Page last updated: 2024-09-05

atropine and amitriptyline

atropine has been researched along with amitriptyline in 76 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(amitriptyline)
Trials
(amitriptyline)
Recent Studies (post-2010) (amitriptyline)
26,7111,2591,6976,9351,3811,060

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)amitriptyline (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.006
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.023
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.081
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.0053
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.3
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.3
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.3
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.044
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.3
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.008
Alpha-2A adrenergic receptorHomo sapiens (human)0.1755
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.3
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.011
D(2) dopamine receptorHomo sapiens (human)1.009
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.044
Alpha-2B adrenergic receptorHomo sapiens (human)0.004
Alpha-2C adrenergic receptorHomo sapiens (human)0.0295
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.02
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.026
D(1A) dopamine receptorHomo sapiens (human)0.355
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.0324
Histamine H2 receptorHomo sapiens (human)0.73
Alpha-1D adrenergic receptorHomo sapiens (human)0.105
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.015
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.006
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)1.02
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 6Rattus norvegicus (Norway rat)0.044
Sodium-dependent serotonin transporterHomo sapiens (human)0.2756
5-hydroxytryptamine receptor 7 Rattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 5ARattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 5BRattus norvegicus (Norway rat)0.044
Histamine H1 receptorHomo sapiens (human)0.0048
D(3) dopamine receptorHomo sapiens (human)0.182
5-hydroxytryptamine receptor 3ARattus norvegicus (Norway rat)0.044
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.07
Histamine H2 receptorCavia porcellus (domestic guinea pig)0.66
5-hydroxytryptamine receptor 6Homo sapiens (human)0.14
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)7.2446
Sodium channel protein type 5 subunit alphaHomo sapiens (human)1.6
Sodium channel protein type 9 subunit alphaHomo sapiens (human)4
5-hydroxytryptamine receptor 4 Rattus norvegicus (Norway rat)0.044
Sodium channel protein type 2 subunit alphaHomo sapiens (human)3.1
Sigma non-opioid intracellular receptor 1Homo sapiens (human)1.031
5-hydroxytryptamine receptor 3BRattus norvegicus (Norway rat)0.044

Research

Studies (76)

TimeframeStudies, this research(%)All Research%
pre-199052 (68.42)18.7374
1990's4 (5.26)18.2507
2000's10 (13.16)29.6817
2010's10 (13.16)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Andrews, PR; Craik, DJ; Martin, JL1
Booth, RG; Brown, RL; Bucholtz, EC; Tropsha, A; Wyrick, SD1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Richelson, E1
Chai, CY; Cheng, JT; Chung, PM; Lee, HK; Wayner, MJ1
Hughes, IE1
Banaszkiewicz, W; Grzymislawska, I; Mrozikiewica, A1
Dissing, S; Hansen, HJ; Nauntofte, B; Undén, M1
Kiselman, IM; Levin, SL1
Anderson, DJ; el-Fakahany, EE; Lee, NH; McKinney, M; Vella-Rountree, L1
Kaada, B1
Akah, PA1
Aaltonen, L; Iisalo, E; Peltomäki, T; Syvälahti, E1
Foote, W; Stevens, J; Wilson, K1
Hansen, V; Hjortkjaer, J; Holmblad, J; Hougs, W; Huld, T; Jorgensen, A; Lassen, N; Nielsen, IM; Nymark, M; Pedersen, V; Petersen, PV1
Greengard, P; Quinn, GP; Reid, MB1
Hartmann, E1
Berry, WK; Davies, DR; Gordon, JJ1
Gyermek, L; Hill, RT; Sigg, EB1
Brittain, RT1
Garattini, S; Jori, A; Paglialunga, S1
Baum, T; Gluckman, MI1
Karlén, B; Sjöqvist, F; Träskman, L1
Kamei, C; Shimomura, K; Ueki, S1
Nymark, M1
Lauer, RM; Mueller, S; Roberts, RJ1
Lapin, IP; Samsonova, ML1
Bazhin, EF; Rafalovich, EG1
Gomez, J1
Atkinson, J; Ladinsky, H1
Consolo, S; Ladinsky, H1
Florio, V; Longo, VG1
Gröningsson, K; Schill, G1
Jones, BJ; Roberts, DJ; Tolman, BD1
Senault, B1
Zetler, G1
Vaillant, GE1
Everett, GM; Plotnikoff, N1
Da Vanzo, JP; Daugherty, M; Kang, L; Ruckart, R1
Nymark, M; Rasmussen, J1
Bhargava, KP; Gupta, ML; Gupta, TK1
Doggrell, SA; Vincent, L1
Hara, C; Ueki, S; Watanabe, S1
Brightman, VJ; Christensen, CM; Navazesh, M1
Clark, HB; Hartman, BK; Preskorn, SH; Raichle, ME; Swanson, LW1
Hartman, BK; Hughes, CW; Irwin, GH; Preskorn, SH1
Kwok, YH; Mitchelson, F1
Erickson, CK; Goldman, ME1
Bowen, DM; Marek, KL1
McKearney, JW1
Danielson, ND; Holeman, JA1
Snape, WJ1
Herrema, I; Yung, M1
ASKEW, BM1
BOFF, E; SCHECKEL, CL1
DAVIS, MA; HERR, F; STEWART, J; SUNAHARA, FA; WINTHROP, SO1
LOEW, D; TAESCHLER, M1
Rowson, J; Squires, N; Wills, A1
de Carvalho, M; Gromicho, M; Pinto, S1

