Page last updated: 2024-09-05

atropine and cisapride

atropine has been researched along with cisapride in 34 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(cisapride)
Trials
(cisapride)
Recent Studies (post-2010) (cisapride)
26,7111,2591,6971,554390110

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)cisapride (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.767
3-hydroxy-3-methylglutaryl-coenzyme A reductaseHomo sapiens (human)3.37
Cytochrome P450 3A4Homo sapiens (human)0.3
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.0098
Alpha-2A adrenergic receptorHomo sapiens (human)3.5923
Cytochrome P450 2D6Homo sapiens (human)0.07
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)0.1701
D(2) dopamine receptorHomo sapiens (human)0.35
Dipeptidyl peptidase 4Rattus norvegicus (Norway rat)2.69
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.0098
Insulin receptor Rattus norvegicus (Norway rat)3.37
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)2.29
Alpha-2B adrenergic receptorHomo sapiens (human)3.3827
Alpha-2C adrenergic receptorHomo sapiens (human)3.26
DRattus norvegicus (Norway rat)0.0065
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.6495
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.0065
D(1A) dopamine receptorHomo sapiens (human)1.7
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.0065
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.0065
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)2.29
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)0.0065
Alpha-1D adrenergic receptorHomo sapiens (human)0.083
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.0054
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.2597
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.6495
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)4.47
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)4.47
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.0098
Sodium-dependent serotonin transporterHomo sapiens (human)0.384
Alpha-1A adrenergic receptorHomo sapiens (human)0.03
Prostaglandin G/H synthase 2Homo sapiens (human)3.37
Alpha-1B adrenergic receptorHomo sapiens (human)0.03
D(3) dopamine receptorHomo sapiens (human)0.144
5-hydroxytryptamine receptor 3ARattus norvegicus (Norway rat)0.9
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.0407
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)2.29
D(2) dopamine receptorRattus norvegicus (Norway rat)0.535
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.2536
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)0.1701
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.994
5-hydroxytryptamine receptor 3BRattus norvegicus (Norway rat)0.9

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199013 (38.24)18.7374
1990's13 (38.24)18.2507
2000's6 (17.65)29.6817
2010's2 (5.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Lepsien, G; Lüdtke, FE; Neufang, T; Schramek, P1
Schuurkes, JA; Van Bergen, PJ; Van Nueten, JM1
Itoh, Z; Mizumoto, A1
Klauser, A; Müller-Lissner, S1
Anzini, F; Bontempo, I; Corazziari, E1
Syed, M; Tokuno, H; Tomita, T1
Hellström, PM; Johansson, C; Lördal, M1
Hindocha, N; Jones, MJ; Mitchell, RW1
Funakoshi, A; Kitani, K; Miyasaka, K; Shinozaki, H1
Funakoshi, A; Ibayashi, H; Miyazaki, K; Nakano, I; Shinozaki, H1
Janssen, PA; Reyntjens, AJ; Schuurkes, JA; Van Daele, PG; Van Nueten, JM1
Carey, HV; Cooke, HJ1
Itano, N; Nakayama, S; Neya, T; Takaki, M; Yamasato, T1
Itoh, Z; Nakamura, T; Nakaya, M; Suzuki, T1
Attia, A; Deen, L; Klopper, PJ; van der Hoeven, CW1
Gregory, PC; McFadyen, M; Rayner, DV1
Kikuchi, Y; Koizumi, M; Meguro, T; Shimosegawa, T; Toyota, T1
de Ridder, WJ; Schuurkes, JA1
Chen, HT; Goh, MH; Pan, S1
Sammarco, J; Washabau, RJ1
Itoh, M; Ohno, N; Suzuki, H; Xue, L; Yamamoto, Y; Zhang, G1
Hirano, H; Koizumi, M; Meguro, T; Shiga, N; Shimosegawa, T; Toyota, T1
Furuse, M; Mabayo, RT; Okumura, J1
Snape, WJ1
Batzias, G; Elezoglou, V; Kounenis, G; Koutsoviti-Papadopoulou, M1
Crema, F; Croci, T; de Ponti, F; Langlois, M; Modini, C1
Inatomi, N; Itoh, Z; Marui, S; Omura, S; Sato, F1
Kollias-Baker, C; Nieto, JE; Snyder, JR; Stanley, S1
Burns, GA; Covasa, M; Ritter, RC1
Arnold, S; Binder, H; Burger, DM; Hubler, M; Keiser, M; Wiestner, T1
Jin, J; Jin, NG; Jin, YR; Piao, XX1

