Page last updated: 2024-09-05

atropine and amiodarone

atropine has been researched along with amiodarone in 36 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(amiodarone)
Trials
(amiodarone)
Recent Studies (post-2010) (amiodarone)
26,7111,2591,6978,1567431,889

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)amiodarone (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.27
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)1.085
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.404
Bile salt export pumpHomo sapiens (human)10
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)9.148
Tyrosine-protein kinase FynHomo sapiens (human)0.817
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.271
Muscarinic acetylcholine receptor M2Homo sapiens (human)5.08
Muscarinic acetylcholine receptor M4Homo sapiens (human)3.63
Muscarinic acetylcholine receptor M5Homo sapiens (human)1.499
Alpha-2A adrenergic receptorHomo sapiens (human)0.312
Thyroid hormone receptor alphaHomo sapiens (human)0.65
Thyroid hormone receptor betaHomo sapiens (human)0.6
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.613
Lethal factorBacillus anthracis3.5
Muscarinic acetylcholine receptor M3Homo sapiens (human)3.201
D(1A) dopamine receptorHomo sapiens (human)9.142
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.271
5-hydroxytryptamine receptor 2AHomo sapiens (human)3.59
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.404
Sodium-dependent serotonin transporterHomo sapiens (human)2.305
Melanocortin receptor 5Homo sapiens (human)9.497
D(3) dopamine receptorHomo sapiens (human)1.208
Sodium channel protein type 1 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 4 subunit alphaHomo sapiens (human)4.8
Squalene synthaseHomo sapiens (human)8
Delta-type opioid receptorHomo sapiens (human)8.014
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.923
Sodium channel protein type 7 subunit alphaHomo sapiens (human)4.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)1.085
Sodium-dependent dopamine transporter Homo sapiens (human)2.505
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)6.206
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)1.085
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)1.085
Sodium channel protein type 5 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 9 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 2 subunit alphaHomo sapiens (human)4.8
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.097
Sodium channel protein type 3 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 11 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 8 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 10 subunit alphaHomo sapiens (human)4.8

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19904 (11.11)18.7374
1990's1 (2.78)18.2507
2000's13 (36.11)29.6817
2010's18 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Budriesi, R; Chiarini, A; Ioan, P; Micucci, M; Novelli, F; Sparatore, A; Sparatore, F; Tasso, B; Tonelli, M; Vazzana, I1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Broustet, JP; Griffo, R; Guern, P; Laylavoix, F; Seriès, E1
Chamberlain, D; von Planta, M1
Antiu'fev, VF; Arkhipov, MV1
Pidrman, V; Pleskot, M; Tilser, P1
Liberman, BA; Teasdale, SJ1
Bellina, V; Dias Da Silva, VJ; Gnecchi-Ruscone, T; Lavelli, B; Malliani, A; Manzella, D; Montano, N; Porta, A1
Bleich, M; Brendel, J; Busch, AE; Knobloch, K; Rosenstein, B; Wirth, KJ1
Borel, CO; Lin, JA; Wang, WB; Wong, CS; Wu, CT; Yang, CP; Yeh, CC1
Chiribiri, A; Di Bella, G; Marte, F; Patanè, S1
Trappe, HJ1
Boyd, T; Brady, W1
Hollinger, MK; Rosini, JM1
Carron, PN; Pasquier, M; Santos, D; Yersin, B1
Mumma, BE; Umarov, T1
Andersen, LW; Berg, KM; Donnino, MW; Grossestreuer, AV; Moskowitz, A; Ross, CE1

Reviews

3 review(s) available for atropine and amiodarone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The "Code Drugs in Cardiac Arrest"--the use of cardioactive medications in cardiac arrest resuscitation.
    The American journal of emergency medicine, 2012, Volume: 30, Issue:5

    Topics: Advanced Cardiac Life Support; Amiodarone; Atropine; Cardiotonic Agents; Epinephrine; Heart Arrest; Humans; Lidocaine; Practice Guidelines as Topic; Resuscitation; Vasopressins

2012
EZ-IO(®) intraosseous device implementation in a pre-hospital emergency service: A prospective study and review of the literature.
    Resuscitation, 2013, Volume: 84, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amiodarone; Analgesics; Anti-Arrhythmia Agents; Atropine; Bronchodilator Agents; Child; Child, Preschool; Critical Illness; Crystalloid Solutions; Emergency Medical Services; Epinephrine; Female; Humans; Hypoglycemia; Infusions, Intraosseous; Isotonic Solutions; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Prospective Studies; Respiratory Distress Syndrome; Shock; Status Epilepticus; Tibia; Wounds and Injuries; Young Adult

2013

Other Studies

33 other study(ies) available for atropine and amiodarone

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water

2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Novel quinolizidinyl derivatives as antiarrhythmic agents: 2. Further investigation.
    Journal of medicinal chemistry, 2010, Jun-24, Volume: 53, Issue:12

    Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Electric Stimulation; Guinea Pigs; Heart; Heart Rate; Ileum; In Vitro Techniques; Muscle, Smooth; Myocardial Contraction; Platelet Aggregation Inhibitors; Quinolizidines; Receptor, Muscarinic M2; Stereoisomerism; Structure-Activity Relationship; Vasodilator Agents

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
[Prinzmetal's angina initiated by interruption of exercise. 5 cases with normal coronary radiograms].
    Archives des maladies du coeur et des vaisseaux, 1979, Volume: 72, Issue:4

    Topics: Adult; Amiodarone; Angina Pectoris; Angina Pectoris, Variant; Atropine; Coronary Angiography; Coronary Disease; Exercise Test; Humans; Male; Middle Aged; Nifedipine

