Compounds > atropine
Page last updated: 2024-09-05

atropine and cinnarizine

atropine has been researched along with cinnarizine in 7 studies

Compound Research Comparison

Studies
(atropine)		Trials
(atropine)		Recent Studies (post-2010)
(atropine)		Studies
(cinnarizine)		Trials
(cinnarizine)		Recent Studies (post-2010) (cinnarizine)
26,7111,2591,697855148190

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)cinnarizine (IC50)
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.832
Muscarinic acetylcholine receptor M4Homo sapiens (human)3.66
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.759
Alpha-2A adrenergic receptorHomo sapiens (human)0.444
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.513
D(2) dopamine receptorHomo sapiens (human)0.776
Alpha-2B adrenergic receptorHomo sapiens (human)2.242
Alpha-2C adrenergic receptorHomo sapiens (human)0.652
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.083
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.762
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.832
Alpha-1D adrenergic receptorHomo sapiens (human)1.167
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.36
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)1.083
Sodium-dependent serotonin transporterHomo sapiens (human)1.09
Histamine H1 receptorHomo sapiens (human)0.074
Mu-type opioid receptorHomo sapiens (human)2.272
D(3) dopamine receptorHomo sapiens (human)0.252
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.731
Sodium-dependent dopamine transporter Homo sapiens (human)1.641
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.04

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19903 (42.86)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Andrews, PR; Craik, DJ; Martin, JL1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Horii, D; Ishibashi, A; Sano, F1

Other Studies

7 other study(ies) available for atropine and cinnarizine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
[Effect of suloctidil on the dynamics of the peripheral artery of the dog].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1983, Volume: 82, Issue:1

    Topics: Animals; Arteries; Atropine; Blood Circulation; Cinnarizine; Dogs; Female; Male; Papaverine; Propanolamines; Regional Blood Flow; Suloctidil

1983