Page last updated: 2024-09-05

atropine and asoxime chloride

atropine has been researched along with asoxime chloride in 110 studies

Compound Research Comparison

Studies (atropine)	Trials (atropine)	Recent Studies (post-2010) (atropine)	Studies (asoxime chloride)	Trials (asoxime chloride)	Recent Studies (post-2010) (asoxime chloride)
26,711	1,259	1,697	398	1	92

Research

Studies (110)

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (14.55)	18.7374
1990's	48 (43.64)	18.2507
2000's	26 (23.64)	29.6817
2010's	20 (18.18)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Jovanović, D; Kovacević, V; Maksimović, M	1
Dochterman, LW; Gresham, VC; Kaminskis, A; Koplovitz, I; Stewart, JR	1
Karlsson, N; Larsson, R; Puu, G	1
Clement, JG	2
Holmstedt, B; Karlén, B; Kimland, M; Nordgren, I; Palmér, L	1
Busker, RW; de Lange, J; Melchers, BP; van der Wiel, HJ; van Helden, HP; Wolthuis, OL	1
Capacio, BR; Koviak, TA; Shih, TM	1
de la Motte, S; Szinicz, L	1
Ligtenstein, DA; Moes, GW	1
Shih, T; Valdes, JJ; Whalley, CE	1
Anderson, DR; Harris, LW; Lennox, WJ; Lieske, CN	1
Brecht, KM; Maxwell, DM	1
Baux, G; Fossier, P; Poulain, B; Tauc, L	1
Shih, TM	1
Joksović, D; Jovanović, D; Randjelović, S	1
Briggs, CJ; Clement, JG; Lee, MJ; Simons, KJ	1
Koplovitz, I; Maxwell, DM	1
Broxup, BR; Hamilton, MG; Hand, BT; Lundy, PM; Yipchuck, G	1
Bosković, B; Krtolica, K; Marinković, S; Poznanović, G; Sevaljević, L	1
Anderson, DR; Harris, LW; Lennox, WJ; Talbot, BG	1
van der Wiel, HJ; Van Helden, HP; Wolthuis, OL	2
Tanasijević, D	1
Arbogast, H; Auburger, G; Hallek, M; Reithmann, C; Szinicz, L	1
Bokonjić, D; Jokanović, M; Jovanović, D; Maksimović, M	1
Anderson, DR; Green, MD; Harris, LW; Lennox, WJ; Talbot, BG	1
Anthony, A; Doebler, JA; Martin, LJ; Shih, TM; Wall, TJ	1
Benschop, HP; Van Helden, HP; Wolthuis, OL	1
Ardab'eva, TV; Khramova, EA; Prozorovskiĭ, VB	1
Bosković, B; Cetković, S; Cosić, M; Cvetković, M; Jandrić, D	1
Bosković, B; Jovanović, D; Kovacević, V	1
Lundy, PM; Shih, TM	1
Clement, JG; Lockwood, PA	1
Dola, T; Lipp, J	1
Koplovitz, I; Young, GD	1
Kleine, A; Szinicz, L; Worek, F	1
Bruijnzeel, PL; Busker, RW; Melchers, BP; van der Laaken, AL; Van Helden, HP	1
Eyer, P; Klimmek, R; Spöhrer, U; Thiermann, H	1
Kirchner, T; Szinicz, L; Worek, F	3
Melchers, BP; Philippens, IH; Wolthuis, OL	1
Bajgar, J; Kassa, J	3
Lau, WM	1
Szinicz, L; Worek, F	2
Koplovitz, I; Stewart, JR	1
Sket, D	1
Bailey, DG; Clement, JG; Madill, HD; Spence, JD; Tran, LT	1
Ivanović-Matić, S; Poznanović, G	1
Cassel, G; Jeneskog, T; Karlsson, L; Larsson, R; Lundström, M; Nyberg, AG; Palmer, L; Persson, SA	1
Cassel, G; Göransson-Nyberg, A; Jeneskog, T; Karlsson, L; Larsson, R; Lundström, M; Persson, SA	1
Busker, RW; Groen, B; Melchers, BP; Philippens, IH; Zijlstra, JJ	1
Eyer, P; Klimmek, R; Radtke, M; Spöhrer, U; Thiermann, H	1
Kassa, J	6
Baubichon, D; Blanchet, G; Brochier, G; Clarencon, D; Galonnier, M; Lallement, G; Mestries, JC	1
Kassa, J; Vachek, J	1
Bielavský, J; Kassa, J	1
Blanchet, G; Carlsson Bratt, I; Clair, P; Granelli, I; Wiberg, K	1
Fusek, J; Kassa, J	1
Cassel, G; Göransson-Nyberg, A	1
Bradamante, V; Domijan, AM; Jukić, I; Lucić, A; Milković-Kraus, S; Peraica, M; Radić, B; Skare, D	1
Kassa, J; Krejcová, G; Vachek, J	2
Kassa, J; Krejèová, G	1
Kassa, J; Krejcová, G; Samnaliev, I	1
Berger, BJ; Davidson, C; Hamilton, MG; Hill, I; Lecavalier, P; Lundy, PM; Vair, C; Weatherby, KL	1
Cassel, G; Svensson, I; Waara, L	1
Go, ML; Loke, WK; Sim, MK	1
Cho, Y; Choi, EK; Huang, ZZ; Hwang, SY; Kang, JK; Kim, JC; Kim, WS; Kim, YB; Nam, SY; Park, SH; Shin, S	1
Aas, P; Enger, S; Myhrer, T	1
Armstrong, S; Mumford, H; Price, M; Scott, L; Wetherell, J	1
Karasova, J; Kassa, J	2
Baille, V; Carpentier, P; Dorandeu, F; Lallement, G; Mikler, J; Sawyer, T; Testylier, G	1
Bajgar, J; Jun, D; Kassa, J; Kuca, K	1
Karasova, J; Kassa, J; Kuca, K; Musilek, K	1
Humlicek, V; Kassa, J	1
Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F	1
Bajgar, J; Karasova, J; Kassa, J; Kuca, K; Musilek, K	1
Joosen, MJ; Jousma, E; Kuijpers, WC; Lucassen, PJ; Smit, AB; van den Boom, TM; van Helden, HP	1
Bajgar, J; Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Tesarova, S	1
Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Tesarova, S	1
Bajgar, J; Capek, L; Fusek, J; Hajek, P; Jun, D; Kassa, J; Krs, O; Kuca, K; Paseka, A; Slizova, D; Zdarova, JK	1
Kassa, J; Kuca, K; Pikula, J; Pohanka, M	1
Bhattacharya, BK; Kumar, S; RamaRao, G; Waghmare, CK	1
Bajgar, J; Kassa, J; Koomlova, M; Musilek, K	1
Bajgar, J; Caisberger, F; Karasova, JZ; Kassa, J; Sepsova, V	1
Cho, Y; Ha, YC; Hur, GH; Kim, WS	1
Kassa, J; Kunesova, G	1
Karasova, JZ; Kassa, J; Misik, J	1
Armstrong, SJ; Docx, CJ; Green, AC; Mumford, H; Price, ME; Tattersall, JE	1
Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Green, CE; Qashu, F; Swezey, R; Yang, C	1
Bykov, VN; Chepur, SV; Nikiforov, AS; Subbotina, SN; Yudin, MA	1
Acharya, J; Afley, P; Bhattacharya, BK; RamaRao, G	1
Horova, A; Kassa, J; Matouskova, L; Musilek, K; Sepsova, V	1
Hamelink, J; Joosen, MJA; Klaassen, SD; van den Berg, RM; Vester, SM	1
Armstrong, SJ; Cook, AR; Emery, E; Flint, D; Mann, T; Price, ME; Rice, H; Roughley, N; Stubbs, S; Tattersall, JEH; Whitmore, C	1
Emery, ER; Green, AC; Laws, TR; Mann, TM; McColm, RR; Perrott, RL; Price, ME; Rice, H; Tattersall, JEH; Whitmore, CL	1
Bird, M; Green, AC; Kassa, J; Tattersall, JEH; Timperley, CM; Williams, RL	1
Cornelissen, AS; Hesseling, P; Joosen, MJA; Klaassen, SD; Lucassen, PJ; Meerhoff, GF; Vester, SM	1
Bokonjić, D; Jokanović, M; Kilibarda, V; Škrbić, R; Stojiljković, MP; Vulović, M	1

