atrial-natriuretic-factor and dynorphin-amide-(1-10)

Intravenous injection of dynorphin A-(1-10) amide (Dyn, 81-324 nmol/kg) induced a dose-dependent hypotensive effect in the rat. This effect was antagonized by pretreatment with immunoglobulin G, purified from a specific antiserum raised against alpha-human atrial natriuretic peptide (anti-hANP-IgG), as well as by high doses of naloxone (2 or 10 mg/kg). In addition, a 12-fold increase in plasma level of atrial natriuretic peptide-like immunoreactivity (ANP-IR) was found following Dyn administration, which was accompanied by a significant decrease of atrial ANP-IR. These results suggest that the stimulated release of ANP-IR from the atrium may constitute one of the mechanisms for the depressor effect of dynorphin peptides.

Topics: Animals; Atrial Natriuretic Factor; Dose-Response Relationship, Drug; Dynorphins; Heart Atria; Hypotension; Immunoglobulin G; Male; Myocardium; Peptide Fragments; Rats; Rats, Inbred Strains; Time Factors

Topics: Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Dynorphins; Male; Peptide Fragments; Rats; Rats, Inbred Strains

Topics: Animals; Atrial Natriuretic Factor; Dynorphins; Heart; Male; Myocardium; Peptide Fragments; Radioimmunoassay; Rats; Rats, Inbred Strains