Page last updated: 2024-09-05

atropine and clozapine

atropine has been researched along with clozapine in 56 studies

Compound Research Comparison

Studies (atropine)	Trials (atropine)	Recent Studies (post-2010) (atropine)	Studies (clozapine)	Trials (clozapine)	Recent Studies (post-2010) (clozapine)
26,711	1,259	1,697	9,691	747	3,148

Protein Interaction Comparison

Protein	Taxonomy	clozapine (IC50)
Adenylate cyclase type 1	Rattus norvegicus (Norway rat)	0.14
Voltage-dependent L-type calcium channel subunit alpha-1F	Homo sapiens (human)	3.6
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	0.032
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	1.47
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	0.476
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	0.045
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	0.1233
Muscarinic acetylcholine receptor M3	Rattus norvegicus (Norway rat)	0.1534
Muscarinic acetylcholine receptor M4	Rattus norvegicus (Norway rat)	0.1534
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	0.15
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	0.031
Muscarinic acetylcholine receptor M5	Rattus norvegicus (Norway rat)	0.1534
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	0.013
Alpha-2A adrenergic receptor	Homo sapiens (human)	0.09
Beta-2 adrenergic receptor	Rattus norvegicus (Norway rat)	0.14
Muscarinic acetylcholine receptor M2	Rattus norvegicus (Norway rat)	0.1534
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	0.0096
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	2
D(2) dopamine receptor	Homo sapiens (human)	0.2044
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	0.0886
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	0.0567
Alpha-2B adrenergic receptor	Homo sapiens (human)	0.023
Alpha-2C adrenergic receptor	Homo sapiens (human)	0.0079
D	Rattus norvegicus (Norway rat)	1.066
D(3) dopamine receptor	Rattus norvegicus (Norway rat)	0.9312
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	1.2695
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)	3.5772
D(2) dopamine receptor	Bos taurus (cattle)	1.804
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	0.078
D(1A) dopamine receptor	Homo sapiens (human)	0.107
D(4) dopamine receptor	Homo sapiens (human)	0.0796
Adenylate cyclase type 3	Rattus norvegicus (Norway rat)	0.14
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)	3.5772
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)	3.5772
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	0.0567
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	1.47
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	5.7544
Histamine H2 receptor	Homo sapiens (human)	3.61
Alpha-1D adrenergic receptor	Homo sapiens (human)	0.035
D(1B) dopamine receptor	Rattus norvegicus (Norway rat)	0.9312
Adenylate cyclase type 2	Rattus norvegicus (Norway rat)	0.14
Adenylate cyclase type 4	Rattus norvegicus (Norway rat)	0.14
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	0.0658
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	0.0658
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	0.373
5-hydroxytryptamine receptor 1D	Rattus norvegicus (Norway rat)	0.587
D(4) dopamine receptor	Rattus norvegicus (Norway rat)	0.9312
5-hydroxytryptamine receptor 1F	Rattus norvegicus (Norway rat)	0.587
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)	0.0338
Histamine H1 receptor	Rattus norvegicus (Norway rat)	0.023
Sodium-dependent serotonin transporter	Homo sapiens (human)	0.546
5-hydroxytryptamine receptor 2C	Mus musculus (house mouse)	0.028
5-hydroxytryptamine receptor 2A	Mus musculus (house mouse)	0.028
Histamine H1 receptor	Homo sapiens (human)	0.0049
D(3) dopamine receptor	Homo sapiens (human)	0.354
Adenylate cyclase type 8	Rattus norvegicus (Norway rat)	0.14
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	0.081
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	0.0567
5-hydroxytryptamine receptor 6	Homo sapiens (human)	0.0171
D(2) dopamine receptor	Mus musculus (house mouse)	0.29
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	0.6759
Voltage-dependent L-type calcium channel subunit alpha-1D	Homo sapiens (human)	3.6
5-hydroxytryptamine receptor 2B	Mus musculus (house mouse)	0.028
Adenylate cyclase type 6	Rattus norvegicus (Norway rat)	0.14
Adenylate cyclase type 5	Rattus norvegicus (Norway rat)	0.14
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	1.4162
Voltage-dependent L-type calcium channel subunit alpha-1S	Homo sapiens (human)	3.6
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	3.6
5-hydroxytryptamine receptor 1A	Mus musculus (house mouse)	2
Adenylyl cyclase 7	Rattus norvegicus (Norway rat)	0.14
D	Bos taurus (cattle)	4.09

