Page last updated: 2024-09-05

atropine and amantadine

atropine has been researched along with amantadine in 37 studies

Compound Research Comparison

Studies (atropine)	Trials (atropine)	Recent Studies (post-2010) (atropine)	Studies (amantadine)	Trials (amantadine)	Recent Studies (post-2010) (amantadine)
26,711	1,259	1,697	4,110	515	753

Protein Interaction Comparison

Protein	Taxonomy	atropine (IC50)	amantadine (IC50)
Matrix protein 2	Influenza A virus (A/udorn/1972(H3N2))		4.7

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (45.95)	18.7374
1990's	3 (8.11)	18.2507
2000's	9 (24.32)	29.6817
2010's	7 (18.92)	24.3611
2020's	1 (2.70)	2.80

Authors

Authors	Studies
Dekker, TG; Fourie, TG; Oliver, DW; Snyckers, FO	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Glen, RC; Lowe, R; Mitchell, JB	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Daniel Falcón, H	1
Borsy, J; Dunai-Kovács, Z; Székely, JI	1
Bermanzohn, PC; Lipper, S	1
Onodera, K; Shinoda, H	1
Gupta, RC; Kadel, WL	1
Bianchi, C; Tomasi, L	1
Gressier, H; Malecot, E; Poignant, JC	1
Costall, B; Naylor, RJ	1
Shibasaki, H	1
Dulska, E; Lacki, M; Wolfarth, S	1
Grossmann, W; Jurna, I; Nell, T; Ruzdić, N	1
Ahtee, L; Kääriäinen, I; Paasonen, MK	1
Cates, LA; Cramer, MB; Gallio, RL	1
Florio, V; Longo, VG	1
Clark, R; Grelak, RP; Stump, JM; Vernier, VG	1
Link, F	1
Manten, A	1
Fincke, M; Gothóni, P; Lehtinen, M	1
Ferraz, MR; Santos, R	1
Adotevi, N; Dabrowska, N; Joshi, S; Kapur, J; Lewczuk, E; Shan, S; Sun, H; Williamson, J	1

Reviews

2 review(s) available for atropine and amantadine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Parkinson's syndrome. Recent progress in the medical treatment and its pharmacological basis. Minnesota medicine, 1971, Volume: 54, Issue:10 Topics: Amantadine; Atropine; Catecholamines; Dihydroxyphenylalanine; Histamine H1 Antagonists; Humans; Imipramine; Parkinson Disease; Tryptophan	1971