Reviews

4 review(s) available for atropine and amitriptyline

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Pharmacological studies of sleep and dreaming: chemical and clinical relationships.
    Biological psychiatry, 1969, Volume: 1, Issue:3

    Topics: Amitriptyline; Amphetamine; Antidepressive Agents; Atropine; Chloralose; Chlordiazepoxide; Chlorpromazine; Desipramine; Dextroamphetamine; Diazepam; Diphenhydramine; Dreams; Glutethimide; Humans; Hypnotics and Sedatives; Imipramine; Lysergic Acid Diethylamide; Meprobamate; Methaqualone; Morphine; Nialamide; Pentobarbital; Reserpine; Sleep; Sleep, REM; Tranquilizing Agents; Tranylcypromine; Triiodothyronine; Tryptophan

1969
Central adrenergic regulation of cerebral microvascular permeability and blood flow: pharmacologic evidence.
    Advances in experimental medicine and biology, 1980, Volume: 131

    Topics: Amitriptyline; Animals; Atropine; Brain; Capillary Permeability; Haplorhini; Microcirculation; Parasympatholytics; Rats; Sympathomimetics

1980
The management of drooling in adults with neurological conditions.
    Current opinion in otolaryngology & head and neck surgery, 2012, Volume: 20, Issue:3

    Topics: Administration, Cutaneous; Adult; Amitriptyline; Atropine; Behavior Therapy; Botulinum Toxins, Type A; Cerebral Palsy; Child; Cholinergic Antagonists; Cooperative Behavior; Deglutition Disorders; Glycopyrrolate; Humans; Interdisciplinary Communication; Motor Neuron Disease; Nervous System Diseases; Parkinson Disease; Patient Care Team; Salivary Glands; Scopolamine; Sialorrhea

2012

Other Studies

72 other study(ies) available for atropine and amitriptyline

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.
    Journal of medicinal chemistry, 1999, Aug-12, Volume: 42, Issue:16

    Topics: Animals; Binding Sites; Binding, Competitive; Brain; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ligands; Models, Molecular; Pyrilamine; Radioligand Assay; Structure-Activity Relationship; Tetrahydronaphthalenes

1999
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Tricyclic antidepressants and histamine H1 receptors.
    Mayo Clinic proceedings, 1979, Volume: 54, Issue:10

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Atropine; Benztropine; Cells, Cultured; Clozapine; Cyproheptadine; Desipramine; Doxepin; Haloperidol; Histamine H1 Antagonists; Hydroxyzine; Imipramine; Mice; Neoplasms, Experimental; Neuroblastoma; Nortriptyline; Protriptyline; Receptors, Histamine; Receptors, Histamine H1; Receptors, Muscarinic

1979
Mechanisms of amitriptyline induced hypothermia in the rat.
    Pharmacology, biochemistry, and behavior, 1977, Volume: 7, Issue:2

