Page last updated: 2024-09-05

atropine and acetaminophen

atropine has been researched along with acetaminophen in 45 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(acetaminophen)
Trials
(acetaminophen)
Recent Studies (post-2010) (acetaminophen)
26,7111,2591,69720,6962,8488,242

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)acetaminophen (IC50)
MyoglobinHomo sapiens (human)2.3

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-199012 (26.67)18.7374
1990's5 (11.11)18.2507
2000's16 (35.56)29.6817
2010's12 (26.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Duffy, EM; Jorgensen, WL1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Lombardo, F; Obach, RS; Waters, NJ1
Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Kaźmierczyk, J1
Booker, PD; Chapman, DH1
Gawrońska-Szklarz, B; Kazimierczyk, J; Wójcicki, J1
Kawazoe, Y; Mizuta, H; Ogawa, K1
Meyer, EC; Moncrieff, J; Sommers, DK; van Wyk, M1
Bateman, DN; Rashid, MU1
Ganshorn, A; Kurz, H1
Cantor, M1
Flores Mercado, F; Gallegos Torres, J1
Burke, D; Senkowski, BZ; Venturella, VS1
Boyd, EM1
Guillory, JK; Hwang, SC; Lach, JL1
Clark, JM; Seager, SJ1
Lacouture, PG; Lovejoy, FH; Mitchell, AA1
Aoyagi, N; Katori, N; Kojima, S1
Andrews, FM; Doherty, TJ; Frazier, DL; Provenza, MK1
COLLIER, HO; SHORLEY, PG1
Green, R; Sitar, DS; Tenenbein, M1
Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM1
Beccaria, P; Cabrini, L; Colombo, S; Garancini, MP1
Ehsani-Kheradgerdi, A; Grünberg, W; Mohri, M; Sharifi, K1
Akhileswaran, R; Heng, CP; Hui, D; Tan, A; Yap, R1
Boncler, M; Dastych, J; Golanski, J; Lukasiak, M; Watala, C1

Reviews

2 review(s) available for atropine and acetaminophen

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Pharmacokinetics of interaction of N-acetyl-P-aminophenol with the drugs affecting the secretory and motor activity of the alimentary tract].
    Annales Academiae Medicae Stetinensis, 1979, Volume: 25

    Topics: Acetaminophen; Atropine; Biotransformation; Calcium Carbonate; Drug Interactions; Ethanol; Gastric Mucosa; Gastrointestinal Motility; Humans; Hydrochloric Acid; Kinetics; Male; Neostigmine; Papaverine; Pituitary Gland, Posterior; Tissue Extracts

1979

Trials

5 trial(s) available for atropine and acetaminophen

ArticleYear
Premedication in children undergoing day-care surgery.
    British journal of anaesthesia, 1979, Volume: 51, Issue:11

    Topics: Acetaminophen; Administration, Oral; Antipyrine; Atropine; Child; Child, Preschool; Chloral Hydrate; Day Care, Medical; Humans; Infant; Injections, Intramuscular; Morphine; Postoperative Complications; Premedication; Surgical Procedures, Operative

1979
Effect of intravenous atropine on gastric emptying, paracetamol absorption, salivary flow and heart rate in young and fit elderly volunteers.
    British journal of clinical pharmacology, 1990, Volume: 30, Issue:1

    Topics: Acetaminophen; Adult; Aged; Aging; Atropine; Dose-Response Relationship, Drug; Double-Blind Method; Gastric Emptying; Gastrointestinal Motility; Half-Life; Heart Rate; Humans; Intestinal Absorption; Middle Aged; Physical Fitness; Salivation; Ultrasonics

1990
[Use of Mesindol in dysmenorrhea].
    Ginecologia y obstetricia de Mexico, 1972, Volume: 32, Issue:193

    Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Atropine; Caffeine; Clinical Trials as Topic; Drug Combinations; Dysmenorrhea; Female; Humans; Placebos; Salicylamides

1972
Gastric emptying following premedication with glycopyrrolate or atropine.
    British journal of anaesthesia, 1983, Volume: 55, Issue:12