Reviews

1 review(s) available for atropine and cisapride

ArticleYear
[What is assured in therapy of gastrointestinal diseases with drugs acting on motility?].
    Der Internist, 1989, Volume: 30, Issue:12

    Topics: Atropine; Calcium Channel Blockers; Cisapride; Dopamine; Dopamine Antagonists; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Narcotic Antagonists; Narcotics; Nitrates; Parasympathomimetics; Piperidines; Sympathomimetics

1989

Trials

2 trial(s) available for atropine and cisapride

ArticleYear
Effects of cisapride on distal esophageal motility in humans.
    Digestive diseases and sciences, 1989, Volume: 34, Issue:10

    Topics: Administration, Oral; Atropine; Catheterization; Cisapride; Drug Administration Schedule; Esophagogastric Junction; Esophagus; Gastrointestinal Motility; Humans; Injections, Intravenous; Manometry; Peristalsis; Piperidines

1989
Effects on the lower oesophageal sphincter of cisapride given before the combined administration of atropine and neostigmine.
    British journal of anaesthesia, 1989, Volume: 62, Issue:2

    Topics: Adult; Atropine; Cisapride; Esophagogastric Junction; Female; Humans; Neostigmine; Piperidines; Pressure; Stomach

1989

Other Studies

31 other study(ies) available for atropine and cisapride

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Cisapride effects on canine lower esophageal sphincter under various pharmacological pretreatments.
    Digestive diseases (Basel, Switzerland), 1991, Volume: 9, Issue:6

    Topics: Animals; Atropine; Calcium Channels; Cisapride; Dogs; Esophagogastric Junction; Muscle Relaxation; Nifedipine; Piperidines; Pressure; Receptors, Muscarinic; Serotonin Antagonists

1991
Prejunctional muscarinic (M1)-receptor interactions on guinea-pig ileum: lack of effect of cisapride.
    British journal of pharmacology, 1988, Volume: 94, Issue:1

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Cisapride; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Piperidines; Pirenzepine; Receptors, Muscarinic

1988
[Anti-cholinesterase activity of dopamine D2 receptor antagonist: its clinical significance].
    Nihon Heikatsukin Gakkai zasshi, 1989, Volume: 25, Issue:4

    Topics: Acetylcholine; Animals; Atropine; Cholinesterase Inhibitors; Cisapride; Dogs; Domperidone; Dopamine Agents; Gastrointestinal Motility; Neostigmine; Piperidines

1989
Effects of cisapride on isolated guinea pig colon.
    Japanese journal of pharmacology, 1989, Volume: 51, Issue:1

    Topics: Acetylcholine; Animals; Atropine; Carbachol; Cisapride; Colon; Electric Stimulation; Female; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Microelectrodes; Muscle, Smooth; Piperidines; Serotonin; Serotonin Antagonists; Tetrodotoxin

1989
Cisapride induces clustered spikes and irregular spiking of the small intestine of the rat.
    Scandinavian journal of gastroenterology. Supplement, 1988, Volume: 152

    Topics: Animals; Atropine; Cisapride; Consciousness; Electrodes, Implanted; Fasting; Ganglionic Blockers; Gastrointestinal Motility; Hexamethonium; Hexamethonium Compounds; Muscle, Smooth; Piperidines; Rats; Rats, Inbred Strains

1988
Effects of cisapride on the pancreatic exocrine secretion in rats.
    Gastroenterologia Japonica, 1988, Volume: 23, Issue:5

    Topics: Acetylcholine; Animals; Atropine; Carbachol; Cholecystokinin; Cisapride; In Vitro Techniques; Male; Pancreas; Pancreatic Juice; Piperidines; Proglumide; Rats; Rats, Inbred Strains; Serotonin Antagonists

1988
Effects of cisapride on the secretion of pancreatic polypeptide in healthy volunteers.
    The Tohoku journal of experimental medicine, 1986, Volume: 150, Issue:2

    Topics: Adult; Atropine; Blood Glucose; Cisapride; Humans; Insulin; Male; Pancreatic Polypeptide; Piperidines; Prolactin

1986
Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:3

    Topics: Acetylcholine; Animals; Atropine; Cisapride; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gastrointestinal Motility; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Intestinal Mucosa; Male; Methacholine Chloride; Methacholine Compounds; Metoclopramide; Muscle Contraction; Nicotine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Tetrodotoxin

1985
Pharmacological analysis of 5-hydroxytryptamine actions on guinea-pig ileal mucosa.
    European journal of pharmacology, 1985, May-20, Volume: 111, Issue:3