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	13 (23.21)	18.7374
1990's	8 (14.29)	18.2507
2000's	16 (28.57)	29.6817
2010's	18 (32.14)	24.3611
2020's	1 (1.79)	2.80

Authors

Authors	Studies
Baldy, WJ; Davis, CB; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Martin, GE; Mathiasen, JR; Scott, MK; Shank, RP	1
Andrews, PR; Craik, DJ; Martin, JL	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Asper, H; Bürki, HR; Ruch, W; Sayers, AC	2
Richelson, E	1
Korf, J; Westerink, BH	1
Closse, A; Hauser, D	1
Bürki, HR; Sayers, AC	1
Marsden, CA; Rivest, R	1
Bolden, C; Cusack, B; Richelson, E	1
Nielsen, EB	1
Mott, J; Sherman, AD	1
de Belleroche, JS; Neal, MJ	1
Baez, LA; Burt, DK; Crowner, ML; Hungerford, SM	1
Herrling, PL; Misbach-Lesenne, B	1
Palumbo, PA; Winter, JC	1
Cawley, TA; Luthin, GR; Ruggieri, MR; Shickley, TJ	1
Brent, PJ; Chahl, LA	1
Csernansky, JG; Nemecek, D; Rastogi-Cruz, D	1
Maullu, C; Olianas, MC; Onali, P	1
Antonello, C; Tessier, P	2
Brar, JS; Chengappa, KN; Kirshner, MA; Levine, J; Parepally, H; Pollock, BG; Zoretich, RA	1
Ash, D; Comley, C; Galletly, C	1
Dahl, E; Dewan, V; Ramaswamy, S; Sharma, A	1
Bourguignon, JJ; Carnicella, S; Mongeot, A; Oberling, P	1
Burke, J; Cox, M; Khan, A; Mustafa, FA; Sherif, S	1
Capurso, NA; Matos Santana, TE; Ranganathan, M; Yoon, G	1
de Alvarenga, KAF; de Rezende, VB; Romano-Silva, MA; Rosa, DV; Sacramento, EK; Souza, BR	1
De Hert, M; van der Poorten, T	1
Lambert, T; Mubaslat, O	1

Reviews

2 review(s) available for atropine and clozapine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Sublingual use of atropine for clozapine-induced sialorrhoea: literature review and two case reports]. Tijdschrift voor psychiatrie, 2019, Volume: 61, Issue:6 Topics: Administration, Sublingual; Atropine; Clozapine; Humans; Sialorrhea	2019

Trials

2 trial(s) available for atropine and clozapine

Article	Year
Anticholinergic differences among patients receiving standard clinical doses of olanzapine or clozapine. Journal of clinical psychopharmacology, 2000, Volume: 20, Issue:3 Topics: Adult; Antipsychotic Agents; Atropine; Autonomic Nervous System Diseases; Benzodiazepines; Cholinergic Antagonists; Clozapine; Female; Humans; Male; Muscarinic Antagonists; Olanzapine; Pirenzepine; Psychiatric Status Rating Scales; Psychotic Disorders; Radioligand Assay; Receptors, Muscarinic	2000
The effect of sublingual atropine sulfate on clozapine-induced hypersalivation: a multicentre, randomised placebo-controlled trial. Psychopharmacology, 2020, Volume: 237, Issue:10 Topics: Administration, Sublingual; Adult; Antipsychotic Agents; Atropine; Clozapine; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscarinic Antagonists; Saliva; Salivation; Sialorrhea; Treatment Outcome	2020

Article

Year

Anticholinergic differences among patients receiving standard clinical doses of olanzapine or clozapine.