Trials

1 trial(s) available for atropine and asoxime chloride

Article	Year
The acetylcholinesterase oxime reactivator HI-6 in man: pharmacokinetics and tolerability in combination with atropine. Biopharmaceutics & drug disposition, 1995, Volume: 16, Issue:5 Topics: Adolescent; Adult; Atropine; Blood Pressure; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Electrocardiography; Glomerular Filtration Rate; Half-Life; Heart Rate; Humans; Injections, Intramuscular; Male; Oximes; Pyridinium Compounds	1995

Article

Year

The acetylcholinesterase oxime reactivator HI-6 in man: pharmacokinetics and tolerability in combination with atropine.

Biopharmaceutics & drug disposition, 1995, Volume: 16, Issue:5

Topics: Adolescent; Adult; Atropine; Blood Pressure; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Electrocardiography; Glomerular Filtration Rate; Half-Life; Heart Rate; Humans; Injections, Intramuscular; Male; Oximes; Pyridinium Compounds

1995

Other Studies

109 other study(ies) available for atropine and asoxime chloride

Article	Year
Pharmacokinetics of the oxime HI-6 from a mixture with atropine sulphate in dogs. Pharmacology & toxicology, 1992, Volume: 71, Issue:5 Topics: Animals; Atropine; Biological Availability; Cholinesterase Reactivators; Dogs; Drug Combinations; Female; Injections, Intramuscular; Male; Oximes; Pyridinium Compounds	1992
Evaluation of the toxicity, pathology, and treatment of cyclohexylmethylphosphonofluoridate (CMPF) poisoning in rhesus monkeys. Archives of toxicology, 1992, Volume: 66, Issue:9 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Lethal Dose 50; Macaca mulatta; Male; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide	1992
Protection of guinea pigs against soman poisoning with ferrocene carbamate. Archives of toxicology, 1992, Volume: 66, Issue:9 Topics: Animals; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Diazepam; Ferrous Compounds; Guinea Pigs; Lethal Dose 50; Male; Metallocenes; Organometallic Compounds; Oximes; Physostigmine; Pyridinium Compounds; Soman	1992
Efficacy of various oximes against GF (cyclohexyl methylphosphonofluoridate) poisoning in mice. Archives of toxicology, 1992, Volume: 66, Issue:2 Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; In Vitro Techniques; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Nervous System Diseases; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds	1992
Intoxications with anticholinesterases: effect of different combinations of antidotes on the dynamics of acetylcholine in mouse brain. Pharmacology & toxicology, 1992, Volume: 70, Issue:5 Pt 1 Topics: Acetylcholine; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Drug Therapy, Combination; Male; Mice; Oximes; Poisoning; Pyridinium Compounds; Soman	1992
Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys. Toxicology and applied pharmacology, 1992, Volume: 115, Issue:1 Topics: Acetylcholinesterase; Animals; Atropine; Brain; Butyrylcholinesterase; Callithrix; Cholinesterase Inhibitors; Cholinesterases; Chromatography, High Pressure Liquid; Diaphragm; Diazepam; Enzyme Activation; Oximes; Poisoning; Pyridinium Compounds; Soman	1992
Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms. Neuroscience and biobehavioral reviews, 1991,Fall, Volume: 15, Issue:3 Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidotes; Atropine; Brain Chemistry; Choline; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Gas Chromatography-Mass Spectrometry; Male; Oximes; Parasympatholytics; Poisoning; Pyridinium Compounds; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Seizures; Soman	1991
Effects of pyridinium, 1-[[(4-carbamoyl-pyridinio) methoxy] methyl]-2-(hydroxyimino-methyl) dichloride monohydrate (HI6) and atropine on the circulation and respiration of anesthetized guinea pigs. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1991, Volume: 14 Topics: Anesthesia; Animals; Antidotes; Atropine; Blood Pressure; Female; Guinea Pigs; Heart Rate; Hemodynamics; Oximes; Pyridinium Compounds; Respiration	1991
The synergism of atropine and the cholinesterase reactivator HI-6 in counteracting lethality by organophosphate intoxication in the rat. Toxicology and applied pharmacology, 1991, Volume: 107, Issue:1 Topics: Animals; Atropine; Cholinesterase Reactivators; Drug Synergism; Lethal Dose 50; Male; Organophosphorus Compounds; Organothiophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Seizures	1991
A comparison of cholinergic effects of HI-6 and pralidoxime-2-chloride (2-PAM) in soman poisoning. Toxicology letters, 1991, Volume: 55, Issue:2 Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Drug Interactions; Lethal Dose 50; Male; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Soman	1991
Evaluation of phosphinates as potential pretreatments for nerve agents. Life sciences, 1991, Volume: 48, Issue:25 Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Reactivators; Evaluation Studies as Topic; Guinea Pigs; Injections, Intramuscular; Lethal Dose 50; Male; Nitrobenzenes; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds	1991
The role of carboxylesterase in species variation of oxime protection against soman. Neuroscience and biobehavioral reviews, 1991,Spring, Volume: 15, Issue:1 Topics: Animals; Atropine; Carboxylic Ester Hydrolases; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Guinea Pigs; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Soman; Species Specificity	1991
Receptor-mediated presynaptic facilitation of quantal release of acetylcholine induced by pralidoxime in Aplysia. Cellular and molecular neurobiology, 1990, Volume: 10, Issue:3 Topics: Acetylcholine; Acetylcholinesterase; Action Potentials; Animals; Aplysia; Atropine; Enzyme Activation; Hemicholinium 3; Neurons; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Receptors, Nicotinic; Secretory Rate; Synapses; Tubocurarine	1990
Anticonvulsant effects of diazepam and MK-801 in soman poisoning. Epilepsy research, 1990, Volume: 7, Issue:2 Topics: Animals; Anticonvulsants; Antidotes; Atropine; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Oximes; Pyridinium Compounds; Rats; Soman	1990