    Topics: Animals; Atropine; Chlorides; Cholinergic Fibers; Cisapride; Electric Conductivity; Electric Stimulation; Female; Furosemide; Guinea Pigs; Ileum; Intestinal Mucosa; Male; Piperidines; Secretory Rate; Serotonin; Tetrodotoxin

1985
[Effects of cisapride on the motility of the digestive tract in dogs and guinea pigs].
    Nihon Heikatsukin Gakkai zasshi, 1985, Volume: 21, Issue:1

    Topics: Animals; Atropine; Biliary Tract; Blood Pressure; Cisapride; Dogs; Dose-Response Relationship, Drug; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Mesentery; Muscle Contraction; Muscle, Smooth; Peripheral Nerves; Piperidines

1985
[Effect of cisapride on contractile activity of the gastrointestinal tract].
    Nihon Heikatsukin Gakkai zasshi, 1985, Volume: 21, Issue:2

    Topics: Animals; Atropine; Cisapride; Dogs; Gastrointestinal Motility; Motilin; Muscle Contraction; Muscle, Smooth; Pentagastrin; Piperidines; Stimulation, Chemical; Stomach

1985
The influence of anaesthetic drugs on the lower oesophageal sphincter in propofol/nitrous oxide anaesthetized dogs. Pressure profilometry in an animal model.
    Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:6

    Topics: Anesthesia; Anesthetics; Animals; Atropine; Cisapride; Dogs; Esophagogastric Junction; Neuromuscular Depolarizing Agents; Neuromuscular Nondepolarizing Agents; Nitrous Oxide; Pancuronium; Parasympatholytics; Piperidines; Pressure; Propofol; Succinylcholine; Vecuronium Bromide

1995
Control of gastric emptying in the pig: influence of cholecystokinin, somatostatin and prokinetic agents.
    Experimental physiology, 1995, Volume: 80, Issue:1

    Topics: Animals; Atropine; Cholecystokinin; Cisapride; Eating; Female; Gastric Emptying; Metoclopramide; Piperidines; Somatostatin; Swine

1995
Effects of cisapride on gallbladder emptying and pancreatic polypeptide and cholecystokinin release in humans.
    Journal of gastroenterology, 1995, Volume: 30, Issue:2

    Topics: Adult; Atropine; Cholecystokinin; Cholinergic Fibers; Cisapride; Fasting; Female; Gallbladder Emptying; Humans; Male; Pancreas; Peptides; Piperidines; Radioimmunoassay

1995
Cisapride and 5-hydroxytryptamine enhance motility in the canine antrum via separate pathways, not involving 5-hydroxytryptamine1,2,3,4 receptors.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:1

    Topics: Animals; Atropine; Benzimidazoles; Cisapride; Dogs; Electric Stimulation; Gastrointestinal Motility; Hexamethonium; Hexamethonium Compounds; Histamine; In Vitro Techniques; Indoles; Muscle Contraction; Muscle, Smooth; Piperidines; Pyloric Antrum; Pyridines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tetrodotoxin; Tropisetron

1993
The effect and mechanism of the prokinetic action of cisapride on gastrointestinal smooth muscle.
    Gastroenterologia Japonica, 1993, Volume: 28, Issue:2

    Topics: Acetylcholine; Animals; Atropine; Cisapride; Colon; Dose-Response Relationship, Drug; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Piperidines; Serotonin Antagonists; Stomach; Tetrodotoxin

1993
Effects of cisapride on feline colonic smooth muscle function.
    American journal of veterinary research, 1996, Volume: 57, Issue:4

    Topics: Acetylcholine; Animals; Atropine; Calcium; Calcium Channels; Cats; Cholecystokinin; Cholinergic Agonists; Cisapride; Colon; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Muscle, Smooth; Neurotensin; Nifedipine; Piperidines; Substance P; Tetrodotoxin

1996
Excitation and inhibition by cisapride of spontaneous and evoked electrical responses in smooth muscles of guinea-pig stomach.
    Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1995, Volume: 112, Issue:2

    Topics: Acetylcholine; Animals; Atropine; Cisapride; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Methysergide; Microelectrodes; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Parasympathetic Nervous System; Parasympatholytics; Parasympathomimetics; Piperidines; Serotonin Antagonists; Stomach

1995
Effects of ethanol on meal-stimulated secretion of pancreatic polypeptide and cholecystokinin: comparison of healthy volunteers, heavy drinkers, and patients with chronic pancreatitis.
    Journal of gastroenterology, 1996, Volume: 31, Issue:1