Other Studies

35 other study(ies) available for atropine and amantadine

Article	Year
Synthesis and biological activity of D3-trishomocubyl-4-amines. Journal of medicinal chemistry, 1991, Volume: 34, Issue:2 Topics: Animals; Antiparkinson Agents; Bridged-Ring Compounds; Catalepsy; Chemical Phenomena; Chemistry; Male; Mice; Stereoisomerism; Structure-Activity Relationship	1991
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
[Collateral effects of antiparkinsonian agents used in psychiatry]. Neurologia, neurocirugia, psiquiatria, 1976, Volume: 17, Issue:1 Topics: Amantadine; Antiparkinson Agents; Atropine; Atropine Derivatives; Benztropine; Brain; Histamine H1 Antagonists; Humans; Phenothiazines; Respiration; Scopolamine	1976
The effect of anti-parkinsonian drugs on chlorpromazine-induced depression of operant behaviour. Pharmacology, 1976, Volume: 14, Issue:3 Topics: Amantadine; Animals; Antiparkinson Agents; Apomorphine; Atropine; Behavior, Animal; Chlorpromazine; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Phenothiazines; Rats; Trihexyphenidyl	1976
Letter: Electroconvulsive therapy in patients with parkinsonism. The American journal of psychiatry, 1975, Volume: 132, Issue:4 Topics: Amantadine; Atropine; Depression; Diphenhydramine; Electroconvulsive Therapy; Female; Humans; Levodopa; Methohexital; Middle Aged; Parkinson Disease; Succinylcholine; Suicide	1975
Pharmacological characteristics of catalepsy induced by intracerebroventricular administration of histamine in mice: the importance of muscarinic step in central cholinergic neurons. Agents and actions, 1991, Volume: 33, Issue:1-2 Topics: Amantadine; Animals; Atropine; Biperiden; Bromocriptine; Catalepsy; Histamine; Injections, Intraventricular; Levodopa; Male; Mice; Neurons; Promethazine; Receptors, Muscarinic; Scopolamine; Trihexyphenidyl	1991
Prevention and antagonism of acute carbofuran intoxication by memantine and atropine. Journal of toxicology and environmental health, 1989, Volume: 28, Issue:1 Topics: Acetylcholinesterase; Amantadine; Animals; Atropine; Carbofuran; Carboxylesterase; Carboxylic Ester Hydrolases; Chemical Phenomena; Chemistry; Cholinesterase Inhibitors; Drug Antagonism; Drug Synergism; Insecticides; Male; Memantine; Rats; Rats, Inbred Strains	1989
Central nervous system and autonomic nervous system effects of amantadine and of some standard anti-Parkinson drugs. Pharmacology, 1973, Volume: 10, Issue:4 Topics: Amantadine; Animals; Antiparkinson Agents; Atropine; Autonomic Nervous System; Body Temperature; Carbachol; Central Nervous System; Dihydroxyphenylalanine; Drug Interactions; Gastrointestinal Motility; Male; Mecamylamine; Mice; Mydriatics; Nicotine; Oxotremorine; Phenothiazines; Pupil; Rats; Trihexyphenidyl	1973
Comparative effects of apomorphine, piribedil and other neurotropic agents on central analgesic-induced catatonia in the rat. European journal of pharmacology, 1974, Volume: 29, Issue:1 Topics: Amantadine; Analgesics, Opioid; Animals; Antiparkinson Agents; Apomorphine; Atropine; Benserazide; Benzyl Compounds; Catatonia; Dextroamphetamine; Dextromoramide; Dihydroxyphenylalanine; Dioxoles; Dose-Response Relationship, Drug; Humans; Male; Morphine; Piperazines; Pyrimidines; Rats; Time Factors; Trihexyphenidyl	1974
Dopamine agonist and antagonist activities of piribedil (ET495)and its metabolites. Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 285, Issue:1 Topics: Amantadine; Amphetamine; Animals; Apomorphine; Atropine; Behavior, Animal; Caudate Nucleus; Dextroamphetamine; Dioxoles; Dopamine; Dopamine Antagonists; Drug Synergism; Haloperidol; Humans; Injections; Male; Methylphenidate; Motor Activity; Nialamide; Piperazines; Pyrimidines; Rats; Stereotyped Behavior; Sulfites	1974