    Topics: Amitriptyline; Animals; Atropine; Body Temperature; Brain Chemistry; Bucladesine; Cyproheptadine; Depression, Chemical; Diphenhydramine; Fenclonine; Haloperidol; Male; Rats; Serotonin; Sympatholytics; Theophylline

1977
The effect of amitriptyline on presynaptic mechanisms in noradrenergic nerves.
    British journal of pharmacology, 1978, Volume: 63, Issue:2

    Topics: Amitriptyline; Animals; Atropine; Cocaine; Electric Stimulation; In Vitro Techniques; Male; Mice; Nervous System; Norepinephrine; Phentolamine; Vas Deferens

1978
Influence of some antidepressant drugs on the circulatory system: II. Action of amitriptyline and nortriptyline on basic circulatory parameters.
    Archivum immunologiae et therapiae experimentalis, 1975, Volume: 23, Issue:6

    Topics: Amitriptyline; Animals; Atropine; Cats; Dihydroergotamine; Hemodynamics; In Vitro Techniques; Muscle, Smooth; Myocardial Contraction; Norepinephrine; Nortriptyline; Propranolol; Quaternary Ammonium Compounds; Rabbits; Respiration

1975
Inhibitory effects of amitriptyline on the stimulation-induced Ca2+ increase in parotid acini.
    European journal of pharmacology, 1990, Feb-20, Volume: 177, Issue:1-2

    Topics: Amitriptyline; Animals; Atropine; Benzofurans; Calcium; Carbachol; Epinephrine; Fura-2; In Vitro Techniques; Kinetics; Light; Male; Parotid Gland; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Scattering, Radiation; Spectrometry, Fluorescence

1990
Salivatory effects induced by pirenzepine, atropine, metacine and hexamethonium in preganglionar chronically denervated human parotid gland.
    The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:12

    Topics: Adult; Amitriptyline; Atropine; Benzilates; Choline; Denervation; Female; Hexamethonium Compounds; Humans; Male; Middle Aged; Parasympatholytics; Parotid Gland; Pirenzepine; Salivation

1989
Non-selectivity of amitriptyline for subtypes of brain muscarinic receptors demonstrated in binding and functional assays.
    European journal of pharmacology, 1988, Nov-15, Volume: 157, Issue:1

    Topics: Amitriptyline; Animals; Atropine; Brain; Cerebral Cortex; Cyclic AMP; Drug Interactions; Hydrolysis; In Vitro Techniques; Kinetics; Male; Phosphatidylinositols; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic

1988
Neurotransmitters in "the smoke reflex" in rabbits.
    General pharmacology, 1987, Volume: 18, Issue:1

    Topics: Amitriptyline; Animals; Atropine; Clonidine; Heart Rate; Neurotransmitter Agents; Nicotiana; Norepinephrine; Plants, Toxic; Rabbits; Reflex; Smoke; Yohimbine

1987
Tricyclic antidepressant inhibition of the electrical evoked responses of the rat urinary bladder strip-effect of variation in extracellular Ca2+ concentration.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 284, Issue:2

    Topics: Amitriptyline; Animals; Atropine; Calcium; Desipramine; Drug Synergism; Electric Stimulation; Female; In Vitro Techniques; Male; Rats; Urinary Bladder

1986
Anticholinergic activity in the serum of patients receiving maintenance amitriptyline or doxepin therapy.
    Acta pharmacologica et toxicologica, 1985, Volume: 56, Issue:1

    Topics: Adult; Amitriptyline; Atropine; Binding Sites; Depression; Doxepin; Female; Humans; Kinetics; Male; Parasympatholytics; Radioligand Assay

1985
GABA blockade, dopamine and schizophrenia: experimental studies in the cat.
    Psychopharmacologia, 1974, Volume: 39, Issue:2

    Topics: Alkaloids; Aminobutyrates; Amitriptyline; Animals; Atropine; Behavior, Animal; Cats; Dextroamphetamine; Dihydroxyphenylalanine; Dioxoles; Dopamine; Electric Stimulation; Electroencephalography; GABA Antagonists; Haloperidol; Humans; Hydroxydopamines; Isoquinolines; Limbic System; Methacholine Compounds; Picrotoxin; Schizophrenia; Self Stimulation; Stereotaxic Techniques; Stereotyped Behavior; Substantia Nigra; Tegmentum Mesencephali

