Page last updated: 2024-09-05

atropine and chloroquine

atropine has been researched along with chloroquine in 38 studies

Compound Research Comparison

Studies (atropine)	Trials (atropine)	Recent Studies (post-2010) (atropine)	Studies (chloroquine)	Trials (chloroquine)	Recent Studies (post-2010) (chloroquine)
26,711	1,259	1,697	16,405	763	4,029

Protein Interaction Comparison

Protein	Taxonomy	chloroquine (IC50)
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	Plasmodium berghei	43
Spike glycoprotein	Betacoronavirus England 1	5.47
Replicase polyprotein 1ab	Betacoronavirus England 1	5.47
Transmembrane protease serine 2	Homo sapiens (human)	5.47
Dihydrofolate reductase	Bos taurus (cattle)	0.0301
Amyloid-beta precursor protein	Homo sapiens (human)	7
Histidine-rich protein PFHRP-II	Plasmodium falciparum (malaria parasite P. falciparum)	0.2383
Procathepsin L	Homo sapiens (human)	5.47
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	5.47
Replicase polyprotein 1ab	Human coronavirus 229E	5.47
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	5.47
Spike glycoprotein	Severe acute respiratory syndrome coronavirus 2	3.58
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	6.375
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	1.5
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	0.27
Beta-secretase 1	Homo sapiens (human)	7
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	5.47
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	2.503
Angiotensin-converting enzyme 2	Homo sapiens (human)	6.235
Cysteine proteinase falcipain 2a	Plasmodium falciparum (malaria parasite P. falciparum)	0.02
Cysteine proteinase falcipain 2a	Plasmodium falciparum (malaria parasite P. falciparum)	0.2

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (39.47)	18.7374
1990's	3 (7.89)	18.2507
2000's	9 (23.68)	29.6817
2010's	11 (28.95)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Amsler, CD; Baker, BJ; Hahn, KN; Kyle, DE; Lebar, MD; Maignan, P; McClintock, JB; Mutka, T; van Olphen, A	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Scott, WA; Solomon, B	1
Bellows, AR; Bienfang, DC; Chylack, LT; Stillman, JS	1
Buxbaum, JD; Chen, HI; Gandy, SE; Greengard, P; Jaffe, EA; Oishi, M; Pinkas-Kramarski, R	1
Wilhelm, RE	1
Jindal, MN; Kelkar, VV; Pandya, KH	1
Furkert, K	1
Olatunde, IA	1
Abdel-Aziz, A; Bakry, N	1
Chrzanowska-Srzednicka, K; Ciechanowska, A	1
Brdicska, M; Simonyi, I	1
Evans, TM	1
Duda, V; Klabusay, L; Pĕgrímová, E; Vrublovský, P; Vykydal, M	1
Lamela, M	1
Ohkuma, S; Poole, B	1
Atlasik, B; Stepien, K; Wilczok, T	1
Lot, TY	1
Ohkuma, S; Takano, T	1
ARORA, RB; LAL, A	1
Liu, JJ; Miao, Y; Ren, J; Sun, L; Wang, H; Yu, XJ; Zang, WJ; Zhao, M	1

Reviews

3 review(s) available for atropine and chloroquine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Antiasthmatics. 12]. Pharmazeutische Praxis, 1967, Volume: 9 Topics: Adrenal Cortex Hormones; Aminophylline; Anti-Bacterial Agents; Asthma; Atropine; Barbiturates; Bronchodilator Agents; Calcium Chloride; Central Nervous System Stimulants; Chloroquine; Ephedrine; Epinephrine; Expectorants; Histamine H1 Antagonists; Humans; Isoproterenol; Papaverine; Phenothiazines; Potassium Iodide; Theophylline; Trypsin	1967
[Negative influence of some agents on eye condition in primary glaucoma]. Przeglad lekarski, 1972, Volume: 29, Issue:7 Topics: Adrenal Cortex Hormones; Atropine; Chloroquine; Cholinesterase Inhibitors; Epinephrine; Eye; Feedback; Glaucoma; Humans; Intraocular Pressure; Nicotine; Optic Nerve; Retina; Scopolamine; Tropanes	1972

