSI, T; TEIR, H1
Bevin, TH; Fuller, JR; Molteno, AC; Vote, B1
Gumpendobler, M; Herholz, C; Laska, H; Probst, S; Trolliet, C; Zink, N1

Reviews

3 review(s) available for atropine and colchicine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Drugs, malnutrition, and carbohydrate absorption.
    The American journal of clinical nutrition, 1973, Volume: 26, Issue:1

    Topics: Aged; Animals; Atropine; Carbohydrate Metabolism; Clinical Enzyme Tests; Colchicine; Cortisone; Dietary Carbohydrates; Digitoxin; Drug-Related Side Effects and Adverse Reactions; Ethacrynic Acid; Glycoside Hydrolases; Humans; Infant; Infant, Newborn; Intestinal Absorption; Intestinal Mucosa; Malabsorption Syndromes; Neomycin; Nutrition Disorders; Phenformin; Protein Deficiency; Sympathomimetics; Xylose

1973
Systemic anti-inflammatory fibrosis suppression in threatened trabeculectomy failure.
    Clinical & experimental ophthalmology, 2004, Volume: 32, Issue:1

    Topics: Anti-Inflammatory Agents; Atropine; Blister; Colchicine; Conjunctiva; Diclofenac; Drug Therapy, Combination; Epinephrine; Fibrosis; Glaucoma; Humans; Ophthalmic Solutions; Postoperative Complications; Prednisone; Trabeculectomy; Treatment Failure

2004

Other Studies

26 other study(ies) available for atropine and colchicine

ArticleYear
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
The modulation of spontaneous and anti-Ig-stimulated motility of lymphocytes by cyclic nucleotides and adrenergic and cholinergic agents.
    Journal of immunology (Baltimore, Md. : 1950), 1975, Volume: 114, Issue:2 pt 2

    Topics: Acetylcholine; Animals; Antibodies, Anti-Idiotypic; Antigen-Antibody Complex; Atropine; B-Lymphocytes; Binding Sites; Carbachol; Cell Membrane; Cell Movement; Colchicine; Cyclic AMP; Cyclic GMP; Endocytosis; Immunoglobulins; Isoproterenol; Mice; Nucleotides, Cyclic; Parasympathomimetics; Phenylephrine; Sympathomimetics; Theophylline

1975
Expression of simian virus 40 gene A affects tubulin stability.
    Journal of virology, 1979, Volume: 32, Issue:1

    Topics: Animals; Antigens, Viral; Atropine; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cell-Free System; Colchicine; Cricetinae; Drug Combinations; Fibroblasts; Genes, Viral; Lung; Mice; Pralidoxime Compounds; Protein Binding; Simian virus 40; Temperature; Trichlorfon

1979
An effect of hyposmolarity on insulin release in vitro.
    The American journal of physiology, 1975, Volume: 228, Issue:3

    Topics: Amiloride; Amylases; Animals; Atropine; Calcium; Choline; Colchicine; Diazoxide; Epinephrine; Glucagon; Glucose; Hypotonic Solutions; Imidazoles; In Vitro Techniques; Insulin; Insulin Secretion; Male; Osmolar Concentration; Ouabain; Pancreas; Phentolamine; Phenytoin; Propranolol; Rats; Sorbitol; Tolbutamide; Trypsin Inhibitors; Vinblastine

1975
In vivo protein secretion by lung. Evidence for active secretion and interspecies differences.
    The Journal of clinical investigation, 1975, Volume: 56, Issue:2

    Topics: Animals; Atropine; Carbon Radioisotopes; Colchicine; Dose-Response Relationship, Drug; Female; Iodoacetates; Leucine; Lung; Male; Mice; Oxygen Consumption; Pilocarpine; Protein Biosynthesis; Pulmonary Surfactants; Rabbits; Rats; Species Specificity; Therapeutic Irrigation

1975
Mechanism of the indirect sympathomimetic effect of 5-hydroxytrypt-amine on the isolated heart of the rabbit.
    British journal of pharmacology, 1976, Volume: 57, Issue:1