1974
Pharmacological studies of a new series of bicyclic thymoleptics.
    Acta pharmacologica et toxicologica, 1966, Volume: 24, Issue:2

    Topics: Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Atropine; Behavior, Animal; Benzofurans; Cocaine; Drug Antagonism; Drug Synergism; Guinea Pigs; Heterocyclic Compounds; Ileum; Indoles; Male; Methadone; Mice; Norepinephrine; Oxazines; Parasympatholytics; Polycyclic Compounds; Quinolines; Reserpine

1966
Prevention by antidepressant drugs of reserpine effect on pyridine nucleotide metabolism.
    Molecular pharmacology, 1966, Volume: 2, Issue:4

    Topics: Aminopyrine; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Atropine; Benactyzine; Caffeine; Chlorpheniramine; Chlorpromazine; Female; Hexobarbital; Hydralazine; Hypothalamus; Imipramine; Iproniazid; Isoniazid; Liver; Meprobamate; Methacholine Compounds; Morphine; NAD; Niacinamide; Pargyline; Pentobarbital; Phenylbutazone; Phenytoin; Quinacrine; Rats; Reserpine; Tranylcypromine; Tripelennamine; Zoxazolamine

1966
Protection of animals against soman (1,2,2-trimethylpropyl methylphosphono-fluoridate) by pretreatment with some other organophosphorus compounds, followed by oxime and atropine.
    Biochemical pharmacology, 1971, Volume: 20, Issue:1

    Topics: Amitriptyline; Animals; Atropine; Bromides; Carbamates; Cholinesterase Inhibitors; Diphosphates; Drug Antagonism; Female; Fluorine; Guinea Pigs; Hydroxamic Acids; Isoflurophate; Lethal Dose 50; Nitrates; Nitrophenols; Nitroso Compounds; Organophosphonates; Organophosphorus Compounds; Orphenadrine; Oximes; Parasympatholytics; Physostigmine; Poisoning; Pyridinium Compounds; Rabbits; Rats; Salicylates; Scopolamine; Species Specificity; Sulfonic Acids; Sulfuric Acids; Thiazoles; Time Factors

1971
Antagonism to reserpine induced depression by imipramine, related psychoactive drugs, and some autonomic agents.
    Psychopharmacologia, 1965, Feb-15, Volume: 7, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Behavior, Animal; Cyproheptadine; Desipramine; Diphenhydramine; Hallucinogens; Histamine H1 Antagonists; Imipramine; Lysergic Acid Diethylamide; Mice; Promazine; Psychopharmacology; Reserpine; Serotonin

1965
The intracerebral effects of noradrenaline and its modification by drugs in the mouse.
    The Journal of pharmacy and pharmacology, 1966, Volume: 18, Issue:9

    Topics: Amitriptyline; Animals; Antidepressive Agents; Ataxia; Atropine; Body Temperature; Brain; Central Nervous System; Chlordiazepoxide; Chlorpheniramine; Chlorpromazine; Diazepam; Drug Antagonism; Haloperidol; Histamine H1 Antagonists; Imipramine; Male; Mice; Norepinephrine; Nortriptyline; Pentobarbital; Phenytoin; Piperazines; Trihexyphenidyl

1966
Effect of antidepressant and adrenergic blocking drugs on hyperthermia induced by reserpine.
    Archives internationales de pharmacodynamie et de therapie, 1967, Volume: 165, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Body Temperature; Chlorisondamine; Chlorpromazine; Desipramine; Ethanolamines; Female; Fever; Hydrazines; Imipramine; Monoamine Oxidase Inhibitors; Norepinephrine; Nortriptyline; Phenoxybenzamine; Phentolamine; Propranolol; Rats; Reserpine; Sympatholytics; Tetrabenazine

1967
The pharmacology of iprindole, a new antidepressant.
    Psychopharmacologia, 1969, Volume: 15, Issue:3

    Topics: Acetylcholine; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Appetite; Atropine; Blepharoptosis; Blood Pressure; Body Temperature; Body Weight; Brain; Chlorpheniramine; Dogs; Drug Synergism; Electric Stimulation; Guanethidine; Guinea Pigs; Histamine H1 Antagonists; Ileum; Imipramine; In Vitro Techniques; Indoles; Liver; Male; Methamphetamine; Mice; Myocardium; Norepinephrine; Rats; Reserpine; Tritium; Vas Deferens