Other Studies

35 other study(ies) available for atropine and chloroquine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs. Bioorganic & medicinal chemistry, 2011, Oct-01, Volume: 19, Issue:19 Topics: Antimalarials; Cell Line, Tumor; Central Nervous System Agents; Humans; Indole Alkaloids; Indoles; Plasmodium falciparum; Pyrimidines; Receptors, Serotonin	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Adenosine 3',5'-cyclic monophosphate and morphology in Neurospora crassa: drug-induced alterations. Journal of bacteriology, 1975, Volume: 122, Issue:2 Topics: Adenylyl Cyclases; Antimalarials; Atropine; Chloroquine; Cyclic AMP; Histamine; Kinetics; Neurospora; Neurospora crassa; Phosphoric Diester Hydrolases; Quinidine; Quinine; Theophylline	1975
Ocular manifestations of juvenile rheumatoid arthritis. American journal of ophthalmology, 1975, Volume: 79, Issue:6 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Arthritis, Juvenile; Atropine; Cataract; Child; Child, Preschool; Chloroquine; Dexamethasone; Endophthalmitis; Eye Diseases; Eye Manifestations; Female; Humans; Hydroxychloroquine; Infant; Infant, Newborn; Male; Retinal Diseases; Scotoma; Sex Factors; Tissue Adhesions; Uveitis; Uveitis, Anterior; Visual Acuity	1975
Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proceedings of the National Academy of Sciences of the United States of America, 1992, Nov-01, Volume: 89, Issue:21 Topics: Acetylcholine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Atropine; Bethanechol; Bethanechol Compounds; Carbachol; Cell Line; Cells, Cultured; Chloroquine; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Interleukin-1; Kinetics; Parasympathomimetics; PC12 Cells; Phorbol 12,13-Dibutyrate; Protein Kinase C; Recombinant Proteins; Umbilical Veins	1992
The newer anti-allergic agents. Transactions - Indiana Academy of Ophthalmology and Otolaryngology, 1967, May-11, Volume: 50 Topics: Air Conditioning; Amino Alcohols; Aminocaproates; Atropine; Bronchodilator Agents; Chloroquine; Cyclizine; Desensitization, Immunologic; Ethylenediamines; gamma-Globulins; Glucocorticoids; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity; Immunotherapy; Lactates; Nitrites; Penicillinase; Phenothiazines; Respiratory Therapy; Serotonin Antagonists; Sympathomimetics; Trypsin	1967
Mechanism of the pressor effect of amodiaquin and chloroquine in methylamphetamine-pretreated anesthetized dogs. The Journal of pharmacology and experimental therapeutics, 1968, Volume: 161, Issue:1 Topics: Amodiaquine; Amphetamine; Animals; Atropine; Blood Pressure; Carotid Arteries; Catecholamines; Chloroquine; Choline; Dogs; Ethanolamines; Femoral Artery; Hexamethonium Compounds; Muscle, Smooth; Norepinephrine; Quinolines; Reserpine; Sympatholytics; Tolazoline; Xylenes	1968
Quantitation of the degree of antagonism of chloroquine to histamine, acetylcholine and serotonin (PA2 values). Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 185, Issue:1 Topics: Acetylcholine; Animals; Atropine; Chloroquine; Histamine H1 Antagonists; Ileum; Muscle, Smooth; Phenoxybenzamine; Rats; Serotonin Antagonists; Time Factors	1970
Effect of chloroquine phosphate on the isolated non-pregnant and pregnant uterus of different species. Acta physiologica Academiae Scientiarum Hungaricae, 1974, Volume: 45, Issue:1-2 Topics: Acetylcholine; Animals; Atropine; Chloroquine; Dinitrophenols; Female; Guinea Pigs; In Vitro Techniques; Lysergic Acid Diethylamide; Oxytocin; Phenoxybenzamine; Pregnancy; Propranolol; Rabbits; Rats; Species Specificity; Tetracaine; Time Factors; Uterine Contraction; Uterus	1974
