Compounds > atropine
Page last updated: 2024-09-05

atropine and clemastine

atropine has been researched along with clemastine in 9 studies

Compound Research Comparison

Studies
(atropine)		Trials
(atropine)		Recent Studies (post-2010)
(atropine)		Studies
(clemastine)		Trials
(clemastine)		Recent Studies (post-2010) (clemastine)
26,7111,2591,69734710566

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)clemastine (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)4.9
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.099
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)3.086
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.02
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.0084
Alpha-2A adrenergic receptorHomo sapiens (human)0.183
Cytochrome P450 2D6Homo sapiens (human)3
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)0.3951
D(2) dopamine receptorHomo sapiens (human)0.136
Alpha-2B adrenergic receptorHomo sapiens (human)0.311
Alpha-2C adrenergic receptorHomo sapiens (human)0.095
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.039
D(1A) dopamine receptorHomo sapiens (human)1.535
Sodium-dependent noradrenaline transporter Homo sapiens (human)3.086
Histamine H2 receptorHomo sapiens (human)0.37
Alpha-1D adrenergic receptorHomo sapiens (human)0.032
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.032
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.099
Cytochrome P450 2C19Homo sapiens (human)0.6
Histamine H1 receptorHomo sapiens (human)0.0004
D(3) dopamine receptorHomo sapiens (human)0.0073
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.036
5-hydroxytryptamine receptor 6Homo sapiens (human)0.077
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)4.9
Sodium-dependent dopamine transporter Homo sapiens (human)0.678
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3951
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)0.3951
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.034

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's0 (0.00)18.2507
2000's3 (33.33)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
von Nieding, G; Wagner, HM1
Rinkema, LE; Silbaugh, SA; Stengel, PW1
Habersang, S; Hempel, R; Nwude, N1
Branga, P; Coelho, D; Fernandes, T; Malheiro, D; Rodrigues, J1

Reviews

1 review(s) available for atropine and clemastine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

8 other study(ies) available for atropine and clemastine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Effects of NO2 on chronic bronchitics.
    Environmental health perspectives, 1979, Volume: 29

    Topics: Adult; Aged; Airway Resistance; Atropine; Bronchitis; Clemastine; Humans; Metaproterenol; Middle Aged; Nitrogen Dioxide; Oxygen; Partial Pressure; Pulmonary Alveoli; Respiration

1979
Pulmonary aerosol actions of LY188695 (KB2413), a new potent H1-receptor antagonist.
    Agents and actions, 1987, Volume: 21, Issue:1-2

    Topics: Aerosols; Airway Obstruction; Animals; Atropine; Benzimidazoles; Bronchial Provocation Tests; Bronchodilator Agents; Chlorpheniramine; Clemastine; Guinea Pigs; Histamine; Histamine H1 Antagonists; Injections, Intravenous; Male; Methacholine Chloride; Methacholine Compounds

1987
Studies on the action and mechanism of action of oxyfedrine on isolated tracheal chains.
    European journal of pharmacology, 1974, Volume: 29, Issue:1

    Topics: Acetylcholine; Adrenergic beta-Agonists; Amphetamine; Animals; Atropine; Clemastine; Dimethylamines; Dose-Response Relationship, Drug; Ephedrine; Epinephrine; Female; Guinea Pigs; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Lysergic Acid Diethylamide; Male; Muscle Contraction; Norepinephrine; Phenylephrine; Propanolamines; Propiophenones; Rabbits; Rats; Reserpine; Serotonin; Species Specificity; Thiazines; Trachea; Tyramine

1974
Intraoperative anaphylaxis after intravenous atropine.
    European journal of anaesthesiology, 2007, Volume: 24, Issue:3

    Topics: Adjuvants, Anesthesia; Aged; Anaphylaxis; Anesthesia, General; Anti-Inflammatory Agents; Atropine; Blood Pressure; Cholinesterase Inhibitors; Clemastine; Elective Surgical Procedures; Heart Rate; Histamine Antagonists; Humans; Hydrocortisone; Injections, Intravenous; Intraoperative Complications; Lumbar Vertebrae; Male; Neostigmine; Norepinephrine; Ranitidine; Skin Tests; Vasoconstrictor Agents

2007