    Topics: Adult; Alcoholism; Analysis of Variance; Atropine; Cholecystokinin; Chronic Disease; Cisapride; Ethanol; Humans; Male; Middle Aged; Pancreatic Polypeptide; Pancreatitis; Parasympathomimetics; Piperidines; Postprandial Period; Radioimmunoassay

1996
Cholinergic factors are not involved in the delayed diet passage from the crop of chicks given medium chain triacylglycerol.
    Comparative biochemistry and physiology. Part A, Physiology, 1997, Volume: 116, Issue:2

    Topics: Animals; Atropine; Birds; Cholinergic Fibers; Cisapride; Diet; Dose-Response Relationship, Drug; Feeding Behavior; Parasympathomimetics; Piperidines; Triglycerides; Vagotomy

1997
Managing the patient with atypical chest pain.
    Hospital practice (1995), 1997, Apr-15, Volume: 32, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Algorithms; Amitriptyline; Anti-Ulcer Agents; Atropine; Chest Pain; Cisapride; Diagnosis, Differential; Esophageal Motility Disorders; Esophagitis, Peptic; Female; Humans; Male; Manometry; Middle Aged; Parasympatholytics; Piperidines; Postprandial Period

1997
Effect of cisapride on the isolated guinea pig gall bladder and common bile duct.
    General pharmacology, 1997, Volume: 29, Issue:5

    Topics: Acetylcholine; Animals; Atropine; Autonomic Pathways; Cisapride; Common Bile Duct; Female; Gallbladder; Gastrointestinal Agents; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Parasympathetic Nervous System; Parasympatholytics; Piperidines

1997
Intestinal prokinesia by two esters of 4-amino-5-chloro-2- methoxybenzoic acid: involvement of 5-hydroxytryptamine-4 receptors and dissociation from cardiac effects in vivo.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:3

    Topics: Aminobenzoates; Animals; Atropine; Chlorobenzoates; Cisapride; Dogs; Duodenum; Electrocardiography; Electrophysiology; Female; Heart Rate; Jejunum; Myoelectric Complex, Migrating; para-Aminobenzoates; Piperidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Serotonin Receptor Agonists

1999
EM574, an erythromycin derivative, improves delayed gastric emptying of semi-solid meals in conscious dogs.
    European journal of pharmacology, 2000, Apr-28, Volume: 395, Issue:2

    Topics: Animals; Atropine; Cisapride; Dogs; Erythromycin; Gastric Emptying; Gastrointestinal Agents; Gastroparesis; Male; Motilin; Muscarinic Antagonists; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists

2000
In vitro effects of 5-hydroxytryptamine and cisapride on the circular smooth muscle of the jejunum of horses.
    American journal of veterinary research, 2000, Volume: 61, Issue:12

    Topics: Animals; Atropine; Cisapride; Drug Synergism; Horses; In Vitro Techniques; Indoles; Isometric Contraction; Jejunum; Ketanserin; Muscle, Smooth; Serotonin; Serotonin Antagonists; Tetrodotoxin; Tropisetron

2000
Cholinergic neurotransmission participates in increased food intake induced by NMDA receptor blockade.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2003, Volume: 285, Issue:3

    Topics: Acetylcholine; Animals; Atropine; Cisapride; Dizocilpine Maleate; Eating; Excitatory Amino Acid Antagonists; Fourth Ventricle; Gastric Emptying; Injections, Intraventricular; Male; Parasympatholytics; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists; Synaptic Transmission

2003
Effect of anticholinergics (atropine, glycopyrrolate) and prokinetics (metoclopramide, cisapride) on gastric motility in beagles and labrador retrievers.
    Journal of veterinary medicine. A, Physiology, pathology, clinical medicine, 2006, Volume: 53, Issue:2

    Topics: Animals; Atropine; Body Weight; Breeding; Cisapride; Dogs; Dose-Response Relationship, Drug; Electromyography; Gastric Emptying; Gastrointestinal Agents; Gastrointestinal Motility; Glycopyrrolate; Metoclopramide; Muscarinic Antagonists

2006
The effect of Taraxacum officinale on gastric emptying and smooth muscle motility in Rodents.
    Neurogastroenterology and motility, 2011, Volume: 23, Issue:8

    Topics: 1-Butanol; Adrenergic alpha-Antagonists; Animals; Atropine; Cisapride; Dose-Response Relationship, Drug; Gastric Emptying; Gastrointestinal Agents; Gastrointestinal Motility; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Phentolamine; Plant Extracts; Pyloric Antrum; Pylorus; Random Allocation; Rats; Rats, Wistar; Rodentia; Taraxacum

2011