    Topics: Acetaminophen; Adolescent; Adult; Atropine; Double-Blind Method; Female; Gastric Emptying; Glycopyrrolate; Humans; Preanesthetic Medication; Pregnancy; Pregnancy Trimester, First; Pyrrolidines

1983
Effect of anticholinergic drugs on the efficacy of activated charcoal.
    Journal of toxicology. Clinical toxicology, 2004, Volume: 42, Issue:3

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Antidotes; Area Under Curve; Atropine; Biological Availability; Charcoal; Cholinergic Antagonists; Cross-Over Studies; Drug Interactions; Female; Half-Life; Heart Rate; Humans; Intestinal Absorption; Male

2004

Other Studies

38 other study(ies) available for atropine and acetaminophen

ArticleYear
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water

2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Determination of log D via automated microfluidic liquid-liquid extraction.
    Journal of medicinal chemistry, 2008, Aug-28, Volume: 51, Issue:16

    Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
[Effect of atropine on the absorption of paracetamol from the digestive tract of healthy subjects].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1977, Jul-18, Volume: 32, Issue:29

    Topics: Acetaminophen; Adult; Atropine; Humans; Intestinal Absorption; Male

1977
Effect of small intestinal transit time on gastrointestinal absorption of 2-[3-(3,5-di-tert-butyl-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-1-yl ] ethyl acetate, a new non-steroidal anti-inflammatory agent.
    Chemical & pharmaceutical bulletin, 1990, Volume: 38, Issue:10

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Dogs; Gastrointestinal Transit; Intestinal Absorption; Male; Pyrazoles; Pyridines

1990
The mean cumulative fraction absorbed-time profiles of paracetamol as an index of gastric emptying.
    Methods and findings in experimental and clinical pharmacology, 1990, Volume: 12, Issue:4

    Topics: Acetaminophen; Adult; Atropine; Biological Availability; Gastric Emptying; Humans; Intestinal Absorption; Male; Metoclopramide; Neostigmine; Pirenzepine

1990
[Differences between the protein binding of newborns and adults and their importance for pharmacological action].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, Volume: 260, Issue:2

    Topics: Acetaminophen; Age Factors; Aminosalicylic Acids; Atropine; Chloramphenicol; Humans; Infant, Newborn; Isoniazid; Methicillin; Morphine; Nitrofurantoin; Oxyphenbutazone; Phenacetin; Phenobarbital; Phenytoin; Promethazine; Protein Binding; Salicylates; Sulfadimethoxine; Thiopental

1968
A comparison of propoxyphene HCl (Darvon) and an analgesic mixture (Percogesic) in pain relief after gingivectomy.
    Journal of oral therapeutics and pharmacology, 1967, Volume: 4, Issue:3

    Topics: Acetaminophen; Adult; Analgesics; Atropine; Caffeine; Dextropropoxyphene; Female; Gingivectomy; Histamine H1 Antagonists; Humans; Male; Middle Aged; Pain

1967
Selective determination of phenylpropanolamine hydrochloride in pharmaceutical dosage forms by reaction with ninhydrin.
    Journal of pharmaceutical sciences, 1974, Volume: 63, Issue:2

    Topics: Acetaminophen; Aspirin; Atropine; Benzaldehydes; Capsules; Chlorpheniramine; Chromatography, Gas; Chromatography, Ion Exchange; Colorimetry; Cyanides; Ethanol; Hydrochloric Acid; Hydrogen-Ion Concentration; Indicators and Reagents; Mathematics; Methods; Oxidation-Reduction; Phenylpropanolamine; Spectrophotometry; Tablets; Time Factors

1974
100-day LD 50 index of chronic toxicity.
    Clinical toxicology, 1971, Volume: 4, Issue:2

    Topics: Acetaminophen; Administration, Oral; Animals; Aspirin; Atropine; Caffeine; DDT; Drug-Related Side Effects and Adverse Reactions; Intubation, Gastrointestinal; Lethal Dose 50; Penicillin G; Phenacetin; Pilocarpine; Rats; Sodium Chloride; Sucrose; Time Factors