A case of unusual suicidal poisoning by the organophosphorus insecticide dimethoate. Human & experimental toxicology, 1990, Volume: 9, Issue:1 Topics: Adult; Antidotes; Atropine; Diazepam; Dimethoate; Humans; Injections, Subcutaneous; Male; Oximes; Pyridinium Compounds; Suicide	1990
Pharmacokinetics of the acetylcholinesterase oxime reactivator, HI-6, in rhesus monkeys (Macaca mulatta): effect of atropine, diazepam, and methoxyflurane anesthesia. Biopharmaceutics & drug disposition, 1990, Volume: 11, Issue:3 Topics: Anesthesia; Animals; Atropine; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Diazepam; Drug Interactions; Half-Life; Macaca mulatta; Male; Methoxyflurane; Oximes; Pyridinium Compounds	1990
Effect of endogenous carboxylesterase on HI-6 protection against soman toxicity. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:2 Topics: Animals; Antidotes; Atropine; Carboxylesterase; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Guinea Pigs; Injections, Intramuscular; Injections, Subcutaneous; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Oximes; Pyridinium Compounds; Soman; Species Specificity	1990
Distribution of the bispyridinium oxime [14C] HI-6 in male and female rats. Archives of toxicology, 1990, Volume: 64, Issue:5 Topics: Animals; Antidotes; Atropine; Autoradiography; Female; Male; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sex Factors; Soman; Tissue Distribution	1990
Soman intoxication-induced increase in the levels of mRNAs coding for acute phase reactants. Life sciences, 1987, Aug-03, Volume: 41, Issue:5 Topics: Acute-Phase Proteins; Acute-Phase Reaction; Animals; Antidotes; Atropine; Liver; Male; Nucleic Acid Hybridization; Oximes; Protein Biosynthesis; Pyridinium Compounds; Rats; Rats, Inbred Strains; RNA, Messenger; Serum Albumin; Soman; Turpentine	1987
The relationship between oxime-induced reactivation of carbamylated acetylcholinesterase and antidotal efficacy against carbamate intoxication. Toxicology and applied pharmacology, 1989, Mar-15, Volume: 98, Issue:1 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Carbaryl; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Interactions; Erythrocytes; Lethal Dose 50; Male; Oximes; Physostigmine; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains	1989
Prophylactic and therapeutic efficacy of the soman-simulator, pinacolyl dimethylphosphinate. The Journal of pharmacy and pharmacology, 1986, Volume: 38, Issue:6 Topics: Animals; Antidotes; Atropine; Injections, Intravenous; Lethal Dose 50; Male; Neuromuscular Junction; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Synaptic Transmission; Time Factors	1986
[The effect of atropine, Hi-6 and diazepam on the levels and metabolism of monoamines in the brain of rats poisoned with VX]. Godisnjak Vojnomedicinske akademije = Annual of the Military Medical Academy, 1986, Volume: 28 Topics: Animals; Atropine; Caudate Nucleus; Cholinesterase Inhibitors; Diazepam; Neurotransmitter Agents; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Rats	1986
Retention of soman in rats, guinea-pigs and marmosets: species-dependent effects of the soman simulator, pinacolyl dimethylphosphinate (PDP). The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:1 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Callitrichinae; Electrophorus; Female; Guinea Pigs; Male; Muscles; Oximes; Pyridinium Compounds; Soman; Species Specificity	1988
Studies on the role of central catecholaminergic mechanisms in the antidotal effect of the oxime HI 6 in soman poisoned mice. Archives of toxicology, 1988, Volume: 62, Issue:1 Topics: Animals; Antidotes; Atropine; Brain Chemistry; Catecholamines; Cholinesterases; Male; Mice; Mice, Inbred Strains; Motor Activity; Oximes; Pyridinium Compounds; Soman	1988
Protective effects of oximes HI-6 and PAM-2 applied by osmotic minipumps in quinalphos-poisoned rats. Archives internationales de pharmacodynamie et de therapie, 1987, Volume: 288, Issue:2 Topics: Animals; Antidotes; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Diazepam; Insecticides; Lethal Dose 50; Male; Muscles; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats	1987
Oxime-induced decarbamylation and atropine/oxime therapy of guinea pigs intoxicated with pyridostigmine. Life sciences, 1987, Feb-09, Volume: 40, Issue:6 Topics: Acetylcholinesterase; Animals; Atropine; Erythrocytes; Guinea Pigs; Male; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide	1987
Effects of HI-6 on brain neuronal RNA and acetylcholinesterase: metabolic responses during acute soman intoxication. Toxicology, 1984, Volume: 33, Issue:3-4 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cerebral Cortex; Cholinesterases; Corpus Striatum; Drug Interactions; Male; Neurons; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; RNA; Soman	1984
New simulators in the prophylaxis against soman poisoning: structural specificity for the depot site(s). The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:5 Topics: Animals; Antidotes; Atropine; Chemical Phenomena; Chemistry, Physical; Male; Neuromuscular Junction; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Soman; Structure-Activity Relationship; Synaptic Transmission	1984
[Trial of cholinesterase reactivators as proserine antagonists]. Biulleten' eksperimental'noi biologii i meditsiny, 1983, Volume: 96, Issue:10 Topics: Animals; Antidotes; Atropine; Butanones; Cholinesterase Reactivators; Diphenylacetic Acids; Drug Synergism; Male; Mice; Neostigmine; Obidoxime Chloride; Oximes; Parasympatholytics; Pralidoxime Compounds; Pyridinium Compounds; Trimedoxime	1983
Effect of PAM-2 Cl, HI-6, and HGG-12 in poisoning by tabun and its thiocholine-like analog in the rat. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:2 Pt 2 Topics: Animals; Atropine; Choline; Cholinesterase Reactivators; Cholinesterases; Female; Guinea Pigs; Heart; Humans; Lethal Dose 50; Male; Muscle Contraction; Muscle, Smooth; Organophosphate Poisoning; Organophosphates; Oximes; Phrenic Nerve; Pralidoxime Compounds; Pyridinium Compounds; Rats; Thiocholine	1984
PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:2 Pt 2 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Dogs; Guinea Pigs; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Soman; Species Specificity	1984
