Page last updated: 2024-09-05

atropine and bumetanide

atropine has been researched along with bumetanide in 30 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(bumetanide)
Trials
(bumetanide)
Recent Studies (post-2010) (bumetanide)
26,7111,2591,6972,033150354

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)bumetanide (IC50)
Solute carrier family 12 member 2Homo sapiens (human)0.8

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19904 (13.33)18.7374
1990's10 (33.33)18.2507
2000's6 (20.00)29.6817
2010's10 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Barker, S; Curry, M; Martinez, JR; Seagrave, JC1
Bindslev, N; Winding, B2
Gaginella, TS; Kachur, JF; Tien, XY; Wallace, LJ; Won-Kim, S1
Levin, RJ; Young, A1
Gaginella, TS; Kachur, JF; Phillips, GS1
Dissing, S; Nauntofte, B1
Carey, HV; Cooke, HJ1
Saga, K; Sato, K1
Dharmsathaphorn, K; Pandol, SJ1
Saga, K; Sato, F; Sato, K1
Barrett, KE; Bidinger, J; Cooke, HJ; Javed, NH; Wang, YZ1
Hansen, MB1
Demedts, MG; Pype, JL; Verleden, GM1
Hosoda, Y; Iwanaga, T; Kuwahara, A; Winarto, A1
Manabe, K; Morishima, S; Okada, Y; Shimizu, T1
Karaki, S; Kuwahara, A1

Reviews

1 review(s) available for atropine and bumetanide

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

29 other study(ies) available for atropine and bumetanide

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
The effect of NH4Cl on Rb+ fluxes in resting and stimulated rat submandibular acinar cells.
    Archives of oral biology, 1992, Volume: 37, Issue:7

    Topics: Acetylcholine; Ammonia; Ammonium Chloride; Animals; Atropine; Bumetanide; Butyrates; Butyric Acid; Charybdotoxin; Dimethylamines; Hydrogen-Ion Concentration; Male; Methylamines; Ouabain; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Scorpion Venoms; Submandibular Gland

1992
Characterization of a muscarinic receptor controlling Cl- secretion in hen trachea.
    The American journal of physiology, 1990, Volume: 258, Issue:6 Pt 1

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Bumetanide; Calcium Channels; Chickens; Chlorides; Dicyclomine; Female; In Vitro Techniques; Ion Channels; Kinetics; Mucous Membrane; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Trachea

1990
Characterization of Ile,Ser-bradykinin-induced changes in short-circuit current across rat colon.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:3

    Topics: Animals; Atropine; Bradykinin; Bumetanide; Chlorides; Colon; Culture Techniques; Electrophysiology; Ion Channels; Male; Rats; Rats, Inbred Strains; Tetrodotoxin

1990
Segmental heterogeneity of rat colonic electrogenic secretion in response to the bacterial enterotoxin Escherichia coli STa in vitro.
    Experimental physiology, 1991, Volume: 76, Issue:6

    Topics: Animals; Atropine; Bacterial Toxins; Bumetanide; Chlorides; Colon; Dose-Response Relationship, Drug; Enterotoxins; Escherichia coli Proteins; Intestinal Mucosa; Male; Membrane Potentials; Rats; Rats, Inbred Strains; Tetrodotoxin

1991
Neuromodulation of guinea pig intestinal electrolyte transport by cholecystokinin octapeptide.
    Gastroenterology, 1991, Volume: 100, Issue:2

    Topics: Animals; Atropine; Biological Transport; Bumetanide; Calcium; Culture Media; Dose-Response Relationship, Drug; Electrolytes; Electrophysiology; Guinea Pigs; Ileum; Intestinal Mucosa; Intestines; Male; Proglumide; Receptors, Cholecystokinin; Sincalide; Tetrodotoxin

1991
Na+ transport properties of isolated rat parotid acini.
    The American journal of physiology, 1990, Volume: 259, Issue:6 Pt 1

    Topics: Acetazolamide; Amiloride; Animals; Atropine; Biological Transport, Active; Bumetanide; Carbachol; Chlorides; Fluoresceins; Fluorescent Dyes; Furosemide; In Vitro Techniques; Kinetics; Male; Ouabain; Parotid Gland; Rats; Rats, Inbred Strains; Sodium

1990
Thyrotropin-releasing hormone (TRH) evokes chloride secretion via cholinergic pathways in the guinea-pig ileum.
    European journal of pharmacology, 1989, Jan-24, Volume: 160, Issue:1

    Topics: Animals; Atropine; Bumetanide; Chlorides; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Mecamylamine; Neural Pathways; Parasympathetic Nervous System; Serotonin; Tetrodotoxin; Thyrotropin-Releasing Hormone

1989
Electron probe X-ray microanalysis of cellular ions in the eccrine secretory coil cells during methacholine stimulation.
    The Journal of membrane biology, 1989, Volume: 107, Issue:1