[The use of sodium lauryl sulfate volumetric solution in the study of injection solutions]. Acta pharmaceutica Hungarica, 1973, Volume: 43, Issue:6 Topics: Atropine; Chloroquine; Chlorpromazine; Codeine; Epinephrine; Injections; Lidocaine; Sodium Dodecyl Sulfate; Solutions; Tripelennamine	1973
Ocular pharmacology and therapeutics. Journal of occupational medicine. : official publication of the Industrial Medical Association, 1971, Volume: 13, Issue:2 Topics: Anesthetics, Local; Anti-Bacterial Agents; Atropine; Chloroquine; Eye; Eye Diseases; Humans; Miotics; Occupational Medicine; Ophthalmic Solutions; Steroids	1971
[Chloroquine antimalarial poisoning]. Vnitrni lekarstvi, 1968, Volume: 14, Issue:2 Topics: Adult; Atropine; Chloroquine; Heart; Humans; Male; Papaverine; Suicide	1968
Combined effects of antiarrhythmic drugs on the experimentally induced fibrillation of isolated rat's atria. Archives internationales de pharmacodynamie et de therapie, 1965, Volume: 157, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atropine; Chloroquine; Diphenhydramine; Heart Atria; Heart Rate; In Vitro Techniques; Phenformin; Quinidine; Rats; Sparteine	1965
Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances. The Journal of cell biology, 1981, Volume: 90, Issue:3 Topics: Amines; Animals; Ascitic Fluid; Atropine; Chloroquine; Hydrogen-Ion Concentration; Lysosomes; Macrophages; Mice; Organoids; Osmosis; Propranolol; Vacuoles	1981
Interaction of drugs with ocular melanin in vitro. Experimental eye research, 1980, Volume: 30, Issue:4 Topics: Animals; Anti-Bacterial Agents; Atropine; Cattle; Chloroquine; Eye; Fluoresceins; In Vitro Techniques; Melanins; Procaine; Sulfacetamide; Tetracaine; Time Factors	1980
The effects of chronic administration of chloroquine and quinacrine on the response of normal and denervated smooth muscle to agonist drugs. Physiology & behavior, 1993, Volume: 54, Issue:2 Topics: Acetylcholine; Age Factors; Animals; Atropine; Chickens; Chloroquine; Culture Techniques; Dose-Response Relationship, Drug; Histamine; Male; Muscle, Smooth; Neurotransmitter Agents; Norepinephrine; Potassium Chloride; Pyrilamine; Quinacrine; Serotonin; Synaptic Transmission	1993
ATP-dependent lysis of isolated lysosomes by basic substances and acidic ionophores. Cell structure and function, 1997, Volume: 22, Issue:2 Topics: Adenosine Triphosphate; Ammonium Chloride; Aniline Compounds; Animals; Atropine; Butylamines; Chloroquine; Cytosol; Ethanolamines; Hydrogen-Ion Concentration; Ionophores; Lysosomes; Male; Methylamines; Osmolar Concentration; Rats; Rats, Wistar; Vacuoles	1997
ANTIMALARIAL DRUGS ON THE AUTOMATICITY OF SINO-AURICULAR AND ATRIO-VENTRICULAR NODES. The Indian journal of medical research, 1963, Volume: 51 Topics: Administration, Intravenous; Amodiaquine; Animals; Anti-Arrhythmia Agents; Antimalarials; Atrioventricular Node; Atropine; Chloroquine; Dogs; Heart Conduction System; Humans; Hydroxychloroquine; Hypotension; Injections, Intravenous; Primaquine; Quinacrine; Quinidine; Research; Statistics as Topic	1963
Acetylcholine mediates AMPK-dependent autophagic cytoprotection in H9c2 cells during hypoxia/reoxygenation injury. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2013, Volume: 32, Issue:3 Topics: Acetylcholine; AMP-Activated Protein Kinases; Animals; Atropine; Autophagy; Autophagy-Related Protein 7; Cell Hypoxia; Cell Line; Cell Survival; Chloroquine; Cytoprotection; Microtubule-Associated Proteins; Muscarinic Antagonists; Myocytes, Cardiac; Phosphorylation; Rats; Receptors, Muscarinic; RNA Interference; RNA, Small Interfering; TOR Serine-Threonine Kinases; Ubiquitin-Activating Enzymes	2013