Compounds > atropine
Page last updated: 2024-09-05

atropine and amoxapine

atropine has been researched along with amoxapine in 6 studies

Compound Research Comparison

Studies
(atropine)		Trials
(atropine)		Recent Studies (post-2010)
(atropine)		Studies
(amoxapine)		Trials
(amoxapine)		Recent Studies (post-2010) (amoxapine)
26,7111,2591,6973925052

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)amoxapine (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.0038
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.013
Muscarinic acetylcholine receptor M2Homo sapiens (human)2.623
Muscarinic acetylcholine receptor M4Homo sapiens (human)1.737
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.856
Alpha-2A adrenergic receptorHomo sapiens (human)1.314
Cytochrome P450 2D6Homo sapiens (human)10
Muscarinic acetylcholine receptor M1Homo sapiens (human)1.192
D(2) dopamine receptorHomo sapiens (human)0.2
Alpha-2B adrenergic receptorHomo sapiens (human)0.558
Alpha-2C adrenergic receptorHomo sapiens (human)3.174
Muscarinic acetylcholine receptor M3Homo sapiens (human)1.781
D(1A) dopamine receptorHomo sapiens (human)0.392
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.013
Alpha-1D adrenergic receptorHomo sapiens (human)0.306
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.0016
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.0038
Sodium-dependent serotonin transporterHomo sapiens (human)0.034
Histamine H1 receptorHomo sapiens (human)0.099
D(3) dopamine receptorHomo sapiens (human)0.134
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.01
5-hydroxytryptamine receptor 6Homo sapiens (human)0.076

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's5 (83.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ahman, M; Holmén, AG; Wan, H1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1

Reviews

1 review(s) available for atropine and amoxapine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

5 other study(ies) available for atropine and amoxapine

ArticleYear
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016