1969
Decreased distribution of oxotremorine to brain after pharmacological blockade of its peripheral acetylcholine-like effects.
    The Journal of pharmacy and pharmacology, 1971, Volume: 23, Issue:10

    Topics: Amitriptyline; Animals; Atropine; Blood Pressure; Body Temperature; Brain Chemistry; Kidney; Liver; Lung; Male; Pyrrolidinones; Rats; Time Factors; Tritium

1971
Significance of withdrawal jumping response in predicting physical dependence in mice.
    Japanese journal of pharmacology, 1973, Volume: 23, Issue:3

    Topics: Amitriptyline; Animals; Atropine; Cannabis; Chlordiazepoxide; Chlorpromazine; Diazepam; Humans; Imipramine; Male; Mephenesin; Methamphetamine; Mice; Morphine Dependence; Naloxone; Pentobarbital; Perphenazine; Phenytoin; Reserpine; Substance Withdrawal Syndrome

1973
Apomorphine provoked stereotype in the dog.
    Psychopharmacologia, 1972, Volume: 26, Issue:4

    Topics: Amitriptyline; Animals; Anisoles; Apomorphine; Atropine; Behavior, Animal; Benzamides; Benztropine; Diazepam; Diphenhydramine; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Ethylamines; Female; Fluphenazine; Haloperidol; Humans; Male; Methyltyrosines; Motor Activity; Phenoxybenzamine; Piperazines; Receptors, Drug; Scopolamine; Stereotyped Behavior; Xanthenes

1972
Propranolol in the treatment of cardiac arrhythmias associated with amitriptyline intoxication.
    The Journal of pediatrics, 1973, Volume: 82, Issue:1

    Topics: Amitriptyline; Arrhythmias, Cardiac; Atropine; Child, Preschool; Electrocardiography; Female; Humans; Injections, Intravenous; Perphenazine; Propranolol

1973
Antidepressants and liver tryptophan pyrrolase activity.
    Biochemical pharmacology, 1973, Jun-15, Volume: 22, Issue:12

    Topics: Adrenal Glands; Adrenalectomy; Amitriptyline; Animals; Antidepressive Agents; Atropine; Benactyzine; Chlorpromazine; Enzyme Induction; Female; Fluorometry; Haloperidol; Hydrocortisone; Hydroxysteroids; Imipramine; Liver; Male; Monoamine Oxidase Inhibitors; Pargyline; Phenelzine; Rats; Stress, Physiological; Time Factors; Tryptophan Oxygenase

1973
[Treatment of hallucinatory disorders in schizophrenia with atropine comas].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1973, Volume: 73, Issue:8

    Topics: Amitriptyline; Atropine; Chlorpromazine; Coma; Drug Therapy, Combination; Epinephrine; Hallucinations; Haloperidol; Histamine; Humans; Schizophrenia

1973
Death after E.C.T.
    British medical journal, 1974, Jul-06, Volume: 3, Issue:5922

    Topics: Amitriptyline; Atropine; Electroconvulsive Therapy; Female; Humans; Middle Aged; Psychotic Disorders

1974
A quantitative study of the anticholinergic action of several tricyclic antidepressants on the rat isolated fundal strip.
    British journal of pharmacology, 1972, Volume: 45, Issue:3

    Topics: Amitriptyline; Animals; Atropine; Carbachol; Desipramine; Dibenzocycloheptenes; Dimethylamines; Female; In Vitro Techniques; Mathematics; Muscle Contraction; Opipramol; Parasympatholytics; Rats; Stomach

1972
Delayed oxyphenylbutazone absorption by some tricyclic compounds in the rat.
    Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 192, Issue:2

    Topics: Absorption; Amitriptyline; Animals; Antidepressive Agents; Atropine; Chlorpromazine; Depression, Chemical; Dibenzocycloheptenes; Female; Methylamines; Opipramol; Oxyphenbutazone; Rats; Stomach; Time Factors