Examination of the role of central cholinergic mechanisms in the therapeutic effects of HI-6 in organophosphate poisoning. Journal of neurochemistry, 1983, Volume: 40, Issue:5 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Injections, Intraventricular; Lethal Dose 50; Male; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin; Soman	1983
HI-6, an oxime which is an effective antidote of soman poisoning: a structure-activity study. Toxicology and applied pharmacology, 1982, Jun-15, Volume: 64, Issue:1 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterases; Male; Mice; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Soman; Structure-Activity Relationship	1982
comparison of the efficacy of HS-6 versus HI-6 when combined with atropine, pyridostigmine and clonazepam for soman poisoning in the monkey. Archives internationales de pharmacodynamie et de therapie, 1980, Volume: 246, Issue:1 Topics: Animals; Atropine; Cholinesterases; Clonazepam; Electroencephalography; Female; Heart Rate; Macaca mulatta; Male; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Respiration; Soman	1980
Acute toxicity of cyclohexylmethylphosphonofluoridate (CMPF) in rhesus monkeys: serum biochemical and hematologic changes. Archives of toxicology, 1995, Volume: 69, Issue:6 Topics: Alanine Transaminase; Animals; Antidotes; Aspartate Aminotransferases; Atropine; Biomarkers; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Creatine Kinase; Injections, Intramuscular; L-Lactate Dehydrogenase; Lethal Dose 50; Macaca mulatta; Male; Organophosphorus Compounds; Oximes; Potassium; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Seizures	1995
Effect of pyridostigmine pretreatment on cardiorespiratory function in tabun poisoning. Human & experimental toxicology, 1995, Volume: 14, Issue:8 Topics: Animals; Atropine; Blood Pressure; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Heart Rate; Hemodynamics; Injections, Intravenous; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Pyridostigmine Bromide; Respiration	1995
Non-reactivating effects of HI-6 on hippocampal neurotransmission. Archives of toxicology, 1994, Volume: 69, Issue:2 Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Hippocampus; Organothiophosphorus Compounds; Oximes; Picrotoxin; Pyridinium Compounds; Rats; Rats, Wistar; Synaptic Transmission	1994
Pharmacokinetics of the oximes HI 6 and HLö 7 in dogs after i.m. injection with newly developed dry/wet autoinjectors. Archives of toxicology, 1994, Volume: 68, Issue:8 Topics: Animals; Antidotes; Atropine; Biological Availability; Cholinesterase Reactivators; Dogs; Hematocrit; Injections, Intramuscular; Male; Oximes; Pyridines; Pyridinium Compounds; Software	1994
Effect of atropine and bispyridinium oximes on respiratory and circulatory function in guinea-pigs poisoned by sarin. Toxicology, 1995, Jan-06, Volume: 95, Issue:1-3 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Blood Pressure; Cholinesterase Reactivators; Drug Therapy, Combination; Female; Guinea Pigs; Heart Rate; Oximes; Poisoning; Pyridines; Pyridinium Compounds; Respiration; Sarin	1995
Effect of atropine, HLö 7 and HI 6 on respiratory and circulatory function in guinea-pigs poisoned by O-ethyl S-[2-(diisopropylamino) ethyl] methylphosponothioate (VX). Pharmacology & toxicology, 1994, Volume: 75, Issue:5 Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Combinations; Erythrocytes; Female; Guinea Pigs; Hemodynamics; Organothiophosphorus Compounds; Oximes; Poisoning; Pyridines; Pyridinium Compounds; Respiration	1994
Efficacy of HI-6 and HLö-7 in preventing incapacitation following nerve agent poisoning. Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:4 Topics: Animals; Atropine; Behavior, Animal; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Conditioning, Operant; Electroencephalography; Guinea Pigs; Lethal Dose 50; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Respiratory Mechanics; Soman	1994
[Comparison of the effect of selected anticholinergic agents on cholinergic and noncholinergic effects of GV substances during acute poisoning in rats]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 1994, Volume: 43, Issue:5 Topics: Acute Disease; Animals; Atropine; Benactyzine; Cholinergic Antagonists; Cholinesterase Reactivators; Cholinesterases; Male; Organophosphorus Compounds; Oximes; Piperidines; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Tyrosine Transaminase	1994
Treatment of tabun poisoned guinea-pigs with atropine, HLö 7 or HI 6: effect on respiratory and circulatory function. Archives of toxicology, 1994, Volume: 68, Issue:4 Topics: Animals; Atropine; Blood Circulation; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Respiration	1994
Protection by tacrine and some adjuncts against the depressant effects of soman in guinea-pig atrium. General pharmacology, 1993, Volume: 24, Issue:6 Topics: Animals; Atropine; Cholinesterase Reactivators; Female; Glycopyrrolate; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Oximes; Parasympatholytics; Pyridinium Compounds; Soman; Tacrine	1993
Investigation of acute cardiovascular and respiratory toxicity of HLö 7 dimethanesulfonate and HI 6 dichloride in anaesthetized guinea-pigs. Pharmacology & toxicology, 1993, Volume: 73, Issue:2 Topics: Acetylcholinesterase; Anesthesia; Animals; Atropine; Blood Pressure; Cardiovascular Diseases; Cardiovascular System; Cholinesterase Reactivators; Female; Guinea Pigs; Heart Rate; Oximes; Pyridines; Pyridinium Compounds; Respiration Disorders; Respiratory System	1993
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit. Toxicology letters, 1994, Feb-15, Volume: 70, Issue:3 Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms	1994
Atropine and oxime treatment in lethal soman poisoning of anaesthetized guinea-pigs: HLö 7 dimethanesulfonate versus HI 6 dichloride. Pharmacology & toxicology, 1993, Volume: 72, Issue:1 Topics: Acetylcholinesterase; Anesthesia; Animals; Antidotes; Atropine; Cholinesterase Reactivators; Disease Models, Animal; Drug Therapy, Combination; Erythrocytes; Female; Guinea Pigs; Hemodynamics; Oximes; Poisoning; Pyridines; Pyridinium Compounds; Respiration; Soman	1993