    Topics: Animals; Atropine; Biological Transport; Bumetanide; Calcium; Cell Nucleus; Cytoplasm; Cytoplasmic Granules; Eccrine Glands; Electrolytes; Electron Probe Microanalysis; Macaca mulatta; Methacholine Chloride; Methacholine Compounds; Spectrum Analysis; Sweat; Sweat Glands

1989
Mechanism of chloride secretion induced by carbachol in a colonic epithelial cell line.
    The Journal of clinical investigation, 1986, Volume: 77, Issue:2

    Topics: Alprostadil; Atropine; Barium; Bumetanide; Calcimycin; Calcium; Carbachol; Cell Line; Cell Membrane; Chlorides; Colon; Cyclic AMP; Drug Synergism; Electric Conductivity; Epithelium; Humans; Kinetics; Potassium; Vasoactive Intestinal Peptide

1986
K+ efflux from the monkey eccrine secretory coil during the transient of stimulation with agonists.
    The Journal of physiology, 1988, Volume: 405

    Topics: Animals; Atropine; Bumetanide; Calcimycin; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Macaca mulatta; Methacholine Chloride; Methacholine Compounds; Methods; Ouabain; Phenylephrine; Physostigmine; Potassium; Sweat Glands

1988
Enhanced tissue responsiveness in colonic ion transport of cow's milk-sensitized guinea pigs.
    Agents and actions, 1994, Volume: 41, Issue:1-2

    Topics: Animals; Atropine; Bumetanide; Cattle; Cells, Cultured; Chlorides; Colon; Dicarboxylic Acids; Electric Stimulation; Guinea Pigs; Histamine Release; Immunization; Intestinal Mucosa; Ion Transport; Lactoglobulins; Leukotriene D4; Male; Mast Cells; Milk; Piroxicam; Tetrodotoxin

1994
ICS 205-930 reduces 5-methoxytryptamine-induced short-circuit current in stripped pig jejunum.
    Canadian journal of physiology and pharmacology, 1994, Volume: 72, Issue:3

    Topics: 5-Methoxytryptamine; Animals; Atropine; Bumetanide; Drug Interactions; Electrophysiology; Female; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Indoles; Jejunum; Kinetics; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Swine; Tetrodotoxin; Theophylline; Tropisetron

1994
Furosemide and bumetanide, but not nedocromil sodium, modulate nonadrenergic relaxation in guinea pig trachea in vitro.
    American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:1

    Topics: Animals; Arginine; Atropine; Bumetanide; Chymotrypsin; Drug Therapy, Combination; Electric Stimulation; Female; Furosemide; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Nedocromil; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Premedication; Propranolol; Trachea; Vasoactive Intestinal Peptide

1994
Desensitization and reactivation of ACh-regulated exocrine secretion in hen tracheal epithelium.
    The American journal of physiology, 1993, Volume: 264, Issue:2 Pt 1

    Topics: Acetylcholine; Animals; Atropine; Bumetanide; Chickens; Chlorides; Electric Conductivity; Epithelium; Exocrine Glands; Female; Osmolar Concentration; Signal Transduction; Trachea

1993
Mode of action of ANG II on ion transport in guinea pig distal colon.
    American journal of physiology. Gastrointestinal and liver physiology, 2000, Volume: 278, Issue:4

    Topics: Angiotensin II; Animals; Atropine; Biological Transport; Bumetanide; Chlorides; Colon; Dinoprostone; Electric Conductivity; Guinea Pigs; Hydrazines; Immunohistochemistry; Ions; Male; Neurokinin-1 Receptor Antagonists; Oxazepines; Prostaglandin Antagonists; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrodotoxin

2000
Regulatory volume increase after secretory volume decrease in colonic epithelial cells under muscarinic stimulation.
    Pflugers Archiv : European journal of physiology, 2004, Volume: 448, Issue:6

    Topics: Animals; Atropine; Bumetanide; Calcium; Carbachol; Cell Line; Cell Size; Cells, Cultured; Colon; Egtazic Acid; Epithelial Cells; Female; Guinea Pigs; Humans; Microscopy, Confocal; Muscarinic Agonists; Niflumic Acid; Patch-Clamp Techniques; Sodium-Potassium-Chloride Symporters

2004
Propionate-induced epithelial K(+) and Cl(-)/HCO3(-) secretion and free fatty acid receptor 2 (FFA2, GPR43) expression in the guinea pig distal colon.
    Pflugers Archiv : European journal of physiology, 2011, Volume: 461, Issue:1

    Topics: Animals; Atropine; Bicarbonates; Bumetanide; Capsaicin; Chlorides; Colon; Dioxanes; Enteroendocrine Cells; Fatty Acids, Nonesterified; Granisetron; Guinea Pigs; Hexamethonium; Intestinal Mucosa; Male; omega-Conotoxin GVIA; Piperidines; Potassium; Propionates; Pyridoxal Phosphate; Receptors, G-Protein-Coupled; Serous Membrane; Suramin; Tetrodotoxin

2011