Journal of clinical psychopharmacology, 2000, Volume: 20, Issue:3

Topics: Adult; Antipsychotic Agents; Atropine; Autonomic Nervous System Diseases; Benzodiazepines; Cholinergic Antagonists; Clozapine; Female; Humans; Male; Muscarinic Antagonists; Olanzapine; Pirenzepine; Psychiatric Status Rating Scales; Psychotic Disorders; Radioligand Assay; Receptors, Muscarinic

2000

The effect of sublingual atropine sulfate on clozapine-induced hypersalivation: a multicentre, randomised placebo-controlled trial.

Psychopharmacology, 2020, Volume: 237, Issue:10

Topics: Administration, Sublingual; Adult; Antipsychotic Agents; Atropine; Clozapine; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscarinic Antagonists; Saliva; Salivation; Sialorrhea; Treatment Outcome

2020

Other Studies

52 other study(ies) available for atropine and clozapine

Article	Year
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. Journal of medicinal chemistry, 1989, Volume: 32, Issue:5 Topics: Animals; Antipsychotic Agents; Avoidance Learning; Dose-Response Relationship, Drug; Piperazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship	1989
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21 Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Anticholinergic properties of antipsychotic drugs and their relation to extrapyramidal side-effects. Psychopharmacology, 1976, Dec-21, Volume: 51, Issue:1 Topics: Animals; Antipsychotic Agents; Atropine; Basal Ganglia Diseases; Clozapine; Corpus Striatum; Drug Interactions; Dyskinesia, Drug-Induced; Female; Haloperidol; Homovanillic Acid; Male; Parasympathetic Nervous System; Physostigmine; Rats; Receptors, Dopamine; Receptors, Muscarinic	1976
Tricyclic antidepressants and histamine H1 receptors. Mayo Clinic proceedings, 1979, Volume: 54, Issue:10 Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Atropine; Benztropine; Cells, Cultured; Clozapine; Cyproheptadine; Desipramine; Doxepin; Haloperidol; Histamine H1 Antagonists; Hydroxyzine; Imipramine; Mice; Neoplasms, Experimental; Neuroblastoma; Nortriptyline; Protriptyline; Receptors, Histamine; Receptors, Histamine H1; Receptors, Muscarinic	1979
Influence of drugs on striatal and limbic homovanillic acid concentration in the rat brain. European journal of pharmacology, 1975, Volume: 33, Issue:1 Topics: Aminooxyacetic Acid; Animals; Atropine; Brain; Brain Chemistry; Clozapine; Corpus Striatum; Fenclonine; Haloperidol; Homovanillic Acid; Limbic System; Male; Morphine; Oxotremorine; Phenylacetates; Physostigmine; Pimozide; Probenecid; Rats; Substantia Nigra; Trihexyphenidyl	1975
3H-Clozapine binding to rat brain membranes. Life sciences, 1978, Aug-14, Volume: 23, Issue:6 Topics: Animals; Atropine; Brain; Butaclamol; Clozapine; Dibenzazepines; In Vitro Techniques; Male; Membranes; Rats; Stereoisomerism	1978
[Effects of anticholinergics and clozapine on the activation of the striatal dopaminergic system in the rat by haloperidol. Pharmacological findings (author's transl)]. Arzneimittel-Forschung, 1976, Volume: 26, Issue:6 Topics: Animals; Apomorphine; Atropine; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Drug Synergism; Haloperidol; Humans; Movement Disorders; Rats; Receptors, Drug; Stereotyped Behavior	1976
[Effects of anticholinergics and clozapine on the activation of the striatal dopaminergic system in the rat by haloperidol. Neurochemical findings (author's transl)]. Arzneimittel-Forschung, 1976, Volume: 26, Issue:6 Topics: Animals; Atropine; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Drug Synergism; Drug Tolerance; Haloperidol; Homovanillic Acid; Rats; Receptors, Drug	1976