1971
Interactions between pharmaceutical compounds by thermal methods.
    Journal of pharmaceutical sciences, 1969, Volume: 58, Issue:3

    Topics: Acetaminophen; Aspirin; Atropine; Bile Acids and Salts; Caffeine; Drug Compounding; Drug Incompatibility; Drug Stability; Methods; Phenacetin; Phenobarbital; Phenytoin; Quinine; Temperature; Theophylline; Thermodynamics; Time Factors; Vitamin K

1969
Acute hypothermia associated with atropine.
    American journal of diseases of children (1960), 1983, Volume: 137, Issue:3

    Topics: Acetaminophen; Adolescent; Atropine; Humans; Hypothermia; Male

1983
Effects of atropine and loperamide on the agitating force and GI transit time in dogs in drug absorption studies.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:10

    Topics: Acetaminophen; Animals; Atropine; Dogs; Drug Delivery Systems; Gastrointestinal Transit; Intestinal Absorption; Loperamide; Male

1996
Acetaminophen as a marker of gastric emptying in ponies.
    Equine veterinary journal, 1998, Volume: 30, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Antiemetics; Area Under Curve; Atropine; Erythromycin; Gastric Emptying; Horses; Metoclopramide; Parasympatholytics; Sympatholytics; Yohimbine

1998
Analgesic antipyretic drugs as antagonists of bradykinin.
    British journal of pharmacology and chemotherapy, 1960, Volume: 15

    Topics: Acetaminophen; Acetylcholine; Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Aspirin; Atropine; Bradykinin; Guinea Pigs; Histamine; Ileum; Kallikreins; Lysergic Acid Diethylamide; Morphine; Phenacetin; Phthalic Acids; Rats; Serotonin

1960
Isobolographic analysis of multimodal analgesia in an animal model of visceral acute pain.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 88, Issue:4

    Topics: Acetaminophen; Acute Disease; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Behavior, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Ketoprofen; Male; Mice; Morphine; Muscarinic Antagonists; Naltrexone; Narcotic Antagonists; Pain; Prazosin

2008
Recurarisation in a surgical ward.
    Anaesthesia and intensive care, 2008, Volume: 36, Issue:6

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous; Atracurium; Atropine; Bradycardia; Bronchodilator Agents; Cholinesterase Inhibitors; Diplopia; Equipment Design; Fentanyl; Humans; Male; Medication Errors; Neostigmine; Neuromuscular Nondepolarizing Agents; Postoperative Complications; Propofol; Respiration, Artificial; Respiratory Insufficiency

2008
Evaluation of a modified acetaminophen absorption test to estimate the abomasal emptying rate in Holstein-Friesian heifers.
    American journal of veterinary research, 2011, Volume: 72, Issue:12

    Topics: Abomasum; Absorption; Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Area Under Curve; Atropine; Cattle; Cross-Over Studies; Female; Gastric Emptying; Infusions, Intravenous; Infusions, Subcutaneous; Intestinal Absorption; Metoclopramide; Parasympatholytics; Veterinary Medicine

2011
Comfort care kit: use of nonoral and nonparenteral rescue medications at home for terminally ill patients with swallowing difficulty.
    Journal of palliative medicine, 2014, Volume: 17, Issue:5

    Topics: Acetaminophen; Adjuvants, Anesthesia; Administration, Rectal; Administration, Sublingual; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Antipsychotic Agents; Atropine; Caregivers; Deglutition Disorders; Female; Haloperidol; Home Care Services; Humans; Lorazepam; Male; Middle Aged; Morphine; Palliative Care; Pilot Projects; Singapore; Terminally Ill

2014
Differentiated mitochondrial function in mouse 3T3 fibroblasts and human epithelial or endothelial cells in response to chemical exposure.
    Basic & clinical pharmacology & toxicology, 2019, Volume: 124, Issue:2

    Topics: 3T3-L1 Cells; A549 Cells; Acetaminophen; Animals; Atropine; Caco-2 Cells; Cell Count; Cell Survival; Cobalt; Endothelial Cells; Ethanol; Hep G2 Cells; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Propranolol

2019