1971
Effects of amantadine and of some synthetic antiparkinsonian drugs on the behavioral response to L-DOPA in mice.
    Physiology & behavior, 1971, Volume: 6, Issue:4

    Topics: Amantadine; Amitriptyline; Animals; Antiparkinson Agents; Atropine; Behavior, Animal; Dihydroxyphenylalanine; Diphenhydramine; Drug Synergism; Imipramine; Mice; Orphenadrine; Parasympatholytics; Pargyline; Trihexyphenidyl

1971
Thin-layer chromatography of ion pairs on impregnated layers.
    Acta pharmaceutica Suecica, 1969, Volume: 6, Issue:4

    Topics: Alkaloids; Amitriptyline; Atropine; Chromatography, Thin Layer; Desipramine; Imipramine; Ions; Scopolamine

1969
Studies on interactions involving antidepressive and other drugs with tetrabenazine and noradnamine on locomotor activity in mice, including details of the experimental design and statistical analysis.
    Psychopharmacologia, 1970, Volume: 18, Issue:3

    Topics: Amitriptyline; Analysis of Variance; Animals; Atropine; Bretylium Compounds; Chlorpromazine; Cycloheptanes; Depression, Chemical; Dextroamphetamine; Dibenzocycloheptenes; Drug Antagonism; Ketones; Male; Mice; Motor Activity; Nialamide; Nortriptyline; Phentolamine; Tetrabenazine

1970
[Intraspecific aggressive behavior induced by apomorphine in the rat].
    Psychopharmacologia, 1970, Volume: 18, Issue:3

    Topics: Acepromazine; Age Factors; Aggression; Amitriptyline; Animals; Apomorphine; Atropine; Behavior, Animal; Caffeine; Chlordiazepoxide; Chlorpromazine; Dextroamphetamine; Diazepam; Drug Antagonism; Electroshock; Environment; Haloperidol; Humans; Hydroxyzine; Imipramine; Male; Meprobamate; Morphine; Rats; Reserpine; Sex Factors; Sound; Species Specificity; Thiazines; Thioridazine

1970
Cataleptic state and hypothermia in mice, caused by central cholinergic stimulation and antagonized by anticholinergic and antidepressant drugs.
    International journal of neuropharmacology, 1968, Volume: 7, Issue:4

    Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Catalepsy; Desipramine; Hexamethonium Compounds; Humans; Hypothermia; Imipramine; Male; Mice; Nicotine; Nicotinic Acids; Nitrophenols; Parasympatholytics; Parasympathomimetics; Phosphoric Acids; Pilocarpine; Pralidoxime Compounds; Scopolamine; Tremorine

1968
Clinical significance of anticholinergic effects of imipramine-like drugs.
    The American journal of psychiatry, 1969, Volume: 125, Issue:11

    Topics: Amitriptyline; Animals; Atropine; Columbidae; Depression; Desipramine; Diphenhydramine; Humans; Imipramine; Parasympatholytics; Scopolamine

1969
Potentiation of evoked cortical responses in the rabbit by methamphetamine and antidepressants.
    Life sciences, 1965, Volume: 4, Issue:11

    Topics: Amitriptyline; Animals; Atropine; Cerebral Cortex; Chlorpromazine; Drug Synergism; Electroencephalography; Electrophysiology; Imipramine; Methamphetamine; Rabbits; Scopolamine

1965
Pharmacological and biochemical studies in isolation-induced fighting mice.
    Psychopharmacologia, 1966, Volume: 9, Issue:3

    Topics: Aggression; Amitriptyline; Amphetamine; Analgesics; Animals; Anticonvulsants; Antidepressive Agents; Atropine; Behavior; Chlorpromazine; Diazepam; Fluphenazine; Humans; Hypnotics and Sedatives; Imipramine; Learning; Male; Meprobamate; Mice; Plants, Medicinal; Rauwolfia; Social Isolation; Tranquilizing Agents

1966
Effect of certain drugs upon amitriptyline induced electrocardiographic changes.
    Acta pharmacologica et toxicologica, 1966, Volume: 24, Issue:2