    Topics: Animals; Atropine; Calcium; Colchicine; Desipramine; Dimethylphenylpiperazinium Iodide; Female; Heart; Heart Rate; Hydroxydopamines; In Vitro Techniques; Male; Norepinephrine; Rabbits; Serotonin; Sympathomimetics; Tetrodotoxin; Tyramine

1976
Mechanisms of lysosomal enzyme release from human leukocytes. II. Effects of cAMP and cGMP, autonomic agonists, and agents which affect microtubule function.
    The Journal of clinical investigation, 1974, Volume: 53, Issue:1

    Topics: Atropine; Carbachol; Cholera; Colchicine; Cyclic AMP; Cyclic GMP; Cytochalasin B; Deuterium; Enterotoxins; Glucuronidase; Histamine; Humans; Isoproterenol; Leukocytes; Lysosomes; Phagocytosis; Phenylephrine; Propranolol; Prostaglandins; Zymosan

1974
Leukocytes as secretory organs of inflammation.
    Agents and actions, 1973, Volume: 3, Issue:5

    Topics: Atropine; Blood Platelets; Bucladesine; Carbachol; Cell Survival; Cells, Cultured; Colchicine; Cyclic AMP; Cyclic GMP; Deuterium; Epinephrine; Glucuronidase; Histamine; Humans; Inflammation; Isoproterenol; Leukocytes; Lymphocytes; Monocytes; Peroxidases; Phenylephrine; Prostaglandins; Theophylline

1973
Opiate receptor: demonstration in nervous tissue.
    Science (New York, N.Y.), 1973, Mar-09, Volume: 179, Issue:4077

    Topics: Analgesics; Animals; Atropine; Binding, Competitive; Brain; Carbachol; Codeine; Colchicine; Dextromethorphan; Dextropropoxyphene; Guinea Pigs; Histamine; Intestinal Mucosa; Levallorphan; Methadone; Mice; Morphine; Nalorphine; Naloxone; Phenazocine; Phenobarbital; Rats; Receptors, Drug; Serotonin; Tritium

1973
Regeneration of the amputated amphibian limb: retardation by hemicholinium-3.
    Science (New York, N.Y.), 1970, Dec-18, Volume: 170, Issue:3964

    Topics: Amputation Stumps; Animals; Atropine; Colchicine; Extremities; Hemicholinium 3; Injections; Morpholines; Regeneration; Time Factors; Urodela

1970
Dissociation of the functioning of a human parotid gland following trauma of the tympanic nerve (a pseudocolchicine phenomenon).
    International journal of clinical pharmacology research, 1983, Volume: 3, Issue:5

    Topics: Adult; Atropine; Colchicine; Humans; Middle Aged; Neuromuscular Junction; Parasympathetic Nervous System; Parotid Gland; Reflex; Salivation; Synaptic Transmission

1983
Vagus nerve modulates secretin binding sites in the rat forestomach.
    The American journal of physiology, 1999, Volume: 276, Issue:4

    Topics: Animals; Atropine; Binding, Competitive; Capsaicin; Cell Membrane; Colchicine; Gastrointestinal Motility; Glucagon; Guanylyl Imidodiphosphate; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Neuropeptides; Peptide PHI; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Receptors, G-Protein-Coupled; Receptors, Gastrointestinal Hormone; Secretin; Stomach; Tetrodotoxin; Vagotomy; Vagus Nerve; Vasoactive Intestinal Peptide

1999
Investigations on the relationship of cell function of cell division in the light of experiments with atropine and pilocarpine.
    Acta anatomica, 1954, Volume: 22, Issue:4

    Topics: Atropine; Cell Division; Cell Physiological Phenomena; Colchicine; Light; Pilocarpine

1954
[Doping relevant substances in horse feed].
    Schweizer Archiv fur Tierheilkunde, 2017, Volume: 159, Issue:4

    Topics: Alkaloids; Animal Feed; Animals; Atropine; Colchicine; Doping in Sports; Food Contamination; Horses; Morphine

2017