Comparison of the effects of the intranigral injections of cholinomimetics with systemic injections of the dopamine receptor stimulating and blocking agents in the rabbit. Neuropharmacology, 1974, Volume: 13, Issue:9 Topics: Acetylcholine; Amantadine; Animals; Apomorphine; Atropine; Caudate Nucleus; Cerebral Cortex; Depression, Chemical; Electrodes, Implanted; Electroencephalography; Hippocampus; Humans; Injections; Locomotion; Methacholine Compounds; Neostigmine; Parasympathomimetics; Rabbits; Receptors, Cholinergic; Spirostans; Stereotyped Behavior; Stimulation, Chemical; Substantia Nigra; Time Factors	1974
The effect of -methyl-p-tyrosine and substantia nigra lesions on spinal motor activity in the rat. European journal of pharmacology, 1972, Volume: 20, Issue:3 Topics: Action Potentials; Amantadine; Animals; Atropine; Dihydroxyphenylalanine; Electrocoagulation; Electromyography; Hydroxydopamines; Methamphetamine; Methyltyrosines; Microinjections; Motor Activity; Motor Neurons; Rats; Reflex; Spinal Nerves; Substantia Nigra	1972
Effect of nalorphine and antiparkinsonian drugs on methadone-induced rigidity; relation to homovanillic acid content of nucleus caudatus. Annales medicinae experimentalis et biologiae Fenniae, 1972, Volume: 50, Issue:4 Topics: Amantadine; Animals; Atropine; Body Temperature; Brain; Caudate Nucleus; Depression, Chemical; Dose-Response Relationship, Drug; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Methadone; Muscle Rigidity; Muscle Tonus; Nalorphine; Parasympatholytics; Phenylacetates; Rats; Serotonin; Spectrometry, Fluorescence; Trihexyphenidyl	1972
Phosphorus--nitrogen compounds. XV. N-1-adamantylphosphoramidic dichloride and dimethyl and diphenyl N-1-adamantylphosphoramidate. Journal of pharmaceutical sciences, 1973, Volume: 62, Issue:10 Topics: Amantadine; Animals; Antiparkinson Agents; Atropine; Guinea Pigs; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred Strains; Motor Activity; Organophosphorus Compounds; Oxotremorine; Perphenazine; Spectrophotometry, Infrared; Tremorine	1973
Effects of amantadine and of some synthetic antiparkinsonian drugs on the behavioral response to L-DOPA in mice. Physiology & behavior, 1971, Volume: 6, Issue:4 Topics: Amantadine; Amitriptyline; Animals; Antiparkinson Agents; Atropine; Behavior, Animal; Dihydroxyphenylalanine; Diphenhydramine; Drug Synergism; Imipramine; Mice; Orphenadrine; Parasympatholytics; Pargyline; Trihexyphenidyl	1971
Amantadine-dopamine interaction: possible mode of action in Parkinsonism. Science (New York, N.Y.), 1970, Jul-10, Volume: 169, Issue:3941 Topics: Acetylcholine; Amantadine; Animals; Atropine; Dogs; Dopamine; Neurons; Parkinson Disease; Stimulation, Chemical; Vagotomy	1970
[Chemotherapy of viral diseases]. Schweizerische medizinische Wochenschrift, 1967, Jul-01, Volume: 97, Issue:26 Topics: Amantadine; Antiviral Agents; Atropine; Biguanides; Humans; Idoxuridine; Scopolamine; Thiosemicarbazones; Virus Diseases	1967
[Chemoprofylaxis of influenza]. Nederlands tijdschrift voor geneeskunde, 1968, Jun-22, Volume: 112, Issue:25 Topics: Amantadine; Animals; Antiviral Agents; Atropine; Biguanides; Humans; Influenza, Human; Mice; Scopolamine	1968
Drugs for Parkinson's disease reduce tremor induced by physostigmine. Naunyn-Schmiedeberg's archives of pharmacology, 1983, Volume: 323, Issue:3 Topics: Amantadine; Animals; Antiparkinson Agents; Atropine; Biperiden; Bromocriptine; Male; Physostigmine; Pimozide; Rats; Rats, Inbred Strains; Tremor	1983
Amantadine stimulates sexual behavior in male rats. Pharmacology, biochemistry, and behavior, 1995, Volume: 51, Issue:4 Topics: Amantadine; Animals; Atropine; Copulation; Cordotomy; Ejaculation; Haloperidol; Male; Penile Erection; Rats; Rats, Wistar; Sexual Behavior, Animal; Stimulation, Chemical	1995
α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Plasticity Sustains Severe, Fatal Status Epilepticus. Annals of neurology, 2020, Volume: 87, Issue:1 Topics: Adamantane; Amantadine; Animals; Atropine; CA1 Region, Hippocampal; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gene Knockdown Techniques; Hippocampus; Male; Mice; Mice, Knockout; Neuronal Plasticity; Receptors, AMPA; Status Epilepticus; Synaptic Transmission	2020