    Topics: Acetylcholine; Amitriptyline; Animals; Atropine; Blood Pressure; Bradycardia; Bundle-Branch Block; Electrocardiography; Epinephrine; Ergotamine; Female; Heart; Heart Rate; Lanatosides; Male; Neostigmine; Norepinephrine; Phentolamine; Plants, Medicinal; Procainamide; Propranolol; Pyridostigmine Bromide; Quinidine; Rabbits; Rauwolfia; Reserpine; Tachycardia

1966
Central anticholinergic activity of imipramine and allied drugs.
    Canadian journal of physiology and pharmacology, 1967, Volume: 45, Issue:2

    Topics: Amitriptyline; Animals; Atropine; Carbachol; Desipramine; Female; Imipramine; Male; Mice; Parasympatholytics; Seizures

1967
The postsynaptic effects of antidepressant drugs in the rat anococcygeus muscle.
    The Journal of pharmacy and pharmacology, 1981, Volume: 33, Issue:11

    Topics: Acetylcholine; Adrenergic alpha-Antagonists; Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Atropine; In Vitro Techniques; Male; Muscle, Smooth; Norepinephrine; Phentolamine; Rats; Rats, Inbred Strains; Synapses

1981
Effects of psychotropic drugs microinjected into the hypothalamus on muricide, catalepsy and cortical EEG in OB rats.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:3

    Topics: Aggression; Amitriptyline; Animals; Atropine; Cerebral Cortex; Chlordiazepoxide; Chlorpromazine; Evoked Potentials; Humans; Hypothalamus; Imipramine; Male; Motor Activity; Neural Inhibition; Norepinephrine; Olfactory Bulb; Psychotropic Drugs; Rats; Rats, Inbred Strains; Serotonin; Synaptic Transmission

1983
Effects of pharmacologic reductions in salivary flow on taste thresholds in man.
    Archives of oral biology, 1984, Volume: 29, Issue:1

    Topics: Adolescent; Adult; Amitriptyline; Atropine; Diphenhydramine; Female; Humans; Male; Saliva; Secretory Rate; Taste; Taste Threshold; Xerostomia

1984
Role of the central adrenergic system in mediating amitriptyline-induced alteration in the mammalian blood-brain barrier in vivo.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 223, Issue:2

    Topics: Amitriptyline; Animals; Atropine; Blood-Brain Barrier; Brain; Cerebrovascular Circulation; Hydroxydopamines; Hydroxyzine; Male; Neurons; Oxidopamine; Phenoxybenzamine; Rats; Rats, Inbred Strains; Serotonin

1982
The effect of amitriptyline, mianserin, and viloxazine at pre- and post-junctional muscarinic receptors in guinea-pig ileal longitudinal muscle.
    Canadian journal of physiology and pharmacology, 1982, Volume: 60, Issue:2

    Topics: Acetylcholine; Amitriptyline; Animals; Antidepressive Agents; Atropine; Carbachol; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mianserin; Muscle, Smooth; Oxotremorine; Receptors, Cholinergic; Receptors, Muscarinic; Viloxazine

1982
Atropine-amitriptyline interactions in the rat central cholinergic nervous system.
    Brain research, 1982, Sep-23, Volume: 248, Issue:1

    Topics: Amitriptyline; Animals; Atropine; Brain; Choline; Hippocampus; Male; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic

1982
Evidence for the pharmacological similarity between the central presynaptic muscarinic autoreceptor and postsynaptic muscarinic receptors.
    British journal of pharmacology, 1982, Volume: 75, Issue:2

    Topics: Acetylcholine; Amitriptyline; Animals; Atropine; Brain; Male; Oxotremorine; Rats; Rats, Inbred Strains; Receptors, Muscarinic

1982
Individual differences in effects of tricyclic antidepressants and anticholinergic drugs on operant behavior in the squirrel monkey.
    Life sciences, 1981, May-04, Volume: 28, Issue:18

    Topics: Amines; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Atropine; Behavior, Animal; Benztropine; Brain; Cebidae; Diphenhydramine; Male; Parasympatholytics; Saimiri

1981
Microbore liquid chromatography of tertiary amine anticholinergic pharmaceuticals with tris(2,2'-bipyridine)ruthenium(III) chemiluminescence detection.
    Journal of chromatographic science, 1995, Volume: 33, Issue:6