Muscarinic antagonists attenuate the increase in accumbens and striatum dopamine metabolism produced by clozapine but not by haloperidol. British journal of pharmacology, 1991, Volume: 104, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Atropine; Clozapine; Corpus Striatum; Dopamine; Electric Stimulation; Extracellular Space; Haloperidol; Male; Nucleus Accumbens; Parasympatholytics; Rats; Rats, Inbred Strains; Scopolamine	1991
Clozapine is a potent and selective muscarinic antagonist at the five cloned human muscarinic acetylcholine receptors expressed in CHO-K1 cells. European journal of pharmacology, 1991, Jan-03, Volume: 192, Issue:1 Topics: Animals; Atropine; Cell Line; Chlorpromazine; Clozapine; Cricetinae; Cricetulus; Female; Humans; Parasympatholytics; Quinuclidinyl Benzilate; Receptors, Muscarinic; Thioridazine	1991
Cholinergic mediation of the discriminative stimulus properties of clozapine. Psychopharmacology, 1988, Volume: 94, Issue:1 Topics: Animals; Atropine; Clozapine; Dibenzazepines; Discrimination, Psychological; Male; Parasympathetic Nervous System; Rats; Rats, Inbred Strains; Reinforcement Schedule; Scopolamine	1988
Direct effect of neuroleptics on glutamate release. Neuropharmacology, 1984, Volume: 23, Issue:11 Topics: Amygdala; Animals; Antipsychotic Agents; Atropine; Avoidance Learning; Butaclamol; Calcium; Chlorpromazine; Clozapine; Glutamates; Glutamic Acid; Glutamine; Haloperidol; In Vitro Techniques; Male; Rats; Synaptosomes	1984
The contrasting effects of neuroleptics on transmitter release from the nucleus accumbens and corpus striatum. Neuropharmacology, 1982, Volume: 21, Issue:6 Topics: Acetylcholine; Animals; Antipsychotic Agents; Atropine; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Female; Haloperidol; Neurotransmitter Agents; Nucleus Accumbens; Potassium; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Dopamine; Septal Nuclei; Thioridazine	1982
Postnatal development of a cholinergic influence on neuroleptic-induced catalepsy. Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:4 Topics: Aging; Animals; Atropine; Brain; Butyrophenones; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Female; Male; Motor Activity; Muridae; Reaction Time; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Muscarinic; Spiperone	1982
Effects of clozapine in a selective muscarinic bioassay and on single cells of the rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology, 1982, Volume: 320, Issue:1 Topics: Acetylcholine; Animals; Astacoidea; Atropine; Carbachol; Cats; Clozapine; Dibenzazepines; Drug Interactions; Electrophysiology; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Muscle Contraction; Rats; Receptors, Cholinergic; Receptors, Muscarinic	1982
Interactions of clozapine with the stimulus effects of DOM and LSD. Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:1 Topics: Animals; Atropine; Clozapine; Discrimination, Psychological; DOM 2,5-Dimethoxy-4-Methylamphetamine; Generalization, Stimulus; Lysergic Acid Diethylamide; Male; Muscarinic Antagonists; Rats; Rats, Inbred F344; Serotonin Antagonists	1994
Effect of chronic neuroleptic treatment on central and peripheral muscarinic receptors. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1 Topics: Animals; Antipsychotic Agents; Atropine; Cell Membrane; Clozapine; Corpus Striatum; Fluphenazine; Male; Myocardium; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Time Factors; Urinary Bladder	1993
Enhancement of the opiate withdrawal response by antipsychotic drugs in guinea-pigs is not mediated by sigma binding sites. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1993, Volume: 3, Issue:1 Topics: Analysis of Variance; Animals; Antipsychotic Agents; Atropine; Behavior, Animal; Clozapine; Dizocilpine Maleate; Female; Guinea Pigs; Ketamine; Kinetics; Male; Morphine; Motor Activity; Naloxone; Phenazocine; Raclopride; Radioligand Assay; Receptors, sigma; Remoxipride; Salicylamides; Substance Withdrawal Syndrome	1993