1979
Drug treatment of arrhythmias during cardiopulmonary resuscitation. A statement for the Advanced Life Support Working Party of the European Resuscitation Council.
    Resuscitation, 1992, Volume: 24, Issue:3

    Topics: Amiodarone; Animals; Arrhythmias, Cardiac; Atropine; Bretylium Compounds; Calcium; Cardiopulmonary Resuscitation; Combined Modality Therapy; Electric Countershock; Humans; Lidocaine; Magnesium; Ventricular Fibrillation

1992
[Anti-arrhythmic activity of atropine, ritmilen, obsidan and cordarone in patients with ventricular allorhythmia].
    Klinicheskaia meditsina, 1989, Volume: 67, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Amiodarone; Anti-Arrhythmia Agents; Atropine; Cardiac Complexes, Premature; Disopyramide; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Propranolol

1989
[Combinations of anti-arrhythmia agents and the heart conduction system].
    Vnitrni lekarstvi, 1988, Volume: 34, Issue:1

    Topics: Aged; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atropine; Drug Therapy, Combination; Electrocardiography; Female; Heart Conduction System; Heart Rate; Humans; Male; Metaproterenol; Middle Aged

1988
Anaesthesia and amiodarone.
    Canadian Anaesthetists' Society journal, 1985, Volume: 32, Issue:6

    Topics: Adult; Aged; Amiodarone; Anesthesia, General; Anesthetics; Atropine; Benzofurans; Bradycardia; Cardiac Output; Drug Interactions; Female; Heart Block; Humans; Male; Middle Aged; Retrospective Studies

1985
Opposite effects of iv amiodarone on cardiovascular vagal and sympathetic efferent activities in rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 283, Issue:2

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atropine; Autonomic Fibers, Preganglionic; Baroreflex; Bradycardia; Cardiovascular System; Decerebrate State; Efferent Pathways; Hypotension; Injections, Intravenous; Muscarinic Antagonists; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Vagus Nerve

2002
Atrial-selective antiarrhythmic actions of novel Ikur vs. Ikr, Iks, and IKAch class Ic drugs and beta blockers in pigs.
    Medical science monitor : international medical journal of experimental and clinical research, 2004, Volume: 10, Issue:7

    Topics: Adrenergic beta-Antagonists; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Function; Atropine; Biphenyl Compounds; Chromans; Flecainide; Heart Atria; Hydantoins; Imidazoles; Imidazolidines; Male; Phenethylamines; Piperazines; Potassium Channel Blockers; Potassium Channels; Propafenone; Propanolamines; Sotalol; Sulfonamides; Swine; Ventricular Function

2004
Anesthetic management of an AAI pacemaker patient with paroxysmal atrial fibrillation during colorectal surgery.
    Journal of clinical anesthesia, 2006, Volume: 18, Issue:5

    Topics: Aged; Amiodarone; Anesthesia, General; Anti-Arrhythmia Agents; Atrial Fibrillation; Atropine; Bradycardia; Calcium Gluconate; Cardiotonic Agents; Colorectal Surgery; Dopamine; Electric Countershock; Epinephrine; Fatal Outcome; Female; Heart Arrest; Heart Massage; Humans; Hypotension; Intraoperative Complications; Multiple Organ Failure; Pacemaker, Artificial; Tachycardia, Ventricular; Vasoconstrictor Agents

2006
Conduction disturbances and paroxysmal atrial fibrillation during acute inferior myocardial infarction.
    International journal of cardiology, 2008, Sep-26, Volume: 129, Issue:2

    Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Atrial Fibrillation; Atropine; Cortisone; Heart Conduction System; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Nitrates; Platelet Aggregation Inhibitors; Potassium

2008
[Life-threatening brady- and tachyarrhythmias].
    Der Internist, 2010, Volume: 51, Issue:8

    Topics: Adenosine; Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atropine; Bradycardia; Defibrillators, Implantable; Electric Countershock; Electrocardiography; Emergencies; Epinephrine; Heart Rate; Humans; Pacemaker, Artificial; Signal Processing, Computer-Assisted; Tachycardia

2010
Advanced cardiac life support: what's new, what's old?
    Journal of emergency nursing, 2012, Volume: 38, Issue:4

    Topics: Advanced Cardiac Life Support; Amiodarone; Anti-Arrhythmia Agents; Atropine; Epinephrine; History, 20th Century; Humans; Muscarinic Antagonists; Practice Guidelines as Topic; Sympathomimetics

2012
Sex differences in the prehospital management of out-of-hospital cardiac arrest.
    Resuscitation, 2016, Volume: 105

    Topics: Aged; Aged, 80 and over; Amiodarone; Arrhythmias, Cardiac; Atropine; Cardiopulmonary Resuscitation; Databases, Factual; Emergency Medical Services; Epinephrine; Female; Humans; Lidocaine; Logistic Models; Male; Middle Aged; Multivariate Analysis; Out-of-Hospital Cardiac Arrest; Practice Guidelines as Topic; Retrospective Studies; Sex Factors; Time-to-Treatment

2016
Trends Over Time in Drug Administration During Adult In-Hospital Cardiac Arrest.
    Critical care medicine, 2019, Volume: 47, Issue:2

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atropine; Bicarbonates; Calcium; Epinephrine; Female; Glucose; Guideline Adherence; Heart Arrest; Hospitalization; Humans; Lidocaine; Logistic Models; Magnesium; Male; Middle Aged; Odds Ratio; Practice Guidelines as Topic; Practice Patterns, Physicians'; Vasoconstrictor Agents; Vasopressins

2019