    Topics: 2,2'-Dipyridyl; Amines; Amitriptyline; Atropine; Butanones; Cholinergic Antagonists; Chromatography, High Pressure Liquid; Cyclopentolate; Dicyclomine; Hydrogen-Ion Concentration; Indicators and Reagents; Luminescent Measurements; Organometallic Compounds; Procyclidine; Scopolamine

1995
Managing the patient with atypical chest pain.
    Hospital practice (1995), 1997, Apr-15, Volume: 32, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Algorithms; Amitriptyline; Anti-Ulcer Agents; Atropine; Chest Pain; Cisapride; Diagnosis, Differential; Esophageal Motility Disorders; Esophagitis, Peptic; Female; Humans; Male; Manometry; Middle Aged; Parasympatholytics; Piperidines; Postprandial Period

1997
Persistent mydriasis following intravenous atropine in a neonate.
    Paediatric anaesthesia, 2000, Volume: 10, Issue:4

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Apnea; Atropine; Bronchodilator Agents; Drug Interactions; Female; Gastroschisis; Humans; Infant, Newborn; Injections, Intravenous; Male; Maternal-Fetal Exchange; Muscarinic Antagonists; Mydriasis; Oxygen Inhalation Therapy; Pregnancy

2000
A SIMPLE SCREENING PROCEDURE FOR IMIPRAMINE-LIKE ANTIDEPRESSANT AGENTS.
    Life sciences (1962), 1963, Volume: 10

    Topics: 5-Hydroxytryptophan; Amitriptyline; Amphetamine; Amphetamines; Antidepressive Agents; Atropine; Bemegride; Chlorpromazine; Diethylpropion; Dihydroxyphenylalanine; Epinephrine; Hypothermia; Hypothermia, Induced; Imipramine; Indoles; Iproniazid; Lysergic Acid Diethylamide; Mice; Morphine; Nialamide; Pentylenetetrazole; Pharmacology; Phenelzine; Promethazine; Research; Reserpine

1963
BEHAVIORAL EFFECTS OF INTERACTING IMIPRAMINE AND OTHER DRUGS WITH D-AMPHETAMINE, COCAINE, AND TETRABENAZINE.
    Psychopharmacologia, 1964, Feb-12, Volume: 5

    Topics: Amitriptyline; Atropine; Avoidance Learning; Chlorpromazine; Cocaine; Desipramine; Dextroamphetamine; Guanethidine; Imipramine; Iproniazid; Isocarboxazid; Methylphenidate; Parasympatholytics; Pharmacology; Piperidines; Promazine; Promethazine; Rats; Research; Scopolamine; Tetrabenazine; Trihexyphenidyl; Tyramine

1964
NEW PSYCHOTROPIC AGENTS. V. DERIVATIVES OF 5-CYANO- AND 5-CARBOXAMIDODIBENZO(A,D)CYCLOHEPTADIENE.
    Journal of medicinal chemistry, 1963, Volume: 6

    Topics: Amitriptyline; Anti-Allergic Agents; Antidepressive Agents; Ataxia; Atropine; Chemistry, Pharmaceutical; Cycloparaffins; Guinea Pigs; Histamine H1 Antagonists; Mice; Muscle Relaxants, Central; Mydriatics; Pharmacology; Promethazine; Psychotropic Drugs; Rats; Research; Toxicology

1963
[RESEARCH ON ANTICHOLINERGIC EFFECTS OF ANTIDEPRESSIVE SUBSTANCES IN THE RABBIT].
    Helvetica physiologica et pharmacologica acta, 1964, Volume: 64

    Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Bradycardia; Cholinergic Antagonists; Desipramine; Imipramine; Parasympatholytics; Pharmacology; Rabbits; Research; Salivation; Sialorrhea

1964
Sialorrhoea and reversals in ALS functional rating scale.
    Journal of neurology, neurosurgery, and psychiatry, 2017, Volume: 88, Issue:2

    Topics: Aged; Amitriptyline; Amyotrophic Lateral Sclerosis; Atropine; Cholinergic Antagonists; Deglutition Disorders; Female; Humans; Male; Middle Aged; Sialorrhea; Surveys and Questionnaires

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