Atropinism may precipitate neuroleptic malignant syndrome during treatment with clozapine. The American journal of psychiatry, 1993, Volume: 150, Issue:10 Topics: Adult; Atropine; Autonomic Nervous System Diseases; Clozapine; Humans; Male; Neuroleptic Malignant Syndrome; Parasympathetic Nervous System; Schizophrenia	1993
Mixed agonist-antagonist properties of clozapine at different human cloned muscarinic receptor subtypes expressed in Chinese hamster ovary cells. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 20, Issue:3 Topics: Animals; Antipsychotic Agents; Atropine; Binding Sites; Cell Membrane; CHO Cells; Cloning, Molecular; Clozapine; Cricetinae; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Sulfur Radioisotopes	1999
Clozapine and sialorrhea: a new intervention for this bothersome and potentially dangerous side effect. Journal of psychiatry & neuroscience : JPN, 1999, Volume: 24, Issue:3 Topics: Antipsychotic Agents; Atropine; Clozapine; Humans; Mydriatics; Parasympatholytics; Sialorrhea; Treatment Outcome	1999
Use of atropine eye drops for clozapine induced hypersalivation. The Australian and New Zealand journal of psychiatry, 2000, Volume: 34, Issue:6 Topics: Adult; Atropine; Chronic Disease; Clozapine; Female; Humans; Ophthalmic Solutions; Schizophrenia; Sialorrhea	2000
Clozapine and sialorrhea: update. Journal of psychiatry & neuroscience : JPN, 2001, Volume: 26, Issue:3 Topics: Administration, Intranasal; Administration, Sublingual; Atropine; Clozapine; Humans; Ipratropium; Sialorrhea	2001
Intraoral application of atropine sulfate ophthalmic solution for clozapine-induced sialorrhea. The Annals of pharmacotherapy, 2004, Volume: 38, Issue:9 Topics: Administration, Oral; Antipsychotic Agents; Atropine; Clozapine; Humans; Male; Middle Aged; Muscarinic Antagonists; Ophthalmic Solutions; Schizophrenia, Paranoid; Sialorrhea	2004
Prefrontal cortex and reversion of atropine-induced disruption of the degraded contingency effect by antipsychotic agents and N-desmethylclozapine in rats. The international journal of neuropsychopharmacology, 2010, Volume: 13, Issue:1 Topics: Animals; Antipsychotic Agents; Atropine; Benzodiazepines; Clozapine; Conditioning, Classical; Drug Interactions; Haloperidol; Male; Muscarinic Antagonists; Olanzapine; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley	2010
Neuroleptics: necrotising enterocolitis. Prescrire international, 2009, Volume: 18, Issue:100 Topics: Antipsychotic Agents; Atropine; Benzodiazepines; Clozapine; Drug Therapy, Combination; Enterocolitis, Necrotizing; France; Humans; Risperidone; Sulpiride	2009
Sublingual atropine for the treatment of severe and hyoscine-resistant clozapine-induced sialorrhea. African journal of psychiatry, 2013, Volume: 16, Issue:4 Topics: Administration, Sublingual; Antipsychotic Agents; Atropine; Clozapine; Dose-Response Relationship, Drug; Drug Resistance; Humans; Male; Middle Aged; Muscarinic Antagonists; Schizophrenia; Scopolamine; Sialorrhea; Treatment Outcome	2013
Sublingual atropine in the treatment of clozapine-induced sialorrhea. Schizophrenia research, 2017, Volume: 182 Topics: Administration, Sublingual; Adult; Antipsychotic Agents; Atropine; Clozapine; Humans; Male; Middle Aged; Muscarinic Antagonists; Psychotic Disorders; Schizophrenia; Sialorrhea	2017
Effects of antipsychotics on intestinal motility in zebrafish larvae. Neurogastroenterology and motility, 2017, Volume: 29, Issue:5 Topics: Animals; Antipsychotic Agents; Atropine; Clozapine; Drug Evaluation, Preclinical; Gastrointestinal Motility; Gastrointestinal Tract; Haloperidol; Larva; Muscarinic Antagonists; Risperidone; Zebrafish	2017