Efficacy of antidotes against soman poisoning in female physostigmine-protected rats. Pharmacology & toxicology, 1993, Volume: 72, Issue:1 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Diazepam; Drug Therapy, Combination; Female; Muscles; Oximes; Physostigmine; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Soman	1993
Pharmacological nature of soman-induced hypothermia in mice. Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:3 Topics: Acetylcholinesterase; Animals; Atropine; Body Temperature; Cholinesterase Inhibitors; Cholinesterase Reactivators; Hypothalamus; Hypothermia; Male; Mecamylamine; Mice; Nicotine; Obidoxime Chloride; Oximes; Oxotremorine; Physostigmine; Pyridinium Compounds; Soman	1993
HI-6 therapy and the acute phase response in the rat. Toxicology, 1996, Jan-08, Volume: 106, Issue:1-3 Topics: Acute-Phase Proteins; Acute-Phase Reaction; Animals; Antidotes; Atropine; Blood Proteins; Blotting, Northern; Corticosterone; Immunoelectrophoresis; Injections, Intraperitoneal; Liver; Male; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; RNA, Messenger; Soman; Turpentine	1996
Pharmacokinetics of HI-6 and atropine in anaesthetized pigs after administration by a new autoinjector. Biopharmaceutics & drug disposition, 1995, Volume: 16, Issue:8 Topics: Acetylcholinesterase; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Antidotes; Atropine; Blood Pressure; Cholinesterase Reactivators; Electrocardiography; Heart Rate; Injections, Intramuscular; Injections, Intravenous; Injections, Jet; Male; Oximes; Pyridinium Compounds; Swine	1995
Comparison of the efficacy of HI-6 and obidoxime against cyclohexyl methylphosphonofluoridate (GF) in rats. Human & experimental toxicology, 1995, Volume: 14, Issue:11 Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Corticosterone; Diaphragm; Drug Interactions; Liver; Male; Obidoxime Chloride; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Tyrosine Transaminase	1995
[Comparison of the therapeutic effectiveness of selected cholinesterase reactivators with atropine in acute fosdrine poisoning in mice]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 1996, Volume: 45, Issue:1 Topics: Acute Disease; Animals; Atropine; Cholinesterase Reactivators; Insecticides; Male; Mevinphos; Mice; Obidoxime Chloride; Oximes; Poisoning; Pyridinium Compounds	1996
Treatment of organophosphate poisoning in pigs: antidote administration by a new binary autoinjector. Archives of toxicology, 1995, Volume: 70, Issue:1 Topics: Animals; Antidotes; Atropine; Drug Combinations; Injections, Intramuscular; Injections, Jet; Male; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Soman; Swine	1995
Comparison of the efficacy of single or repeated HI-6 treatment following soman poisoning in guinea pigs and marmoset monkeys. Toxicology, 1996, Sep-02, Volume: 112, Issue:3 Topics: Animals; Antidotes; Area Under Curve; Atropine; Avoidance Learning; Behavior, Animal; Callithrix; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Electroencephalography; Female; Guinea Pigs; Half-Life; Injections, Intramuscular; Injections, Subcutaneous; Lethal Dose 50; Male; Muscarinic Antagonists; Neurophysiology; Oximes; Pyridinium Compounds; Soman	1996
Pharmacokinetics of atropine in dogs after i.m. injection with newly developed dry/wet combination autoinjectors containing HI 6 or HLö 7. Archives of toxicology, 1996, Volume: 70, Issue:5 Topics: Animals; Atropine; Binding, Competitive; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Dogs; Drug Combinations; Half-Life; Injections, Intramuscular; Male; Muscarinic Antagonists; Oximes; Pyridines; Pyridinium Compounds; Radioligand Assay; Rats; Rats, Sprague-Dawley	1996
Importance of cholinolytic drug selection for the efficacy of HI-6 against soman in rats. Toxicology, 1997, Jan-15, Volume: 116, Issue:1-3 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Benactyzine; Biperiden; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Corticosterone; Diaphragm; Drug Interactions; Liver; Male; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Stress, Physiological; Tyrosine Transaminase	1997
Efficacy of atropine/pralidoxime/diazepam or atropine/HI-6/prodiazepam in primates intoxicated by soman. Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:2 Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Diazepam; Dipeptides; Drug Therapy, Combination; Electrocardiography; Electroencephalography; Macaca fascicularis; Male; Oximes; Poisoning; Pralidoxime Compounds; Prodrugs; Pyridinium Compounds; Soman	1997
[The effect of parasympatholytics on the therapeutic effectiveness of the oxime HI-6 against organophosphorus compounds (Soman, substance VX, Fosdrin) in mice]. Casopis lekaru ceskych, 1997, Feb-12, Volume: 136, Issue:4 Topics: Animals; Antidotes; Atropine; Benactyzine; Biperiden; Cholinesterase Reactivators; Male; Mevinphos; Mice; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Parasympatholytics; Pyridinium Compounds; Soman	1997
The efficacy of monopyridinium (2-PAAM, 2-PAEM) and bispyridinium (obidoxime, HI-6) oximes against mevinphos in mice. Pharmacology & toxicology, 1997, Volume: 81, Issue:3 Topics: Animals; Atropine; Cholinesterase Reactivators; Insecticides; Lethal Dose 50; Male; Mevinphos; Mice; Muscarinic Antagonists; Obidoxime Chloride; Oximes; Pyridinium Compounds; Structure-Activity Relationship	1997
[The effect of pharmacologic prophylaxis with Panpal on acetylcholinesterase activity in the diaphragm and various parts of the brain in rats during treated and untreated Soman poisoning]. Casopis lekaru ceskych, 1998, May-18, Volume: 137, Issue:10 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Benactyzine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Drug Combinations; Male; Oximes; Poisoning; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Wistar; Soman; Trihexyphenidyl	1998
A comparison of the efficacy of new asymmetric bispyridinium oxime BI-6 with other oximes (obidoxime, HI-6) against soman in rats. Human & experimental toxicology, 1998, Volume: 17, Issue:6 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Diaphragm; Drug Therapy, Combination; Liver; Male; Obidoxime Chloride; Oximes; Poisoning; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Tyrosine Transaminase	1998
