Page last updated: 2024-09-05

atropine and buspirone

atropine has been researched along with buspirone in 16 studies

Compound Research Comparison

Studies (atropine)	Trials (atropine)	Recent Studies (post-2010) (atropine)	Studies (buspirone)	Trials (buspirone)	Recent Studies (post-2010) (buspirone)
26,711	1,259	1,697	2,096	351	382

Protein Interaction Comparison

Protein	Taxonomy	buspirone (IC50)
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	0.025
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	1.75
Angiotensin-converting enzyme	Homo sapiens (human)	0.024
D(2) dopamine receptor	Homo sapiens (human)	0.323
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	2.125
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	4.16
D	Rattus norvegicus (Norway rat)	0.12
D(3) dopamine receptor	Rattus norvegicus (Norway rat)	0.12
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	0.0266
D(2) dopamine receptor	Bos taurus (cattle)	4
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	4.16
Alpha-1D adrenergic receptor	Homo sapiens (human)	1.077
D(1B) dopamine receptor	Rattus norvegicus (Norway rat)	0.12
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	2.286
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	0.016
D(4) dopamine receptor	Rattus norvegicus (Norway rat)	0.12
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)	2.125
D(3) dopamine receptor	Homo sapiens (human)	0.044
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	0.75
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	4.16
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	0.2055
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	3.9811
Alpha-2A adrenergic receptor	Bos taurus (cattle)	0.025
Multidrug and toxin extrusion protein 1	Homo sapiens (human)	1.7
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	0.2666
Lysosomal alpha-glucosidase	Bos taurus (cattle)	0.03

Research

Studies (16)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (6.25)	18.7374
1990's	2 (12.50)	18.2507
2000's	4 (25.00)	29.6817
2010's	9 (56.25)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Ahman, M; Holmén, AG; Wan, H	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Glen, RC; Lowe, R; Mitchell, JB	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Caliendo, G; Capasso, R; Ciano, A; Corvino, A; Di Vaio, P; Fiorino, F; Frecentese, F; Izzo, AA; Kędzierska, E; Kotlińska, JH; Magli, E; Massarelli, P; Orzelska-Gòrka, J; Perissutti, E; Rossi, I; Saccone, I; Santagada, V; Severino, B	1
Hong, E; Meneses, A	1
Oriowo, MA	1
Camilleri, M; Coulie, BJ; Farrugia, G; Locke, GR; Meulemans, A; Schuurkes, JA; Szurszewski, JH; Xue, L	1
Agretti, P; De Marco, G; Dimida, A; Ferrarini, E; Pinchera, A; Rodrìguez Gonzàlez, JC; Santini, F; Tonacchera, M; Vitti, P	1

Reviews

1 review(s) available for atropine and buspirone

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

15 other study(ies) available for atropine and buspirone

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
New 5-HT Bioorganic & medicinal chemistry, 2017, 10-15, Volume: 25, Issue:20 Topics: Animals; Binding Sites; Biological Assay; Ileum; Ligands; Maze Learning; Molecular Structure; Picolines; Protein Binding; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin Receptor Agonists	2017
Effects of serotonergic compounds on associative learning. Proceedings of the Western Pharmacology Society, 1991, Volume: 34 Topics: Animals; Atropine; Buspirone; Conditioning, Operant; Ketanserin; Learning; Male; Quinazolines; Rats; Rats, Inbred Strains; Ritanserin; Serotonin; Serotonin Antagonists	1991
Neural inhibition in the rat lower esophageal sphincter: role of beta 3-adrenoceptor activation. General pharmacology, 1998, Volume: 30, Issue:1 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atropine; Buspirone; Carbachol; Electric Stimulation; Electrophysiology; Esophagogastric Junction; Ethanolamines; Male; Muscle Relaxation; Neural Inhibition; Nitric Oxide Synthase; Oxidopamine; Propranolol; Rats; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-3; Serotonin Receptor Agonists; Tetrodotoxin; Vasoconstrictor Agents	1998
Effect of modulation of serotonergic, cholinergic, and nitrergic pathways on murine fundic size and compliance measured by ultrasonomicrometry. American journal of physiology. Gastrointestinal and liver physiology, 2006, Volume: 290, Issue:1 Topics: Animals; Atropine; Bethanechol; Buspirone; Gastric Fundus; Male; Mice; Muscle Contraction; Muscle, Smooth; Nitroglycerin; Reproducibility of Results; Serous Membrane; Signal Transduction; Sumatriptan; Ultrasonography	2006
Study of potential inhibitors of thyroid iodide uptake by using CHO cells stably expressing the human sodium/iodide symporter (hNIS) protein. Journal of endocrinological investigation, 2011, Volume: 34, Issue:3 Topics: 14-alpha Demethylase Inhibitors; Amphotericin B; Animals; Anti-Allergic Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Atropine; Biotin; Buspirone; CHO Cells; Cricetinae; Cricetulus; Econazole; Humans; Hydrocortisone; Iodides; Metronidazole; Muscarinic Antagonists; Papaverine; Perchlorates; Phosphodiesterase Inhibitors; Promethazine; Serotonin Receptor Agonists; Sulfadiazine; Symporters; Thiocyanates; Thyroid Gland	2011