[Comparison of the effects of BI-6, a new asymmetric bipyridine oxime, with HI-6 oxime and obidoxime in combination with atropine on soman and fosdrine toxicity in mice]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 1999, Volume: 48, Issue:1 Topics: Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Insecticides; Male; Mevinphos; Mice; Mice, Inbred Strains; Obidoxime Chloride; Oximes; Pyridinium Compounds; Soman	1999
Stability study of a new antidote drug combination (Atropine-HI-6-Prodiazepam) for treatment of organophosphate poisoning. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2000, Volume: 9, Issue:3 Topics: Antidotes; Atropine; Cholinergic Antagonists; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Diazepam; Dipeptides; Drug Combinations; Drug Stability; Organophosphate Poisoning; Oximes; Prodrugs; Pyridinium Compounds	2000
[The effect of panpal prophylaxis on acetylcholinesterase activity in the blood, diaphragm and various parts of the brain in rats during treated and untreated poisoning with the organophosphorus insecticide phosdrine]]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2000, Volume: 49, Issue:1 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Benactyzine; Brain; Cholinesterase Reactivators; Diaphragm; Drug Combinations; Insecticides; Male; Mevinphos; Oximes; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Wistar; Trihexyphenidyl	2000
The influence of anticholinergic drug selection on the efficacy of antidotal treatment of soman-poisoned rats. Toxicology, 2000, Nov-23, Volume: 154, Issue:1-3 Topics: Animals; Antidotes; Atropine; Benactyzine; Biperiden; Blood Pressure; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Electrocardiography; Heart Rate; Male; Muscarinic Antagonists; Oximes; Pyridinium Compounds; Rats; Scopolamine; Soman	2000
[Effect of diazepam on the effectiveness of antidote therapy in eliminating the acute lethal effects of soman in mice]. Casopis lekaru ceskych, 2001, Volume: 140, Issue:16 Topics: Acute Disease; Animals; Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Male; Mice; Mice, Inbred Strains; Oximes; Poisoning; Pyridinium Compounds; Soman	2001
Cardiopulmonary effects of HI-6 treatment in soman intoxication. Journal of applied toxicology : JAT, 2001, Volume: 21 Suppl 1 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Blood Pressure; Chemical Warfare Agents; Muscarinic Antagonists; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Regional Blood Flow; Respiration; Soman	2001
Adamantyl tenocyclidines--adjuvant therapy in poisoning with organophosphorus compounds and carbamates. Archives of toxicology, 2002, Volume: 76, Issue:3 Topics: Adamantane; Animals; Antidotes; Atropine; Carbamates; Cholinesterase Reactivators; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Mice, Inbred CBA; Organophosphate Poisoning; Oximes; Poisoning; Pyridinium Compounds	2002
Effect of atropine and the oxime HI-6 on low-level sarin-induced alteration of performance of rats in a T-maze. Acta medica (Hradec Kralove), 2002, Volume: 45, Issue:3 Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Maze Learning; Muscarinic Antagonists; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Sarin	2002
The impairment of spatial memory following low-level sarin inhalation exposure and antidotal treatment in rats. Acta medica (Hradec Kralove), 2002, Volume: 45, Issue:4 Topics: Administration, Inhalation; Animals; Antidotes; Atropine; Male; Maze Learning; Memory; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Sarin	2002
Neuroprotective effects of currently used antidotes in tabun-poisoned rats. Pharmacology & toxicology, 2003, Volume: 92, Issue:6 Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Motor Activity; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar	2003
A comparison of the neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in soman-poisoned rats. Acta medica (Hradec Kralove), 2003, Volume: 46, Issue:3 Topics: Animals; Antidotes; Atropine; Benactyzine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Combinations; Drug Therapy, Combination; Male; Neuroprotective Agents; Oximes; Premedication; Pyridinium Compounds; Pyridostigmine Bromide; Rats; Rats, Wistar; Soman; Trihexyphenidyl	2003
The pharmacokinetics and pharmacodynamics of two HI-6 salts in swine and efficacy in the treatment of GF and soman poisoning. Toxicology, 2005, Mar-30, Volume: 208, Issue:3 Topics: Animals; Atropine; Chemical Warfare Agents; Dose-Response Relationship, Drug; Guinea Pigs; Male; Neuroprotective Agents; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Soman; Swine; Time Factors	2005
Effects of HI 6, diazepam and atropine on soman-induced IL-1 beta protein in rat brain. Neurotoxicology, 2005, Volume: 26, Issue:2 Topics: Animals; Atropine; Brain; Diazepam; Drug Therapy, Combination; Electroencephalography; Interleukin-1; Male; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Soman	2005
Novel neuroprotective effects with O-benzyl derivative of pralidoxime in soman-intoxicated rodents. European journal of pharmacology, 2005, Oct-03, Volume: 521, Issue:1-3 Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Analysis of Variance; Animals; Anticonvulsants; Atropine; Benzene Derivatives; Cholinesterase Inhibitors; Cholinesterase Reactivators; Corpus Striatum; Dopamine; Drug Synergism; Electroencephalography; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Mice; Microdialysis; Neuroprotective Agents; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Serotonin; Soman; Survival Rate; Time Factors	2005
Protection by a transdermal patch containing physostigmine and procyclidine of soman poisoning in dogs. European journal of pharmacology, 2005, Nov-21, Volume: 525, Issue:1-3 Topics: Administration, Cutaneous; Animals; Atropine; Cholinesterase Inhibitors; Dogs; Female; Muscarinic Antagonists; Neuroprotective Agents; Oximes; Physostigmine; Procyclidine; Pyridinium Compounds; Soman	2005
Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats. Basic & clinical pharmacology & toxicology, 2006, Volume: 98, Issue:2 Topics: Animals; Anticonvulsants; Atropine; Brain; Diazepam; Dipeptides; Drug Combinations; Lethal Dose 50; Male; Oximes; Pentobarbital; Procyclidine; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Soman	2006
Development of next generation medical countermeasures to nerve agent poisoning. Toxicology, 2007, Apr-20, Volume: 233, Issue:1-3 Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Dipeptides; Disease Models, Animal; Drug Therapy, Combination; Guinea Pigs; Ileal Diseases; Intussusception; Lethal Dose 50; Male; Neurotoxicity Syndromes; Oximes; Physostigmine; Pyridinium Compounds; Scopolamine Derivatives; Soman; Time Factors	2007
A comparison of the potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, HI-6) to counteract tabun-induced neurotoxicity in rats. Toxicology, 2007, Jan-05, Volume: 229, Issue:1-2 Topics: Animals; Antidotes; Atropine; Behavior, Animal; Butanes; Chemical Warfare Agents; Cholinergic Antagonists; Dose-Response Relationship, Drug; Injections, Intramuscular; Lacrimal Apparatus; Male; Miosis; Molecular Structure; Muscle Tonus; Neurotoxicity Syndromes; Obidoxime Chloride; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Tears; Time Factors; Toxicity Tests; Treatment Outcome	2007
Protective effects of S+ ketamine and atropine against lethality and brain damage during soman-induced status epilepticus in guinea-pigs. Toxicology, 2007, May-20, Volume: 234, Issue:3 Topics: Animals; Atropine; Brain Damage, Chronic; Cholinesterase Inhibitors; Excitatory Amino Acid Antagonists; Guinea Pigs; Ketamine; Lethal Dose 50; Male; Muscarinic Antagonists; Oximes; Pyridinium Compounds; Soman; Status Epilepticus; Stereoisomerism	2007
A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) to counteract soman-induced neurotoxicity in rats. Drug and chemical toxicology, 2007, Volume: 30, Issue:2 Topics: Animals; Antidotes; Atropine; Autonomic Nervous System; Behavior, Animal; Butanes; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Motor Activity; Neuroprotective Agents; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Structure-Activity Relationship	2007
Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats. Basic & clinical pharmacology & toxicology, 2007, Volume: 101, Issue:5 Topics: Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Lethal Dose 50; Male; Muscarinic Antagonists; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Soman	2007
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology, 2008, Jan-20, Volume: 243, Issue:3 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Injections, Intramuscular; Lethal Dose 50; Male; Mice; Molecular Structure; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Species Specificity; Toxicity Tests, Acute; Trimedoxime	2008
A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, trimedoxime, HI-6) to counteract acute toxic effects of tabun and cyclosarin in mice. Drug and chemical toxicology, 2008, Volume: 31, Issue:1 Topics: Animals; Antidotes; Atropine; Butanes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Poisoning; Pyridinium Compounds; Trimedoxime	2008
A structure-activity analysis of the variation in oxime efficacy against nerve agents. Toxicology and applied pharmacology, 2008, Sep-01, Volume: 231, Issue:2 Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship	2008
An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice. Clinical toxicology (Philadelphia, Pa.), 2009, Volume: 47, Issue:1 Topics: Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Diaphragm; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Molecular Structure; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Treatment Outcome	2009
Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning. Neurotoxicology, 2009, Volume: 30, Issue:1 Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Benzodiazepines; Cholinesterase Reactivators; Corpus Striatum; Doublecortin Protein; Hippocampus; Male; Maze Learning; Neurogenesis; Olanzapine; Oximes; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Seizures; Soman	2009
Evaluation of the neuroprotective efficacy of newly developed oximes (K206, K269) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats. Basic & clinical pharmacology & toxicology, 2009, Volume: 104, Issue:3 Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Muscarinic Antagonists; Neuroprotective Agents; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar	2009
A comparison of the ability of newly-developed bispyridinium oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) to counteract the acute neurotoxicity of soman in rats. Toxicology mechanisms and methods, 2010, Volume: 20, Issue:8 Topics: Animals; Atropine; Behavior, Animal; Chemical Warfare Agents; Drug Therapy, Combination; Male; Motor Activity; Neuroprotective Agents; Neurotoxicity Syndromes; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman	2010
A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques. Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:6 Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Frontal Lobe; GPI-Linked Proteins; Lethal Dose 50; Obidoxime Chloride; Organ Specificity; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Reticular Formation	2010
Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model. Bratislavske lekarske listy, 2011, Volume: 112, Issue:10 Topics: Animals; Antidotes; Atropine; Biomarkers; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Trimedoxime	2011
Gene expression and phosphoprotein profile of certain key neuronal signaling proteins following soman intoxication. Toxicology, 2011, Dec-18, Volume: 290, Issue:2-3 Topics: Acetylcholinesterase; Animals; Atropine; Cerebellum; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Drug Therapy, Combination; Gene Expression Regulation; Hippocampus; Olfactory Pathways; Oximes; Phosphorylation; Polymerase Chain Reaction; Pyridinium Compounds; Rats; Rats, Wistar; Soman	2011
A comparison of the efficacy of newly developed reversible inhibitors of acetylcholinesterase with commonly used pyridostigmine as pharmacological pre-treatment of soman-poisoned mice. Basic & clinical pharmacology & toxicology, 2012, Volume: 110, Issue:4 Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Isoquinolines; Lethal Dose 50; Male; Mice; Oximes; Pyridinium Compounds; Pyridostigmine Bromide; Soman	2012
A comparison of the reactivating and therapeutic efficacy of chosen combinations of oximes with individual oximes against VX in rats and mice. International journal of toxicology, 2011, Volume: 30, Issue:5 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Lethal Dose 50; Male; Mice; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime	2011
Minimum effective drug concentrations of a transdermal patch system containing procyclidine and physostigmine for prophylaxis against soman poisoning in rhesus monkeys. Environmental toxicology and pharmacology, 2012, Volume: 33, Issue:1 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Lethal Dose 50; Macaca mulatta; Male; Muscarinic Antagonists; Oximes; Physostigmine; Poisoning; Procyclidine; Pyridinium Compounds; Soman; Transdermal Patch	2012
The benefit of combination of oximes for the neuroprotective efficacy of antidotal treatment of sarin-poisoned rats. Toxicology mechanisms and methods, 2012, Volume: 22, Issue:4 Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Molecular Structure; Neuroprotective Agents; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Trimedoxime	2012
A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats. Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:5 Topics: Animals; Antidotes; Atropine; Autonomic Nervous System; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Czech Republic; Drug Therapy, Combination; Lethal Dose 50; Male; Muscarinic Antagonists; Neurons; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Psychomotor Performance; Pyridinium Compounds; Rats; Rats, Wistar; Sarin	2012
Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning. Chemico-biological interactions, 2013, Mar-25, Volume: 203, Issue:1 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Reactivators; Diazepam; Guinea Pigs; Humans; Injections, Intramuscular; Male; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds	2013
Efficacy of the GluK1/AMPA receptor antagonist LY293558 against seizures and neuropathology in a soman-exposure model without pretreatment and its pharmacokinetics after intramuscular administration. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:1 Topics: Animals; Anticonvulsants; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Electroencephalography; Fluoresceins; Fluorescent Dyes; Injections, Intramuscular; Isoquinolines; Male; Muscarinic Antagonists; Nerve Degeneration; Oximes; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Soman; Tetrazoles; Tissue Fixation	2013
Prospects of using benzodiazepines in complex therapy of poisonings with anticholinesterase agents. Bulletin of experimental biology and medicine, 2013, Volume: 155, Issue:3 Topics: Animals; Atropine; Benzodiazepines; Cholinesterase Inhibitors; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Injections, Intramuscular; Male; Mice; Midazolam; Oximes; Pyridinium Compounds; Statistics, Nonparametric; Toxicity Tests	2013
Efficacy of antidotes (midazolam, atropine and HI-6) on nerve agent induced molecular and neuropathological changes. BMC neuroscience, 2014, Apr-04, Volume: 15 Topics: Animals; Antidotes; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; GABA Modulators; Male; Midazolam; Muscarinic Antagonists; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Soman; Survival Rate; Treatment Outcome	2014
A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice. Toxicology mechanisms and methods, 2015, Volume: 25, Issue:3 Topics: Acetylcholinesterase; Animals; Animals, Outbred Strains; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Mice; Muscarinic Antagonists; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats, Wistar; Sarin	2015
Increasing nerve agent treatment efficacy by P-glycoprotein inhibition. Chemico-biological interactions, 2016, Nov-25, Volume: 259, Issue:Pt B Topics: Acetylcholinesterase; Animals; ATP Binding Cassette Transporter, Subfamily B; Atropine; Blood-Brain Barrier; Brain; Dogs; Madin Darby Canine Kidney Cells; Male; Nerve Agents; Oximes; Pyridinium Compounds; Quinolines; Rats; Rats, Wistar; Seizures; Soman; Substrate Specificity	2016
The efficacy of HI-6 DMS in a sustained infusion against percutaneous VX poisoning in the guinea-pig. Toxicology letters, 2018, Sep-01, Volume: 293 Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Guinea Pigs; Infusions, Intravenous; Male; Muscarinic Antagonists; Nerve Agents; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Survival Analysis	2018
Bioscavenger is effective as a delayed therapeutic intervention following percutaneous VX poisoning in the guinea-pig. Toxicology letters, 2018, Sep-01, Volume: 293 Topics: Administration, Cutaneous; Animals; Antidotes; Atropine; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Reactivators; Cholinesterases; Dipeptides; Guinea Pigs; Male; Muscarinic Antagonists; Nerve Agents; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Time-to-Treatment; Toxicokinetics	2018
Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice. Toxicology, 2018, 09-01, Volume: 408 Topics: Animals; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Time Factors	2018
Potentiation of antiseizure and neuroprotective efficacy of standard nerve agent treatment by addition of tariquidar. Neurotoxicology, 2018, Volume: 68 Topics: Animals; Anticonvulsants; Astrocytes; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; Diazepam; Male; Microglia; Neurons; Neuroprotective Agents; Oximes; Pyridinium Compounds; Quinolines; Rats, Wistar; Seizures; Soman	2018
Prophylactic potential of memantine against soman poisoning in rats. Toxicology, 2019, 03-15, Volume: 416 Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Behavior, Animal; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; GPI-Linked Proteins; Male; Memantine; Neuromuscular Junction; Organophosphate Poisoning; Oximes; Pyridinium Compounds; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Soman; Synaptic Transmission	2019